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Molecular Diagnosis Of Malaria, Veerachai Eursitthichai

Asian Medical Journal and Alternative Medicine

Malaria is an important infectious disease and causes severe public health problems in many tropicalcountries including Thailand. An effective diagnosis to discriminate the various Plasmodium species is needed toselect the proper regimen for malarial treatment. Diagnosis of malaria by thick or thin blood films under the lightmicroscope is the gold standard. The limitations of this technique are low sensitivity (5-20 parasites/μl) and theneed for an experienced examiner able to discriminate the Plasmodium species. Diagnosis can also be based onthe detection of circulating antibodies and antigens. The sensitivity of the immuno-chromatographical test (ICT)in detection of antigen is 100 parasites/μl. Nucleic acid …

Jefferson Alumni Bulletin – Volume 59, Number 3, Summer 2010

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 59, Number 3, Summer 2010

Dean's Message, page 2

Findings: Researchers Find Breast Tumor Suppressor, page 4

Computational Biology: Turning Data into Knowledge, page 6

Entire Back File of Jefferson Alumni Bulletins Available Online, page 10

Healthcare Reform: What Does it Mean for Physicians and Medical Students?, page 12

Faculty Profile: Janet Larson: Pioneering Fetal Gene Technologies, page 18

On Campus, page 20

Class Notes, page 26

In Memoriam, page 30

By the Numbers, page 33

2010 July, Office Of Communications & Marketing, Morehead State University.

Morehead State Press Release Archive, 1961 to the Present

Press releases for July of 2010.

Release Of Hmgb1 In Response To Pro-Apoptotic Glioma Killing Strategies: Efficacy And Neurotoxicity, Marianela Candolfi, Kader Yagiz, David Foulad, Gabrielle Alzadeh, Matthew Tesarfreund, Akm Ghulam Muhammad, Mariana Puntel, Kurt Kroeger, Chunyan Liu, Sharon Lee, James Curtin, Gwendalyn D. King, Jonathan Lerner, Katsuaki Sato, Yohei Mineharu, Weidong Xiong, Pedro R. Lowenstein, Maria Castro

Articles

Purpose In preparation for a Phase I clinical trial utilizing a combined cytotoxic/immunotherapeutic strategy using adenoviruses expressing Flt3L (Ad-Flt3L) and thymidine kinase (Ad-TK) to treat glioblastoma (GBM), we tested the hypothesis that Ad-TK+GCV would be the optimal tumor killing agent in relation to efficacy and safety when compared to other pro-apoptotic approaches. Experimental Design and Results The efficacy and neurotoxicity of Ad-TK+GCV was compared with Ads encoding the pro-apoptotic cytokines (TNF-α, TRAIL, FasL), alone or in combination with Ad-Flt3L. In rats bearing small GBMs (day 4), only Ad-TK+GCV or Ad-FasL improved survival. In rats bearing large GBMs (day 9), the …

Naturalism, Theism, Obligation And Supervenience, Alvin Plantinga

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

Apo B100 Similarities To Viral Proteins Suggest Basis For Ldl-Dna Binding And Transfection Capacity, Juan Guevara, Nagindra Prashad, Boris Ermolinsky, John W. Gaubatz, Dongcheul Kang, Andrea E. Schwarzbach, David S. Loose, Natalia Valentinova Guevara

Physics & Astronomy Faculty Publications

LDL mediates transfection with plasmid DNA in a variety of cell types in vitro and in several tissues in vivo in the rat. The transfection capacity of LDL is based on apo B100, as arginine/lysine clusters, suggestive of nucleic acid-binding domains and nuclear localization signal sequences, are present throughout the molecule. Apo E may also contribute to this capacity because of its similarity to the Dengue virus capsid proteins and its ability to bind DNA. Synthetic peptides representing two apo B100 regions with prominent Arg/Lys clusters were shown to bind DNA. Region 1 (0014Lys-Ser 0160) shares sequence motifs present in …

Developing Sustainable Life Support System Concepts, Evan A. Thomas

Mechanical and Materials Engineering Faculty Publications and Presentations

Sustainable spacecraft life support concepts may allow the development of more reliable technologies for long-duration space missions. Currently, life support technologies at different levels of development are not well evaluated against each other, and evaluation methods do not account for long-term reliability and sustainability of the hardware. This paper presents point-of-departure Sustainable System Mass (SSM) evaluation criteria for life support systems that may allow more robust technology development, testing, and comparison. An example sustainable water recovery system concept is presented.

Getting Up To Speed: Acceleration Strategies In The Florida Scrub Lizard, Sceloporus Woodi, Eric J. Mcelroy, Lance D. Mcbrayer

Biology: Faculty Publications

Small animals typically rely on quick bursts and intermittent pauses when moving in the wild. Hence, the study of acceleration capacity is important for understanding the ecology and evolution of locomotor performance. In this study, we investigate intraspecific variation in the acceleration capacity of a small lizard (Sceloporus woodi). To quantify animal acceleration performance, the momentum‐impulse theorem is applied to data collected from high‐speed video recordings of individuals accelerating from a standstill and over a subsequent distance of 0.4 m. Unlike earlier studies, the momentum‐impulse approach allows one to directly and precisely quantify the per step contribution to …

Enrollment Report, Summer 2010, Planning, Research, And Policy Analysis

Enrollment Reports (2004-2019)

Enrollment Report for Summer 2010 for Illinois State University

Communicator, Summer 2010, Wnec Alumni Association

Alumni Magazines

No abstract provided.

The Accidental Practitioner: Principles Of Rational Emotive Behavior Therapy In The Works Of Kurt Vonnegut, Joseph J. Ward

USF Tampa Graduate Theses and Dissertations

Just as psychology and philosophy have influenced the field of literary studies, literature provides insight about the theories and practices of its sister disciplines. The purpose of this thesis is to demonstrate how literary works of Kurt Vonnegut illuminate principles of the influential branch of psychotherapy known as Rational Emotive Behavior Therapy (REBT).

This thesis traces the similar philosophies and shared beliefs of Vonnegut and REBT's founder, Albert Ellis, and details how Ellis's REBT is illustrated in selected works of Vonnegut, specifically, Slaughterhouse-Five, Breakfast of Champions, Galapagos, and Timequake. The thesis concludes by suggesting that Vonnegut's …

Community Structure And Dynamics Of Monogenea And Trematoda In Three North American Cyprinid Species In The Salt Valley Watershed, Nebraska, Alaine Kathryn Knipes

School of Biological Sciences: Dissertations, Theses, and Student Research

An investigation was made of the communities of gill monogene genus Dactylogyrus (Platyhelminthes, Monogenea) and the populations of blackspot parasite (Platyhelminthes, Trematoda) of Pimephales promelas, Notropis stramineus, and Semotilus atromaculatus in 3 distinct sites along the 3 converging tributaries in southeastern Nebraska from 2004 to 2006. This work constitutes the first multi-site, multi-year study of a complex community of Dactylogyrus spp. and their reproductive activities on native North American cyprinid species. The biological hypothesis that closely related species with direct lifecycles respond differently to shared environmental conditions was tested. It was revealed that in this system that, Cyprinid …

Physiological Studies On Candida Albicans, Swetha Tati

School of Biological Sciences: Dissertations, Theses, and Student Research

Candida albicans is a common opportunistic, dimorphic human fungal pathogen. One of its virulence factors is the morphological switch between yeasts and hyphal or pseudohyphal forms, which can invade tissues and cause damage. Our studies focus on factors regulating pseudohyphae and epigenetic modifications of C. albicans. Regulating factors of pseudohyphae are aromatic alcohols and high phosphate. At low concentrations, exogenous aromatic alcohols induced pseudohyphae, as did high phosphate. For addressing the pathways involved in inducing pseudohyphae by aromatic alcohols or high phosphate, we used mutants defective in cAMP dependent PKA pathway (efg1/efg1), MAP kinase pathway (cph1/cph1), or both (cph1/cph1/efg1/efg1). …

Presidents, Preemption, And The States, Michele E. Gilman

All Faculty Scholarship

Early in his administration, President Obama issued a memorandum about preemption that ordered federal agencies to fully consider state interests before preempting state laws. The Obama memorandum was a rebuke to the Bush Administration, which had regularly inserted preemption provisions into federal regulations in areas affecting health, consumer safety, and the environment. As a result of preemption, state laws could not be more protective than federal standards, and corporations were spared state tort lawsuits and state regulatory regimes. Preemption not only tends to pit corporate interests against the public welfare, but it can also undermine federalism. There is currently a …

Mollusk Species At A Pliocene Shelf Whale Fall (Orciano Pisano, Tuscany), S Danise, S Dominici, U Betocchi

School of Geography, Earth and Environmental Sciences

The recovery of an intact, 10 m long fossil baleen whale from the Pliocene of Tuscany (Italy) offers the first opportunity to study the paleoecology of a fully developed, natural whale-fall community at outer shelf depth. Quantitative data on mollusk species from the whale fall have been compared with data from the sediments below and around the bones, representing the fauna living in the muddy bottom before and during the sinking of the carcass, but at a distance from it. Although the bulk of the fauna associated with the fossil bones is dominated by the same heterotrophs as found in …

Effects Of Trace Metals On Cellular Immune Responses, Tissue Injury And Gene Expression In The Mussell, Mytilus Edulis: Implications For Biological Monitoring Of Marine Pollution., Sherin Khalifa Hadda Sheir

School of Biological and Marine Sciences Theses

The immunotoxic effects of trace metal exposure in bivalves are poorly understood and whether or not stimulation of the immune system exacerbates metal toxicity is still unclear. The mussel, Mytilus edulis, was exposed to 50 or 500 µg 1̵¹ total Hg or 20 0r 50 µg 1̵¹ total Cd for up to 11 days compared to no added Hg or Cd controls.

Contesting Sphere Boundaries Online: Private/Technical/Public Discourses In Polycystic Ovarian Syndrome Discussion Groups, Kittie E. Grace

Department of Communication Studies: Dissertations, Theses, and Student Research

The internet is fast becoming a means for people to obtain information, creating a unique forum for the intersection of the public, technical, and private spheres. To ground my research theoretically, I used Jürgen Habermas’s sphere theory. Habermas (1987) explains that the technical sphere colonizes the private sphere, which decreases democratic potential. In particular, the internet is a place for altering technical colonization of the private and public spheres.

My research focuses on women’s health because it is a particularly useful case study for examining sphere tensions. Historically, the biomedical health establishment has been a powerful agent of colonization, resulting …

Equally Insured? Lasting Insurance Industry Reform Came Only With A Rethinking Of Race, Mary L. Heen

Law Faculty Publications

Earlier this decade, some of America’s best-known life insurance companies quietly settled multimillion-dollar civil rights lawsuits challenging race-based life insurance rates and benefits. As a result, those companies closed a chapter of American economic history that began after the Civil War with the door-to-door marketing of small individual life insurance policies to poor workers, including former slaves, and their families. The closing of this chapter in history also marked the end of a form of Jim Crow race discrimination largely invisible to the American public.

Mechanical Testing Device For Viscoelastic Biomaterials, Jeff D. Berg

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

Nearly all biologic tissues exhibit viscoelastic behavior. This behavior is characterized by hysteresis in the response of the material to load or strain. This information can be utilized in extrapolation of life expectancy of vascular implant materials including native tissues and synthetic materials. This behavior is exhibited in many engineering materials as well such as the polymers PTFE, polyamide, polyethylene, etc. While procedures have been developed for evaluating the engineering polymers the techniques for biologic tissues are not as mature. There are multiple reasons for this. A major one is a cultural divide between the medical and engineering communities. Biomedical …

Exploiting Metaheuristics To Strategize On Performance-Based Logistics Contracts For Mro Services, Arnd Schirrmann, Elaine Wong, Zhichao Zheng

Research Collection Lee Kong Chian School Of Business

An inherent challenge of using Performance-Based Logistics (PBL) contracts for aircraftmaintenance, repair and overhaul (MRO) services is pricing. As with traditional bricks andmortar services, under-priced contracts cannot cover costs, while overpriced contracts loseout to competition. Furthermore MRO services have an additional element of uncertainty.Performance uncertainties arise due to the inability to accurately forecast demand of spareparts, while cost uncertainties are a result of globally distributed operations subjected tofluctuating economic conditions. Previous work to solve this contracting problem adoptedthe principal-agent model, obtaining an optimal solution from the perspective of both riskaverseparties (i.e., a price-sensitive customer and a profit-driven service provider). Thiswork …

Geographic Distribution, Host Range And Perennation Of Cotesia Sesamiae And Cotesia Flavipes Cameron In Cultivated And Natural Habitats In Kenya, Duna Madu Mailafiya, Bruno Pierre Le Ru, Eunice Waitherero Kairu, Paul André Calatayud, Stéphane Dupas

All Peer-Reviewed Publications

Field surveys were carried out in four agroecological zones to assess the geographic distribution, host range and perennation of Cotesia sesamiae and Cotesia flavipes in cultivated and natural habitats in Kenya. The distribution of the two Cotesia species in different ecological regions was most affected by the suitability of the local stem borer species for parasitoid development, and temperature, as both species were found in localities dominated by their suitable host(s) where temperature favoured their occurrence. Fourteen years after its release, C. flavipes has maintained a high level of specificity to its target host Chilo partellus on maize and sorghum …

Histamine Reduces Flash Sensitivity Of On Ganglion Cells In The Primate Retina, Nikolay P Akimov, David W Marshak, Laura J Frishman, Randolph D Glickman, Rafail G Yusupov

Faculty, Staff and Student Publications

PURPOSE. In Old World primates, the retina receives input from histaminergic neurons in the posterior hypothalamus. They are a subset of the neurons that project throughout the central nervous system and fire maximally during the day. The contribution of these neurons to vision, was examined by applying histamine to a dark-adapted, superfused baboon eye cup preparation while making extracellular recordings from peripheral retinal ganglion cells. METHODS. The stimuli were 5-ms, 560-nm, weak, full-field flashes in the low scotopic range. Ganglion cells with sustained and transient ON responses and two cell types with OFF responses were distinguished; their responses were recorded …

Lps-Induced Production Of Inflammatory Mediators In The Liver Of Postnatal Animals, Valerie P. Le Rouzic

Seton Hall University Dissertations and Theses (ETDs)

Lipopolysaccharide (LPS) is the primary component of the outer membrane of Gram-negative bacteria and is responsible for the majority of inflammatory effects of infections from Gram-negative bacteria. To gain better understanding of the effects that postnatal age has on the inflammatory response, pups were randomly assigned to be treated with 250 µg/kg of LPS or saline at postnatal day (P) 1, P21, and P70. Two hours post stimulation, the pups were sacrificed and their livers were harvested for total RN A extraction. Relative mRNA levels of inflammatory genes and �-actin were determined using RT-PCR analysis with appropriate rat sense and …

Tracking Chemistry Self-Efficacy And Achievement In A Preparatory Chemistry Course, Carmen Alicia Garcia

USF Tampa Graduate Theses and Dissertations

Self-efficacy is a person's own perception about performing a task with a certain level of proficiency (Bandura, 1986). An important affective aspect of learning chemistry is chemistry self-efficacy (CSE). Several researchers have found chemistry self-efficacy to be a fair predictor of achievement in chemistry. This study was done in a college preparatory chemistry class for science majors exploring chemistry self-efficacy and its change as it relates to achievement. A subscale of CAEQ, Chemistry Attitudes and Experiences Questionnaire (developed by Dalgety et al, 2003) as well as student interviews were used to determine student chemistry self-efficacy as it changed during the …

Malaria In Prehistoric Sardinia (Italy): An Examination Of Skeletal Remains From The Middle Bronze Age, Teddi J. Setzer

USF Tampa Graduate Theses and Dissertations

Sardinia was an island with a history of a malarious environment until eradication efforts were conducted from 1946 to 1950. While historic documents suggest the disease was introduced from North Africa around 500 BC, no study has been conducted to test for the presence of malaria in prehistoric native populations, such as the Nuragic people of the Bronze Age. However, it has been suggested that aspects of the Nuragic culture, for example the stone structures found throughout the island, are adaptations to a malarious environment. The purpose of this dissertation is to test the hypothesis that malaria was present in …

An Ecology Of Performance: Gregory Bateson's Cybernetic Performance, Daniel Matthew Blaeuer

USF Tampa Graduate Theses and Dissertations

This dissertation is a case study of the public performances of Gregory Bateson at The Esalen Institute. The case study is a reconsideration of the work of Gregory Bateson from the perspective of performance studies. The author brings together performativity, cybernetics, and the sacred to argue that Gregory Bateson, in his public performances, was striving for grace in encounters with others. The author has conducted archival research into Bateson’s presentations and has spoken with several close to Bateson to get a sense of how his process of public presentation paralleled his ideas—a process of continually working through ideas in conversation …

A Functional Polymorphism In The Hmgcr Promoter Affects Transcriptional Activity But Not The Risk For Alzheimer Disease In Swedish Populations., Lina Keller, Charlotte Murphy, Steve Meaney

Articles

Variations in genes associated with cholesterol homeostasis have been reported to modify the risk of developing Alzheimer disease (AD). To date there have been few investigations into variations in genes directly involved in cholesterol biosynthesis and AD. We investigated the influence of the -911C>A polymorphism (rs3761740) in the hydroxy-methyl-glutaryl CoA reductase (HMGCR) gene promoter on basal and regulated transcription, plasma cholesterol levels and the association with AD. Under in vitro conditions the A allele was found to be significantly more responsive to SREBP-2 mediated regulation than the C allele. In an age and sex matched case-control study, the genotype …

Richmond Law Magazine: Summer 2010

Richmond Law Magazine

Features:

Veterans on a Mission

Healing in Rwanda

Equally Insured?

Driven to Serve

The Aggregated Influences Of Poverty Impacting Dental Care Access And Oral Health Among Migrant Farmworkers In Tampa, Florida, Nolan Kline

USF Tampa Graduate Theses and Dissertations

Oral health is an important aspect of overall health, but many vulnerable populations such as migrant farmworkers are without access to oral healthcare. Although some non-government organizations such as faith-based organizations have attempted to fill gaps left by government and private sectors, a lack of a dental safety net creates limited access to oral health services for migrant farmworkers. Access to care is further constrained by structural factors including low wages, migration route, and high costs of care. Building off a critical medical anthropology approach in understanding oral healthcare access, I argue that limited oral health access for migrant workers …

An Integrated Building Water Management Model For Green Building, Caryssa Joustra

USF Tampa Graduate Theses and Dissertations

The U.S. Green Building Council (USGBC) is the developer of the Leadership in Energy and Environmental Design (LEED™) green building scoring system. On first inspection of LEED points, few address water efficiency. However, water management encompasses other points beyond the Water Efficiency (WE) category. In general, the industry is apt to take a somewhat compartmentalized approach to water management. The use of alternative water sources or the reuse of wastewater significantly complicates the water budget picture. A total water management systems approach, taking into consideration water from various sources, both inside and outside the building, should be implemented in order …