Digital Commons Network^™

Relationship With Cambodian School Children Leads To Long-Term Service Learning Project For Wente '13, University Relations

Campus News Archive

Wente and her alumni parents, Mark ’87 and Lori Halverson-Wente ’88, Dodge Center, have been instrumental in planning and implementing projects focused on the people of Cambodia.

Polyphenol Proteasome Inhibitors, Synthesis, And Methods Of Use, Q. Ping Dou, Tak-Hang Chan, David M. Smith

USF Patents

The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in methods of inhibiting proteasomes and of treating cancers.

Electromanipulation Device And Method, Andrew M. Hoff, Richard Gilbert, Richard Heller, Mark J. Jaroszeski

USF Patents

The present invention is a device for electromanipulation of chemical species in vivo relative to a target tissue including a nonconductive, conformable array base adapted to be placed coincident to the target tissue, a plurality of electrode elements projecting from the array base towards the target tissue, the electrode elements addressable individually, an electrical source coupled to the plurality of electrodes, a control means interposed between the electrical source and the plurality of electrode elements and in circuit communication therein, the control means adapted to establish an electrical potential between at least two electrodes, and a delivery means adapted to …

Plastid Genetic Engineering Via Somatic Embryogenisis, Henry Daniell, Shashi Kumar, Shashi Kumar

UCF Patents

A method of transforming plant plastids and regenerating fertile transplastomic plants by somatic embryogenesis is disclosed. The method involves transforming a plant plastid in a plant cell capable of being regenerated through somatic embryogenesis with a plastid expression cassette comprising one or more selectable marker genes that express in both green and non-green tissue and in light and dark conditions wherein the selectable marker plant cell is cultured in the presence of the plant cell to a selection agent. The transplastomic plant cell is cultured in the presence of the selection agent under conditions to cause the formation of a …

Cross-Reactivity Of Antibodies Against Leptospiral Recurrent Uveitis-Associated Proteins A And B (Lrua And Lrub) With Eye Proteins, Ashutosh Verma, Pawan Kumar, Kelly Babb, John F. Timoney, Brian Stevenson

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Infection by Leptospira interrogans has been causally associated with human and equine uveitis. Studies in our laboratories have demonstrated that leptospiral lipoprotein LruA and LruB are expressed in the eyes of uveitic horses, and that antibodies directed against LruA and LruB react with equine lenticular and retinal extracts, respectively. These reactivities were investigated further by performing immunofluorescent assays on lenticular and retinal tissue sections. Incubation of lens tissue sections with LruA-antiserum and retinal sections with LruB-antiserum resulted in positive fluorescence. By employing two-dimensional gel analyses followed by immunoblotting and mass spectrometry, lens proteins cross-reacting with LruA antiserum were identified to …

Volumetric Growth Model Of Human Medulloblastoma In The Nude Mouse Cerebellum, Thomas Gavigan

Theses and Dissertations

Medulloblastoma is the most common brain tumor in children, accounting for 10-20% of primary central nervous system (CNS) neoplasms and approximately 40% of all posterior fossa tumors. It is a highly invasive embryonal neuroepithelial tumor that typically arises in the cerebellar vermis and has a tendency to disseminate throughout the CNS early in its course. The molecular mechanisms of the disease largely remain uncharacterized, as the clinical treatment is still associated with mortality and severe side effects. The development of a clinically relevant in vivo model is important not only to further understand the disease but also to provide a …

Bilinear Programming And Protein Structure Alignment, J. Cain, D. Kamenetsky, N. Lavine

Mathematical Sciences Technical Reports (MSTR)

Proteins are a primary functional component of organic life, and understanding their function is integral to many areas of research in biochemistry. The three-dimensional structure of a protein largely determines this function. Protein structure alignment compares the structure of a protein with known function to that of a protein with unknown function. A protein’s three-dimensional structure can be transformed through a smooth piecewise-linear sigmoid function to a real symmetric contact matrix that represents the functional significance of certain parts of the protein. We address the protein alignment problem as a minimization of the 2-norm difference of two proteins’ contact matrices. …

Identification And Structural Characterization Of Fyve Domain-Containing Proteins Of Arabidopsis Thaliana, Ewa Wywial, Shaneen M. Singh

Publications and Research

Background FYVE domains have emerged as membrane-targeting domains highly specific for phosphatidylinositol 3-phosphate (PtdIns(3)P). They are predominantly found in proteins involved in various trafficking pathways. Although FYVE domains may function as individual modules, dimers or in partnership with other proteins, structurally, all FYVE domains share a fold comprising two small characteristic double-stranded β-sheets, and a C-terminal α-helix, which houses eight conserved Zn2+ ion-binding cysteines. To date, the structural, biochemical, and biophysical mechanisms for subcellular targeting of FYVE domains for proteins from various model organisms have been worked out but plant FYVE domains remain noticeably under-investigated.

Results We carried out an …

Cgag46 Hyperspectral Sensing Possibilities Using Continuum Removal Index In Early Detection Of Ganoderma In Oil Palm Plantation, M.N.M. Nisfariza, Z.M.S. Helmi, A.S. Idris, M. Steven, D. Boyd, M.H.A. Mior

Research Publications (2006 to 2010)

This study focuses on the possibility of early detection of Basal Stem Rot (BSR) disease caused by Ganoderma spp. a wood decaying fungi in oil palm plantation. The datasets were based on reflectance spectra measured with a GER 1500 spectroradiometer in the range of 350 – 1050nm. Relationship of oil-palm leaves reflectance spectra with the infestation of BSR was investigated. Two datasets from the same plantation were analysed; the young palm (5 years old) and the mature palm (17 years old). The palms were classified to three groups: T1 – healthy palm, T2 – palm infected with Ganoderma without any …

A Potential Tolerogeneic Role Of Skin Grafts In Previously Tolerant Animals, Joshua Weiner

Yale Medicine Thesis Digital Library

A POTENTIAL TOLEROGENEIC ROLE OF SKIN GRAFTS IN PREVIOUSLY TOLERANT ANIMALS Joshua Weiner, Kazuhiko Yamada, Joseph Scalea, Yoshinori Ishikawa, Masayoshi Okumi, Adam Griesemer, Atsushi Hirakata, Justin Etter, Akira Shimizu, and David H. Sachs. Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA. (Sponsored by Sukru H. Emre, Department of Surgery, Section of Transplantation and Immunology, Yale University School of Medicine). We have previously shown that long-term tolerance to class I disparate renal allografts in miniature swine is induced by a short course of Cyclosporine A (CyA). In these tolerant animals (TOL), the tolerance has been shown to …

Evidence For Association Of Non-Acetylated Histones With Newly Replicated Epstein-Barr Virus Dna, Sungeeta Agrawal

Yale Medicine Thesis Digital Library

Epstein-Barr Virus (EBV) has two states of infection, latent and lytic. During the latent state the viral genome remains stable in cells as episomes and replicates with cellular DNA. During the lytic cycle the viral DNA becomes amplified and packaged in newly formed virions. An unsolved problem is whether newly replicated EBV DNA produced upon lytic cycle activation is associated with histones, and if so, whether these histones are acetylated. This question has biological significance as knowing the chromatin structure of genes is important in determining their function and expression profile. Our hypothesis is that newly synthesized EBV lytic DNA …

Socially-Perceived Race, Perceived Healthcare Discrimination And Preventive Health Service Utilization, Tracy Macintosh

Yale Medicine Thesis Digital Library

SOCIALLY-PERCEIVED RACE, PERCEIVED HEALTHCARE DISCRIMINATION AND PREVENTIVE HEALTH SERVICE UTILIZATION Tracy St. Louis MacIntosh, Mayur M. Desai, and Marcella Nunez-Smith. Department of Internal Medicine, Yale University School of Medicine, New Haven, CT. Self-identified racial/ethnic minorities are less likely to receive preventive care and more likely to report healthcare discrimination than whites. However, these outcomes may vary depending on whether racial/ethnic minorities are socially-perceived as minority versus white. We hypothesized that self-identified racial/ethnic minorities who believe they are socially-perceived as white have higher rates of preventive care and are less likely to report healthcare discrimination compared to minorities who believe they …

Monitor Newsletter August 02, 2010, Bowling Green State University

Monitor

Official Publication of Bowling Green State University for Faculty and Staff

The Role Of Nitric Oxide, Acetylcholine, And Vasoactive Intestinal Peptide On Skin Blood Flow During In-Vivo Electrical Field Stimulation, Robert S. Thiebaud

Theses and Dissertations

The purpose of this study was to characterize a novel technique to study neurogenic control of cutaneous vasodilation. We monitored skin blood flow (SkBF) during in-vivo electrical stimulation (e-stim) intended to activate cutaneous nerves and used intradermal microdialysis to deliver receptor antagonists to characterize their contribution to cutaneous vasodilation. We examined the role of acetylcholine receptors (RACh), nitric oxide (NO), and vasoactive intestinal peptide receptors (RVIP) on the cutaneous vasodilation induced by e-stim in the absence of the sympathetic adrenergic nervous system. Six men and three women participated in the study. Three intradermal microdialysis probes were placed in the skin …

Metallic Nanoparticle On Micro Ring Resonator For Bio Optical Detection And Sensing, Ali Haddadpour, Yasha Yi

Publications and Research

We have numerically investigated the unique effects of metallic nanoparticle on the ring resonator, especially multiple Au nanoparticles on the micro ring resonator with the 4-port configuration on chip. For the Au nanoparticle, because it has smaller real refractive index than air and large absorption refractive index, we found that there is a blue shift for the ring resonance wavelength, instead of red shift normally observed for dielectric nanoparticles. The drop port intensity is strongly dependent on both number and size of nanoparticles, while relatively independent on position of nanoparticles. The correlation between the penetration depth of Au and the …

A Coupled Finite Element-Boundary Element Method For Modeling Diffusion Equation In 3d Multi-Modality Optical Imaging, Subhadra Srinivasan, Hamid R. Ghadyani, Brian W. Pogue, Keith D. Paulsen

Dartmouth Scholarship

Three dimensional image reconstruction for multi-modality optical spectroscopy systems needs computationally efficient forward solvers with minimum meshing complexity, while allowing the flexibility to apply spatial constraints. Existing models based on the finite element method (FEM) require full 3D volume meshing to incorporate constraints related to anatomical structure via techniques such as regularization. Alternate approaches such as the boundary element method (BEM) require only surface discretization but assume homogeneous or piece-wise constant domains that can be limiting. Here, a coupled finite element-boundary element method (coupled FE-BEM) approach is demonstrated for modeling light diffusion in 3D, which uses surfaces to model exterior …

Factors Affecting Gingival Excess, Altered Passive Eruption And Recession In The Mandibular Anterior And Premolar Sites, William Bohlen

Theses and Dissertations

Abstract FACTORS AFFECTING GINGIVAL EXCESS, ALTERED PASSIVE ERUPTION AND RECESSION IN THE MANDIBULAR ANTERIOR AND PREMOLAR SITES By William F Bohlen, D.M.D. A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Dentistry at Virginia Commonwealth University. Virginia Commonwealth University, 2010 Major Director: Thomas Waldrop, DDS, MS Program director, Department of Periodontics, Virginia Commonwealth University AIM: The aim of this study was to determine the factors affecting gingival excess, altered passive eruption and recession. METHODS: 100 subjects were examined clinically and models of their mandible were fabricated. Demographic, periodontal and cast measurements were …

Barley For Brewing: Characteristic Changes During Malting, Brewing And Applications Of Its By-Products, Mahesh Gupta, Nissreen Abu-Ghannam, Eimear Gallaghar

Articles

Barley is the basic raw material for brewing. Its chemical composition, brewing, and technological indices are highly determinative for the beer quality and the economical efficiency of the brewing process. Barley is rich in protein, carbohydrates, dietary fibers, minerals, and vitamins. The presence of non starch polysaccharides as mixed linkage (1-3),(1-4)-β-D-glucans and arabinoxylans together with the enzymes are responsible for barley modification. Malting is a complex process that involves many enzymes; important ones are α-amylase, β-amylase, α-glucosidase, and limit dextrinase. During the process of malting and brewing, the by-products left after separation of the wort are rich in protein, fibers, …

The Perilipin Homologue, Lipid Storage Droplet 2, Regulates Sleep Homeostasis And Prevents Learning Impairments Following Sleep Loss, Matthew S. Thimgan, Yasuko Suzuki, Laurent Seugnet, Laura Gottschalk, Paul J. Shaw

Biological Sciences Faculty Research & Creative Works

Extended periods of waking result in physiological impairments in humans, rats, and flies. Sleep homeostasis, the increase in sleep observed following sleep loss, is believed to counter the negative effects of prolonged waking by restoring vital biological processes that are degraded during sleep deprivation. Sleep homeostasis, as with other behaviors, is influenced by both genes and environment. We report here that during periods of starvation, flies remain spontaneously awake but, in contrast to sleep deprivation, do not accrue any of the negative consequences of prolonged waking. Specifically, the homeostatic response and learning impairments that are a characteristic of sleep loss …

Reverse Engineering Of Oxygen Transport In The Lung: Adaptation To Changing Demands And Resources Through Space-Filling Networks, Chen Hou, Stefan Gheorghiu, Virginia H. Huxley, Peter Pfeifer

Biological Sciences Faculty Research & Creative Works

The space-filling fractal network in the human lung creates a remarkable distribution system for gas exchange. Landmark studies have illuminated how the fractal network guarantees minimum energy dissipation, slows air down with minimum hardware, maximizes the gas- exchange surface area, and creates respiratory flexibility between rest and exercise. In this paper, we investigate how the fractal architecture affects oxygen transport and exchange under varying physiological conditions, with respect to performance metrics not previously studied. We present a renormalization treatment of the diffusion-reaction equation which describes how oxygen concentrations drop in the airways as oxygen crosses the alveolar membrane system. The …

Litomosoides (Nemata: Filarioidea) Of Bats From Bolivia With Records For Three Known Species And The Description Of A New Species, Juliana Notarnicola, F Agustín Jiménez-Ruíz, Scott L Gardner

Publications

Herein, we describe Litomosoides salazari n. sp. collected from the body cavity of the yellow bat, Lasiurus ega , from Bolivia. This new species of filarioid nematode is most closely related to the carinii group and is characterized by its relatively small size with the vulva located slightly posterior to the esophago-intestinal junction; an arrow-shaped buccal capsule; and a short, rounded tail. New host and locality records for both Litomosoides hamletti and L. chandleri in phyllostomid bats, and L. brasiliensis occurring in both phyllostomid and vespertilionid bats, are provided. The morphological variability of the specimens is documented by providing comparative …

Book Review Of What Blood Won't Tell: A History Of Race On Trial In America, By Ariela J. Gross, Lucy E. Salyer

Journal of Legal Education

No abstract provided.

Corrosion Dynamics Of Cobalt-Chromium Alloy F-75 Powder, Tedman Tong

Master's Theses

The increasing usage of metal-on-metal joint replacements consisting of a cobalt-chromium-molybdenum alloy requires increasing concern regarding the inevitable generation of metallic wear debris. Patients with these joint replacements exhibit elevated concentrations of cobalt and chromium ions within their serum, blood and urine. The presence of these metal ions suggests the potential for bodily damage and indicates corrosive processes are acting upon wear debris.

To understand the behavior of these corrosive processes, powders of cobalt-chromium-molybdenum alloy F-75 were studied. Four powder sizes (44, 74, 105, and 420 µm diameter) were subjected to Hank’s Balanced Salt Solution (HBSS) for a 42 day …

Great Men, Little Black Dresses, & The Virtues Of Keeping One’S Feet On The Ground, Babette Babich

Articles and Chapters in Academic Book Collections

One can use phenomenology, along with the usual tools of scholarship and analysis, to make the point that the promises of the 1960’s and 1970’s especially those of the women’s movement, have yet to bear significant fruit in the academy. Hence, for everybody’s non-thingly phenomenology of non-practice, a handy-dandy wiki-check on the net yields the claim that “U.S. Department of Education reports indicate that philosophy is one of the least proportionate, and possibly the least proportionate, fields in the humanities with respect to gender,” with a rather dismal addendum reporting that in “2004, the percentage of Ph.D.s in philosophy going …

Polymorphisms In The Macrophage Migration Inhibitory Factor Gene And Bone Loss In Postmenopausal Women, George A. Kuchel, Anne M. Kenny

UCHC Articles - Research

Osteoporosis is a severe condition in postmenopausal women and a common cause of fracture. Osteoporosis is a complex disease with a strong genetic impact, but susceptibility is determined by many genes with modest effects and environmental factors. Only a handful of genes consistently associated with osteoporosis have been identified so far. Inflammation affects bone metabolism by interfering with the interplay between bone resorption and formation, and many inflammatory mediators are involved in natural bone remodeling. The cytokine macrophage migration inhibitory factor (MIF) has been shown to affect bone density in rodents, and polymorphisms in the human MIF promoter are associated …

Lynx Tale, August 2010, Lindenwood University

Lynx Tale

The Lynx Tale was a Lindenwood University-Belleville student centered newspaper that informed students on upcoming events and news on campus.

Seasonal Carotenoid Variation In American Kestrels, Christeena H. Sevy, Julie A. Heath

IDeA Network for Biomedical Research Excellence (INBRE)

Carotenoids are micronutrient pigments produced by plants that may convey immunological benefits to consumers. Animals with high levels of carotenoid intake may have improved health and higher survival. American Kestrels (Falco sparverius) from broods hatched early in the breeding season are more likely to survive and return to the breeding population than birds hatched later in the season. We hypothesized that breeding adults and nestlings may be affected by seasonal patterns in primary productivity that lead to changes in prey quality and availability; therefore affecting carotenoid intake. We collected blood samples from American Kestrels breeding in nestboxes south of Boise, …

Effects Of Antibiotics On The Expression Of Toxin Genes And Their Regulators In Streptococcus Pyogenes, Dawn Mikelonis

IDeA Network for Biomedical Research Excellence (INBRE)

Background: Streptococcus pyogenes, also known as group A streptococcus (GAS) or “the flesh-eating bacteria”, is a Gram positive human pathogen that causes many diseases, ranging in severity from milder infections such as pharyngitis to life-threatening necrotizing fasciitis/myonecrosis and streptococcal toxic shock syndrome (1). Although GAS remains susceptible to penicillin, this beta-lactam antibiotic (a cell wall-synthesis inhibitor) is not efficacious in treating severe GAS myonecrosis, whereas treatment with clindamycin (a lincosamide that inhibits protein synthesis) is 80-100% protective. We have previously demonstrated that sub-inhibitory concentrations of the beta-lactam antibiotic, nafcillin, increases and prolongs extracellular protein production in Staphylococcus aureus, …

Influence Of A Single Swim Training On The Scapular Position And Isometric Muscle Strength In Young Swimmers, Annemie Van De Velde, Kristof De Mey, Patrick Calders, Ann Cools

International Journal of Aquatic Research and Education

The purpose of our study was to investigate the influence of one swim training on isometric scapular muscle strength and the static position of the scapula in a sample of 30 healthy adolescent swimmers who were measured on two sessions at a local aquatic center. Fatigue as result of a single swim training may influence scapular position and strength. Measures included isometric evaluation of serratus anterior and upper trapezius peak isometric force using a push and shrug procedure, serratus anterior to upper trapezius strength ratios, and a semi-dynamic evaluation of lateral scapular displacement employing the Kibler method. When tested using …

Medical School Watercooler Newsletter - August 1, 2010, Lindsey Lyle

Watercooler Newsletter

This is the August 1, 2010 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

• August Med School Café - "Autism Services in South Alabama"
• Dr. Jane Reusch Speaks at 37th Annual Medical Student Research Day
• USA Surgical Research Fellow Wins Paper Competition at 2010 ACS Meeting
• "Room with a View" Photography Exhibit at USA Library Features Mike Carmichael
• Bioimaging Core Facility Installs Nikon A-1 Spectral Confocal Microscope