Digital Commons Network^™

Structure Of The Cholera Toxin Secretion Channel In Its Closed State, Steve Reichow, Konstantin V. Korotkov, Wim Gj Hol, Tamir Gonen

Chemistry Faculty Publications and Presentations

The type II secretion system (T2SS) is a macromolecular complex spanning the inner and outer membranes of Gram-negative bacteria. Remarkably, the T2SS secretes folded proteins including multimeric assemblies like cholera toxin and heat-labile enterotoxin from Vibrio cholerae and enterotoxigenic Escherichia coli, respectively. The major outer membrane T2SS protein is the “secretin” GspD. Electron cryomicroscopy reconstruction of the V. cholerae secretin at 19 Å resolution reveals a dodecameric structure reminiscent of a barrel with a large channel at its center that appears to contain a closed periplasmic gate. The GspD periplasmic domain forms a vestibule with a conserved constriction, and binds …

Focus, 2010, Fall, Andrews University

Focus

FOCUS (ISSN 1077-9345) is published quarterly, free of charge, for alumni and friends of Andrews University, an institution owned and operated by the Seventh-day Adventist Church.

Growing The Future, Tennessee Agriculture 2010 Department Report & Statistical Summary, Tennessee. Department Of Agriculture.

Annual Report

No abstract provided.

Zoo Registrars: A Bewildering Bureaucracy, Irus Braverman

Duke Environmental Law & Policy Forum

No abstract provided.

The New Hampshire, Vol. 100 [101], No. 8 (Oct. 1, 2010), The New Hampshire

The New Hampshire Print Edition

An independent student produced newspaper from the University of New Hampshire. This volume was printed as 100, but it is the 101st volume in the series. This was corrected in pencil.

Development Of A Unique Whole-Brain Model For Upper Extremity Neuroprosthetic Control, Dominic Nathan

Dissertations (1934 -)

Neuroprostheses are at the forefront of upper extremity function restoration. However, contemporary controllers of these neuroprostheses do not adequately address the natural brain strategies related to planning, execution and mediation of upper extremity movements. These lead to restrictions in providing complete and lasting restoration of function. This dissertation develops a novel whole-brain model of neuronal activation with the goal of providing a robust platform for an improved upper extremity neuroprosthetic controller. Experiments (N=36 total) used goal-oriented upper extremity movements with real-world objects in an MRI scanner while measuring brain activation during functional magnetic resonance imaging (fMRI). The resulting data was …

How's The Water?, Michelle R. Marlow

Social Sciences

Man's manipulation of fresh water and the consequences of said manipulation.

Rod Library Newsletter: Rod Notes, V3n2, October 2010, University Of Northern Iowa. Rod Library.

Rod Library newsletter: Notes for the Stalled

Contents:

-- For Sale: Library Books!
-- Art on Campus
-- Ring Our Bell!
-- Oooooh - New and Updated Databases

Mph Principles Of Public Health: Fall 2010 Syllabus, Nina Wallerstein, Robert Rhyne, Jonathan Eldredge

Principles of Public Health 2010-2017

No abstract provided.

Water Resources 2010 Apr Self-Study & Documents, University Of New Mexico

UNM Academic Program Review

UNM Water Resources APR self-study report, review team report, and response to review report for Fall 2010, fulfilling requirements of the Higher Learning Commission.

Flattening Single-Vertex Origami: The Non-Expansive Case, Gaiane Panina, Ileana Streinu

Computer Science: Faculty Publications

A single-vertex origami is a piece of paper with straight-line rays called creases emanating from a fold vertex placed in its interior or on its boundary. The Single-Vertex Origami Flattening problem asks whether it is always possible to reconfigure the creased paper from any configuration compatible with the metric, to a flat, non-overlapping position, in such a way that the paper is not torn, stretched and, for rigid origami, not bent anywhere except along the given creases. Streinu and Whiteley showed how to reduce the problem to the carpenter's rule problem for spherical polygons. Using spherical expansive motions, they solved …

Explaining Long-Distance Dispersal: Effects Of Dispersal Distance On Survival And Growth In A Stream Salamander, Winsor H. Lowe

Biological Sciences Faculty Publications

Long-distance dispersal (LDD) may contribute disproportionately to range expansions, the creation of new evolutionary lineages, and species persistence in human-dominated landscapes. However, because data on the individual consequences of dispersal distance are extremely limited, we have little insight on how LDD is maintained in natural populations. I used six years of spatially explicit capture–mark–recapture (CMR) data to test the prediction that individual performance increases with dispersal distance in the stream salamander Gyrinophilus porphyriticus. Dispersal distance was total distance moved along the 1-km study stream, ranging from 0 to 565 m. To quantify individual performance, I used CMR estimates of …

Capture Of Ungulates In Central Asia Using Drive Nets: Advantages And Pitfalls Illustrated By The Endangered Mongolian Saiga Saiga Tatarica Mongolica, Joel Berger, Kim M. Murray, Bayarbaatar Buuveibaatar, Michael R. Dunbar, Badamjav Lkhagvasuren

Biological Sciences Faculty Publications

The study of mammals suffering intense poaching in remote areas poses an increasingly difficult conservation challenge, in part because the extreme flightiness of such species complicates safe capture. The benefits of handling (an opportunity to obtain biological information and attach radio collars) must be weighed against stress to the animals and potential capture-related mortality. In parts of Central Asia this problem is not trivial, as populations have been heavily harvested and opportunities for restraint are often limited. Mongolian saiga Saiga tatarica mongolica, being both Endangered and poached, typifies these issues. Here we describe capture protocols for adult females handled quickly …

Mathematical Manipulative Models: In Defense Of "Beanbag Biology", John R. Jungck, Holly Gaff, Anton E. Weisstein

Biological Sciences Faculty Publications

Mathematical manipulative models have had a long history of influence in biological research and in secondary school education, but they are frequently neglected in undergraduate biology education. By linking mathematical manipulative models in a four-step process-1) use of physical manipulatives, 2) interactive exploration of computer simulations, 3) derivation of mathematical relationships from core principles, and 4) analysis of real data sets-we demonstrate a process that we have shared in biological faculty development workshops led by staff from the BioQUEST Curriculum Consortium over the past 24 yr. We built this approach based upon a broad survey of literature in mathematical educational …

Managing Depression During The Menopausal Transition, Quinn M. Pearson

Adultspan Journal

No abstract provided.

The Effect Of Ionic Dissolution Products Of Ca-Sr-Na-Zn-Si Bioactive Glass On In Vitro Cytocompatibility, S. Murphy, A. W. Wren, Mark R. Towler, D. Boyd

Chemical and Biochemical Engineering Faculty Research & Creative Works

Many commercial bone grafts cannot regenerate healthy bone in place of diseased bone. Bioactive glasses have received much attention in this regard due to the ability of their ionic dissolution products to promote cell proliferation, cell differentiation and activate gene expression. Through the incorporation of certain ions, bioactive glasses can become therapeutic for specific pathological situations. Calcium-strontium-sodium-zinc-silicate glass bone grafts have been shown to release therapeutic levels of zinc and strontium, however the in vitro compatibility of these materials is yet to be reported. In this study, the in vitro cytocompatibility of three different calcium-strontium-sodium-zinc-silicate glasses was examined as a …

An Automated Phenotype-Driven Approach (Geneforce) For Refining Metabolic And Regulatory Models, Dipak Barua, Joonhoon Kim, Jennifer L. Reed

Chemical and Biochemical Engineering Faculty Research & Creative Works

Integrated constraint-based metabolic and regulatory models can accurately predict cellular growth phenotypes arising from genetic and environmental perturbations. Challenges in constructing such models involve the limited availability of information about transcription factor-gene target interactions and computational methods to quickly refine models based on additional datasets. In this study, we developed an algorithm, GeneForce, to identify incorrect regulatory rules and gene-protein-reaction associations in integrated metabolic and regulatory models. We applied the algorithm to refine integrated models of Escherichia coli and Salmonella typhimurium, and experimentally validated some of the algorithm's suggested refinements. The adjusted E. coli model showed improved accuracy …

Pathways Regulating Cytosolic Phospholipase A2 Activation And Eicosanoid Production In Macrophages By Candida Albicans, Saritha Suram, Todd A. Gangelhoff, Philip R. Taylor, Marcela Rosas, Gordon D. Brown, Joseph V. Bonventre, Shizuo Akira, Satoshi Uematsu, David L. Williams, Robert C. Murphy, Christina C. Leslie

ETSU Faculty Works

Resident tissue macrophages are activated by the fungal pathogen Candida albicans to release eicosanoids, which are important modulators of inflammation and immune responses. Our objective was to identify the macrophage receptors engaged by C. albicans that mediate activation of group IVA cytosolic phospholipase A2 (cPLA2α), a regulatory enzyme that releases arachidonic acid (AA) for production of prostaglandins and leukotrienes. A comparison of peritoneal macrophages from wild type and knock-out mice demonstrates that the β-glucan receptor Dectin-1 and MyD88 regulate early release of AA and eicosanoids in response to C. albicans. However, cyclooxygenase 2 (COX2) expression and later phase eicosanoid production …

Child And Caregiver Social Behavior And Joint Attention Change Following P.L.A.Y. Project Intervention, Jeffrey Scott Karst

Master's Theses (2009 -)

Autism is a complex, developmental disorder affecting approximately one in 110 children in the United States. Children with autism spectrum disorders demonstrate a variety of significant deficits, including social impairment. The limitations in social ability may be in part a product of limited joint attention development at an early age. Joint attention refers to the triadic attention between an individual, another person, and an object or event and has been shown to moderate the effectiveness of certain autism interventions. The P.L.A.Y. Project, developed by Dr. Richard Solomon, aims to train parents of children with autism to be their child's own …

Hours Of Boredom, Moments Of Terror: Temporal Desynchrony In Military And Security Force Operations, Peter A. Hancock, Gerald P. Krueger

Defense and Technology Papers

The authors examine resultant psychological and behavioral implications for combatant and security personnel performance as viewed through application of a traditional human psychological stress model. Inadequate recognition of the implications resulting from long lull periods, combat pulses, and the need to recover from stress can lead to dysfunctional soldiering as well as poor individual and small unit performance.

Bio-Inspired Innovation And National Security, Robert E. Armstrong, Mark D. Drapeau, Cheryl A. Loeb, James J. Valdes

Books

Despite various treaties and protocols, offensive biological weapons use has continued to this day, with the anthrax attacks of 2001 being the most recent incident. Such activity has led to a strong defensive program, with medical science developing numerous countermeasures that have benefited both civilian and military populations.

Approval Of New Pharmacogenomic Tests: Is The Canadian Regulatory Process Adequate?, Yann Joly, Emma Ramos-Paque

Canadian Journal of Law and Technology

In the first part of our analysis, we will examine the impact which pharmacogenomics is expected to have on drug research and development, on the drug approval process and on post-marketing surveillance and clinical practice. This will allow us to show how pharmacogenomic testing could be beneficial to drug companies, regulatory bodies, and patients. The second part of our analysis will focus on the regulatory framework applicable to the approval of pharmacoge- nomic tests in Canada, although we are aware of the fact that most manufacturers decide to approve their tests outside of Canada. As mentioned, the applicable regu- lations …

The Bg News October 1, 2010, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. October 1, 2010. Volume 101-Issue 30.

Panorama October 2010, Southern Adventist University

Panorama Parent Newsletter

This issue of the Panorama parent newsletter contains information about Southern's technology, a profile on Bernelle Taitague, and information on the expansion of Campus Ministries.

Zoo Registrars: A Bewildering Bureaucracy, Irus Braverman

Journal Articles

While their counterparts in the museum world have received some scholarly attention, no scholarly account of zoo registrars has been published to date. Why bother studying zoo registrars? Firstly, in the (contained) wildness of the zoo, the registrar performs the role of law and order. She (typically this position is employed by females) manages the administrative side of the zoo: a junction between data management and small-scale legal administration. Secondly, registrars both depict and represent the significant transformations that have occurred in North American zoos over the last few decades, from insular urban institutions exhibiting exotic animals for entertainment, to …

Survival And Harvest Characteristics Of Giant Canada Geese In Eastern South Dakota, 2000–2004, Charles D. Dieter, Jeffrey S. Gleason, Bobby J. Anderson, Spencer Vaa, Paul W. Mammenga

Natural Resource Management Faculty Publications

The population of giant Canada geese (Branta canadensis maxima) in eastern South Dakota has increased substantially since reintroduction efforts began in the 1960s. Breeding population estimates of Canada geese exceeded the population management objective of the South Dakota Game, Fish and Parks by the mid-1990s and has continued to increase at an estimated rate of 3 to 5% per year. Goose-related crop damage complaints have also increased. In 1996, a September hunting season (September 1 to 15) was implemented in 10 counties in eastern South Dakota and was expanded in 2000 to include most of eastern South Dakota. …

Late Summer Movements By Giant Canada Geese In Relation To A September Hunting Season, Charles D. Dieter, Bobby J. Anderson, Jeffrey S. Gleason, Paul W. Mammenga, Spencer Vaa

Natural Resource Management Faculty Publications

The population of giant Canada geese (Branta canadensis maxima) breeding in eastern South Dakota has increased dramatically since reintroduction efforts began in the 1960s. May breeding population levels of giant Canada geese exceeded population management goals set by the South Dakota Department of Game, Fish and Parks (SDGFP) by the mid-1990s, and the population has continued to increase into the 2000s. This population increase was accompanied by an increase in goose-related conflicts such as crop depredation. In 1996, a September hunting season was implemented in select counties in eastern South Dakota in an effort to reduce the giant …

Dispersal Movements Of Subadult Cougars From The Black Hills: The Notions Of Range Expansion And Recolonization, D. J. Thompson, J. A. Jenks

Natural Resource Management Faculty Publications

Dispersal plays a vital role in cougar (Puma concolor) population ecology, creating genetic viability and maintaining gene flow between populations. The naturally recolonized cougar population in the Black Hills is at the edge of the species’ range in North America and completely surrounded by the grasslands of the Northern Great Plains. Our objective was to document dispersal movements and possible range expansion of subadult cougars captured within the Black Hills ecosystem of southwestern South Dakota and eastern Wyoming. Twenty-four (n ¼ 14 males, n ¼ 10 females) subadult cougars were captured in the Black Hills. Independence of cougars from females …

Editors’ Introduction: What Is Outsider Criticism?, Marc Ouellette

Reconstruction: Studies in Contemporary Culture

[First paragraph]

In 1979, Jean-François Lyotard published the results of a study he was commissioned to write for the Conseil des universités du Québec in which he made the claim that, in a university system devoted to functionalism rather than experimentation, “it is safe to assume that responsibility for [experimentation] will devolve upon extrauniversity networks.” This proclamation may have been shocking to university administrators, who have often equated the university with knowledge as if such a linking were inevitable, but from Lyotard’s perspective of a growing, capitalist-fueled technocracy, and now ours, in which this technocracy has grown in size and …

The Image – By Any Means, Richard Minard

Theses

Art is inherently a reflection of the human condition. As I am working, my intention is to make images that, at the very least, capture the audience's attention. By adding layers and fracturing the images, I want the audience to see through various visual relationships. These visual relationships can be interpreted as a metaphor of the often hectic and unstable qualities of daily life. As the human figure is my connection to the work, it also serves as the viewer's connection. The blending of media and mixing up of figurative representation with abstraction is my attempt to challenge the viewer …