Digital Commons Network^™

Importance Of Contact Chemical Cues In Host Recognition And Acceptance By The Braconid Larval Endoparasitoids Cotesia Sesamiae And Cotesia Flavipes, Meshack Obonyo, Fritz Schulthess, Bruno Le Ru, Johnnie Van Den Berg, Jean François Silvain, Paul André Calatayud

All Peer-Reviewed Publications

The ability of the congeneric braconid parasitoids Cotesia sesamiae (Cameron) and Cotesia flavipes Cameron to discriminate between stemborer larval cues upon contact was studied using their natural hosts, namely the noctuid Busseola fusca (Fuller) and the crambid Chilo partellus (Swinhoe), respectively, and the pyralid non-host Eldana saccharina (Walker). When the natural host larvae were washed in distilled water, parasitoid behavior was similar to that displayed when in contact with E. saccharina, characterized by the absence of ovipositor insertion. When washed host or non-host larvae were bathed with water extracts of their natural host, the parasitoids showed a significant increase in …

Geographic And Breed Distribution Patterns Of An A/G Polymorphism Present In The Mx Gene Suggests Balanced Selection In Village Chickens, S. Ommeh, L. N. Jin, H. Eding, F. C. Muchadeyi, S. Sulandari, M. S.A. Zein, G. Danbaro, C. E. Wani, S. G. Zhao, Q. H. Nie, X. Q. Zhang, M. Ndila, R. Preisinger, G. H. Chen, I. A. Yousif, K. N. Heo, S. J. Oh, M. Tapio, D. Masiga, O. Hanotte, H. Jianlin, S. Weigend

All Peer-Reviewed Publications

An A/G Single Nucleotide Polymorphism (SNP) at position 1,892 of the Mx gene coding sequence has been linked to susceptibility/resistance to avian viral infection in vitro. Using PCR-RFLP and sequencing methods, 1,946 samples from 109 populations from Asia, Africa and Europe; grouped as indigenous village, commercial, fancy chicken as well as wild junglefowl were genotyped for the polymorphism. Allele and genotype frequencies were calculated. Only the G allele was present in Ceylon junglefowl Gallus lafayetti. Using the wild red junglefowl G. gallus population as reference, we assessed if the A/G alleles and genotypes frequencies have been affected by the breeding …

Do New Access And Benefit Sharing Procedures Under The Convention On Biological Diversity Threaten The Future Of Biological Control?, Matthew J.W. Cock, Joop C. Van Lenteren, Jacques Brodeur, Barbara I.P. Barratt, Franz Bigler, Karel Bolckmans, Fernando L. Cônsoli, Fabian Haas, Peter G. Mason, José Roberto P. Parra

All Peer-Reviewed Publications

Under the Convention on Biological Diversity (CBD) countries have sovereign rights over their genetic resources. Agreements governing the access to these resources and the sharing of the benefits arising from their use need to be established between involved parties [i. e. Access and Benefit Sharing (ABS)]. This also applies to species collected for potential use in biological control. Recent applications of CBD principles have already made it difficult or impossible to collect and export natural enemies for biological control research in several countries. If such an approach is widely applied it would impede this very successful and environmentally safe pest …

Economic Threshold For The Management Of Plutella Xylostella With Granulovirus In Cauliflower Ecosystem, S. Subramanian, R. J. Rabindra, N. Sathiah

All Peer-Reviewed Publications

Resistance to chemicals and some biological control agents by Plutella xylostella has resulted in the search for alternatives, such as P. xylostella granulovirus (PlxyGV), for the management of P. xylostella. However, use of PlxyGV would be economical only if it is applied at the right crop stage and at economic threshold levels. Hence, we evaluated the field level economic threshold for application of PlxyGV at the reproductive phase of cauliflower taking into consideration both the economic threshold model and the economic optimization model. PlxyGV was found to be very effective in management of the pest and was comparable to weekly …

Development Of Ratiometric Probes For Microemulsion Studies, Greg Wright

Theses

Water-in-oil reverse-phase microemulsions were studied to determine the effects of changing the concentrations of the components of the microemulsions on the shape, sizes, and interactions of the particles of the microemulsion system. Two fluorescent probes were used in the measurement and analysis of bis(2-ethylhexyl) sulfosuccinate (AOT) water in octane reverse phase microemulsions. Dansylpiperidine and 9-aminoacridine were chosen as the fluorescent probes used in the analysis. The experiment consisted of the analysis in solvents of differing polarity, AOT microemulsion solutions of various water, surfactant, and octane ratios, and four component microemulsions. The four component microemulsions consisted of solutions containing AOT, water, …

Threshold Interval Indexing Techniques For Complicated Uncertain Data, Andrew Knight

Theses

Uncertain data is an increasingly prevalent topic in database research, given the advance of instruments which inherently generate uncertainty in their data. In particular, the problem of indexing uncertain data for range queries has received considerable attention. To efficiently process range queries, existing approaches mainly focus on reducing the number of disk I/Os. However, due to the inherent complexity of uncertain data, processing a range query may incur high computational cost in addition to the I/O cost. In this paper, I present a novel indexing strategy focusing on one-dimensional uncertain continuous data, called threshold interval indexing. Threshold interval indexing is …

Evolutionary Spectral Co-Clustering, Nathan S. Green

Theses

The field of mining evolving data is relatively new and evolutionary clustering is among the latest in this trend. Presently, there are algorithms for evolutionary k-means, agglomerative hierarchical, and spectral clustering. These have been excellent in showing the advantages of using evolving data snapshots for better clustering results. From these algorithms the key portion of the conversion from static data handling to evolving data handling has been the addition of the historical cost function. The cost function is what determines whether or not instances should be moved from one cluster to the next between time-steps based on the historical cuts …

Make Him An Offer He Can't Refuse: Avoiding Conflicts Through Side Payments, Erik O. Kimbrough, Roman M. Sheremeta

ESI Working Papers

The equilibrium of a two-stage conflict game with side-payments predicts that with binding stage-one offers, proposers make and responders accept side-payments, generating settlements that strongly favor proposers. When side-payments are non-binding, proposers offer nothing and conflicts always arise. Laboratory experiments confirm that binding side-payments reduce conflicts. However, 30% of responders reject binding offers, and offers are more egalitarian than predicted. Surprisingly, non-binding side-payments also improve efficiency, although less than binding. With binding side-payments, 98% of efficiency gains come from avoided conflicts. However, with non-binding side-payments, only 49% of gains come from avoided conflicts and 51% from reduced conflict expenditures.

Mine And Thine: The Territorial Foundations Of Human Property, Peter Descioli, Bart J. Wilson

ESI Working Papers

Research shows that many animal species have morphological and cognitive adaptations for fighting with others to gain resources, but it remains unclear how humans make fighting decisions. Non-human animals often adaptively calibrate fighting behavior to ecological variables such as resource quantity and whether the resource is distributed uniformly or clustered in patches. Also, many species use strategies to reduce fighting costs such as resolving disputes based on power asymmetries or conventions. Here we show that humans apply an ownership convention in response to the problem of severe fighting. We designed a virtual environment where ten participants, acting as avatars, could …

A Generalized Tullock Contest, Subhashish M. Chowdhury, Roman M. Sheremeta

ESI Working Papers

We construct a generalized Tullock contest under complete information where contingent upon winning or losing, the payoff of a player is a linear function of prizes, own effort, and the effort of the rival. This structure nests a number of existing contests in the literature and can be used to analyze new types of contests. We characterize the unique symmetric equilibrium and show that small parameter modifications may lead to substantially different types of contests and hence different equilibrium effort levels.

The Role Of The Methyl Dna Binding Domain Protein 2 (Mbd2) In Breast Cancer, Omar Mian

Theses and Dissertations

Methyl-CpG Binding Proteins (MCBPs) are thought to function as the interpreters of epigenetic information encoded in cytosine methylation. Their ability to translate DNA methylation into local transcriptional repression has sparked interest in the role of Methyl-Binding Domain Proteins (MBDs) in cancer, where repatterning of CpG methylation is common. In this dissertation I summarize and discuss observations made in the Ginder Lab linking MCBPs to the progression of neoplastic disease. It is clear from our work that the Methyl Binding Domain Protein 2 (MBD2) is necessary for the persistent repression of critical tumor suppressor genes in breast cancer. We show that …

Interplay Between Keratin And Vimentin Expression In Oral Cancer, Mary Catherine Mcginn

Theses and Dissertations

Previous research in our laboratory found that inhibiting expression of vimentin, a marker of epithelial-to mesenchymal transition, inhibited cell growth and motility in vitro and in vivo. Tumors derived from vimentin knockdown cells showed features of epithelial redifferentiation and increased expression of differentiation-specific keratins. It is unknown what causes re-expression of keratins when vimentin is inhibited. Although, canonical Wnt signaling may activate NF-κB and repress of keratin and/or induce vimentin expression through β-catenin. We hypothesize that downregulation of differentiation-specific keratins contributes to tumor progression, mediated directly or indirectly by expression of vimentin. Vimentin-negative HN4 cells were transfected with plasmids encoding …

Periodontal Bacterial-Dna Initiated Immuno-Inflammatory Responses In Human Osteoblastic Cells, Chebel Najib Bou

Theses and Dissertations

Periodontitis is a chronic inflammatory disease initiated by gram negative anaerobic bacteria. These bacteria possess pathogen-associated molecular patterns (PAMPs) that interact with various receptors including Toll like receptors (TLRs). Bacterial DNA (bDNA) is one of the PAMPs mainly recognized by TLR9. Interaction of bDNA and its receptors leads to activation of inflammatory signaling pathways potentially resulting in periodontal bone destruction. The aim of this study was to determine the production of IL- 6 and IL-8 in response to periodontal bDNA from human osteoblastic cells (MG-63). MG- 63 cells were stimulated in duplicate for 20 hours with 100ng/μl of bDNA from …

Ipla2Β, Alternative Splicing And Apoptosis Of Pancreatic Islets, Bhargavi Emani

Theses and Dissertations

Ceramides are bioactive lipids that can promote splicing of apoptosis-related genes, including caspase 9 and BCL-x. A recent study demonstrated that expression of neutral sphingomyelinase (NSMase), an enzyme that hydrolyzes sphingomyelins to generate ceramide, is regulated by Group VIA phospholipase A2 (iPLA2β)-dependent mechanism during β-cell apoptosis. This prompted us to hypothesize that iPLA2 is upstream of ceramide generation in the process regulating splicing of apoptotic genes. To test this, Jurkat T cells were treated with the selective inhibitor of iPLA2β, bromoenol lactone (BEL), RNA was isolated and converted to cDNA, and caspase 9 and BCL-x mRNA viii species were amplified …

Alternative Regulation Of The Alginate Algd Operon By An Activated Algb In Nonmucoid Pseudomonas Aeruginosa Is Dependent On Sigma 54, Jean Kim

Theses and Dissertations

Alginate overproduction by Pseudomonas aeruginosa, which causes a mucoid phenotype, is a major virulence factor associated with chronic pulmonary infections in cystic fibrosis patients. Expression of the algD operon for alginate biosynthesis requires three major regulators in association with the ECF sigma factor, σ22, in mucoid strains that are typically defective in anti-sigma factor, MucA. One such algD regulator is AlgB, a member of the NtrC family of two-component systems, which typically utilize σ54. However, neither σ54 nor the cognate sensor kinase (KinB) of AlgB are required for algD expression in such mucoid strains. I hypothesized that KinB-phosphorylated AlgB must …

Influence Of Retinal States On The Development And Maintenance Of Retinofugal Projections, Duncan Morhardt

Theses and Dissertations

Vision provides a critical interface with the physical world. This work examines visual development and vision loss in mice to glean the influence of the retinal state on visual connections. I first assessed the impact of retinal activity on the eye-specific segregation of retinal afferents in the lateral geniculate nucleus (LGN) of young Gβ5 -/- mice. Gβ5 is the fifth member of the β subfamily of heterotrimeric G proteins. Gβ5 binds and stabilizes the R7 family of regulators of G-protein signaling (RGS), which accelerate Gi/o GTP hydrolysis. Gβ5 -/- mice, which lack R7RGS activity, have malformed synapses in the outer …

Novel Cinnamic Acid-Based Dehydropolymers For Emphysema: In Vitro And In Vivo Assessment Of Their Activities, Bhawana Saluja

Theses and Dissertations

Pulmonary emphysema is a serious worldwide illness, causing progressive and irreversible alveolar wall loss and difficulty in breathing. It is caused mostly by cigarette smoking. However, its unresolved complex and multiple pathogenic mechanisms have left this disease without effective pharmacotherapy. This project hypothesized that cinnamic acid-based dehydropolymers (DHPs), originally discovered as novel anti-coagulants, protect against emphysema through their potent triple inhibitory actions against oxidative stress, inflammation and elastase, some of the pathogenic mechanisms associated with this disease. Three in vitro inhibitory activity assays for oxidative stress, lung inflammation and neutrophil elastase (NE) were developed and used to identify the most …

Cell-Cell Junction Signaling Regulating Dna Double-Strand Break Repair In Breast Cells, Sinduja Ethiraj

Theses and Dissertations

Genomic instability and acquisition of invasiveness through the basement membrane extracellular matrix (ECM) are two major processes for epithelial cell malignancy in breast cancer. DNA double-strand break repair (DSBR) is one of the processes that get misregulated during breast cancer progression. In addition, radiation induced breaks such as those induced during radiation therapy to treat breast cancer patients are repaired by DSBR, rendering this pathway relevant for therapy as well. DSBR can occur either by homologous recombination (HR) or non-homologous end-joining (NHEJ). HR is accepted as the more error-free pathway. HR is regulated by the cell cycle status such that …

Modeling Hydrophobic Effects At Different Lengthscales, Jihang Wang

Theses and Dissertations

Understanding hydrophobic effects at different length scales is relevant to many complex and poorly understood everyday phenomena in materials science and biology. In this thesis, a variety of theory/computational methods in statistical physics and statistical mechanics are used to address three separated, but interconnected problems: (1) How solvation free energy scales with a partical size that is charged? This problem has never been attempted to solve before despite its immense importance in colloidal and protein solutions (J. Wang, D. Bratko, K. Leung and A. Luzar, Hydrophobic hydration at different length-scales: manipulating the crossover by charges, to be submitted to J. …

Patient Ventilator Dyssynchrony: Types, Frequency And Patterns In Critically Ill Adults, Karen Mellott

Theses and Dissertations

Patient ventilator dyssynchrony (PVD) occurs frequently, but little is known about the types, frequency and patterns of PVD for longer than 30 minutes. Deeper levels of sedation are associated with PVD. Evaluation of ventilator graphics and the ability to identify PVD should assist clinicians to optimize patient ventilator interactions and promote earlier interventions. The purpose of this study was to identify the different types, frequency and patterns of PVD in critically ill adults and determine the effect of sedation level on PVD. Thirty medical and surgical ICU adult patients were enrolled; 27 were used for analysis. Pressure/time and flow/ time …

Contributions Of Neglect Subtypes And Family History In Dsm-Iv Disorders: Findings From The Ncs-R, Leanne Heaton

Theses and Dissertations

Despite the prevalence of neglect in the child welfare system, understanding of the etiology of neglect remains limited in scope. Limitations are driven by the frequent reliance on child protective services (CPS) data which consists of identified cases and consequently, the most serious of all cases, or through a few population based studies that operationalize neglect as a homogenous phenomenon rather than as distinct subtypes. Furthermore, most studies of neglect focus on maternal deficiencies while paternal factors are largely ignored. This study is meant to address these considerations by utilizing the National Comorbidity Survey Replication (NCS-R), a broad population based …

Generation Y And Vocal Fry, Paul Michael Valley

Theses and Dissertations

In this thesis, the author explores a vocal phenomenon called “vocal fry” and why this dysphonia has emerged as one of the primary means of communication for the population referred to as “Generation Y.” The first chapter defines what vocal fry is and why it is of modest value to the stage actor. The second chapter defines the physiological means by which the human body creates sound, what good sound is and how vocal fry is created. The third and fourth chapters define several generations as well as what defines Gen Y, and the communication physiologies associated with those generations. …

A Verbal Snapshot Of Visual Scrutiny Primarily In The Sphere Of Art, Matthew Alverson

Theses and Dissertations

Finding and extracting meaning from the world I encounter every day is the primary motivation behind my creativity. Filtering perception and separating the important bits of information by selection or elimination is the crux of this investigation. This process is one of finding rationale in futility and applying meaning to meaningless encounters. The significance of life is not fixed and it is our responsibility to make it up to best suit the desire to have purpose. Depending on the way something is looked at determines the meaning behind it. Anything can have content if it is seen and translated a …

An Analytic Investigation Into Self Organizing Maps And Their Network Topologies, Renee Baltimore

Theses

This paper details master's thesis work involving research and investigation into the approach of self-organizing maps for clustering of data, more specifically, clustering of image data, and how this can be used in understanding image composition. This work will build upon ideas which have previously been explored, such as using self organizing maps for identifying and grouping different regions of an image which may possess similar features. A large part of this research is based upon experimentation with a variety of topological models of the self-organizing map network and investigation into what advantages these different topologies afford the network in …

Characterization Of The Effects Of The Human Head On Communication With Implanted Antennas, Michael A. Pecoraro

Theses

Cranially implanted sensors and electrodes have been used in practice for several years; their applications range from the recording of neural signals for use in Brain-Computer Interfaces to help the disabled, to the treatment of diseases and conditions ranging from Parkinson's disease, multiple sclerosis, depression, etc. Current communication methods with implants, however, are lacking; they run the gamut from physical, percutaneous connections that increase the risk of infection, to wireless links that are slow and uncomfortable for patients. The present work focuses on the characterization of the effects of the human head on communication with cranially implanted antennas for its …

The Prognostic Potential Of The Epidermal Growth Factor Receptor And Nuclear Factor Kappa B Pathways And Associated Therapeutic Strategies In Patients With Squamous Cell Carcinoma Of The Head And Neck, Pamela Wirth

Theses and Dissertations

Little is known about the signaling pathways that contribute to treatment response in advanced stage head and neck tumors. Increased expression of epidermal growth factor receptor (EGFR) and downstream pathways such as nuclear factor kappa B (NFκB) are implicated in aggressive tumor phenotypes and limited response to therapy. This study explored the rationale for combining the proteasome inhibitor bortezomib with the EGFR inhibitor gefitinib in a subset of head and neck squamous cell carcinomas with high EGFR gene amplification. Drug responses of gefitinib and bortezomib as single agents and in combination within head and neck squamous cell carcinoma cell lines …

Interparental Conflict In Context: Exploring Relations Between Parenting Processes And Children's Conflict Appraisals., Renee Lynn Deboard-Lucas, Gregory M Fosco, Sarah R. Raynor, John H. Grych

Psychology Faculty Research and Publications

Children's appraisals of conflict are a mechanism by which parental discord can lead to child maladjustment. The cognitive-contextual framework proposes that parent-child relationships may affect how children perceive conflict, but this idea has rarely been examined empirically. This study investigated relations between conflict appraisals, parenting, and child adjustment in a sample of 150 8- to 12-year-old children, using a multi-informant, multimethod design. Mothers' coercive/controlling and emotionally unsupportive parenting magnified the relation between conflict and children's self-blame; emotionally supportive parenting diminished this association. Children's secure attachment with fathers was linked with less threat and self-blame; more security reduced self-blame for conflict. …

The Sagebrush Steppe Treatment Evaluation Project (Sagestep): A Test Of State-And Transition Theory., J. D. Mciver, Mark W. Brunson, S. Buntin, J. Chambers, N. Devoe, P. Doescher, J. Grace, D. Johnson, S. Knick, R. Miller

Environment and Society Faculty Publications

No abstract provided.

Downloading Personhood: A Hegelian Theory Of Copyright Law, Karla M. O'Regan

Canadian Journal of Law and Technology

This article will examine these responses, identifying the competing interests at work in both traditional copyright schemes and contemporary Internet-based criticisms, and put forth a theory of copyright law capable of ad- dressing the needs of these rival interests in an advanced technological era.

Part I delineates some of the more prominent theories copyright scholars have offered in response to the “IP-IT crisis.” Part II attempts to identify the source of these problems by first examining conventional justifications for copyright and the competing interests inherently at work in its conception. Part III identifies three specific factors I argue are particularly …

Clinical Knowledge Management Systems: Literature Review And Research Issues For Information Systems, Matthew J. Wills, Surendra Sarnikar, Omar F. El-Gayar, Amit Deokar

Research & Publications

Knowledge Management (KM) has emerged as a possible solution to many of the challenges facing U.S. and international healthcare systems. These challenges include concerns regarding the safety and quality of patient care, critical inefficiency, disparate technologies and information standards, rapidly rising costs and clinical information overload. In this paper, we focus on clinical knowledge management systems (CKMS) research. The objectives of the paper are to evaluate the current state of knowledge management systems diffusion in the clinical setting, assess the present status and focus of CKMS research efforts, and identify research gaps and opportunities for future work across the medical …