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2010

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Computational Fluctuating Fluid Dynamics, Alejandro Garcia, J. B. Bell, S. Williams Jan 2010

Computational Fluctuating Fluid Dynamics, Alejandro Garcia, J. B. Bell, S. Williams

Faculty Publications

This paper describes the extension of a recently developed numerical solver for the Landau-Lifshitz Navier-Stokes (LLNS) equations to binary mixtures in three dimensions. The LLNS equations incorporate thermal fluctuations into macroscopic hydrodynamics by using white-noise fluxes. These stochastic PDEs are more complicated in three dimensions due to the tensorial form of the correlations for the stochastic fluxes and in mixtures due to couplings of energy and concentration fluxes (e.g., Soret effect). We present various numerical tests of systems in and out of equilibrium, including time-dependent systems, and demonstrate good agreement with theoretical results and molecular simulation

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Seasonal Distribution Of Dissolved Inorganic Carbon And Net Community Production On The Bering Sea Shelf, J. T. Mathis, J. N. Cross, N. R. Bates, S. Bradley Moran, M. W. Lomas, C. W. Mordy, P. J. Stabeno Jan 2010

Seasonal Distribution Of Dissolved Inorganic Carbon And Net Community Production On The Bering Sea Shelf, J. T. Mathis, J. N. Cross, N. R. Bates, S. Bradley Moran, M. W. Lomas, C. W. Mordy, P. J. Stabeno

Graduate School of Oceanography Faculty Publications

In order to assess the current state of net community production (NCP) in the southeastern Bering Sea, we measured the spatio-temporal distribution and controls on dissolved inorganic carbon (DIC) concentrations in spring and summer of 2008 across six shelf domains defined by differing biogeochemical characteristics. DIC concentrations were tightly coupled to salinity in spring and ranged from ~1900 μmoles kg−1 over the inner shelf to ~2400 μmoles kg−1 in the deeper waters of the Bering Sea. In summer, DIC concentrations were lower due to dilution from sea ice melt, terrestrial inputs, and primary production. Concentrations were found to …

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An Investigation Into Sustainable Forest Policies And Practices In Syria, Rim Rateb Al Berni Jan 2010

An Investigation Into Sustainable Forest Policies And Practices In Syria, Rim Rateb Al Berni

School of Geography, Earth and Environmental Sciences Theses

Appreciation of how forest land can be managed in a sustainable way in arid and semi-arid zones (ASAZs) of centralized countries is limited. Accordingly, this thesis seeks to analyse the role of government and communities, including women, in the formulation and implementation of sustainable forest management (SFM) policy and practices in the semi-arid environment of Syria where such land is limited in extent (e.g. 3% forest and 57% rangeland) and yet where its high biodiversity value is of international significance. The thesis employs a variety of methods: a case study approach (Syria); a questionnaire (i.e. 142 respondents); face-to-face interviews (i.e. …

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Aqueous And Solid Phase Interactions Of Radionuclides With Organic Complexing Agents, Estela Reinoso-Maset Jan 2010

Aqueous And Solid Phase Interactions Of Radionuclides With Organic Complexing Agents, Estela Reinoso-Maset

School of Geography, Earth and Environmental Sciences Theses

Characterising the geochemistry and speciation of major contaminant radionuclides is crucial in order to understand their behaviour and migration in complex environmental systems. Organic complexing agents used in nuclear decontamination have been found to enhance migration of radionuclides at contaminated sites; however, the mechanisms of the interactions in complex environments are poorly understood. In this work, radionuclide speciation and sorption behaviour were investigated in order to identify interactions between four key radionuclides with different oxidation states (Cs(I) and Sr(II) as important fission products; Th(IV) and U(VI) as representative actinides), three anthropogenic organic complexing agents with different denticities (EDTA, NTA and …

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Sex Representation On The Bench: Legitimacy And International Criminal Courts, Nienke Grossman Jan 2010

Sex Representation On The Bench: Legitimacy And International Criminal Courts, Nienke Grossman

All Faculty Scholarship

This essay examines the relationship between legitimacy and the presence of both male and female judges on international criminal court benches. It argues that sex representation – an approximate reflection of the ratio of the sexes in the general population – on the bench is an important contributor to legitimacy of international criminal courts. First, it proposes that sex representation affects normative legitimacy because men and women bring different perspectives to judging. Consequently, without both sexes, adjudication is inherently biased. Second, even if one rejects the proposition that men and women "think differently", sex representation affects sociological legitimacy because sex …

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Marine Benthic Habitat Mapping Of Muir Inlet, Glacier Bay National Park And Preserve, Alaska With An Evaluation Of The Coastal And Marine Ecological Classification Standard Iii, Luke D. Mitchell, Guy R. Cochrane, Lisa Etherington, Ross D. Powell, Larry A. Mayer Jan 2010

Marine Benthic Habitat Mapping Of Muir Inlet, Glacier Bay National Park And Preserve, Alaska With An Evaluation Of The Coastal And Marine Ecological Classification Standard Iii, Luke D. Mitchell, Guy R. Cochrane, Lisa Etherington, Ross D. Powell, Larry A. Mayer

Center for Coastal and Ocean Mapping

Seafloor geology and potential benthic habitats were mapped in Muir Inlet, Glacier Bay National Park and Preserve, Alaska, using multibeam sonar, ground-truth information, and geological interpretations. Muir Inlet is a recently deglaciated fjord that is under the influence of glacial and paraglacial marine processes. High glacially derived sediment and meltwater fluxes, slope instabilities, and variable bathymetry result in a highly dynamic estuarine environment and benthic ecosystem. We characterize the fjord seafloor and potential benthic habitats using the Coastal and Marine Ecological Classification Standard (CMECS) recently developed by the National Oceanic and Atmospheric Administration (NOAA) and NatureServe. Substrates within Muir Inlet …

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Pah Mineralization And Bacterial Organotolerance In Surface Sediments Of The Charleston Harbor Estuary, Michael T. Montgomery, Thomas J. Boyd, Christopher L. Osburn, David C. Smith Jan 2010

Pah Mineralization And Bacterial Organotolerance In Surface Sediments Of The Charleston Harbor Estuary, Michael T. Montgomery, Thomas J. Boyd, Christopher L. Osburn, David C. Smith

Graduate School of Oceanography Faculty Publications

Semi-volatile organic compounds (SVOCs) in estuarine waters can adversely affect biota but watershed sources can be difficult to identify because these compounds are transient. Natural bacterial assemblages may respond to chronic, episodic exposure to SVOCs through selection of more organotolerant bacterial communities. We measured bacterial production, organotolerance and polycyclic aromatic hydrocarbon (PAH) mineralization in Charleston Harbor and compared surface sediment from stations near a known, permitted SVOC outfall (pulp mill effluent) to that from more pristine stations. Naphthalene additions inhibited an average of 77% of bacterial metabolism in sediments from the more pristine site (Wando River). Production in sediments nearest …

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Toward Linking Ocean Models To Fish Population Dynamics, Lawrence J. Buckley, Lauren B. Buckley Jan 2010

Toward Linking Ocean Models To Fish Population Dynamics, Lawrence J. Buckley, Lauren B. Buckley

Graduate School of Oceanography Faculty Publications

We discuss Lehodey et al.’s (2009) approach to linking ocean models to population dynamics of large marine predators, consider its benefits and limitations, and outline alternative approaches. We advocate a middle ground between Lehodey et al.’s pragmatic, phenomenological approach and the detailed mechanistic approach common to most individual based models. These models should capture the essence of critical processes controlling recruitment and dynamic density-dependent and environmental effects.

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The Design Of A Novel Tip Enhanced Near-Field Scanning Probe Microscope For Ultra-High Resolution Optical Imaging, Derek Brant Nowak Jan 2010

The Design Of A Novel Tip Enhanced Near-Field Scanning Probe Microscope For Ultra-High Resolution Optical Imaging, Derek Brant Nowak

Dissertations and Theses

Traditional light microscopy suffers from the diffraction limit, which limits the spatial resolution to λ/2. The current trend in optical microscopy is the development of techniques to bypass the diffraction limit. Resolutions below 40 nm will make it possible to probe biological systems by imaging the interactions between single molecules and cell membranes. These resolutions will allow for the development of improved drug delivery mechanisms by increasing our understanding of how chemical communication within a cell occurs. The materials sciences would also benefit from these high resolutions. Nanomaterials can be analyzed with Raman spectroscopy for molecular and atomic bond information, …

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Resilience Against Death Anxiety In Relationship To Post-Traumatic Stress Disorder And Psychiatric Co-Morbidity, Mark Hoelterhoff Jan 2010

Resilience Against Death Anxiety In Relationship To Post-Traumatic Stress Disorder And Psychiatric Co-Morbidity, Mark Hoelterhoff

Other Faculty of Science and Engineering Theses

Research was conducted examining death anxiety from existential, psychodynamic, cognitive and sociological perspectives. The intent was to consider the role of death anxiety on well-being; four studies were conducted to examine how death anxiety influenced PTSD and mental health among people who have experienced a life-threatening event. These studies were conducted using undergraduate university students in Lithuania. The first study used a mixed-method design and in phase 1, participants (N=97) completed self-report questionnaires that gathered information on demographics, death anxiety, trauma and well-being. Results indicated a significant correlation between death anxiety and PTSD, but not psychiatric co-morbidity. Phase 2 attempted …

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Effects Of Oil Exposure And Oil-Related Compounds On The Immune System Of The Arctic And Temperate Scallops, Chlamysislandica And Pecten Maximus, Marie Lyn Lynhannam Jan 2010

Effects Of Oil Exposure And Oil-Related Compounds On The Immune System Of The Arctic And Temperate Scallops, Chlamysislandica And Pecten Maximus, Marie Lyn Lynhannam

Other Faculty of Science and Engineering Theses

With the current expansion of offshore oil activities in Arctic regions, there is an urgent need to establish the potential effects of oil-related compounds on Arctic organisms. The scallop Chlamys islandica is distributed throughout the sub-Arctic and has been proposed as a sentinel species for this region. In addition, the temperate scallop Pecten maximus occurs in regions of oil activity and, with increasing sea temperatures, the limit of its distribution may extend further into sub-Arctic regions. P. maximus also accumulates contaminants to a greater extent than the current temperate sentinel Mytilus edulis. A hierarchical approach, similar to that adopted to …

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The Development Of Reasoning Heuristics In Autism And In Typical Development, Kinga Ella Morsanyi Jan 2010

The Development Of Reasoning Heuristics In Autism And In Typical Development, Kinga Ella Morsanyi

Other Faculty of Science and Engineering Theses

Reasoning and judgment under uncertainty are often based on a limited number of simplifying heuristics rather than formal logic or rule-based argumentation. Heuristics are low-effort mental shortcuts, which save time and effort, and usually result in accurate judgment, but they can also lead to systematic errors and biases when applied inappropriately. In the past 40 years hundreds of papers have been published on the topic of heuristics and biases in judgment and decision making. However, we still know surprisingly little about the development and the cognitive underpinnings of heuristics and biases. The main aim of my thesis is to examine …

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Factors Controlling The Quality And Safety Of Fish Using Mackerel (Scomber Scombrus) Shelf-Life Model In The Context Of Sanitary And Phytosanitary (Sps) Measures For The Gambian Fisheries., Bamba A.M. Banja Jan 2010

Factors Controlling The Quality And Safety Of Fish Using Mackerel (Scomber Scombrus) Shelf-Life Model In The Context Of Sanitary And Phytosanitary (Sps) Measures For The Gambian Fisheries., Bamba A.M. Banja

Other Faculty of Science and Engineering Theses

Food quality, including safety, is a major concern facing the food industry today. The effects of sanitary and phytosanitary (SPS) measures in the fisheries sector of The Gambia including the factors affecting the safety and spoilage of fish were investigated. Effects of SPS measures are important impediments for exporting fish and fishery products originating from The Gambia to the international food commodity trade. The inadequate scientific and technical expertise in addition to the general lack of information and finance are the major contributing factors to these impediments. The Government must build capacity, improve infrastructure and increase the number of trained …

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Communicating Marine Environmental Health: Connecting Science, Social And Policy Values, Rebecca Louise Jefferson Jan 2010

Communicating Marine Environmental Health: Connecting Science, Social And Policy Values, Rebecca Louise Jefferson

Other Faculty of Science and Engineering Theses

Human activities are degrading marine ecosystems and undermining the ecological functions and processes which provide valued goods and services. European and UK marine policy developments aim to implement the Ecosystem Approach to support better management of activities and maintain the health of regional seas. Current public perceptions of the UK marine environment are overwhelmingly negative, creating a barrier to engaging society with marine environmental issues and policy. This thesis conducts a study of the attributes of a suite of 72 UK marine species to identify those which contribute most to marine ecological health. The findings show that structurally complex species …

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Amergent Music: Behavior And Becoming In Technoetic & Media Arts, Norbert F. Herber Jan 2010

Amergent Music: Behavior And Becoming In Technoetic & Media Arts, Norbert F. Herber

Other Faculty of Arts, Humanities and Business Theses

Technoetic and media arts are environments of mediated interaction and emergence, where meaning is negotiated by individuals through a personal examination and experience—or becoming—within the mediated space. This thesis examines these environments from a musical perspective and considers how sound functions as an analog to this becoming. Five distinct, original musical works explore the possibilities as to how the emergent dynamics of mediated, interactive exchange can be leveraged towards the construction of musical sound. In the context of this research, becoming can be understood relative to Henri Bergson’s description of the appearance of reality—something that is making or unmaking but …

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Participation As Media: A Compositional System For Staging Participation With Reflective Scenography, Karin Sondergaard Jan 2010

Participation As Media: A Compositional System For Staging Participation With Reflective Scenography, Karin Sondergaard

Other Faculty of Arts, Humanities and Business Theses

The practice-led research develops a compositional system for staging participation within reflective scenographies, and suggests an artistic concept of 'participation as media', which propose the participatory involvement as compositional material in itself. The research takes a starting point in the author's expert practice as a performer and director, and identifies key compositional problems from analysis of previous productions of participatory artworks. The practice-led research processes were organised into two laboratory events, a series of method investigations, and the production of two participatory installation artworks Mirror-Zone-Site and Zen- Sofa Arrangement. The approach is to rethink theatre as a complex communicational system …

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Inter-Continental Patterns In The Fine-Scale Spatial Ecology Of Rain Forest Termites, Olivia Ingrid Scholtz Jan 2010

Inter-Continental Patterns In The Fine-Scale Spatial Ecology Of Rain Forest Termites, Olivia Ingrid Scholtz

Other Faculty of Science and Engineering Theses

In this thesis I describe fine-scale spatial patterns in rain forest termites, from the colony to the assemblage level, sampled from one hectare plots in Central African and South East Asian lowland rain forest. By so doing the ecological interactions that structure this functionally important and abundant soil community were identified. The African termite assemblage, dominated by soil-feeding termites, saturated the upper soil profile (collected from 90% of soil pits). In contrast termites were collected from <50% of soil pits in Asia, with this difference reflecting the lower species densities and abundances of soil-feeding termites in Asian forests. Territoriality and inter-specific competition was shown to be important between colonies of soil-feeding species in the African plot. The termite assemblages were spatially associated with several environmental properties. However these could not explain the spatial patterns in the functional components of the assemblages. Wood-feeding termites were highly patchily distributed, due to the heterogeneous nature of their food material, but also due to possible competitive interactions for this. Humus-feeding termites were homogenously structured, due to the continuous nature of soil as their feeding and nesting material. True soil-feeding termites, unique to the African assemblage, were heterogeneously distributed despite the equally continuous nature of their feeding and nesting material. This structure may arise from facilitative interactions, such as co-operative defence against ant predation which may be intense in African systems, or through the transfer of soil material at different stages of decomposition. Competition for space is apparent in both regions, both at the colony level among soil-feeding genera, and between aggregations of functional groups. Positive and negative biotic interactions, operating at various spatial and functional scales, appear to be important in influencing how assemblage composition is spatially structured. If indeed facilitation is important in maintaining the taxonomic and functional diversity in termite assemblages, it would be valuable to confirm the mechanism(s) that drives this (i.e. predation and/or food transfer), as these may then influence ecosystem stability.

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The Physiological And Molecular Characteristics Of Chemically Induced Abiotic Stress Resistant Mutants Of Cauliflower (Brassica Oleracea Var. Botrytis), Fazal Hadi Jan 2010

The Physiological And Molecular Characteristics Of Chemically Induced Abiotic Stress Resistant Mutants Of Cauliflower (Brassica Oleracea Var. Botrytis), Fazal Hadi

Other Faculty of Science and Engineering Theses

N-nitroso-N-ethyleurea (NEU) and N-nitroso-N-methyleurea (NMU) induced mutants and control plants had been maintained in in-vitro condition for 3 years by continuous sub-culturing and screened 2 generations for resistant mutants selection. In this study highly resistant mutants were regenerated and assessed by leaf discs assay for drought, salt and frost resistance to confirm the persistence of mutation over generations of subculture. Assessment was carried out using mannitol (drought stress), NaCl (salt stress) and freezing (frost stress). Cold-acclimated and non-acclimated leaves were assessed for frost resistance. Results confirmed the persistence of mutations in clones with enhanced tolerance levels to stresses over control …

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An Evaluation Of The Relative Influences Of Elevated Temperature And Ocean Acidification On Processes Influencing The Distribution Of Intertidal Barnacles, Helen Sarah Findlay Jan 2010

An Evaluation Of The Relative Influences Of Elevated Temperature And Ocean Acidification On Processes Influencing The Distribution Of Intertidal Barnacles, Helen Sarah Findlay

Other Faculty of Science and Engineering Theses

Ocean acidification and climate change are occurring as a result of anthropogenic release of carbon dioxide (C02) into the atmosphere. Changes in climate and ocean chemistry are occurring concomitantly and at a faster rate than previously recorded in Earth's history, yet little is understood about how they will influence the population dynamics and ecology of many marine organisms. The barnacle Semibalanus balanoides is a major space occupier on rocky shores in northern Europe and hence changes in its population ecology can have a broad influence on other species. An intertidal high CO2 microcosm system was developed in order to determine …

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A Biophysical Model Of The Role Of The Outer Hair Cell In Cochlear Nonlinearity, Beibei Jiang Jan 2010

A Biophysical Model Of The Role Of The Outer Hair Cell In Cochlear Nonlinearity, Beibei Jiang

Other Faculty of Science and Engineering Theses

It has been observed that the response characteristics of the basilar membrane in normal living cochleae are both frequency and level-sensitive (Robles & Ruggero 2001). The quality factor of the tuning curve is large at low sound levels and decreases as the sound level increases, and the peak of the tuning curve moves towards lower frequencies as the sound level increases. The current study proposes a nonlinear cochlear model that responds adaptively to the incoming sounds via feedback control arising from the mechanical attributes of the cochlear partition. These attributes are dependent on the membrane potential of the outer hair …

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In Momentum: The Navigation, Narration, And Negotiation Of Continuing Professional Development By Mid-Career Artists In South West England, Karen Mary Smith Jan 2010

In Momentum: The Navigation, Narration, And Negotiation Of Continuing Professional Development By Mid-Career Artists In South West England, Karen Mary Smith

Other Faculty of Arts, Humanities and Business Theses

This thesis explores the Continuing Professional Development (CPD) of mid-career artists in England and the South West of England in particular during 2000 to 2010. It identifies what their needs are and asks what CPD means to them; how they navigate their careers through their practice; how they articulate their needs; and how they negotiate to fulfil those needs. It examines to what extent the providers’ thinking about, and provision of, CPD in the region is aligned with the needs of the artists themselves. The individual narratives of artists are represented at the centre of this research. The research was …

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An Exploration Into How Students With Dyslexia Identify With Their Condition, With Particular Reference To The Tensions Which Surround Public And Private Perceptions Of Dyslexia, Deborah A Shenton Jan 2010

An Exploration Into How Students With Dyslexia Identify With Their Condition, With Particular Reference To The Tensions Which Surround Public And Private Perceptions Of Dyslexia, Deborah A Shenton

Other Faculty of Arts, Humanities and Business Theses

This thesis, discusses the implications of the social and private constructions of dyslexia for the individual with dyslexia and the dyslexic identity. In view of the difficulties inherent in higher education this study interviews people with dyslexia who successfully entered degree courses at university. It explores their experiences in an effort to gain an understanding of how people with dyslexia form an identity. Issues surrounding 'dyslexia' have increasingly focused on its credibility as a 'genuine' medical and disabling condition. The social expectations of the condition and the differing social and medical models of conditions warranting the label 'disability' have complicated …

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Why Bother With Podcasting? A View From The Legal Practice Course, Maggie Hemsworth Jan 2010

Why Bother With Podcasting? A View From The Legal Practice Course, Maggie Hemsworth

The Plymouth Law and Criminal Justice Review

No abstract provided.

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Coastal New England Pilot Study To Determine Fossil And Biogenic Formaldehyde Source Contributions Using Radiocarbon, Haiwei Shen, Brian G. Heikes, John T. Merrill, Ann P. Mcnichol, Li Xu Jan 2010

Coastal New England Pilot Study To Determine Fossil And Biogenic Formaldehyde Source Contributions Using Radiocarbon, Haiwei Shen, Brian G. Heikes, John T. Merrill, Ann P. Mcnichol, Li Xu

Graduate School of Oceanography Faculty Publications

Compound specific radiocarbon analyses of atmospheric formaldehyde are reported as fraction modern (Fm) for a limited number of winter and summer air samples collected in coastal southern New England in 2007. The 11 of 13 samples with Fm < 0.2 were collected under the influence of the semipermanent Bermuda high‐pressure system with transport from the Washington, D. C., to New York City urban corridor. The two samples with Fm > 0.2 (max ∼ 0.35) were collected on days with strong northwesterly flow and the least urban impact. The Fm data were combined with VOC observations from the Rhode Island Department of Environmental Management, estimates of oxygenated VOC (OVOC), and back trajectories to interpret the relative contributions of biogenic and fossil carbon sources. It is argued that CH2O sources were dominated …

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Climate Variability, Oceanography, Bowhead Whale Distribution, And Iñupiat Subsistence Whaling Near Barrow, Alaska, Carin J. Ashjian, Stephen R. Braund, Robert Campbell, J. C. "Craig" George, Jack Kruse, Wieslaw Maslowski, Sue E. Moore, Craig R. Nicolson, Stephen R. Okkonen, Barry F. Sherr, Evelyn B. Sherr, Yvette H. Spitz Jan 2010

Climate Variability, Oceanography, Bowhead Whale Distribution, And Iñupiat Subsistence Whaling Near Barrow, Alaska, Carin J. Ashjian, Stephen R. Braund, Robert Campbell, J. C. "Craig" George, Jack Kruse, Wieslaw Maslowski, Sue E. Moore, Craig R. Nicolson, Stephen R. Okkonen, Barry F. Sherr, Evelyn B. Sherr, Yvette H. Spitz

Graduate School of Oceanography Faculty Publications

The annual migration of bowhead whales (Balaena mysticetus) past Barrow, Alaska, has provided subsistence hunting to Iñupiat for centuries. Bowheads recurrently feed on aggregations of zooplankton prey near Barrow in autumn. The mechanisms that form these aggregations, and the associations between whales and oceanography, were investigated using field sampling, retrospective analysis, and traditional knowledge interviews. Oceanographic and aerial surveys were conducted near Barrow during August and September in 2005 and 2006. Multiple water masses were observed, and close coupling between water mass type and biological characteristics was noted. Short-term variability in hydrography was associated with changes in wind …

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Sayre: Undergraduate Catalog 2010-2011, Southwestern Oklahoma State University Jan 2010

Sayre: Undergraduate Catalog 2010-2011, Southwestern Oklahoma State University

Undergraduate Catalogs

No abstract provided.

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Redressing The Unconscionable Health Gap: A Global Plan For Justice, Lawrence O. Gostin Jan 2010

Redressing The Unconscionable Health Gap: A Global Plan For Justice, Lawrence O. Gostin

Georgetown Law Faculty Publications and Other Works

Consider two children—one born in sub-Saharan Africa and the other in the United States. The African child is twenty-five times more likely to die in the first five years of life; if she lives to child-bearing age, she is a two hundred times more likely to die in labor; and overall, she will die thirty years earlier than the American child. The international community is deeply resistant to taking bold remedial action—more concerned with their geostrategic interests than the health of the poor. The scale of foreign aid is both insufficient and unsustainable and fails to address the key determinants …

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Women, Language And Social Roles, Kifayat Aghayeva Jan 2010

Women, Language And Social Roles, Kifayat Aghayeva

Khazar Journal of Humanities and Social Sciences

No abstract provided.

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Adjacent Slice Prostate Cancer Prediction To Inform Maldi Imaging Biomarker Analysis, Shao-Hui Chuang, Xiaoyan Sun, Lisa Cazares, Julius Nyalwidhe, Dean Troyer, O. John Semmes, Jiang Li, Frederic D. Mckenzie, Nico Karssemeijer (Ed.), Ronald M. Summers (Ed.) Jan 2010

Adjacent Slice Prostate Cancer Prediction To Inform Maldi Imaging Biomarker Analysis, Shao-Hui Chuang, Xiaoyan Sun, Lisa Cazares, Julius Nyalwidhe, Dean Troyer, O. John Semmes, Jiang Li, Frederic D. Mckenzie, Nico Karssemeijer (Ed.), Ronald M. Summers (Ed.)

Electrical & Computer Engineering Faculty Publications

Prostate cancer is the second most common type of cancer among men in US [1]. Traditionally, prostate cancer diagnosis is made by the analysis of prostate-specific antigen (PSA) levels and histopathological images of biopsy samples under microscopes. Proteomic biomarkers can improve upon these methods. MALDI molecular spectra imaging is used to visualize protein/peptide concentrations across biopsy samples to search for biomarker candidates. Unfortunately, traditional processing methods require histopathological examination on one slice of a biopsy sample while the adjacent slice is subjected to the tissue destroying desorption and ionization processes of MALDI. The highest confidence tumor regions gained from the …

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Prostate Cancer Region Prediction Using Maldi Mass Spectra, Ayyappa Vadlamudi, Shao-Hui Chuang, Xiaoyan Sun, Lisa Cazares, Julius Nyalwidhe, Dean Troyer, O. John Semmes, Jiang Li, Frederic D. Mckenzie Jan 2010

Prostate Cancer Region Prediction Using Maldi Mass Spectra, Ayyappa Vadlamudi, Shao-Hui Chuang, Xiaoyan Sun, Lisa Cazares, Julius Nyalwidhe, Dean Troyer, O. John Semmes, Jiang Li, Frederic D. Mckenzie

Electrical & Computer Engineering Faculty Publications

For the early detection of prostate cancer, the analysis of the Prostate-specific antigen (PSA) in serum is currently the most popular approach. However, previous studies show that 15% of men have prostate cancer even their PSA concentrations are low. MALDI Mass Spectrometry (MS) proves to be a better technology to discover molecular tools for early cancer detection. The molecular tools or peptides are termed as biomarkers. Using MALDI MS data from prostate tissue samples, prostate cancer biomarkers can be identified by searching for molecular or molecular combination that can differentiate cancer tissue regions from normal ones. Cancer tissue regions are …

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