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The Use Of Natural Product Substrates For The Synthesis Of Libraries Of Biologically Active, New Chemical Entities, Joshua Bryant Phillips

Graduate Student Theses, Dissertations, & Professional Papers

Since Alexander Fleming first noted the killing of a bacterial culture by a mold, antibiotics have revolutionized medicine, being able to treat, and often cure life-threatening illnesses and making surgical procedures possible by eliminating the possibility of opportunistic infection. However, during the past 30 years many of the infections that were once easily cured by the proper antibiotic are no longer so due to a precipitous rise in multi-drug resistant organisms. This rise in multi-drug resistant organisms poses a grave threat to the medical advances that have been made in the past century and underscores the need for new antibiotics. …

Terrorism And Game Theory: From The Terrorists’ Point Of View, Kevin Chlebik

Pepperdine Policy Review

This paper investigates the interplay between two distinct terrorist cells of the same terrorist organization using game-theoretic models. It will discuss the economic consequences of terrorism and provide a literature review. Much of the available literature focuses on national policies and the effects such policies have on terrorists’ behavior. The approach taken here differs in that the primary focus is on terrorists’ behavior. By studying decisions terrorists make and understanding why they make them, better counterterrorism policies can be developed.

Bio/Organic Compound Detection Using Sodium Sulfate Minerals: Implications In The Search For Life On Mars And Europa, Charles Doc Richardson

Graduate Student Theses, Dissertations, & Professional Papers

With the discovery of Na-sulfate minerals (thenardite, mirabilite) on Mars and Europa, recent studies using these minerals have focused on their ability to assist in the detection of biosignatures. On Earth, biotic and biotic processes can assist in the formation and deposition of these minerals. A primary objective of these studies is the detection of bio/organic compounds that may be associated with the mineral. These biosignatures would imply biological involvement during mineral formation. The following research presents a series of natural and synthetic investigations to determine if biological activity is associated with Na-sulfate mineralization, and if these minerals can assist …

The Discipline Of Happiness, Courtney Leigh Christopher

Graduate Student Theses, Dissertations, & Professional Papers

A deeply personal Journey, “The Discipline of Happiness” blends fundamental philosophy with the power of visual art. In a 42‐year quest for purpose certain theories have been tried, championed, discredited, and discarded. The distillation of these ideas into my current theory provides, more saliently than the theory itself, a venue for discussion of the creative process. My creativity often manifests itself in visual terms. Through the medium of an extended artist statement I reflect on the virtues of thinking in both a linguistic and spatial manner. Orchestrating the dual modes of inquiry, semantic and visual, into a single narrative highlights …

Factors Associated With Weaning Practices In Term Infants: A Prospective Observational Study In Ireland., Roslyn Tarrant, Katherine Younger, Margaret Sheridan-Pereira, Martin White, John Kearney

Articles

The WHO (2001) recommends exclusive breast-feeding and delaying the introduction of solid foods to an infant’s diet until 6 months postpartum. However, in many countries, this recommendation is followed by few mothers, and earlier weaning onto solids is a commonly reported global practice. Therefore, this prospective, observational study aimed to assess compliance with the WHO recommendation and examine weaning practices, including the timing of weaning of infants, and to investigate the factors that predict weaning at #12 weeks. From an initial sample of 539 pregnant women recruited from the Coombe Women and Infants University Hospital, Dublin, 401 eligible mothers were …

The Puzzle Of Problem-Solving Efficacy: Understanding Anxiety Among Urban Children Coping With Asthma-Related And Life Stress, Kara Klein Murdock, Carolyn Greene, Sue K. Adams, William Hartmann, Sally Bittinger, Kelly Will

Human Development and Family Science Faculty Publications

Children with asthma living in urban environments are at risk for experiencing anxiety by virtue of both social context and health-related stressors. Although the use of active coping strategies is generally associated with more optimal psychosocial functioning, there is evidence that active coping is less helpful in response to uncontrollable or severe stress. Expectations that one can fix a problem that is uncontrollable or insurmountable may create distress. Problem-solving efficacy was examined as a moderator of the association between stress and anxiety among children residing in inner-city neighborhoods. It was hypothesized that children's perceptions of high problem-solving efficacy would exacerbate …

Pk/Pd Modelling Of Comb-Shaped Pegylated Salmon Calcitonin Conjugates Of Differing Molecular Weights, Sinead Ryan, Jesus Maria Frias, David H. Haddleton, David J. Brayden

Articles

Salmon calcitonin (sCT) was conjugated via cysteine-1 to novel combed-shaped end-functionalised poly(PEG) methyl ether methacrylate) (sCT-P) comb-shaped polymers, to yield conjugates of total molecular weights (MW) inclusive of sCT: 6.5, 9.5, 23 and 40 kDa. The conjugates were characterised by HPLC and their in vitro and in vivo bioactivity was measured by cAMP assay on human T47D cells and following intravenous (i.v.) injection to rats, respectively. Stability against endopeptidases, rat serum and liver homogenates was assessed. There were linear and exponential relationships between conjugate MW with potency and efficacy respectively, however the largest MW conjugate still retained 70% of E …

Purification And Properties Of Amycolatopsis Mediterranei Dsm 43304 Lipase And Its Potential In Flavour Ester Synthesis, Dharmendra Dheeman, Gary Henehan, Jesus Maria Frias

Articles

An extracellular thermostable lipase from Amycolatopsis mediterranei DSM 43304 has been purified to homogeneity using ammonium sulphate precipitation followed by anion exchange chromatography and hydrophobic interaction chromatography. This protocol resulted in 398 fold purification with 36% final recovery. The purified A. mediterranei DSM 43304 lipase (AML) has an apparent molecular mass of 33 kDa. The N-terminal sequence, AANPYERGPDPTTASIEATR, showed highest similarity to a lipase from Streptomyces exfoliatus. The values of and for p-nitrophenyl palmitate (p-NPP) under optimal temperature (60°C) and pH (8.0) conditions were 0.10 ± 0.01 mM and 2.53 ± 0.06 mmol/minmg, respectively. The purified …

Inactivation Of Escherichia Coli By Ozone Treatment Of Apple Juice At Different Ph Levels, Sonal Patil, Vasilis Valdramidis, Patrick J. Cullen, Jesus Maria Frias, Paula Bourke

Articles

This research investigated the efficacy of gaseous ozone for the inactivation of Escherichia coli ATCC 25922 and NCTC 12900 strains in orange juice. Orange juice inoculated with E. coli (10⁶ CFU mL^-1) as a challenge microorganism was treated with ozone at 75-78µg mL^-1 for different time periods (0-18 min). The efficacy of ozone for inactivation of both strains of E. coli was evaluated as a function of different juice types: model orange juice, fresh unfiltered juice, juice without pulp, and juice filtered through 500mm or 1mm sieves. Fast inactivation rates for total reduction of E. coli …

Prediction Of Polyphenol Oxidase Activity Using Visible Near-Infrared Hyperspectral Imaging On Mushroom (Agaricus Bisporus) Caps., Edurne Gaston, Jesus Maria Frias, Patrick J. Cullen, Colm O'Donnell, Aoife Gowen

Articles

Physical stress (i.e. bruising) during harvesting, handling and transportation triggers enzymatic discoloration of mushrooms, a common and detrimental phenomenon largely mediated by polyphenol oxidase (PPO) enzymes. Hyperspectral imaging (HSI) is a non-destructive technique that combines imaging and spectroscopy to obtain information from a sample. The objective of this study was to assess the ability of HSI to predict the activity of PPO on mushroom caps. Hyperspectral images of mushrooms subjected to various damage treatments were taken, followed by enzyme extraction and PPO activity measurement. Principal component regression (PCR) models (each with 3 PCs) built on raw reflectance and multiple scatter …

An Evaluation Of A Community Dietetics Intervention On The Management Of Malnutrition For Healthcare Professionals, Sharon Kennelly, N. P. Kennedy, G. Flanaghan-Rughoobur, C. Glennon-Slattery, Sheila Sugrue

Articles

Background: Healthcare professionals working in the community setting have limited knowledge of the evidence-based management of malnutrition. The present study aimed to evaluate a community dietetics intervention, which included an education programme for healthcare professionals in conjunction with the introduction of a community dietetics service for patients ‘at risk’ of malnutrition. Changes in nutritional knowledge and the reported management of malnourished patients were investigated and the acceptability of the intervention was explored. Methods: An education programme, incorporating ‘Malnutrition Universal Screening Tool (MUST)’ training, was implemented in eight of 10 eligible primary care practices (14 general practitioners and nine practice nurses …

Naturally Understanding Naturalism, Stewart Goetz

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

Methademic: Drug Panic In An Age Of Ambivalence, Deborah Ahrens

Faculty Articles

The story of criminal sanctions in modern America is a familiar-and depressing narrative. According to the narrative, we live in an era where the dynamics of popular politics, the practices of the media, and the (often racialized) anxieties of modern life combine to create a one-way ratchet, in which we identify perceived new threats to public order and respond unthinkingly with harsh new criminal sanctions. On the surface, the wave of concern over methamphetamine that swept the nation in the middle part of this decade followed this script, as a media panic led to substantial popular concern and significant new …

Brilliant Disguise: An Empirical Analysis Of A Social Experiment Banning Affirmative Action, Deirdre M. Bowen

Faculty Articles

The notion of a colorblind society captured the imagination of voters who passed propositions banning affirmative action in higher education admissions in California, Washington, more recently in Michigan, and on November 4th, in Nebraska. Affirmative action is no longer required, proponents assert, because society no longer judges people by their skin color. They argue that the need for affirmative action is a vestige of a bygone era, and such a policy only creates resentment and stigma. This paper confronts the colorblind ideal myths of stigma and resentment, which appear at much greater rates in anti-affirmative action states. In analyzing data …

Making Up Is Hard To Do: Race/Gender/Sexual Orientation In The Law School Classroom, Robert S. Chang, Adrienne D. Davis

Faculty Articles

This exchange of letters picks up where Professors Adrienne Davis and Robert Chang left off in an earlier exchange that examined who speaks, who is allowed to speak, and what is remembered.' Here, Professors Davis and Chang explore the dynamics of race, gender, and sexual orientation in the law school classroom. They compare the experiences of African American women and Asian American men in trying to perform as law professors, considering how makeup and other gender tools simultaneously assist and hinder such performances. Their exchange examines the possibility of bias that complicates the use of student evaluations in assessing teaching …

The Terrorism Bar To Asylum In Australia, Canada, The United Kingdom, And The United States: Transporting Best Practices, Won Kidane

Faculty Articles

The contemporary threat of terrorism that the Western world faces is primarily from so-called “aliens.” As such, the laws that are meant to combat terrorism necessarily involve the regulation of the admission and exclusion of aliens. This type of regulation is traditionally the purview of immigration law. Although the link between national security and immigration is by no means contemporary, the existing level of intersection between antiterrorism laws and immigration is essentially a post- 9/11 phenomenon.

The reason for this phenomenon is that the 9/11 attacks were planned and executed by aliens. Although there has not been a terrorist attack …

Law Of Geography And The Geography Of Law: A Post-Colonial Mapping, Tayyab Mahmud

Faculty Articles

This article examines the relationship between law and geography through the prisms of colonialism and neoliberal Empire. Using two novels set in nineteenth and twenty-first century India, respectively, it evaluates the so-called first law of geography, namely that "everything is related to everything else, but near things are more related than distant things." It argues that the formative and enduring relationship between global systems of domination and modern law has created a geolegal space that has a global dimension. This geolegal space creates norms and subjectivities that are intimately related to spatially distant forces and projects. Emergence and consolidation of …

Physician-Assisted Suicide And Dementia: The Impossibility Of A Workable Regulatory Regime, John B. Mitchell

Faculty Articles

Currently, four-and-a-half million Americans are afflicted with Alzheimer’s Disease, accounting for roughly half the cases of adult dementia, and fourteen million cases are projected by mid-century. With the coalescence of the baby boomers, managed health care, and increasingly scarce health care resources, our society must brace to face a social and legal policy challenge of enormous importance and complexity. In this circumstance, the inevitable call for access to physician-assisted suicide, likely triggered through some form of living will, will need to be considered within a context far different than the current focus of the assisted-suicide debate on terminal illness. Asserting …

Estimating Relative Distribution Of Raccoons, Opossums, Skunks, And Foxes Using Animal Control Data, Christine Klinkowski-Clark, Michael J. Kutilek, John O. Matson, Paula Messina, Kevin Earley, Shannon M. Bros-Seemann

Human–Wildlife Interactions

We used indices of animal control reports per capita and areas of land covers to assess the relative habitat-use of raccoons (Procyon lotor), opossums (Didelphis virginiana), skunks (Spilogale putorius and Mephitis mephitis), and foxes (Vulpes vulpes and Urocyon cinereoargenteus). We used confirmed (hereafter, verified) calls made to Brevard Animal Services, Florida, and assessed potential human demographic influences associated with unconfirmed (hereafter, unverified) reports where it was uncertain whether or not an animal was present. To estimate habitat use, we performed quadrat sampling using a geographic information system (GIS) and obtained areas of …

Selection Of Pathways To Foraging Sites In Crop Fields By Flightless Canada Geese, Troy M. Radtke, Charles D. Dieter

Human–Wildlife Interactions

Geese, especially when they are flightless, can cause significant crop damage. We determined the effects of shoreline characteristics on foraging site selection by flightless Canada geese (Branta canadensis) in South Dakota. Distance from edge of crop field to wetland and visual obstruction by vegetation were important determinants of pathway selection by geese. Geese used crop fields for foraging that were closer to water than unused fields. Geese accessed those fields along pathways with less visual obstruction by vegetation than unused pathways. Our data suggest that this distance of crops to wetlands is the most important shoreline characteristic determining …

Domestication Alone Does Not Lead To Inequality: Intergenerational Wealth Transmission Among Horticulturalists, Michael Gurven, Monique Borgerhoff Mulder, Paul L. Hooper, Hillard Kaplan, Robert Quinlan, Rebecca Sear, Eric Schniter, Christopher Von Rueden, Samuel Bowles, Tom Hertz, Adrian Bell

Psychology Faculty Articles and Research

We present empirical measures of wealth inequality and its intergenerational transmission among four horticulturalist populations. Wealth is construed broadly as embodied somatic and neural capital, including body size, fertility and cultural knowledge, material capital such as land and household wealth, and relational capital in the form of coalitional support and field labor. Wealth inequality is moderate for most forms of wealth, and intergenerational wealth transmission is low for material resources and moderate for embodied and relational wealth. Our analysis suggests that domestication alone does not transform social structure; rather, the presence of scarce, defensible resources may be required before inequality …

Functionality, Parsimony, Discovery, Avoiding Hamartia: How Evolutionary Perspectives Are Changing Psychology, Brooke N. Jenkins, Aaron T. Goetz

Psychology Faculty Articles and Research

Evolutionary psychology offers an important perspective to scientific psychology. Evolutionary psychology, in its short existence, has added an abundance of knowledge to the social sciences, let alone psychology. The study of human cognition and behavior remains incomplete without an evolutionary perspective. Here, we argue that evolutionary psychology uniquely provides a complete understanding of scientific psychology because it explains the functions of our psychological traits, provides us with the most parsimonious explanation of many psychological phenomena, predicts undocumented phenomena, and possibly allows us to avoid the downfalls of some of our contemptible evolved psychological mechanisms.

Relative Doubt: Familial Searches Of Dna Databases, Erin Murphy

Michigan Law Review

The continued growth of forensic DNA databases has brought about greater interest in a search method known as "familial" or "kinship" matching. Whereas a typical database search seeks the source of a crime-scene stain by making an exact match between a known person and the DNA sample, familial searching instead looks for partial matches in order to find potential relatives of the source. The use of a familial DNA search to identify the alleged "Grim Sleeper" killer in California brought national attention to the method, which has many proponents. In contrast, this Article argues against the practice of familial searching …

Racial /Ethnic Disparities In Hypertension In United States Residents: A Cross-Sectional Study Of Potential Explanatory Covariates, Franklin I. Opara

Walden Dissertations and Doctoral Studies

Racial/ethnic disparities persist in hypertension (HTN) prevalence in the United States, and African Americans are disproportionately affected. The incidence is more than two-folds in African Americans compared to Caucasians, and mortality is highest among African Americans. Understanding the risk factors in HTN and how these factors vary across racial/ethnic groups is essential to reducing the mortality among African Americans. This study examined the prevalence of HTN among a sample non-institutionalized U.S. residents (N = 30,852), assessed racial/ethnic disparities and determined factors associated with racial/ethnic variance in HTN. A cross-sectional design was used to address these aims, utilizing the National Health …

The Experience Of Students Who Identify As Jewish And Greek : Influences On Spiritual Development, Alexandra D. Froehlich

University of the Pacific Theses and Dissertations

Seven percent of the national four year college population is involved in Greek Life (Microsoft Encarta Online Encyclopedia, 2008, ~5) with over sixty percent on some campuses (Finkel, 201 0). An often unexamined aspect of collegiate learning pertaining to this context is students' spiritual development, yet this is a vital part of a student's life throughout college and critical to whole student learning (Love & Talbot, 2005). Students report a high level of interest in spiritual activities while struggling with existential questions on a regular basis (Higher Education Research Institute, 2003). Most social fraternities and sororities embrace Christian ideals, making …

China, Wei Cui

All Faculty Publications

The Chinese indirect tax system is on the eve of a major overhaul, with the integration of the VAT and business tax (BT) to start in select industries in Shanghai on January 1, 2012. This paper provides an overview of China's idiosyncratic VAT as well as the BT as they stood towards the end of 2010. BT law and practice are discussed only in connection with select conceptual issues such as the exclusion from the VAT/BT base, place of supply, etc. This decision is based on the considerations that many of the legal issues arising under the VAT cannot be …

As The Creek Trickles: Land Use Debates In The Rock Creek Drainage, Carly Christine Phillips

Graduate Student Theses, Dissertations, & Professional Papers

Rural areas in Montana are increasing in population as more and more people move to or buy second homes in these areas in search of scenic amenities and a better quality of life. Academics, policy makers, and the general public are concerned that such development pressure may have negative consequences for important habitat, ecosystems, rural communities, people’s livelihoods, and social networks. Rock Creek, Montana is a small, rural area that has seen a large increase in population in the last twenty years. Population increase and development pressure in the area has led to many debates about proper land use on …

The Psychology Of Good Character, Alice Woolley, Jocelyn Stacey

All Faculty Publications

This paper explores the significance of the changing nature of the good character requirement for law society admission in Canada. It posits that good character has shifted from a philosophical concept into a psychological concept, with evidence of past bad acts claimed to be relevant for whether an applicant represents a future risk to the public. This shifting conception of character has, however, been only partial, and the decision-making processes of Canadian law societies have not kept pace with it. Instead, the decision-making process defines character generally and generically, with only occasional emphasis on character as a relevant predictor of …

Bioelectric Applications For Treatment Of Melanoma, Stephen J. Beebe, Karl H. Schoenbach, Richard Heller

Bioelectrics Publications

Two new cancer therapies apply bioelectric principles. These methods target tumor structures locally and function by applying millisecond electric fields to deliver plasmid DNA encoding cytokines using electrogene transfer (EGT) or by applying rapid rise-time nanosecond pulsed electric fields (nsPEFs). EGT has been used to locally deliver cytokines such as IL-12 to activate an immune response, resulting in bystander effects. NsPEFs locally induce apoptosis-like effects and affect vascular networks, both promoting tumor demise and restoration of normal vascular homeostasis. EGT with IL-12 is in melanoma clinical trials and nsPEFs are used in models with B16F10 melanoma in vitro and in …

Rule-Based Cell Systems Model Of Aging Using Feedback Loop Motifs Mediated By Stress Responses, Andres Kriete, William Bosl, Glenn Booker

Nursing and Health Professions Faculty Research and Publications

Investigating the complex systems dynamics of the aging process requires integration of a broad range of cellular processes describing damage and functional decline co-existing with adaptive and protective regulatory mechanisms. We evolve an integrated generic cell network to represent the connectivity of key cellular mechanisms structured into positive and negative feedback loop motifs centrally important for aging. The conceptual network is casted into a fuzzy-logic, hybridintelligent framework based on interaction rules assembled from a priori knowledge. Based upon a classical homeostatic representation of cellular energy metabolism, we first demonstrate how positive-feedback loops accelerate damage and decline consistent with a vicious …