Digital Commons Network^™

Joep Franssens' Harmony Of The Spheres: A Conductor's Analysis, David Andrew Hobson

LSU Doctoral Dissertations

Harmony of the Spheres is Dutch composer Joep Franssens’ most extensive choral work to date, exhibiting a substantial possibility to enter the international repertoire as a complete work; however, several of the movements can stand alone effectively. Presented in five symmetrically conceived movements, Franssens scores the piece for SSAATTBB chorus with only the addition of full string orchestra for Movement III. The composition seeks to explore profound connections between science, music, philosophy, religion, and human relationships, intertwining excerpts from Benedict de Spinoza’s magnum opus, Ethica, allusions to the ancient idea of the music of the spheres, and European minimalism. Franssens …

In Vitro And In Vivo Evaluation Of A Brucella Putative Hemagglutinin, Lauren E. Duhon

LSU Doctoral Dissertations

Brucellosis, a zoonotic disease caused by Brucella spp., presents both health and economic difficulties for livestock, wildlife, and humans. While brucellosis is nearly eradicated in the United States, the disease remains detrimental in many countries worldwide. Attempts to produce a safe and effective small ruminant vaccine have been met with limited success. The current vaccine for bovine brucellosis in the United States is B. abortus RB51. This strain transiently colonizes the host and induces a cell-mediated immune response. Levels of protection have not been demonstrated in goats and thus it is considered a relatively poor caprine vaccine that probably does …

"Teach Us Incessantly": Lessons And Learning In The Antebellum Gulf South, Sarah L. Hyde

LSU Doctoral Dissertations

Before 1860 people in the Gulf South valued education and sought to extend schooling to residents across the region. Southerners learned in a variety of different settings – within their own homes taught by a family member or hired tutor, at private or parochial schools as well as in public free schools. Regardless of the venue, the ubiquity of learning in the region reveals the importance of education in Southern culture. In the 1820s and 1830s, legislators in Louisiana, Mississippi, and Alabama sought to increase access to education by offering financial assistance to private schools in order to offset tuition …

Dissolution Of Chitosan In Ionic Liquids For Acylation Chemistry And Formation Of Cellulose-Chitosan Blends, Cristina Stefanescu

LSU Doctoral Dissertations

Dissolution of chitosan in ionic liquids was accomplished. It has been shown that 1-butyl-3-methylimidazolium acetate (BMIMAc) is a better solvent than 1-butyl-3-methylimidazolium chloride (BMIMCl). Dissolution of chitosan in BMIMCl required a prior regeneration of chitosan from 1% acetic acid solution. In the case of BMIMAc, both dried chitosan and regenerated chitosan from acetic acid solution have been dissolved in a relatively short amount of time. While concentrations up to 2 wt% of chitosan in BMIMCl could be obtained, concentrations of 10 wt % of chitosan in BMIMAc were realized. Homogeneous phthalation and benzoylation of chitosan were achieved in these ionic …

The Effects Of A Freshwater Diversion Of Nekton Species Biomass Distributions, Food Web Pathways, And Community Structure In A Louisiana Estuary, Kim De Mutsert

LSU Doctoral Dissertations

A current method to restore Louisiana’s estuaries includes reintroducing freshwater and sediments to wetlands that are hydrologically isolated from the Mississippi River due to the construction of levees. In this dissertation, I examined effects of the second largest freshwater diversion in Louisiana, the Caernarvon Freshwater Diversion (CFD), on estuarine nekton in Breton Sound. Before focusing on Breton Sound, I examined the status of nekton communities in the northern Gulf of Mexico (GOM), and Louisiana wetlands in particular, using the mean trophic level index (MTLI). I demonstrated that commercial targeting caused the previously reported low and declining MTLI from the GOM. …

Effect Of Resistant Starch On Microbial Content Of The Intestinal Tract, Reshani Nisansala Senevirathne

LSU Doctoral Dissertations

Resistant starch (RS) increases beneficial gastro-intestinal bacterial populations simultaneously increasing short-chain fatty acids (SCFA) such as butyrate. Butyrate acts as energy source for epithelial cells of colonic mucosa which stimulates intestinal cell proliferation and has been implicated as important in reducing obesity, diabetes and cancer. The Lactobacillus spp, Bifidobacterium spp, Bacteroides thetaiotaomicron, Clostridium cluster IV and Clostridium cluster XIV are mainly involved in the production of butyrate by fermenting RS in the large intestine. With age there is a decline in these gut bacteria, but in the present study RS and diet restriction both enhanced the bacteria involved in butyrate …

Probing The Finance Gap Theory: Does Gender Affect Campaign Contributions?, Rhonda Wrzenski

LSU Doctoral Dissertations

In our field, scholarly literature contends that women win a similar percentage of the vote and raise a similar amount of money as their male opponents when they campaign (Newman 1994; Burrell 1994; Seltzer et al. 1997; Dolan 2006; Darcy et al. 1994; Wilhite and Theilmann 1986; Burrell 1985; Uhlaner and Schlozman 1986; Welch et al. 1985). However, women are still underrepresented at all levels of government and this may be a function of biases in the campaign finance network that have gone largely undetected. Differences may be more readily apparent at the sub-national level and among particular classes of …

Optimized Extraction Of Soluble Defatted Rice Bran Fiber And Its Application For Microencapsulation Of Fish Oil, Yuting Wan

LSU Master's Theses

Defatted rice bran (DRB) is a byproduct of rice milling and rice bran oil extraction. Soluble rice bran fiber (SRBF) extracted from defatted rice bran is known for its antioxidant activity and hypocholesterolemic effects in human, while purified menhaden oil (PMO) is a good source of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The goal of the study was to estimate optimum extraction conditions to extract SRBF from DRB, develop a cost effective method to purify SRBF and produce microencapsulated PMO with SRBF. The response surface methodology showed that an estimated optimum yield of SRBF (7.89%) could be extracted from …

Dietary Resistant Starch Improved Maternal Glycemic Control In Goto-Kakizaki Rat, Li Shen

LSU Doctoral Dissertations

Treatment for maternal hyperglycemia is limited on account of safety concerns for fetus. Our previous work has shown that inclusion of resistant starch in the diet decreases body fat accumulation in rodents, increases GLP-1 at both the gene expression level and plasma levels, and improves glucose tolerance in STZ-induced diabetic mice. However, studies concerning dietary resistant starch and maternal hyperglycemia are scarce. In this project, we examined the effects of dietary resistant starch in pregnant Goto-Kakizaki (GK) rats to improve glycemic control. Animal experiments were conducted to test the hypotheses. In study 1, the female GK rats were randomly grouped …

Interaction Of Tumor Necrosis Factor-Alpha And The Renin Angiotensin System In The Pathogenesis Of Hypertension, Srinivas Sriramula

LSU Doctoral Dissertations

Hypertension is a major predisposing factor for the development of cardiovascular and renal diseases. The renin-angiotensin system (RAS) plays a pivotal role in the pathogenesis of cardiovascular diseases such as hypertension, myocardial infarction, heart failure, and stroke. Angiotensin II (Ang II), the effector peptide of the RAS, activates a wide spectrum of signaling responses via the Ang II type-I receptor that mediate its physiological control of blood pressure, thirst and sodium balance. For the past two decades, increasing evidence has demonstrated that the circulatory RAS and local/tissue RAS components (heart and brain) may contribute to the development of hypertensive response. …

Maladies Of Modernity: Scientism In Politics, David Nathan Whitney

LSU Doctoral Dissertations

This dissertation explores the complex relationship between science and politics. More specifically, it focuses on the problem of scientism. Features of scientism include the dogmatic faith in the methods of the natural sciences (and the accompanying assumption that those methods can be successfully imported into the social sciences), a materialistic worldview, the rejection of the bios theoretikos, the prohibition of philosophical questions, and an emphasis on immanent fulfillment through the power of science. I seek to demonstrate that scientism is intellectually impoverishing and politically dangerous. Given the lack of full-length studies on the subject, I trace the development of scientism …

Texasweed (Caperonia Palustris (L.) St. Hil.) Interference And Management In Drill-Seeded Rice, Rakesh K. Godara

LSU Doctoral Dissertations

Field research was conducted from 2006 to 2009 to study Texasweed [Caperonia palustris (L.) St. Hil.] interference and management in Cocodrie rice. Texasweed interference at 10 plants/m2 caused 24 to 31% rice yield reduction. The maximum possible yield loss was estimated to be 81%. Rice yield reduction was primarily due to a reduction in culms/m2 and filled grains per panicle. For maximum yield, Texasweed must be removed by two weeks after emergence and managed until permanent flood establishment. Shade had no effect on Texasweed emergence but significantly reduced growth and reproduction. At 100 days after emergence, 50, 70, and 90% …

Evolution Of Yy1, Yy2, Rex1 And Dna-Binding Motifs In Vertebrate Genomes, Christopher Don Faulk

LSU Doctoral Dissertations

Transcription factors are important for many aspects of gene regulation in eukaryotes. YY1 (Yin-Yang 1) is a particularly interesting example of a highly conserved zinc-finger transcription factor, involved in transcriptional activation, repression, initiation, and in chromatin modification. YY1 is ubiquitously expressed in mammals, and its binding sites are found in ~10% of human genes as well as in repetitive elements. It is a targeting protein of the Polycomb complex and is involved in mammalian genomic imprinting. First, we explored the evolutionary history of YY1 using 62 species and formation of its paralogs, YY2 and REX1, which are found in mammals, …

A Study Of The Elongation Of Fibrils Of The Alzheimer's Amyloid Beta Protein With A Coarse-Grained Force Field, Ana Rojas

LSU Doctoral Dissertations

Alzheimer’s disease (AD) is a brain disorder named after the German psychiatrist Alois Alzheimer, who first described the disease in 1906. AD is a form of dementia, characterized by impairment of memory and other intellectual abilities, caused by the loss of neurons and synapses (the structures that permit communication between neurons) in certain regions of the brain. Although the mechanism by which neurons are affected is not yet well understood, research points to a small protein, the beta-amyloid peptide (Abeta), as the first suspect. Ab chains are present in the brains of healthy individuals, but in AD patients, they associate …

Iron (Iii) Oxide And Copper (Ii) Oxide Mediated Formation Of Pcdd/Fs From Thermal Degradation Of 2-Mcp And 1,2-Dcbz, Shadrack Kirwa Nganai

LSU Doctoral Dissertations

Formation of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) which occurs inexorably from most thermal and combustion processes constitutes a major toxic component of environmental pollutants. Generally, it is well established that transition metal-mediated reactions account for the majority of PCDD/F emissions from combustion sources. Specifically, both copper and iron ions, which occur abundantly in combustion generated particulate matter, are considered probably the most active in promoting PCDD/F formation typically in the low temperature post-combustion zone and flue gas pollution control devices. It has also been demonstrated that chlorinated phenols are key intermediates in essentially all pathways of PCDD/F formation. Chlorinated benzenes …

Artisanal Whaling In The Atlantic: A Comparative Study Of Culture, Conflict, And Conservation In St. Vincent And The Faroe Islands, Russell Fielding

LSU Doctoral Dissertations

Whalers from the Caribbean island of St. Vincent and the North Atlantic archipelago of the Faroe Islands hunt pilot whales and a variety of other small cetaceans for food. Vincentian whalers use harpoons, thrown by hand or fired from a modified shotgun mounted on the boat. Faroese whalers, using several dozen boats, work cooperatively to drive an entire pod of whales ashore, where shore-based whalers are waiting to complete the kill with traditional whaling knives. Vincentian whaling traces its origins to the late nineteenth century. Records of Faroese whaling date to the late sixteenth century but the practice is thought …

The Conserved Deda Family Of E. Coli Membrane Proteins: Genetic And Topological Analysis, Kandi Sheral Thompkins

LSU Doctoral Dissertations

Ludox density gradients were used to enrich for Escherichia coli mutants with conditional growth defects and alterations in membrane composition. A temperature-sensitive mutant named Lud135 was isolated with mutations in two related, nonessential genes: yghB and yqjA. yghB harbors a single missense mutation (G203D) and yqjA contains a nonsense mutation (W92TGA) in Lud135. Both mutations are required for the temperature-sensitive phenotype: targeted deletion of both genes in a wild-type background results in a strain with a similar phenotype and expression of either gene from a plasmid restores growth at elevated temperatures. The mutant has altered membrane phospholipid levels, with elevated …

Population Genetics And Systematics Of A Species-Rich Clade Of Neotropical Reef Fishes, The Tubeblenny Genus Acanthemblemaria, Ron Israel Eytan

LSU Doctoral Dissertations

Neotropical coral reef fish communities are species-poor compared to those of the Indo-West Pacific. An exception to that pattern is the blenny clade Chaenopsidae, one of only three coral reef fish families endemic to the Neotropics. Within the chaenopsids, the genus Acanthemblemaria is the most species-rich. To understand the origin and maintenance of genetic and species diversity in these fishes, I characterized the population genetics for two Acanthemblemaria species, reconstructed the phylogeny of the group, and identified suites of correlated morphological characters responsible for the distinctive skull morphology of these fishes. By combining nuclear and mitochondrial sequence data I was …

Spectroscopy And Structures Of Metal-Cyclic Hydrocarbon Complexes, Jung Sup Lee

University of Kentucky Doctoral Dissertations

Metal-cyclic hydrocarbon complexes were prepared in a laser-vaporization molecular beam source and studied by single-photon zero electron kinetic energy (ZEKE) and IR-UV resonant two-photon ionization (R2PI) spectroscopy. The ionization energies and vibrational frequencies of the metal complexes were measured from the ZEKE spectra. Metal-ligand bonding and low-lying electronic states of the neutral and ionized complexes were analyzed by combining the ZEKE measurements with density functional theory (DFT) calculations. In addition, C-H stretching frequencies were measured from the R2PI spectra.

In this dissertation, metal complexes of 1, 3, 5, 7-cyclo-octatetraene (COT), toluene, p-xylene, mesitylene, hexamethylbenzene, biphenyl, naphthalene, pyrene, perylene, and …

The Role Of Racial Information In Infant Face Processing, Angela Nicole Hayden

University of Kentucky Doctoral Dissertations

The present research addressed the development of specialization in face processing in infancy by examining the roles of race and emotion. An other-race face among own-race faces draws adults’ attention to a greater degree than an own-race face among other-race faces due to the “other-race” feature in other-race faces. This feature underlies race-based differences in adults’ face processing. The current studies investigated the development of this mechanism as well as the influence that this mechanism has on emotion processing in infancy.

In Experiment 1, Caucasian 3.5- and 9- month-olds exhibited a preference for a pattern containing an Asian face among …

The Role Of Abcg2 In Drug Active Transport In Milk, Lipeng Wang

University of Kentucky Doctoral Dissertations

Drug active transport into milk is a major concern for breastfeeding mothers and healthcare providers. Studies from the literature indicated that breast cancer resistance protein (ABCG2) plays an important role in drug transfer into milk. There has been limited study on stereoselective interactions with ABCG2. A mechanistic analysis of flux across cell monolayer model is a critical first step toward extrapolating in vitro results for predicting in vivo disposition (including distribution into milk), drug disposition or drug-drug interactions.

The objectives of this thesis were (1) to establish a “Chemical knockout model” in rat for studying drug accumulation into milk, (2) …

Yersinia Pestis Virulence Factor Yopm Undermines The Function Of Distinct Ccr2+Gr1+ Cells In Spleen And Liver During Systemic Plague, Zhan Ye

University of Kentucky Doctoral Dissertations

Yersinia pestis, the infective agent of bubonic and pneumonic plague, is classified as a category A agent of bioterrorism. YopM, a protein toxin of Y. pestis, is necessary for full virulence in a systemic plague mouse model with ambient-temperature grown bacteria. We used this model to identify the cells undermined by YopM. Natural killer (NK) cells were previously reported to be lost in spleen and blood in a YopM-associated way; however, NK cell depletion was found not to occur in liver, and ablation of NK cells had no effect on bacterial growth, indicating that NK cells are redundant …

Protection Against Endothelial Inflammation By Green Tea Flavonoids, Yuanyuan Zheng

University of Kentucky Doctoral Dissertations

Endothelial inflammation is a pivotal early event in the development of atherosclerosis. Long term exposure to cardiovascular risk factors will ultimately exhaust those protective anti-inflammatory factors such as the heme oxygenase (HO) system. The HO system plays a critical role in cellular and tissue self-defense against oxidative stress and inflammation. Caveolae are membrane domains and are particularly abundant in endothelial cells, where they are believed to play a major role in the regulation of endothelial vesicular trafficking as well as the uptake of lipids and related lipophilic compounds, possibly including bioactive food components such as flavonoids. Research in this dissertation …

Effects Of Habitat Structural Complexity On Nekton Assemblages: Lab And Field Observations In Southern Louisiana, Austin T. Humphries

LSU Master's Theses

Greater structural complexity is often associated with more diverse and abundant species assemblages. Biogenic reefs formed by the eastern oyster (Crassostrea virginica) are structurally complex in nature and have been recognized for their potential habitat value in estuarine systems along the Atlantic and Gulf of Mexico coasts. To determine how the structural complexity of newly created oyster reefs may influence the abundance and distribution of species, three objectives were established. First, to examine spatial and temporal patterns of nekton use at newly created oyster reefs, as well as the impact of wave exposure, six paired oyster reef and mud-bottom treatments …

Arsenite Oxidation By Pure Cultures Of Thiomonas Arsenivorans Strain B6 In Bioreactor Systems, Aniruddha Dastidar

University of Kentucky Doctoral Dissertations

The removal of arsenic toxicity from water is accomplished by a preliminary preoxidative step transforming the most toxic form, arsenite (As (III)), to the least toxic form, arsenate (As (V)). The potential of As (III) oxidation to As (V) was initially investigated in batch reactors using the chemoautotrophic Thiomonas arsenivorans strain b6 under varying initial As (III) and cell concentrations and at optimal pH and temperature conditions (pH 6.0 and temperature 30°C). The strain b6 completely oxidized As (III) to As (V) during exponential growth phase for lower levels of As (III) concentrations (≤ 100 mg/L) but continued into stationary …

Morphology And Systematics Of Braconid Wasps, Charles Andrew Boring

University of Kentucky Doctoral Dissertations

The following morphological structures of the ovipositor of Homolobus truncator (Say) (Hymenoptera : Braconidae) are described and hypotheses of their functions are proposed: a series of sharp ridges on the distal surface of the notch helps maintain a grip on the inner surface of the host cuticle; the sperone directs eggs away from the inner surface of the ventral valves; a flap-like structure on each ventral valve covers the portal through which eggs pass; the valvillus maintains position of the egg within the ovipositor and acts against the egg to force it out; ctenidia on the inner surface of the …

Nm23-H1 Blocks Cell Motility Independently Of Its Known Enzymatic Activities In A Cohort Of Human Melanoma Cells, Joseph Robert Mccorkle

University of Kentucky Doctoral Dissertations

The metastasis suppressor gene NM23-H1 has been shown to possess three enzymatic activities including nucleoside diphosphate kinase, histidine-dependent protein kinase and 3’-5’ exonuclease activity. While these properties have been demonstrated in vitro using recombinant proteins, the contribution of these activities to suppression of metastatic dissemination is unknown. Site-directed mutagenesis studies were used to identify amino acid residues which are required for proper function of each enzymatic activity associated with H1, providing a platform for studying the importance of each function on an individual basis. To assess the relevance of these activities to melanoma progression, a panel of mutants harboring selective …

Remote Controlled Hydrogel Nanocomposites: Synthesis, Characterization, And Applications, Nitin S. Satarkar

University of Kentucky Doctoral Dissertations

There is significant interest in the development of hydrogels and hydrogel nanocomposites for a variety of biomedical applications including drug delivery, sensors and actuators, and hyperthermia cancer treatment. The incorporation of nanoparticulates into a hydrogel matrix can result in unique material characteristics such as enhanced mechanical properties, swelling response, and capability of remote controlled (RC) actuation. In this dissertation, the development of hydrogel nanocomposites containing magnetic nanoparticles/carbon nanotubes, actuation with remote stimulus, and some of their applications are highlighted.

The primary hydrogel nanocomposite systems were synthesized by incorporation of magnetic nanoparticles into temperature responsive N-isopropylacrylamide (NIPAAm) matrices. Various nanocomposite properties …

Studies Of The Effects Of Dopamine Neuron Stimulating Peptides In Rodent Models Of Normal And Dysfunctional Dopaminergic Systems, Joshua Lee Fuqua

University of Kentucky Doctoral Dissertations

A theoretical post-translational processing model of the proprotein form of glial cell line-derived neurotrophic factor (GDNF) likely produces three biologically active peptides. The three prospective peptides formed are 5, 11, and 17 amino acid peptides, entitled dopamine neuron stimulating peptide -5 (DNSP-5), -11 (DNSP-11), and -17 (DNSP-17), respectively. The DNSPs were hypothesized to increase dopaminergic neuron function because of their relationship to GDNF: a molecule with established neurotrophic actions on dopaminergic neurons. The DNSPs have the potential to provide a therapeutic molecule similar to GDNF, but with increased ease of delivery and improved bioavailability.

Neurochemical effects of DNSPs were examined …

Implementation And Analysis Of A Top-K Retrieval System For Strings, Sabrina Chandrasekaran

LSU Master's Theses

Given text which is a union of d documents of strings, D = d1, d2,...., dd, the emphasis of this thesis is to provide a practical framework to retrieve the K most relevant documents for a given pattern P, which comes as a query. This cannot be done directly, as going through every occurrence of the query pattern may prove to be expensive if the number of documents that the pattern occurs in is much more than the number of documents (K) that we require. Some advanced query functionality will be required, as compared to listing the documents that the …