Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2010

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 12661 - 12690 of 18907

Full-Text Articles in Entire DC Network

Assessing Sandhill Crane Flight Alterations To Power Lines In Southcentral Wisconsin, Kimberly H. Ness, Anne E. Lacy Jan 2010

Assessing Sandhill Crane Flight Alterations To Power Lines In Southcentral Wisconsin, Kimberly H. Ness, Anne E. Lacy

Proceedings of the North American Crane Workshop

We examined how weather and power line type affected abrupt flight alterations of sandhill cranes (Grus canadensis tabida) near electric lines in south-central Wisconsin at 4 U.S. Fish and Wildlife Service fall crane roost count sites near the Wisconsin River in Adams, Columbia, and Iowa counties between September and November 2007. We selected 4 distribution (10-12 m tall, <50 kV) and 2 transmission lines (>20 m tall, >110 kV) in high crane density areas near corn fields within 1.6 km of either the Wisconsin River or local roosting wetland. We recorded frequencies of 3 types of abrupt flight alterations near power lines across 1-2 …

Go to article

Mississippi Sandhill Crane Chicks Produced From Cryopreserved Semen, Anahid M. Pahlawanian, Megan L. Savoie, Vanessa Peery, Betsy L. Dresser, S. P. Leibo Jan 2010

Mississippi Sandhill Crane Chicks Produced From Cryopreserved Semen, Anahid M. Pahlawanian, Megan L. Savoie, Vanessa Peery, Betsy L. Dresser, S. P. Leibo

Proceedings of the North American Crane Workshop

The Mississippi sandhill crane (MSC, Grus canadensis pulla), 1 of 6 subspecies of sandhill cranes, is classified as critically endangered and was placed on the United States' List of Endangered Fish and Wildlife in 1973. For 13 years starting in 1996, the Audubon Center for Research of Endangered Species (ACRES) and Freeport-McMoran Species Survival Center (SSC) in New Orleans have been contributing to the MSC Recovery Program. Through successful captive propagation of MSCs by use of natural breeding and artificial insemination, more than 150 chicks raised at SSC have been released into the wild population at the MSC National …

Go to article

The Effects Of Anticoagulant Choice And Sample Processing Time On Hematologic Values Of Juvenile Whooping Cranes, Joan Maurer, Betsy Reichenberg, Cristin Kelley, Barry K. Hartup Jan 2010

The Effects Of Anticoagulant Choice And Sample Processing Time On Hematologic Values Of Juvenile Whooping Cranes, Joan Maurer, Betsy Reichenberg, Cristin Kelley, Barry K. Hartup

Proceedings of the North American Crane Workshop

Blood collected from juvenile whooping cranes (Grus americana) in 2007 and 2008 was divided and placed in either the anticoagulant lithium heparin (LiHep) or tri-potassium ethylenediaminetetraacetic acid (K3EDTA) for diagnostic hematology. Thin smears were prepared from the anticoagulated blood in the field with no delay and in the laboratory after a 4-6-hour delay, and then used to determine differential and total leukocyte counts. Manual heterophil and eosinophil counts were greater in LiHep-treated samples compared to K3EDTA samples (P < 0.05), but there was no difference in the total leukocyte concentration or differential leukocyte counts between anticoagulants based on blood smears prepared with no delay (n = 15). Marked differences were noted in relative heterophil (P < 0.05) and lymphocyte (P < 0.05) counts and total leukocyte (P < 0.05) concentrations of K3EDTA-treated samples processed after the delay (n = 7), suggesting a negative effect on lymphocyte integrity from the anticoagulant. Microscopically, lymphocytes were more intact and easily differentiated from thrombocytes in LiHep-treated samples than K3EDTA, but modest thrombocyte clumping in the LiHep samples was a concern. Either anticoagulant appears adequate for diagnostic hematology in juvenile whooping cranes based on this limited analysis, but blood smears should be prepared immediately under controlled conditions for best results.

Go to article

Reproductive Health And Performance Of The Florida Flock Of Introduced Whooping Cranes, Marilyn G. Spalding, Martin J. Folk, Stephen A. Nesbitt, Richard Kiltie Jan 2010

Reproductive Health And Performance Of The Florida Flock Of Introduced Whooping Cranes, Marilyn G. Spalding, Martin J. Folk, Stephen A. Nesbitt, Richard Kiltie

Proceedings of the North American Crane Workshop

We retrospectively examined the reproductive parameters of 122 breeding-age whooping cranes (Grus americana) in a reintroduced flock in central Florida from 1992 to 2007. The flock performed poorly when compared with an existing wild flock for all reproductive parameters when controlled for age. Pairs first formed in 1995, nested in 1999, and the first chick fledged in 2002. By 2007, 19 of 63 clutches produced 25 chicks, 9 of which fledged. Drought conditions were ruled out as the sole cause of failure when the drought lessened and productivity increased, but not in all years. We examined adult health, …

Go to article

A Retrospective Of Whooping Cranes In Captivity, Cindi Barrett, Thomas V. Stehn Jan 2010

A Retrospective Of Whooping Cranes In Captivity, Cindi Barrett, Thomas V. Stehn

Proceedings of the North American Crane Workshop

Early records of captive whooping cranes (Grus americana) were compiled from historical files kept at the Aransas National Wildlife Refuge and other literature. Additional early records of captive whooping cranes in Europe were discovered. Annual numbers and location for all captive whooping cranes were tabulated. Starting in 1949, initial attempts at breeding the species in captivity were conducted opportunistically with a few injured birds captured from the wild. Acaptive breeding flock was started in 1966 at the Patuxent Wildlife Research Center in Laurel, Maryland, from second eggs collected in Canada from the only remaining wild flock. In 1989, the flock …

Go to article

Changes In Winter Whooping Crane Territories And Range 1950–2006, Thomas V. Stehn, Felipe Prieto Jan 2010

Changes In Winter Whooping Crane Territories And Range 1950–2006, Thomas V. Stehn, Felipe Prieto

Proceedings of the North American Crane Workshop

The whooping crane (Grus americana) winters on the Texas coast primarily in salt marsh habitat. The location of adult whooping crane winter territories during 9 winters between 1950 and 2006 was derived from aerial census data digitized onto infrared photos using GIS software. Range expansion, including changes in distribution and size of winter territories, was analyzed over a 57-year period as flock size increased by 765%. Crane pairs have opted to establish territories in or close to the traditional winter area rather than moving long distances along the coast. This distribution seems based on the preference of the …

Go to article

Habitat Selection Of Eastern Migratory Whooping Cranes On Their Wintering Grounds, Lara E. A. Fondow, Stanley A. Temple Jan 2010

Habitat Selection Of Eastern Migratory Whooping Cranes On Their Wintering Grounds, Lara E. A. Fondow, Stanley A. Temple

Proceedings of the North American Crane Workshop

As a monitoring technician for the Whooping Crane Eastern Partnership, I (LEAF) noted that birds in years following release selected wintering habitats that differed greatly from those into which they were initially released. An analysis of the habitat preferences of these birds was needed in order to determine any possible implications to the reintroduction efforts. During the winters of 2004-2005 and 2005-2006, I recorded the locations, habitat use, social associations, and behaviors of all migratory whooping cranes (Grus americana) at known locations in Florida. I used compositional analysis to determine whether habitat use was random at the following …

Go to article

Design, Development And Biomechanical Analysis Of Scaffolds For Augmentation Of Rotator Cuff Repairs, Amit Aurora Jan 2010

Design, Development And Biomechanical Analysis Of Scaffolds For Augmentation Of Rotator Cuff Repairs, Amit Aurora

ETD Archive

Rotator cuff tears are a source of debilitating pain that commonly affects more than 40 of our aging population. Despite advances in surgical treatment, the failure rate of rotator cuff repairs is as high as 20-90 . Extracellular matrix (ECM) derived scaffolds have recently been investigated as augmentation devices for rotator cuff repairs, but none has yet demonstrated both the appropriate biological and mechanical properties for mitigating re-tears and enhancing healing. This dissertation proposes to engineer the mechanical properties of allograft fascia lata in a manner that will allow its use as an augmentation device for rotator cuff repairs. This …

Go to article

The Role Of Ceruloplasmin In Colitis, Bakytzhan Bakhautdin Jan 2010

The Role Of Ceruloplasmin In Colitis, Bakytzhan Bakhautdin

ETD Archive

Ceruloplasmin (Cp) is an acute phase, plasma protein with multiple enzymatic activities consistent with both pro- and anti-inflammatory functions. Our laboratory has recently reported the presence of Cp in intestinal epithelial cells. To determine the potential role of Cp in intestinal inflammation, we induced colitis in Cp-deficient mice by continuous administration of dextran sodium sulfate (DSS) ad libitum in the drinking water. The Cp-null mice rapidly lost weight and all were moribund by day 14, while about 90 of the wild-type (WT) mice survived at least 20 days. Higher amounts of TNF-alpha, and neutrophil (KC) and macrophage (MCP-1) chemokines, were …

Go to article

The Influence Of Training And Gender In Mentoring On Novice School Administrators, Kimberly S. Benetto Jan 2010

The Influence Of Training And Gender In Mentoring On Novice School Administrators, Kimberly S. Benetto

ETD Archive

The role of the principal, as an instructional leader is one of the most important roles in education today. The demands of high accountability that are placed on school principals have caused legislators and educational reformers to require more rigorous training for school leaders. Many states now have mandated state mentoring programs for entry year principals. The purpose of this study was to examine and describe the roles and relationships between mentors and their mentees in the training and professional development of school administrators. This research was important because mentoring programs are not standardized and until recently, the majority of …

Go to article

Genetics And Genomics Of Complex Diseases;Mouse Atherosclerosis Modifier Genes And Human Gene Expression After Bariatric Surgery, Stela Z. Berisha Jan 2010

Genetics And Genomics Of Complex Diseases;Mouse Atherosclerosis Modifier Genes And Human Gene Expression After Bariatric Surgery, Stela Z. Berisha

ETD Archive

The overall goal of our research was to study and identify genes involved in the development of complex diseases in mice and humans through integrative genetic/genomic approaches. Two complex diseases were the focus of research, atherosclerosis and type 2 diabetes. Mouse models of atherosclerosis, in which the genetic background and the environment can be controlled for, were used to identify and validate atherosclerosis modifier genes. We studied an atherosclerosis quantitative trait locus (QTL) on the distal end of chromosome 5, called Ath24, and generated interval-specific congenic mice on the atherosclerosis resistant AKR and susceptible DBA/2 apoE-deficient strains. To date we …

Go to article

Design, Synthesis And Characterization Of Oriented Glyco-Affinity Macroligands For Glyco-Capturing, Glycomics And Glycoproteomics Applications, Srinivas Chalagalla Jan 2010

Design, Synthesis And Characterization Of Oriented Glyco-Affinity Macroligands For Glyco-Capturing, Glycomics And Glycoproteomics Applications, Srinivas Chalagalla

ETD Archive

Cell surface carbohydrates existing as parts of glycoproteins, glycolipids, and other conjugates present the first information about cell to the outside world and are intimately involved in various biological events such as intercellular communication, and molecular and cellular targeting. However, mechanisms of most processes at the molecular level are still unclear. Therefore, it is very important to develop carbohydrate-specific binding molecules for rapid, efficient, sensitive purification and accurate analysis of complex carbohydrate structures as well as their functions. Furthermore, carbohydrate-specific binding molecules can be expected to be used in medical diagnostic applications for carbohydrate biomarkers. In this thesis study, oriented …

Go to article

The Role Of Sigirr In Innate And Adaptive Immunity, Muhammet Fatih Gulen Jan 2010

The Role Of Sigirr In Innate And Adaptive Immunity, Muhammet Fatih Gulen

ETD Archive

Single immunoglobulin IL-1R-related receptor (SIGIRR) is a transmembrane protein, which belongs to interleukin 1 receptor (IL-1R)/Toll like receptor (TLR) superfamily (Toll-IL-1R superfamily). SIGIRR has been identified as a negative modulator for IL-1R/TLR signaling. Recently, detailed structural and functional analysis of SIGIRR has been published, however physiological function of SIGIRR has not been studied. To asses the physiological function of SIGIRR, the expression of SIGIRR mRNA in different mouse tissues was analyzed. Although SIGIRR is expressed in many tissues, its expression in different cell types was more restricted, with extremely high expression in primary kidney, colon epithelial cells and T cells, …

Go to article

Interactions Among Top-Down Regulators In A Temperate Forest Floor Ecosystem;Effects On Macrofauna, Mesofauna, Microbes And Litter Decay, Cari-Ann M. Hickerson Jan 2010

Interactions Among Top-Down Regulators In A Temperate Forest Floor Ecosystem;Effects On Macrofauna, Mesofauna, Microbes And Litter Decay, Cari-Ann M. Hickerson

ETD Archive

High species diversity and complexity of forest-floor food webs present a challenge for understanding the role of species interactions (e.g. competition and predation) as regulatory mechanisms for ecosystem processes such as decomposition and nutrient cycling. In particular, we understand very little about the roles of forest-floor predators in regulating diversity and abundance of lower trophic levels and ecosystem processes. However, ecological theory and several studies suggest that interactions among intraguild predators (IGP) may be important controls of diversity and abundance of organisms and detritus in lower trophic levels within food webs. A key prediction is that interactions among predators weaken …

Go to article

Effects Of Forest Edges, Exotic Ants And Nonnative Plants On Local Ant (Hymenoptera: Formicidae) Diversity In Urban Forest Fragments Of Northeastern Ohio, Kaloyan Ivanov Jan 2010

Effects Of Forest Edges, Exotic Ants And Nonnative Plants On Local Ant (Hymenoptera: Formicidae) Diversity In Urban Forest Fragments Of Northeastern Ohio, Kaloyan Ivanov

ETD Archive

Urbanization has resulted in massive transformation of natural habitats with profound effects on biodiversity. Addressing the problems associated with anthropogenic deterioration of the environment requires solid understanding of the factors driving these changes. Habitat patch size, edge effects, and the presence of invasive species are among the key features of the urban landscape affecting local communities. My study focused on the effects of habitat edges, the exotic ant Nylanderia flavipes, and the invasive herb garlic mustard on local ant diversity in deciduous forest fragments of northeastern Ohio. In addition, I explored the value of common ant collecting techniques for estimating …

Go to article

Surface Microtopography Modulation Of Biomaterials For Bone Tissue Engineering Applications, Eun Jung Kim Jan 2010

Surface Microtopography Modulation Of Biomaterials For Bone Tissue Engineering Applications, Eun Jung Kim

ETD Archive

The ultimate goal of this project is to develop a biodegradable and implantable scaffold with precise surface topographies that can provide osteoconductive stimuli to connective tissue progenitor cells (CTPs), and subsequently, enhance bone regeneration applications without the complications of autogenous cancellous bone grafts. This dissertation presents the modification of surface microtextures to provide osteoconductive stimuli to CTPs for bone regeneration applications. First, the effect of surface topography on cell proliferation and osteogenic differentiation was validated through experiments using surface post microtextures and CTPs. Post microtextures accelerated CTP growth behaviors compared to smooth polydimethylsiloxane (PDMS) and standard cell culture dishes. Second, …

Go to article

Developing A Protocol For An Environmentally Preferable Purchasing Plus (Epp+) Program At Nasa Glenn Research Center, Amarin Kongtawelert Jan 2010

Developing A Protocol For An Environmentally Preferable Purchasing Plus (Epp+) Program At Nasa Glenn Research Center, Amarin Kongtawelert

ETD Archive

EPP+ or Environmentally Preferable Purchasing Plus is a Environmentally Preferable Purchasing program with incorporated a unique Life Cycle Assessment (LCA) scoring system which implemented at NASA, Glenn Research Center. A protocol has been developed to aid in selecting among products based on principles of Environmentally Preferable Purchasing (EPP) and Life Cycle Assessment (LCA). The protocol has been developed for use at NASA Glenn Research Center (GRC) but is intended to benefit anyone wishing to make sustainable purchasing decision. The protocol was designed as a web-based application which evaluates the life cycle factors, affirmative procurements, price, and performance of products that …

Go to article

Dna Mutation/Methylation Screening Method For Colon Cancer Screening, Wei Meng Jan 2010

Dna Mutation/Methylation Screening Method For Colon Cancer Screening, Wei Meng

ETD Archive

Cancer is a result of unregulated cell growth. For all types of cancer currently studied, the transition from a healthy cell to a malignant tumor cell is a step-by-step process which requires mutation in at least several oncogenes and tumor suppressor genes together. Another cancer early event is DNA methylation. Cancer-related DNA methylation focuses on promoter hypermethylation of the certain genes. The DNA mutation and methylation profile can serve as biomarkers for diagnosing early stage of cancer. Colorectal cancer is the third most common cancer type in the United States and has been well studied. The essential mechanism of cancer …

Go to article

Molecular Basis Of The Role Of Kindlin 2 In Cell Adhesion, Hettiarachchige Dhanuja Deepamalee Perera Jan 2010

Molecular Basis Of The Role Of Kindlin 2 In Cell Adhesion, Hettiarachchige Dhanuja Deepamalee Perera

ETD Archive

Kindlins are a novel family of cytoskeleton proteins that plays an important role in the activation of heterodimeric integrin transmembrane receptors. These receptors play a vital role in cell adhesion, cell migration and other cellular processes. The Kindlin protein family consists of three homologous proteins, Kindlin 1, 2 and 3 with differential tissue distribution and varying expression levels in human. Mutations of Kindlin 1 protein are clinically linked to Kindler Syndrome. Kindlin 2 knockdown studies have shown embryonic lethality in mouse, but no diseases have been clinically testified. Kindlin 3 mutations are associated with bleeding disorders, e.g. LADIII. Talin is …

Go to article

An Assessment Of The Evolutionary Stability Of Distyly In Hedyotis Caerulea (Rubiaceae), Dennis Archie Sampson Jan 2010

An Assessment Of The Evolutionary Stability Of Distyly In Hedyotis Caerulea (Rubiaceae), Dennis Archie Sampson

ETD Archive

Distylous species of flowers possess two distinct floral morphs that are generally found in equal numbers in naturally occurring populations. The flower form that has a relatively long style is called a "pin" the form with a short style is a "thrum." Within the distylous mating system, selfing and intramorph mating are prevented due to the spatial separation of stigmas and anthers and by a self-incompatibility system that is inherited along with the dimorphic floral structure and ancillary polymorphisms. However, a breakdown of distyly has been documented in several families, either through the development of completely separate sexes (dioecy), or, …

Go to article

Cell-Taught Gene Therapy For The Preservation And Regeneration Of Cardiac Tissue Following Chronic Heart Failure, Srividya Sundararaman Jan 2010

Cell-Taught Gene Therapy For The Preservation And Regeneration Of Cardiac Tissue Following Chronic Heart Failure, Srividya Sundararaman

ETD Archive

Heart failure is the primary cause of mortality and morbidity in the Western world. Although cell therapy has demonstrated improvement in cardiac function, these benefits are being attributed to the activation of paracrine factors, rather than the differentiation and integration of the transplanted cells into the host tissue. Based on this knowledge the focus of this thesis work was to deliver paracrine factors, and evaluate its effect on cardiac function. Gene therapy has evolved as a promising option to deliver pro-angiogenic proteins to infarct zones, thus providing cardiac benefit. This study has identified a gene design without the use of …

Go to article

Human Prostate Cancer Cell Apoptosis Induced By Interferon-Y And Double-Stranded Rna And Studies On The Biological Roles Of Transmembrane And Coiled-Coil Domains 1, Haiyan Tan Jan 2010

Human Prostate Cancer Cell Apoptosis Induced By Interferon-Y And Double-Stranded Rna And Studies On The Biological Roles Of Transmembrane And Coiled-Coil Domains 1, Haiyan Tan

ETD Archive

No abstract provided.

Go to article

Individual Growth Analysis Of Children's Reading Performance During The First Years Of School, Regina Giraldo Jan 2010

Individual Growth Analysis Of Children's Reading Performance During The First Years Of School, Regina Giraldo

ETD Archive

Using data from the National Center for Education Statistics (Early Childhood Longitudinal Study, Kindergarten Class of 1998-1999 (ECLS-K)), the study utilized an individual growth model (Bryk & Raudenbush, 2002), the purpose of which was to assess the nature of progress in children's reading performance between kindergarten and 3rd grade and second, to determine the extent to which parental involvement predicts both the initial reading ability as well as the rate of progress. Children's cognitive development in reading was used as the dependent variable and parental involvement as the primary independent variable with gender and race/ethnicity as control variables.The study used …

Go to article

The Differences Between How Boys And Girls Learn And The Benefits Of Single Gender Schools, Devin M. Demaske Jan 2010

The Differences Between How Boys And Girls Learn And The Benefits Of Single Gender Schools, Devin M. Demaske

ETD Archive

A developing trend in the world of education is separating students by gender via single gender schools, classrooms, or separation for certain subjects. The goal is finding out whether or not this segregation is beneficial to student achievement, if boys and girls learn differently, and whether or not these differences are biological or due to socialization. It is important to find these answers for educators to best serve their students. The approach was a review of the available literature, analyzing the studies involving student achievement at single gender schools, and studies about the differences in between the male and female …

Go to article

A Reexamination Of The Obsessive-Compulsive Personality Disorder Questionnaire Reliability And Validity In A College Student Sample, Rachel Martukovich Jan 2010

A Reexamination Of The Obsessive-Compulsive Personality Disorder Questionnaire Reliability And Validity In A College Student Sample, Rachel Martukovich

ETD Archive

The present research was designed to evaluate the reliability and validity of a new measure for Obsessive Compulsive Personality Disorder, namely the Obsessive Compulsive Personality Disorder Questionnaire (OCPDQ). One hundred and forty students at a Midwestern urban university were administered the OCPDQ as well as the Leyton Obsessional Inventory (LOI Cooper, 1970) and the Padua Inventory-Washington State University Revision (PI-WSUR Burns, Keortege, Formea, & Sternberger, 1996). The reliability and validity of the OCPDQ were analyzed and each of the eight subscales that corresponded to the eight criteria for OCPD were examined. The OCPDQ had a high level of reliability with …

Go to article

Suicide Pelicans, Amanda A. Mccoy Jan 2010

Suicide Pelicans, Amanda A. Mccoy

ETD Archive

The suicide pelican lives in Costa Rica. You may not believe me, but I've seen it with my own eyes. Blindness is common for these birds, mostly caused by their form of fishing: dive-bombing into the water at full speed and spearing fish with their beaks. This head-first diving damages the eyes over the years. Once blind, some of the pelicans intentionally crash into rocks to avoid an unbearable, unnatural existence. These birds and their surprisingly beautiful, graceful suicide plunges influenced this collection of short stories aptly titled Suicide Pelicans. Though my collection is mostly about women and not actual …

Go to article

Perception Becomes Reality: Student-Teacher Relationships And Verbally Aggressive Messages, Angela Buford Jan 2010

Perception Becomes Reality: Student-Teacher Relationships And Verbally Aggressive Messages, Angela Buford

ETD Archive

This study examined the impact of verbal aggression toward students when recalling a hurtful incident between a teacher and a student. Specifically, this study investigated the relationship between students reported verbally aggressive incidents with teachers, self-esteem and student-teacher relational satisfaction. A total of 83 participants were surveyed to obtain recollections of verbally aggressive incidents and their reported impact. Verbally aggressive messages were represented by Infante's (1987) typologies of verbally aggressive messages, which included character attacks, competence attacks, background attacks, physical appearance attacks, maledictions, teasing, ridicule, threats, profanity and nonverbal emblems. The researcher also included a "never experienced" category for respondents …

Go to article

Characterization Of A Microrna Harboring Intron For Pre-Mrna Splicing And Microrna Processing, Neha Aggarwal Jan 2010

Characterization Of A Microrna Harboring Intron For Pre-Mrna Splicing And Microrna Processing, Neha Aggarwal

ETD Archive

Nuclear pre-mRNA splicing is an important step in eukaryotic RNA processing and can yield a variety of transcripts. Further, it is known that nuclear pre-mRNA introns are of two types, U2-dependent and U12-dependent. Recently discovered, microRNAs (miRNA) are short, endogenous, 20-22 nucleotide long, non-coding RNA molecules that base pair with target mRNAs to modulate translation. Current evidence suggests that processing of intronic miRNA does not affect the splicing. Since, intronic miRNAs are involved in essential cellular processes, we surmised if splice sites of miRNA coding introns are flexible to support productive precursor and mature miRNA processing. We constructed a minigene …

Go to article

Targets Of Hsa-Mir-488* In Human Prostate Carcinoma Cells, Jinani E. Slaibi Jan 2010

Targets Of Hsa-Mir-488* In Human Prostate Carcinoma Cells, Jinani E. Slaibi

ETD Archive

Prostate cancer (PCa) is one of the most prevalent forms of cancer among men in America and is second only to lung cancer as a cause of cancer-related deaths in men. Recent epidemiological study shows that one in every six men over the age of forty five is at risk of PCa. Androgen receptor (AR) plays a causative role in the development of PCa. Hormonal blockade therapy which inhibits the expression of AR eventually fails and disease progresses to fatal androgen-refractory stage from androgen-dependent stage. Therefore, novel molecular approaches which can target and block the expression of AR are required. …

Go to article

Study Of Drug Delivery Behavior Through Biomembranes Using Thermal And Bioanalytical Techniques, Hareesha Reddy Venumuddala Jan 2010

Study Of Drug Delivery Behavior Through Biomembranes Using Thermal And Bioanalytical Techniques, Hareesha Reddy Venumuddala

ETD Archive

This Master of Science thesis encompasses two projects in chemical pharmaceuticals. The first is a study of excipients and the added new information collected beyond Thermal Gravimetric Analysis and Differential Scanning Calorimetry from Dielectric Analysis. These new properties enhance our global knowledge of excipients by thermal analytical methods. Excipients, the inactive ingredients in formulated drugs, aid different functions of the active pharmacy ingredient, the drugs. Low temperature transitions, by DEA including melting of frozen solvents, e.g. water, are more definitive than observed by low temperature DSC. Millions of dollars are expended annually on pharmaceutical testing to qualify excipients for fully …

Go to article

First Prev Next Last