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Articles 10201 - 10230 of 18960
Full-Text Articles in Entire DC Network
Temperature Affects Adhesion Of The Acorn Barnacle (Balanus Amphitrite), Laurel A. Johnston
Temperature Affects Adhesion Of The Acorn Barnacle (Balanus Amphitrite), Laurel A. Johnston
Master's Theses
Biofouling is the accumulation of sessile marine organisms, such as algae, tube worms and barnacles on man-made substrata and has negative economic and ecological implications. Ship hulls are readily fouled, which significantly increases drag while decreasing ship fuel efficiency when moving through water. Fouled hulls have also become important vectors of invasive species. These problems are minimized when hulls are painted with a toxic anti-fouling or non-toxic foul-release coating. Due to recent restrictions of anti-fouling paint use, research and development of non-toxic alternatives has increased.
Novel hull coating efficiency is often quantified by the critical removal stress value of barnacles …
Performance Of A Stormwater Filter And Bacteria Inactivation Using Biocidal Media, Alexander Scott Bowerman
Performance Of A Stormwater Filter And Bacteria Inactivation Using Biocidal Media, Alexander Scott Bowerman
Master's Theses
There are many possible ways to mitigate stormwater pollution, but this study focused on the DrainPacTM catchment basin insert and the feasibility of integrating N-halamine biocidal brominated beads into the filter system. This study was divided into three sections. The first section involved testing a DrainPacTM filter for treatable flow rates, head loss, and removal of solids, oil, and bacteria. The DrainPacTM filter is designed to be installed in a stormwater catch basin. The filter is composed of a 12 x 41 inch metal frame with textile filter media attached to it in a basket shape. The upper portion of …
Developing A Source Water Protection Plan For Boron In The San Luis Obispo County Water Supply, Jenny Macartney
Developing A Source Water Protection Plan For Boron In The San Luis Obispo County Water Supply, Jenny Macartney
Master's Theses
The goal of this project is to design a feasible way to develop a protection plan for boron in the surface waters and groundwater of San Luis Obispo County. Boron is a micronutrient needed by all plants and animals but the threshold for toxicity in plants is narrow. As the need for water increases and the production of wastewater and irrigation water infiltrates the soil and waters of the County, an understanding of background soil and water concentrations, as well as anthropogenically produced sources of boron must be quantified and mapped so that intelligent planning decisions can be made.
Many …
Don't Tease Me, I'M Working: Examining Humor In A Midwestern Organization Using Ethnography Of Communication, Ajay K. Ojha, Taimmy L. Holmes
Don't Tease Me, I'M Working: Examining Humor In A Midwestern Organization Using Ethnography Of Communication, Ajay K. Ojha, Taimmy L. Holmes
The Qualitative Report
Within organizations, the communicative phenomenon of humor is commonplace. Humorous talk is just as important and frequent to regular discourse that takes place between organizational members. In this inquiry we examine humor as a particular way of communicating between members of a small Midwestern United States organization. Specifically, we examine how three functions of humor (i.e., joking, sarcasm, and teasing) are used amongst members during normal business hours (8:00 a.m. - 5:00 p.m.). Using ethnography of communication, we conduct both fieldwork and interviews discovering that this organization exemplifies humor as a socially constructed phenomenon to complete the typical workday.
Parity-Induced Decrease In Systemic Growth Hormone Alters Mammary Gland Signaling: A Potential Role In Pregnancy Protection From Breast Cancer, Robert K. Dearth, David A. Delgado, Jill K. Hiney, Thushangi Pathiraja, Steffi Oesterreich, Dan Medina, W. Les Dees, Adrian V. Lee
Parity-Induced Decrease In Systemic Growth Hormone Alters Mammary Gland Signaling: A Potential Role In Pregnancy Protection From Breast Cancer, Robert K. Dearth, David A. Delgado, Jill K. Hiney, Thushangi Pathiraja, Steffi Oesterreich, Dan Medina, W. Les Dees, Adrian V. Lee
School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)
Early full-term pregnancy is an effective natural protection against breast cancer in both humans and experimental rodents. The protective effect of an early pregnancy is in part linked to changes in circulating hormones that are involved in both normal breast development and breast cancer. For example, a reduction in circulating growth hormone (GH) has been shown to protect rats from carcinogen-induced mammary tumors. We examined the ability of a full-term pregnancy to alter the endocrine GH/IGF-I axis and how this change affected normal mammary gland function in two commonly used rat models (Sprague-Dawley and Wistar-Furth). Circulating GH and IGF-I were …
Cardioprotection By Regular Ethanol Consumption: Potential Mechanisms And Clinical Application., Masami Miyamae, Kazuhiro Kaneda, Naochika Domae, Vincent M. Figueredo, M.D.
Cardioprotection By Regular Ethanol Consumption: Potential Mechanisms And Clinical Application., Masami Miyamae, Kazuhiro Kaneda, Naochika Domae, Vincent M. Figueredo, M.D.
Division of Cardiology Faculty Papers
Epidemiological studies demonstrate that excessive drinking is associated with hypertension, cerebral bleeding and loss of cardiac contractility. Conversely, studies have shown that mortality rates for people who regularly drink ethanol in moderation are lower than in abstainers, primarily due to decreased fatal ischemic heart disease. Further, moderate ethanol consumers have lower rates of myocardial infarction compared with abstainers. These beneficial cardiac effects may be due to pleiotropic effects of ethanol on lipids, platelets, and fibrinolytic activity. During the past decade, studies conducted in several animal models have revealed that light to moderate regular ethanol consumption renders hearts more tolerant to …
Molecular Diagnosis Of A Previously Unreported Predator-Prey Association In Coffee: Karnyothrips Flavipes Jones (Thysanoptera: Phlaeothripidae) Predation On The Coffee Berry Borer, Juliana Jaramillo, Eric G. Chapman, Fernando E. Vega, James D. Harwood
Molecular Diagnosis Of A Previously Unreported Predator-Prey Association In Coffee: Karnyothrips Flavipes Jones (Thysanoptera: Phlaeothripidae) Predation On The Coffee Berry Borer, Juliana Jaramillo, Eric G. Chapman, Fernando E. Vega, James D. Harwood
All Peer-Reviewed Publications
The coffee berry borer, Hypothenemus hampei, is the most important pest of coffee throughout the world, causing losses estimated at US 500 million/year. The thrips Karnyothrips flavipes was observed for the first time feeding on immature stages of H. hampei in April 2008 from samples collected in the Kisii area of Western Kenya. Since the trophic interactions between H. hampei and K. flavipes are carried out entirely within the coffee berry, and because thrips feed by liquid ingestion, we used molecular gut-content analysis to confirm the potential role of K. flavipes as a predator of H. hampei in an organic …
The Sexual Economy Of The Islamic Republic: Birth Control, Female Sexual Awakening, And The Gay Lifestyle, Janet Afary
The Sexual Economy Of The Islamic Republic: Birth Control, Female Sexual Awakening, And The Gay Lifestyle, Janet Afary
Khazar Journal of Humanities and Social Sciences
No abstract provided.
Knowledge, Attitudes And Practices Regarding Dengue Fever Among Adults Of High And Low Socioeconomic Groups, Madiha Syed, Taimur Saleem, Umme-Rubab Syeda, Manal Habib, Rehan Zahid, Atif Bashir, Madiha Rabbani, Madiha Khalid, Asif Iqbal, Ehsen Zawwar Rao, Shujja-Ur-Rehman, Sarah Saleem
Knowledge, Attitudes And Practices Regarding Dengue Fever Among Adults Of High And Low Socioeconomic Groups, Madiha Syed, Taimur Saleem, Umme-Rubab Syeda, Manal Habib, Rehan Zahid, Atif Bashir, Madiha Rabbani, Madiha Khalid, Asif Iqbal, Ehsen Zawwar Rao, Shujja-Ur-Rehman, Sarah Saleem
Community Health Sciences
OBJECTIVE: To ascertain the knowledge, attitudes and practices of selected adult population in Pakistan regarding Dengue Fever.METHODS: A cross sectional survey was conducted among selected communities with different socio-economic backgrounds in Karachi, Pakistan. A sample size of 440 adults (aged 18 years and above) were interviewed using a pre-tested questionnaire regarding their knowledge, attitude and practices about dengue fever. A composite scoring system, based on the answers given in the questionnaire, was used to establish the level of awareness in the population. The division of the higher and lower socio-economic groups was based on their income and locality; both these …
Enhancing Student Usability Of The Osmette, Mitchell Foutz
Enhancing Student Usability Of The Osmette, Mitchell Foutz
Biomedical Engineering
Precision Systems' Micro-Osmette located in the St. Jude Lab at Cal Poly SLO is a freezing-point depression osmometer capable of measuring the osmolality, the concentration of hydrated species in osmoles per-kilogram of water, with unrivaled speed and accuracy. The Osmette could be used extensively by students in a wide variety of applications if students are able to become acquainted with the device in an accelerated manner. The amount of time required to safely and effectively operate the micro-Osmette using the operator's manual provided with the device is prohibitive of widespread use by students. Revisions and improvements to the existing operator's …
Sequence Analysis Of Leuconostoc Mesenteroides Bacteriophage Φ1-A4 Isolated From An Industrial Vegetable Fermentation, Jean Lu, Eric Altermann, Frederick Breidt, Sergei Kozyavkin
Sequence Analysis Of Leuconostoc Mesenteroides Bacteriophage Φ1-A4 Isolated From An Industrial Vegetable Fermentation, Jean Lu, Eric Altermann, Frederick Breidt, Sergei Kozyavkin
Faculty Articles
Vegetable fermentations rely on the proper succession of a variety of lactic acid bacteria (LAB) including Leuconostoc mesenteroides. L. mesenteroides initiates the fermentation, producing lactic and acetic acids, CO2, and many flavor compounds. As the fermentation proceeds, L. mesenteroides dies off and other LAB complete the fermentation. Phage infecting L. mesenteroides may significantly influence the die-off of L. mesenteroides. However, no L. mesenteroides phages have been previously sequenced and genetically characterized. Knowledge of more phage genome sequences may provide new insights into phage genomics and phage-host interactions. We have determined the complete genome sequence of L. mesenteroides phage (phi)1-A4, which …
Magnetic Resonance Imaging Findings In Patients With Schizophrenia, Waseem Akhtar, Haider A Naqvi, Sajjad Hussain, Arif Ali, Nadeem Ahmad
Magnetic Resonance Imaging Findings In Patients With Schizophrenia, Waseem Akhtar, Haider A Naqvi, Sajjad Hussain, Arif Ali, Nadeem Ahmad
Department of Radiology
OBJECTIVE: To determine structural abnormalities in the brain of patients with schizophrenia by Magnetic Resonance Imaging (MRI).
STUDY DESIGN: Comparative study.
PLACE AND DURATION OF STUDY: The Departments of Radiology and Psychiatry, the Aga Khan University Hospital, Karachi, from January 2007 to June 2008.
METHODOLOGY: Thirty-three cases of schizophrenia (n=33) and thirty-three age-matched controls, (n=33) were enrolled for this study. Screening Magnetic Resonance Imaging (MRI) of brain was done in order to see structural changes in brain matter. Findings were compared among groups using chi-square and Fisher's exact test with significance at p < 0.05.
RESULTS: Among the total of 66 (n=66) …
Siltcoos Lake Nonpoint Source Implementation Grant: Water Quality Conditions And Nutrient Sources, Mark D. Sytsma, Rich Miller
Siltcoos Lake Nonpoint Source Implementation Grant: Water Quality Conditions And Nutrient Sources, Mark D. Sytsma, Rich Miller
Center for Lakes and Reservoirs Publications and Presentations
Siltcoos Lake is a large (1280 hectares), shallow (mean depth 3.3 m; maximum depth 6.7 m) lake located on the Central Oregon Coast, just south of Florence and bordered by Dunes City, Oregon. The outflow and water level of Siltcoos Lake is regulated by a dam on the Siltcoos River 4 km upstream from the Pacific. Several permanent streams feed the lake from its 176 square kilometer watershed including Fiddle Creek, Maple Creek, and Woahink Creek, the outflow from Woahink Lake. Much of the watershed is forested and used for timber harvest, residential development, and limited agricultural production.
The lake …
Patient And Physician Perceptions Of Dimensions Of Necessity Of Medical Utilization, Peggy J. Wagner, Peter R. Warren, Ginger Mosely
Patient And Physician Perceptions Of Dimensions Of Necessity Of Medical Utilization, Peggy J. Wagner, Peter R. Warren, Ginger Mosely
The Qualitative Report
The goal of this research was to understand better the perspectives held by physicians and patients regarding what factors determine the appropriateness of medical visits. We also wished to create a convenient measure of those perspectives. In our first study, we conducted focus groups separately composed of 22 physicians and 16 patients to determine their respective views. In our second study, a 40-item measure derived from Study 1 themes was administered to a sample of 202 patients. Study 1 identified 20 themes, collapsing into 6 dimensions. Physicians held views that some patients were manipulative when seeking medical care. Study 2 …
Sailing Stormy Seas: The Illness Experience Of Persons With Parkinson's Disease, Melinda Stanley-Hermanns, Joan Engebretson
Sailing Stormy Seas: The Illness Experience Of Persons With Parkinson's Disease, Melinda Stanley-Hermanns, Joan Engebretson
The Qualitative Report
Parkinson's disease is a chronic, progressive disorder with no known cause or promising cure. While substantial information is known about the pathophysiology, little is known about the illness experience of living with the disease. A qualitative study using an ethnographic approach was conducted to provide a rich understanding of the illness experience. The illness experience was apprehended through field work in two support groups and the personal accounts of 14 participants with Parkinson's disease. The metaphor, "Sailing the Sea in The Eye of the Storm," is the overarching theme and was chosen to conceptualize the voyage of persons living with …
Usd Magazine Spring 2010, University Of San Diego
Usd Magazine Spring 2010, University Of San Diego
University of San Diego Magazine (1992- )
Editorial License; Letters to the Editor; Contents; Around the Park; Torero Athletics; Point of View; iSPY; How Can I Keep from Singing? Home Away; Class Notes
2010 March, Office Of Communications & Marketing, Morehead State University.
2010 March, Office Of Communications & Marketing, Morehead State University.
Morehead State Press Release Archive, 1961 to the Present
Press releases for March of 2010.
Dispersion Of Single-Walled Carbon Nanotubes In Organic Solvents, Qiaohuan Cheng
Dispersion Of Single-Walled Carbon Nanotubes In Organic Solvents, Qiaohuan Cheng
Doctoral
This thesis contains a systematic study of the dispersion of pristine HiPco Single Walled Carbon Nanotubes (SWNTs) in a series of organic solvents. A double beamed UV-Vis-NIR absorption spectrometer coupled with an integrating sphere was employed to demonstrate the dispersibility of SWNTs in different solvents. Raman Spectroscopy and Atomic Force Microscopy (AFM) were used to confirm the debundling and exfoliation of SWNTs aggregates. An investigation of the solubility of SWNTs in four chlorinated aromatic solvents demonstrated that the similarity in structure between solvent molecules and nanotube sidewall is not a dominant factor to obtain stable SWNT solutions. A comparative study …
Top-K Aggregation Queries Over Large Networks, Xifeng Yan, Bin He, Feida Zhu, Jiawei Han
Top-K Aggregation Queries Over Large Networks, Xifeng Yan, Bin He, Feida Zhu, Jiawei Han
Research Collection School Of Computing and Information Systems
Searching and mining large graphs today is critical to a variety of application domains, ranging from personalized recommendation in social networks, to searches for functional associations in biological pathways. In these domains, there is a need to perform aggregation operations on large-scale networks. Unfortunately the existing implementation of aggregation operations on relational databases does not guarantee superior performance in network space, especially when it involves edge traversals and joins of gigantic tables. In this paper, we investigate the neighborhood aggregation queries: Find nodes that have top-k highest aggregate values over their h-hop neighbors. While these basic queries are common in …
Medially: A Provenance-Aware Remote Health Monitoring Middleware, Atanu Roy Chowdhury, Ben Falchuk, Archan Misra
Medially: A Provenance-Aware Remote Health Monitoring Middleware, Atanu Roy Chowdhury, Ben Falchuk, Archan Misra
Research Collection School Of Computing and Information Systems
This paper presents MediAlly, a middleware for supporting energy-efficient, long-term remote health monitoring. Data is collected using physiological sensors and transported back to the middleware using a smart phone. The key to MediAlly's energy efficient operations lies in the adoption of an Activity Triggered Deep Monitoring (ATDM) paradigm, where data collection episodes are triggered only when the subject is determined to possess a specified context. MediAlly supports the on-demand collection of contextual provenance using a novel low-overhead provenance collection sub-system. The behaviour of this sub-system is configured using an application-defined context composition graph. The resulting provenance stream provides valuable insight …
Yeast Cell Adhesion Molecules Have Functional Amyloid-Forming Sequences, Caleen B. Ramsook, Cho Tan, Melissa C. Garcia, Raymond Fung, Gregory Soybelman, Ryan Henry, Anna Litewka, Shanique O’Meally, Henry N. Otoo, Roy A. Khalaf, Anne M. Dranginis, Nand K. Gaur, Stephen A. Klotz, Jason M. Rauceo, Chong K. Jue, Peter N. Lipke
Yeast Cell Adhesion Molecules Have Functional Amyloid-Forming Sequences, Caleen B. Ramsook, Cho Tan, Melissa C. Garcia, Raymond Fung, Gregory Soybelman, Ryan Henry, Anna Litewka, Shanique O’Meally, Henry N. Otoo, Roy A. Khalaf, Anne M. Dranginis, Nand K. Gaur, Stephen A. Klotz, Jason M. Rauceo, Chong K. Jue, Peter N. Lipke
Publications and Research
The occurrence of highly conserved amyloid-forming sequences in Candida albicans Als proteins (H. N. Otoo et al., Eukaryot. Cell 7:776–782, 2008) led us to search for similar sequences in other adhesins from C. albicans and Saccharomyces cerevisiae. The beta-aggregation predictor TANGO found highly beta-aggregation-prone sequences in almost all yeast adhesins. These sequences had an unusual amino acid composition: 77% of their residues were beta-aggregation aliphatic amino acids Ile, Thr, and Val, which is more than 4-fold greater than their prevalence in the S. cerevisiae proteome. High beta-aggregation potential peptides from S. cerevisiae Flo1p and C. albicans Eap1p rapidly formed insoluble …
Structure And Function Of Glycosylated Tandem Repeats From Candida Albicans Als Adhesins, Aaron T. Frank, Caleen B. Ramsook, Henry N. Otoo, Cho Tan, Gregory Soybelman, Jason M. Rauceo, Nand K. Gaur, Stephen A. Klotz, Peter N. Lipke
Structure And Function Of Glycosylated Tandem Repeats From Candida Albicans Als Adhesins, Aaron T. Frank, Caleen B. Ramsook, Henry N. Otoo, Cho Tan, Gregory Soybelman, Jason M. Rauceo, Nand K. Gaur, Stephen A. Klotz, Peter N. Lipke
Publications and Research
Tandem repeat (TR) regions are common in yeast adhesins, but their structures are unknown, and their activities are poorly understood. TR regions in Candida albicans Als proteins are conserved glycosylated 36-residue sequences with cell-cell aggregation activity (J. M. Rauceo, R. De Armond, H. Otoo, P. C. Kahn, S. A. Klotz, N. K. Gaur, and P. N. Lipke, Eukaryot. Cell 5:1664–1673, 2006). Ab initio modeling with either Rosetta or LINUS generated consistent structures of three-stranded antiparallel beta-sheet domains, whereas randomly shuffled sequences with the same composition generated various structures with consistently higher energies. O- and N-glycosylation patterns showed that each TR …
Platelet Alpha- And Beta- Secretase Activities Are Not Significantly Affected By Dementia Or Mild Cognitive Impairment In Swedish Patients., Paul Gorham, Natalie Bark, Ingemar Bjorkhem, Steve Meaney, Milita Crisby
Platelet Alpha- And Beta- Secretase Activities Are Not Significantly Affected By Dementia Or Mild Cognitive Impairment In Swedish Patients., Paul Gorham, Natalie Bark, Ingemar Bjorkhem, Steve Meaney, Milita Crisby
Articles
The processing of the Amyloid Precursor Protein (APP) is a critical event in the formation of amyloid plaques which are composed of the 4kDa amyloid β-peptide (Aβ). Processing of APP occurs through a non-amyloidogenic pathway, mediated by initial α-secretase cleavage or through an amyloidogenic pathway via sequential cleavage by β- and γ- secretase enzymes, which produces Aβ peptides. Currently, the diagnosis of probable or possible Alzheimer's disease (AD) is primarily based on neuropsychological and neuroradiological assessment. Recent reports indicate that platelet β- secretase activity is moderately increased in patients with AD and mild cognitive impairment (MCI). To our knowledge platelet …
March 2010 Newsletter, Career Center, Illinois Wesleyan University
March 2010 Newsletter, Career Center, Illinois Wesleyan University
Career Connections Newsletter
Issue Highlights:
- Following Your Dream is the Art Decision
- Alumni Profile of Erin Anderson, Class 2007: Medicinal Chemist/Future PhD
- Get Professional with LinkedIn
Partitioning Paternity: The German Approach To A Disjuncture Between Genetic And Legal Paternity With Implications For American Courts, Shelly Ann Kamei
Partitioning Paternity: The German Approach To A Disjuncture Between Genetic And Legal Paternity With Implications For American Courts, Shelly Ann Kamei
San Diego International Law Journal
This paper will address the strengths and weaknesses of the German approach as well as the potential use of this approach by American states, with particular emphasis given to the conflict between the right to know one’s origins and a child’s right to care and support. Part II discusses the challenge of defining legal paternity in an age of genetic certainty. It will first give a brief explanation of how courts have used functional–social and genetic considerations in defining legal paternity. It will then evaluate the legal implications of this approach on the rights of the father, mother, and child. …
Carbon Down Under - Lessons From Australia: Two Recommendations For Clarifying Subsurface Property Rights To Facilitate Onshore Geologic Carbon Sequestration In The United States, Tracy J. Logan
San Diego International Law Journal
This Comment’s analysis requires a few necessary assumptions. First, the feasibility of large-scale deployment of geologic CCS technology for the purposes of permanently storing CO2 is assumed. Second, the establishment of a regulatory framework with incentives to mitigate or offset GHGs is assumed. Third, the carbon-capture technology retrofitting of point-source emitters is assumed. And finally, the existence of infrastructure to transport supercritical CO2 to a storage site is assumed. This Comment contains five parts: Part I provides an introduction and overview to contextualize the need for CCS; Part II details the technology of GS; Part III is an overview of …
Editorial Special Issue On Enhancement Algorithms, Methodologies And Technology For Spectral Sensing, James O. Jensen, Robert J. Trew, Dwight L. Woolard, Neelam Gupta, Jean-Marc Theriault, Majeed M. Hayat, Yanqiu Li, Patti Gillespie
Editorial Special Issue On Enhancement Algorithms, Methodologies And Technology For Spectral Sensing, James O. Jensen, Robert J. Trew, Dwight L. Woolard, Neelam Gupta, Jean-Marc Theriault, Majeed M. Hayat, Yanqiu Li, Patti Gillespie
Electrical and Computer Engineering Faculty Research and Publications
The paper is an editorial issue on enhancement algorithms, methodologies and technology for spectral sensing and serves as a valuable and useful reference for researchers and technologists interested in the evolving state-of-the-art and/or the emerging science and technology base associated with spectral-based sensing and monitoring problem. This issue is particularly relevant to those seeking new and improved solutions for detecting chemical, biological, radiological and explosive threats on the land, sea, and in the air.
An Investigation Into Factors Influencing The Sensory Properties Of Selected Irish Grown Organic And Conventional Vegetables, Clare Gilsenan
An Investigation Into Factors Influencing The Sensory Properties Of Selected Irish Grown Organic And Conventional Vegetables, Clare Gilsenan
Doctoral
Research studies conducted on organic produce have given conflicting results whether they have superior sensory qualities when compared to conventionally cultivated produce. The development and implementation of a reliable testing system is therefore required. In this study Irish grown organic and conventional carrots (cv. Nairobi), potatoes (cv. Orla) and tomatoes (cv. Amoroso) were selected for physicochemical (size, colour, dry matter, texture, sugars, o Brix & pH), volatile emissions and sensory analysis (trained and consumer panels). All vegetables were tested in both a raw and cooked state. Few significant differences were apparent between the organic and conventional vegetables for the physicochemical …
Biomimetics Learning From Nature, H Le, Ca Wang, Y Huang
Biomimetics Learning From Nature, H Le, Ca Wang, Y Huang
School of Biological and Marine Sciences
No abstract provided.
A Five‐Gene Signature As A Potential Predictor Of Metastasis And Survival In Colorectal Cancer, J Hao, J Chen, H Sui, X Si‐Ma, Et Al
A Five‐Gene Signature As A Potential Predictor Of Metastasis And Survival In Colorectal Cancer, J Hao, J Chen, H Sui, X Si‐Ma, Et Al
School of Biomedical Sciences
To understand the molecular mechanisms of metastasis and prognosis of colorectal cancer (CRC), we isolated single cell-derived progenies (SCPs) from SW480 cells in vitro and compared their metastatic potential in an orthotopic CRC tumour model in vivo. Two groups of SCPs with the capability of high and low metastasis, respectively, were obtained. By analysing the gene expression profiles of high (SCP51), low (SCP58) metastatic SCPs, and their parental cell line (SW480/EGFP), we demonstrated that 143 genes were differentially expressed either between SCP51 and SCP58 or between SCP58 and SW480/EGFP. Gene-annotation enrichment analysis of DAVID revealed 80 genes in the top …