Digital Commons Network^™

Pp32 (Anp32a) Expression Inhibits Pancreatic Cancer Cell Growth And Induces Gemcitabine Resistance By Disrupting Hur Binding To Mrnas., Timothy K Williams, Christina L Costantino, Nikolai A Bildzukewicz, Nathan G Richards, David W Rittenhouse, Lisa Einstein, Joseph A Cozzitorto, Judith C Keen, Abhijit Dasgupta, Myriam Gorospe, Gregory E Gonye, Charles J Yeo, Agnieszka K Witkiewicz, Jonathan R Brody

Department of Surgery Faculty Papers

The expression of protein phosphatase 32 (PP32, ANP32A) is low in poorly differentiated pancreatic cancers and is linked to the levels of HuR (ELAV1), a predictive marker for gemcitabine response. In pancreatic cancer cells, exogenous overexpression of pp32 inhibited cell growth, supporting its long-recognized role as a tumor suppressor in pancreatic cancer. In chemotherapeutic sensitivity screening assays, cells overexpressing pp32 were selectively resistant to the nucleoside analogs gemcitabine and cytarabine (ARA-C), but were sensitized to 5-fluorouracil; conversely, silencing pp32 in pancreatic cancer cells enhanced gemcitabine sensitivity. The cytoplasmic levels of pp32 increased after cancer cells are treated with certain stressors, …

Towards Improving Collaboration Success In Virtual Teams Through Collaboration Training, Dawn R. Dittman

Masters Theses & Doctoral Dissertations

No abstract provided.

Suicides On Commuter Rail In California: Possible Patterns — A Case Study, Research Report 10-05, Jan L. Botha, Kristina A. Elmasu, Philip J. Leitzell

Mineta Transportation Institute

Suicides on rail systems constitute a significant social concern. Reports in local media, whether in newspapers, television, or radio, have brought awareness to this very sensitive and personal subject. This is also true for the San Francisco Bay Area. These events also cause severe trauma for the train operators and staff of the system as well as disruption and cost to society. The overall objective of this project was to conduct a pilot study to identify possible patterns in suicides associated with urban commuter rail systems in California. The Caltrain commuter rail system in the San Francisco Bay Area was …

A Proposal To Develop Christian Leaders For South Africa's Kingdom-Focused Church, Roney Lucas Ndala

Doctoral Dissertations and Projects

My proposal centers around developing Christian leaders to believe in themselves and aspire to building kingdom- focused churches in line with the Great Commission. With the alarming growth of churches in South Africa it is imperative to focus attention to the development of leaders who will align and focus the growth to the kingdom. The purpose of this project is to introduce leaders to the concept of kingdom- focused churches that will move people within the ministry of the growing church. The project reviews some principles of a healthy growing church and the need for alignment during this growth stage. …

A 30-Per-Cent Deviation Is Too Wide, Tan K. B. Eugene

Research Collection Yong Pung How School Of Law

Following Prime Minister Lee's recent announcement that the Electoral Boundaries Review Committee (EBRC) had been convened, SMU Assistant Professor Eugene Tan opined that the 30-per-cent deviation rule, of which the EBRC operates on, is too wide and ?overly-generous? in small and compact Singapore. Professor Tan also commented that the committee's redrawing of electoral boundaries should avoid being seen as gerrymandering.

Extremely Elevated Erythrocyte Sedimentation Rate. Etiology At A Tertiary Care Center In Saudi Arabia, Muhammad Yousuf, Javed Akhter, Khalid Al-Khairy, Mohammed A. Al-Saadan, Salih Bin-Salih

Saudi Medical Journal

OBJECTIVE: To evaluate the etiology of extremely elevated erythrocyte sedimentation rate (ESR) in adolescents and adults at a tertiary care center. METHODS: This retrospective, cross-sectional, observational study was carried out at King Abdulaziz Medical City, Riyadh, Saudi Arabia using the Westergren method of determining ESR in adolescents and adults aged >/=12 years. The patients included inpatients and outpatients with medical, surgical, and gynecological problems. During a period from June 2007 to October 2008, consecutive, non-repetitive patients with ESR >/=100 mm/hour were evaluated for possible etiology by checking the electronic and paper data file of each patient. RESULTS: During the study …

The Inhibitory Effect Of Cyclopamine On Human Non-Small Cell Lung Cancer, Wei G. Hu, Yi Yao

Saudi Medical Journal

No abstract provided.

The Economic Impact Of Local Immigration Regulation: An Empirical Analysis, Huyen Pham, Pham Hoang Van

Cardozo Law Review

A wave of local anti-immigration laws has swept the country, triggering contentious debate and raising significant legal and policy issues. One critical dimension that has been largely ignored, however, is the economic impact of these laws: Are jurisdictions with them better off economically than those without them?

In the first empirical study of this issue, we analyze the economic impact of local anti-immigration laws. The laws take different forms - some authorize local police to enforce federal immigration laws, some restrict benefits like housing and employment to those with legal immigration status, and some require all government transactions to be …

The Cyclin E Regulator Cullin 3 Prevents Mouse Hepatic Progenitor Cells From Becoming Tumor-Initiating Cells, Uta Kossatz, Kai Breuhahn, Benita Wolf, Matthias Hardtke-Wolenski, Ludwig Wilkens, Doris Steinemann, Stephan Singer, Felicitas Brass, Stefan Kubicka, Brigitte Schlegelberger, Peter Schirmacher, Michael P. Manns, Jeffrey D. Singer, Nisar P. Malek

Biology Faculty Publications and Presentations

Cyclin E is often overexpressed in cancer tissue, leading to genetic instability and aneuploidy. Cullin 3 (Cul3) is a component of the BTB-Cul3-Rbx1 (BCR) ubiquitin ligase that is involved in the turnover of cyclin E. Here we show that liver-specific ablation of Cul3 in mice results in the persistence and massive expansion of hepatic progenitor cells. Upon induction of differentiation, Cul3-deficient progenitor cells underwent substantial DNA damage in vivo and in vitro, thereby triggering the activation of a cellular senescence response that selectively blocked the expansion of the differentiated offspring. Positive selection of undifferentiated progenitor cells required the expression of …

Ereview, Print Industry Center

RIT Digital Archives

No abstract provided.

Mooting The Night Away: Postinauguration Midnight-Rule Changes And Vacatur For Mootness, Ari Cuenin

Duke Law Journal

No abstract provided.

Political Party Restrictions And The Appointments Clause: The Federal Election Commission's Appointments Process Is Constitutional, Joshua Kershner

Cardozo Law Review

No abstract provided.

Bandwidth-Efficient Frequency-Domain Equalization For Single Carrier Multiple-Input Multiple-Output Underwater Acoustic Communications, Jian Zhang, Yahong Rosa Zheng

Electrical and Computer Engineering Faculty Research & Creative Works

This paper proposes a single carrier (SC) receiver scheme with bandwidth-efficient frequency-domain equalization (FDE) for underwater acoustic (UWA) communications employing multiple transducers and multiple hydrophones. Different from the FDE methods that perform FDE on a whole data block, the proposed algorithm implements an overlapped-window FDE by partitioning a large block into small subblocks. a decision-directed channel estimation scheme is incorporated with the overlapped-window FDE to track channel variations and improve the error performance. the proposed algorithm significantly increases the length of each block and keeps the same number of training symbols per block, hence achieving better data efficiency without performance …

Challenging Supremacy: Virginia's Response To The Patient Protection And Affordable Care Act, Matthew R. Farley

University of Richmond Law Review

No abstract provided.

Community Development Authorities, Andrew A. Painter

University of Richmond Law Review

Today, CDAs of varying sizes and purposes have been authorized by at least fourteen Virginia localities, and approximately twenty have issued bonds." Despite progress, CDAs occupy anarea of Virginia law largely in its infancy. Case law directly related to their use remains limited, and many localities remain uncertain about their use since the unique marriage of private development and public power inherent in the CDA process has, at times, fostered controversy and apprehension. While this article does not directly address the public policy implications of using CDAs to finance infrastructure, the author hopes this review will generate further ideas for …

A Thermal Simulation Process Based On Electrical Modeling For Complex Interconnect, Packaging, And 3di Structures, Lijun Jiang, Chuan Xu, Barry J. Rubin, Alan J. Weger, Alina Deutsch, Howard Smith, Alain Caron, Kaustav Banerjee

Electrical and Computer Engineering Faculty Research & Creative Works

To reduce the product development time and achieve first-pass silicon success, fast and accurate estimation of very-large-scale integration (VLSI) interconnect, packaging and 3DI (3D integrated circuits) thermal profiles has become important. Present commercial thermal analysis tools are incapable of handling very complex structures and have integration difficulties with existing design flows. Many analytical thermal models, which could provide fast estimates, are either too specific or oversimplified. This paper highlights a methodology, which exploits electrical resistance solvers for thermal simulation, to allow acquisition of thermal profiles of complex structures with good accuracy and reasonable computation cost. Moreover, a novel accurate closed-form …

On The Evasion Of Executive Term Limits, Tom Ginsburg, James Melton, Zachary Elkins

Public Law and Legal Theory Working Papers

Executive term limits are pre-commitments through which the polity restricts its ability to retain a popular executive down the road. But in recent years, many presidents around the world have chosen to remain in office even after their initial maximum term in office has expired. They have largely done so by amending the constitution, sometimes by replacing it entirely. The practice of revising higher law for the sake of a particular incumbent raises intriguing issues that touch ultimately on the normative justification for term limits in the first place. This article reviews the normative debate over term limits and identifies …

Identification And Characterization Of Salmonella Serotypes Isolated From Pork And Poultry From Commercial Sources, Yulie Edith Meneses-GonzáLez

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Salmonella is one of the leading causes of foodborne illness worldwide, and it is estimated that 1.4 million infections occur annually in the U.S. alone. The Premi®Test Salmonella (PTS), is a potential tool for rapid detection and identification of Salmonella serovars. The objective of this project was to evaluate the use of the PTS system as a serotyping tool to identify pork and poultry isolates obtained from vertically integrated operations and to characterize their antibiotic resistance. Two hundred isolates were evaluated. All isolates were serotyped using the traditional Kaufmann-White scheme and the PTS system. Among the isolates 63 different serotypes …

Neonatal Mortality And Prevalence Of Practices For Newborn Care In A Squatter Settlement Of Karachi, Pakistan: A Cross-Sectional Study., Afsheen Ayaz, Sarah Saleem

Department of Pathology and Laboratory Medicine

Background: During the past two decades there has been a sustained decline in child and infant mortality, however neonatal mortality has remained relatively unchanged. Almost all neonatal deaths (99%) occur in developing countries, where the majority are delivered at homes. Evidence suggests that these deaths could be prevented by simple, inexpensive practices and interventions during the pregnancy, delivery and postnatal period. In Pakistan over the last decade extensive efforts have been made by the international donors and government to implement these practices. However, limited attempts have been made to explore if these efforts have made a difference at the grass …

Career Motivation In Newly Licensed Registered Nurses: What Makes Them Remain, Zarata Mann Banks, Jessica H. Bailey

The Qualitative Report

Despite vast research on newly licensed registered nurses (RNs), we don't know why some newly licensed registered nurses remain in their current jobs and others leave the nursing profession early in their career. Job satisfaction, the most significant factor emerging from the literature, plays a significant role in nurses' decisions to remain in their current jobs. This study examined the lived experiences of newly licensed registered nurses early in their careers. The researcher interviewed 14 newly licensed registered nurses to ask why they chose nursing as a profession and to determine factors that would influence their choice to stay in …

Arts-Based Research In Education: A Review, Pamela Smithbell

The Qualitative Report

What is the difference between research that uses art, research about art, and research through art? Is arts-based educational research (ABER) a method or medium? What does arts-based research look like? How is it used and evaluated? Editors Cahnmann-Taylor and Siegesmund recruited an arresting array of contributors: paradigmatic pioneers, noted artist-scholars, as well as newcomers to the field. This volume condenses the history, unique features, social contributions, and controversy into a readable, scholarly, and practical text. Each artist-researcher develops a chapter comprised of multiple elements: biography, explanation of intent, critique, photos and open-ended questions. True to ABER epistemology, these contributors …

Interview With Chester Stanley And Grenville Kent, Gerald A. Klingbeil

Faculty Publications

No abstract provided.

The Impact Of Social Media On Software Engineering Practices And Tools, Margaret-Anne Storey, Christoph Treude, Arie Van Deursen, Li-Te Cheng

Research Collection School Of Computing and Information Systems

Today's generation of software developers frequently make use of social media, either as an adjunct or integrated into a wide range of tools ranging from code editors and issue trackers, to IDEs and web-based portals. The role of social media usage in software engineering is not well understood, and yet the use of these mechanisms influences software development practices. In this position paper, we advocate for research that strives to understand the benefits, risks and limitations of using social media in software development at the team, project and community levels. Guided by the implications of current tools and social media …

Deafdigest: Gold Edition, October 31, 2010, Barry Strassler

DeafDigest Gold 2010

No abstract provided.

Dewi Anggraeni, Mereka Bilang Aku China; Jalan Mendaki Menjadi Bagian Bangsa. Yogyakarta: Bentang Pustaka, 2010, Ix + 289 Pp. Isbn978-602-8864-05-3. Price: Idr 40,000 (Soft Cover)., Mely G. Tan

Wacana, Journal of the Humanities of Indonesia

No abstract provided.

Gender And The Indonesian Pronouns, Hein Steinhauer

Wacana, Journal of the Humanities of Indonesia

The absence of a gender opposition in the Indonesian pronominal system requires special strategies in the translation from languages which do have such an opposition illustrated in the first part opf this article. In the second part the lexical and morphological means are discussed with which Indonesian expresses gender, culminating in a description of the use of perempuan and wanita, pria and laki-laki.

Climate And Culture Changes, Lessons, And Challenges, Yunita T. Winarto

Wacana, Journal of the Humanities of Indonesia

From generation to generation over the centuries, people in all parts of the world have developed adaptive social-cultural institutions and strategies of natural resource management based on the intimate relationship they had with their environment. At present, recent global warming is threatening people's lives. Unfortunately, climate change is a natural phenomenon which is neither easy to observe, nor to predict and anticipate accurately. In many places, local people can no longer rely on earlier experiences and existing socio-cultural institutions to adjust to unprecedented changes. We are in urgent need of specific efforts to re-interpret and enrich our knowledge of this …

Interview With Carol Cisneros, Carol Cisneros, California State University, Monterey Bay

Chinatown Renewal Project

Carol Cisneros recalls her childhood memories of Chinatown in Salinas, California from the 1950's, 1960's, and 1970's. She emphasizes that her memories came from a child's point of view. She begins by telling us about her family history. Carol's father and Mother were born in Japan, but her mother was raised in Sacramento. Her parents got married in 1932 and came to US that same year or following year. Cisneros grew up with twelve siblings, she was number ten. Although her family was poor, Cisneros’s father owned a garage on California Street across the Buddhist Temple. She mentions that as …

Data For Lexicography; The Central Role Of The Corpus, Allan F. Lauder

Wacana, Journal of the Humanities of Indonesia

This paper looks at the nature of data for lexicography and in particular on the central role that electronic corpora can play in providing it. Data has traditionally come from existing dictionaries, citations, and from the lexicographer's own knowledge of words, through introspection. Each of these is examined and evaluated. Then the electronic corpus is considered. Different kinds of corpora are described and key design criteria are explained, in particular the size of corpus needed for lexicography as well as the issue of representativeness and sampling. The advantages and disadvantages of corpora are weighed and compared against the other types …

Aspect And Modality In Indonesian; The Case Of "Sudah", "Telah", "Pernah", And "Sempat", Philippe Grangé

Wacana, Journal of the Humanities of Indonesia

In this paper, I describe four Indonesian aspect markers, sudah, telah, pernah, and sempat, showing that the main opposition between them relies not only on their aspectual meanings, but also on the various modalities they express. The opposition between the very frequent markers sudah and telah is analysed in detail. The syntactic and semantic survey shows that these two markers are not synonyms in most contexts.