Digital Commons Network^™

Labeling Of Fluorescein Dye On Folate Binding Protein, Sravanth Reddy Lakshmareddygari

All Capstone Projects

Discovery and development of folic acid based receptor targeting started in late 1991 and early 1992 when researchers came to know that folate receptors (FR) are over expressed on malignant tissues. The malignant tissues over express special folate receptors to capture more folate from the blood stream as folate is required for cell division. The researchers found that folate can be used as an optimal targeting ligand that would bind selectively to pathologic cells, displaying no affinity for healthy cells. Then they focused on attaching a drug molecule to the folate ligand that can be delivered directly to the cells …

Labeling Of Folic Acid On Bovine Serum Albumin, Hari Krishna Kosuri

All Capstone Projects

Recent Clinical research focused mainly on the therapeutic safety which mainly involves the avoidance of toxicities. To prevent the toxicities, site targeted drugs are improved which exhibit their therapeutic action on the specific target or the diseased target without disturbing the healthy cells. Folic acid, a natural Vitamin (Vit B9) has shown promising results in site specificity mainly in the cancer cells where they are abundantly present.

Folic acid is of great importance because of the promising results of several clinical trials which demonstrate that Folic acid increases the potency and simultaneously reducing the toxicity of the cancer therapies. Various …

Total Protein Determination Using Micro Plate Assay, Julie Ruffatti

All Capstone Projects

One of the largest challenges that food manufactures are facing today is the management of food allergens. Allergenic protein in trace amounts, part per million concentrations, will trigger a reaction in some individuals. Food manufacturers need to prevent allergen cross-contamination by performing adequate sanitation after production of an allergenic containing food. Allergen detection kits are used to determine if sufficient protein was removed from the equipment surfaces during sanitation. One kit on the market is the 3M™ Clean- Trace™ Surface Protein (Allergen) swab tests. The test qualitatively detects the presence of protein based on the biuret reaction and will yield …

Purification And Analysis Of Folate-Dye Conjugate, Dilipkumar Sakhiya

All Capstone Projects

The folate receptor has achieved great importance for use in targeted drug delivery and in vitro and in vivo diagnostic assays. The folate receptor (FR) is over-expressed on several cancer cell types and activated macrophages, but exists in relatively low abundance on the surface of non-cancerous tissue and non inflammatory cells. This unique attribute is the hallmark of folate-targeted methodologies allowing the diagnostic agent and/or drug to be ferried to the specific disease sites while preventing “off target” effects in normal tissues. Protein toxins, chemotherapeutic agents, radioimaging agents, magnetic resonance imaging (MRI) contrast agents liposomes with entrapped drugs, radiotherapeutic agents, …

Degree Of Labeling Of Folate-Bsa With Rhodamine Dye, Prathibha Yazala

All Capstone Projects

Folic acid is a very important vitamin. It is needed by cells for various physiological functions. It plays an important role in growth and multiplication of cells and therefore is needed very much by cancerous cells. One of the ways folate reaches the cells is the folate receptor mediated endocytosis. Therefore folate binding proteins are abundant on cancerous cells. Clinical trials proved that the folate receptor targeted drug delivery is very promising to increase the drug exposure to malignant cells and to reduce the toxicity to healthy cells. It was recently discovered that folate receptor is also over expressed on …

Cooperative Learning And The Gifted Student In Elementary Mathematics, Christine C. Hecox

Doctoral Dissertations and Projects

The research was a quantitative research project dealing with Florida Comprehensive Assessment Test (FCAT) Mathematics scores of fourth grade students, including gifted and high-achieving students, in 2008-2009 under the exposure of daily cooperative learning in mathematics. The problem statement was as follows: In Polk County, Florida, how does cooperative learning affect the FCAT Mathematics scores among fourth grade students, including gifted and high-achieving students? The purpose of the quasi-experimental study was to explore the relationship of cooperative learning versus traditional learning on their student achievement. The null hypothesis was that cooperative learning would have no effect on fourth grade gifted …

Mathematics Self-Efficacy Of Community College Students In Developmental Mathematics Courses, David Walker Clutts

Doctoral Dissertations and Projects

Mathematics self-efficacy was defined as an individual's beliefs about how he or she would perform a specific math task or in a specific mathematics or related course. Mathematics self-efficacy was differentiated from self-esteem. Previous literature found self-efficacy in general and mathematics self-efficacy in particular to be significantly related to enrollment, retention, and completion. This study used the Mathematics Self-Efficacy Survey to investigate whether age, gender, developmental mathematics course, or developmental mathematics grade were significantly predictive of mathematics self-efficacy among developmental mathematics students course at a Kentucky community college. Multiple linear regression found that none of these variables were statistically significant …

Synthesis And Structural Characterization Of The Peptide Epitope Of The Ovarian Cancer Biomarker Ca125 (Muc16), Rebecca J. Whelan, Zach T. Berman, Lee J. Moore, Kathleen E. Knudson

Faculty & Staff Scholarship

A highly conserved region of 21 amino acids flanked by cysteine residues, contained within a larger repeated domain, has been proposed to be the antibody-binding site in the ovarian cancer biomarker CA125 (MUC16). In this study solid-phase peptide synthesis with Fmoc protection chemistry was used to assemble a 21-mer peptide corresponding to the most frequently occurring antibody binding sequence in CA125. Potentially significant sequence variants were also synthesized. Peptide secondary structure was investigated using Fourier transform infrared spectroscopy, revealing the consensus sequence peptide to be largely unstructured at physiological pH whether the cysteine residues were reduced or were oxidized to …

Valuing Environmental Quality: A Space-Based Strategy, John I. Carruthers, David E. Clark

Economics Faculty Research and Publications

This paper develops and applies a space-based strategy for overcoming the general problem of deriving the implicit demand for nonmarket goods. It focuses specifically on evaluating one form of environmental quality, distance from Environmental Protection Agency designated environmental hazards, via the single-family housing market in the Puget Sound region of Washington State. A spatial two-stage hedonic price analysis is used to: (i) estimate the marginal implicit price of distance from air release sites, hazardous waste generators, hazardous waste handlers, superfund sites, and toxic release sites; and (ii) estimate a series of implicit demand functions describing the …

A Comparative Study Of Learning Styles Of Business Students In The United States And The Dominican Republic, Bijayananda Naik, Deb Tech, Miguelina Franco

Research & Publications

The Index of Learning Styles (ILS) instrument based on the Felder-Silverman Learning Style Model was used to compare distribution of learning styles of business students in the United States and the Dominican Republic. Results show that majority of business students have a balanced learning style in each of the four learning styles dimensions examined. Difference in learning style preference between United States and Dominican Republic was statistically significant only for the sensing-intuitive and active-reflective dimensions of the FelderSilverman model. The knowledge of statistically significant difference in learning styles of the U.S. and non-U.S. students may help American faculty pay attention …

Sacred Heart University Fact Sheet - Fall 2010, Office Of Institutional Research

News, Magazines and Reports

No abstract provided.

Going Mobile: Launching A Mobile Website And Other Mobile Resources, Elizabeth Palena Hall, Alexandra Gomes, Laura E. Abate, Paul Levett, Morgan Wilcoxson, Steven W. Brown, Jolinda Thompson, John B. Lopez, Velda Jones

Himmelfarb Library Faculty Posters and Presentations

In spring 2010, the staff of Himmelfarb Health Sciences Library met to discuss ideas for a mobile web page and review ways to reach out to users in the mobile environment. By fall 2010, the library launched a mobile website and LibGuide, including drop-in help sessions provided for students. This poster presentation is an overview of the mobile support that the library currently provides to users.

War Of The Words: How Courts Can Use Dictionaries In Accordance With Textualist Principles, Phillip A. Rubin

Duke Law Journal

No abstract provided.

Jointly Modeling Aspects And Opinions With A Maxent-Lda Hybrid, Xin Zhao, Jing Jiang, Hongfei Yan, Xiaoming Li

Research Collection School Of Computing and Information Systems

Discovering and summarizing opinions from online reviews is an important and challenging task. A commonly-adopted framework generates structured review summaries with aspects and opinions. Recently topic models have been used to identify meaningful review aspects, but existing topic models do not identify aspect-specific opinion words. In this paper, we propose a MaxEnt-LDA hybrid model to jointly discover both aspects and aspect-specific opinion words. We show that with a relatively small amount of training data, our model can effectively identify aspect and opinion words simultaneously. We also demonstrate the domain adaptability of our model.

Context Modeling For Ranking And Tagging Bursty Features In Text Streams, Xin Zhao, Jing Jiang, Jing He, Xiaoming Li, Hongfei Yan, Dongdong Shan

Research Collection School Of Computing and Information Systems

Bursty features in text streams are very useful in many text mining applications. Most existing studies detect bursty features based purely on term frequency changes without taking into account the semantic contexts of terms, and as a result the detected bursty features may not always be interesting or easy to interpret. In this paper we propose to model the contexts of bursty features using a language modeling approach. We then propose a novel topic diversity-based metric using the context models to find newsworthy bursty features. We also propose to use the context models to automatically assign meaningful tags to bursty …

Rich Internet Geoweb For Spatial Data Infrastructure, Tin Seong Kam

Research Collection School Of Computing and Information Systems

In this information age, more and more public statistical data such as population census, household living, local economy and business establishment are distributed over the internet within the framework of spatial data infrastructure. By and large, these data are organized geographically such as region, province as well as district. Usually, they are published in the form of digital maps over the internet as simple points, lines and polygons markers limited or no analytical function available to transform these data into useful information. To meet the analytical needs of casual public data users, we contribute RIGVAT, a rich internet geospatial visual …

Spatiotemporal Two-Dimensional Solitons In The Complex Ginzburg-Landau Equation, Florent Berard, S.C. Mancas

Publications

We introduce spatiotemporal solitons of the two-dimensional complex Ginzburg-Landau equation (2D CCQGLE) with cubic and quintic nonlinearities in which asymmetry between space-time variables is included. The 2D CCQGLE is solved by a powerful Fourier spectral method, i.e., a Fourier spatial discretization and an explicit scheme for time differencing. Varying the system's parameters, and using different initial conditions, numerical simulations reveal 2D solitons in the form of stationary, pulsating and exploding solitons which possess very distinctive properties. For certain regions of parameters, we have also found stable coherent structures in the form of spinning (vortex) solitons which exist as a result …

Lsuhsc Facilities Daily Update: October 2010, Lsuhsc Property And Facilities Management

LSUHSC Facilities Daily Updates: 2010

LSUHSC Facilities Daily Updates from October 2010.

October 4, 2010 is listed as a daily update but that page is blank in all seven instances captured by Archive.org.

These updates describe damage and a timeline of repairs at the LSU Health Sciences Center - New Orleans campus due to Hurricane Katrina which made landfall August 29, 2005.

Lsuhsc Facilities Biweekly Update: October 2010, Lsuhsc Property And Facilities Management

LSUHSC Facilities Biweekly Updates: 2010

LSUHSC Facilities Biweekly Updates from October 8 and 22, 2010.

These updates describe damage and a timeline of repairs at the LSU Health Sciences Center - New Orleans campus due to Hurricane Katrina which made landfall August 29, 2005.

Willpower Taxes, Lee Anne Fennell

Public Law and Legal Theory Working Papers

Self-control and related concepts appear regularly in tax discussions, but often they are invoked hazily or blurred together with other aspects of choice over time. Despite the evident relevance of willpower to consumption patterns, wealth accumulation, and, ultimately, well-being, there is no consensus about whether and how heterogeneity along this dimension should factor into tax policy. There is support in the tax literature for such divergent responses as funneling more resources to low-willpower people, penalizing them for their lapses, and limiting their choices. Whether we should follow one of these approaches, or some other approach entirely, requires a careful analysis …

Flattening Single-Vertex Origami: The Non-Expansive Case, Gaiane Panina, Ileana Streinu

Computer Science: Faculty Publications

A single-vertex origami is a piece of paper with straight-line rays called creases emanating from a fold vertex placed in its interior or on its boundary. The Single-Vertex Origami Flattening problem asks whether it is always possible to reconfigure the creased paper from any configuration compatible with the metric, to a flat, non-overlapping position, in such a way that the paper is not torn, stretched and, for rigid origami, not bent anywhere except along the given creases. Streinu and Whiteley showed how to reduce the problem to the carpenter's rule problem for spherical polygons. Using spherical expansive motions, they solved …

Effects Of National Culture On Types Of Knowledge Sharing In Virtual Communities, Keng Siau, J. Erickson, Fiona Fui-Hoon Nah

Research Collection School Of Computing and Information Systems

Organizations are using virtual communities to facilitate knowledge management and to enhance communication among employees, customers, and other interested individuals. Individual users can use virtual communities to engage in knowledge sharing. Professional communicators need to understand and adapt to a globalized and “flat” world, where people across different cultures interact freely and easily with one another in virtual communities. An intriguing question regarding virtual communities relates to whether national culture affects communication and types of knowledge sharing. This study examines the influence of US and Chinese national cultures on types of knowledge-sharing activities in virtual communities. The findings indicate that …

Trajectory-Based Visualization Of Web Video Topics, Juan Cao, Chong-Wah Ngo, Yong-Dong Zhang, Dong-Ming Zhang, Liang Ma

Research Collection School Of Computing and Information Systems

While there have been research efforts in organizing largescale web videos into topics, efficient browsing of web video topics remains a challenging problem not yet addressed. The related issues include how to efficiently browse and track the evolution of topics and eventually locate the videos of interest. In this paper, we introduce a novel interface for visualizing video topics as evolution trajectories. The trajectory visualization is capable of highlighting milestone events and depicting the topical hotness over time. The interface also allows multi-level browsing from topics to events and to videos, resulting in search exploration could be more efficiently conducted …

Detecting Product Review Spammers Using Rating Behaviors, Ee Peng Lim, Viet-An Nguyen, Nitin Jindal, Bing Liu, Hady Wirawan Lauw

Research Collection School Of Computing and Information Systems

This paper aims to detect users generating spam reviews or review spammers. We identify several characteristic be- haviors of review spammers and model these behaviors so as to detect the spammers. In particular, we seek to model the following behaviors. First, spammers may target specific products or product groups in order to maximize their im- pact. Second, they tend to deviate from the other reviewers in their ratings of products. We propose scoring methods to measure the degree of spam for each reviewer and apply them on an Amazon review dataset. We then select a sub- set of highly suspicious …

Mining Interesting Link Formation Rules In Social Networks, Cane Wing-Ki Leung, Ee Peng Lim, David Lo, Jianshu Weng

Research Collection School Of Computing and Information Systems

Link structures are important patterns one looks out for when modeling and analyzing social networks. In this paper, we propose the task of mining interesting Link Formation rules (LF-rules) containing link structures known as Link Formation patterns (LF-patterns). LF-patterns capture various dyadic and/or triadic structures among groups of nodes, while LF-rules capture the formation of a new link from a focal node to another node as a postcondition of existing connections between the two nodes. We devise a novel LF-rule mining algorithm, known as LFR-Miner, based on frequent subgraph mining for our task. In addition to using a support-confidence framework …

Finding Unusual Review Patterns Using Unexpected Rules, Nitin Jindal, Bing Liu, Ee Peng Lim

Research Collection School Of Computing and Information Systems

In recent years, opinion mining attracted a great deal of research attention. However, limited work has been done on detecting opinion spam (or fake reviews). The problem is analogous to spam in Web search [1, 9 11]. However, review spam is harder to detect because it is very hard, if not impossible, to recognize fake reviews by manually reading them [2]. This paper deals with a restricted problem, i.e., identifying unusual review patterns which can represent suspicious behaviors of reviewers. We formulate the problem as finding unexpected rules. The technique is domain independent. Using the technique, we analyzed an Amazon.com …

Cast2face: Character Identification In Movie With Actor-Character Correspondence, Mengdi Xu, Xiaotong Yuan, Jialie Shen, Shuicheng Yan

Research Collection School Of Computing and Information Systems

We investigate the problem of automatically identifying characters in a movie with the supervision of actor-character name correspondence provided by the movie cast. Our proposed framework, namely Cast2Face, is featured by: (i) we restrict the names to assign within the set of character names in the cast; (ii) for each character, by using the corresponding actor's name as a key word, we retrieve from Google image search a group of face images to form the gallery set; and (iii) the probe face tracks in the movie are then identified as one of the actors by robust multi-task joint sparse representation …

Secureangle: Improving Wireless Security Using Angle-Of-Arrival Information, Jie Xiong, Kyle Jamieson

Research Collection School Of Computing and Information Systems

Wireless networks play an important role in our everyday lives, at the workplace and at home. However, they are also relatively vulnerable: physically located off site, attackers can circumvent wireless security protocols such as WEP, WPA, and even to some extent WPA2, presenting a security risk to the entire network. To address this problem, we propose SecureAngle, a system designed to operate alongside existing wireless security protocols, adding defense in depth. SecureAngle leverages multi-antenna APs to profile the directions at which a client's signal arrives, using this angle-of-arrival (AoA) information to construct signatures that uniquely identify each client. We identify …

A Virtual Infrastructure For Mitigating Typical Challenges In Sensor Networks, Hady S. Abdel Salam

Computer Science Theses & Dissertations

Sensor networks have their own distinguishing characteristics that set them apart from other types of networks. Typically, the sensors are deployed in large numbers and in random fashion and the resulting sensor network is expected to self-organize in support of the mission for which it was deployed. Because of the random deployment of sensors that are often scattered from an overflying aircraft, the resulting network is not easy to manage since the sensors do not know their location, do not know how to aggregate their sensory data and where and how to route the aggregated data. The limited energy budget …

Optimization And Oscillation Of A Two-Dimensional Bump To Enhance Airfoil Performance, Dinesh Atchala

Mechanical & Aerospace Engineering Theses & Dissertations

The objective of this project is to improve the aerodynamic performance of an aircraft in transonic speed using a two dimensional contour bump. A natural laminar flow airfoil, RAE5243, has been chosen for the validation case to demonstrate the adequacy of the flow solver used in this study. 2D contour bump is parameterized as the bump position via airfoil, the crest position via bump, maximum height and length of the bump for the parametric study. After these studies, one of the gradient based optimization techniques is utilized to optimize the 2D bump parameters to achieve an augmentation in lift-to-drag …