Digital Commons Network^™

Comparison Of Pcr And Rt-Pcr In The First Report Of Batrachochytrium Dendrobatidis In Amphibians In New Jersey, Usa, Kirsten Monsen, Lisa Hazard, Rakesh Dussa

Department of Biology Faculty Scholarship and Creative Works

No abstract provided.

Commercial Sex Workers: Lives And Practices, Sarah J. Knowles

UNLV Theses, Dissertations, Professional Papers, and Capstones

Commercial sex workers epitomize a population who is both stigmatized and underrepresented in marriage and family therapy research. Through this research I hope to gain understanding about the gains of being a commercial sex worker, which many people may overlook due to their moral opposition to the occupation. I will also be exploring some of the challenges that commercial sex workers face that are unique to their line of work, especially in regards to their relationships, as many aspects of this may have been generalized or disregarded. Finally, I plan to address any implications for therapists who work with commercial …

Vertical Transmission Of West Nile Virus In Culex Spp. Mosquitoes Of Clark County, Nevada, Vivek K. Raman

UNLV Theses, Dissertations, Professional Papers, and Capstones

West Nile Virus (WNV) is an RNA arbovirus that cycles between mosquitoes and birds, but also infects and causes disease in humans, horses and other vertebrate species. Although most infections are asymptomatic, WNV has emerged as the most common cause of epidemic meningoencephalitis in North America and the leading cause of arboviral encephalitis in the United States.

Mosquitoes of the genus Culex are the most active vectors of WNV in North America. Approximately 85% of human WNV infections in the United States occur in late summer with a peak number of cases in August and September. Vertical transmission is defined …

Women As Subject And Audience In World War Ii Venereal Disease Posters, Kyra Whitton

Dissertations, Theses and Capstone Projects (Full IR Collection)

Internationally, venereal disease first became a major health concern during World War I. Venereal diseases were some of the most common infections and led to more hospitalizations among soldiers than wounds or battle-related illness. The Selective Service discovered that almost fifteen percent of those who were eligible for the draft were already infected with a venereal disease, sparking an intense anti-venereal disease campaign across America. Red-light districts were shut down, and American cities sought new laws that would criminalize prostitution to protect young men from contracting a venereal infection.

Though venereal disease rates were still high during World War II, …

Community's Safety Net: A Comparative Analysis Of The Role Of Nonprofit Hospitals In Barrow And Clayton Counties In Providing Services To Its Medicaid Population, Carlene Coggins, Julie John

Dissertations, Theses and Capstone Projects (Full IR Collection)

Nonprofit hospitals serve as part of the healthcare safety net to deliver a significant level of care to low-income, uninsured, underinsured, Medicaid and other vulnerable groups in society. Safety net hospitals are defined as those hospitals where at least 10 percent of the costs of care provided is uncompensated. Nonprofit hospitals are granted tax exemptions from the government and in exchange they are required to meet community benefit standards which include offering care to a relatively large proportion of uninsured or socially disadvantaged individuals.

Increasing poverty levels due to rising unemployment, foreclosures and economic distress have placed the safety net …

Violence, Symbols, And The Archaeological Record: A Case Study Of Cahokia's Mound 72, Kathryn Koziol

Graduate Theses and Dissertations

Acts of violence are not always easily distinguished in their form. Given the additional difficulties caused by the obscure nature of the archaeological record, it is no wonder that interpretations of these behaviors are so skewed both between and within fields of research. There is little consistency in this academic dialogue, which prevents researchers from grappling with the larger perspectives that should be approached. For instance, just how far back in our human history have events such as genocide occurred? Are these modern in origin? The scale of ancient events and our anthropological scopes need more adjustment to the unique …

Ecology And Transmission Of Buruli Ulcer Disease: A Systematic Review, Richard W. Merritt, Edward D. Walker, Pamela L. C. Small, John R. Wallace, Paul D. R. Johnson, Mark Eric Benbow, Daniel A. Boakye

Biology Faculty Publications

Buruli ulcer is a neglected emerging disease that has recently been reported in some countries as the second most frequent mycobacterial disease in humans after tuberculosis. Cases have been reported from at least 32 countries in Africa (mainly west), Australia, Southeast Asia, China, Central and South America, and the Western Pacific. Large lesions often result in scarring, contractual deformities, amputations, and disabilities, and in Africa, most cases of the disease occur in children between the ages of 4–15 years. This environmental mycobacterium, Mycobacterium ulcerans, is found in communities associated with rivers, swamps, wetlands, and human-linked changes in the aquatic environment, …

Global Stability Of Worms In Computer Network, Bimal Kumar Mishra, Aditya Kumar Singh

Applications and Applied Mathematics: An International Journal (AAM)

An attempt has been made to show the impact of non-linearity of the worms through SIRS (susceptible – infectious – recovered - susceptible) and SEIRS (susceptible – exposed – infectious – recovered - susceptible) e-epidemic models in computer network. A very general form of non-linear incidence rate has been considered satisfying the worm propagating behavior in computer network. The concavity conditions with a non-linear incidence rate and under the constant population size assumption are shown to be stable. Such systems have either a unique and stable endemic equilibrium state or no endemic equilibrium state at all; in the latter case, …

Effects Of Acculturation On Hiv/Aids Sexual Risk Behaviors Among Asian And Pacific Islander (Api) Women, Margaret Cabotage Salud

Loma Linda University Electronic Theses, Dissertations & Projects

Background. In the US women are the fastest growing group for sexually transmitted infections (STIs), including HIV and AIDS. In addition, the estimated AIDS cases among female adults and adolescents, aged 13-19, increased from 7% in 1985 to approximately 26% in 2002. Most infections occur by heterosexual transmission with 53% occurring through contact with a high-risk sexual partner. While overall HIV/AIDS rates in the Asian Pacific Islander (API) community remain low, they are rising and HIV testing rates, one of the major prevention strategies for HIV, are lower than that of other populations. Furthermore, very little is known about APIs …

Characterization Of The Sero-Reactivity Of Proteins Map1152 And Map1156 From Mycobacterium Avium Subspecies Paratuberculosis, Avery L. Paulson

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

Mycobacterium avium subsp. paratuberculosis (MAP) causes Johne’s disease (JD) in ruminants. Development of genetic tools and completion of the MAP genome sequencing project expanded opportunities for antigen discovery. In this thesis, I review the current trends in diagnosis and disease control of JD and present the results of the studies on the seroreactivity of two proteins encoded for by the MAP1152-MAP1156 gene cluster. MAP1152 encodes for a PPE protein and MAP1156 encodes a diacylglycerol acyltransferase involved in triglyceride metabolism and classified in the uncharacterized protein family UPF0089. Maltose-binding protein (MBP) tagged recombinant MAP proteins were purified from Escherichia coli. …

Staphylococcus Aureus Virulence Factors Synthesis Is Controlled By Central Metabolism, Yefei Zhu

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

Staphylococcus aureus is a versatile pathogen that can survive in diverse host environments. This versatility depends on its ability to sense nutrients and respond by modulating gene expression, including the synthesis of virulence determinants. In addition to its ability to synthesize virulence factors, the capacity of S. aureus to form biofilms is an important mediator of virulence in certain infections. Biofilms are a complex aggregation of bacteria commonly encapsulated by an adhesive exopolysaccharide matrix (polysaccharide intercellular adhesin; PIA). To study S. aureus biofilm formation, we assessed the metabolic requirements of S. aureus growing in a biofilm and …

Impact Of Information Sources On The Knowledge Of Adolescents About Hepatitis B, Ali Minhal Thaver, Ameera Kamal

Section of Internal Medicine

OBJECTIVE: To assess the impact of various sources of information on school going adolescents (belonging to higher social strata between ages 14-19 years) regarding Hepatitis B; its various types, importance, symptoms and cures.METHODS: A self-administered survey was conducted among the secondary school students (9-12 grades) of a private school for this purpose.RESULTS: A total of 160 students were approached from which 158 (98%) agreed to take part in the survey. Overall 98% students claimed to know something about Hepatitis B. But only 52% of all had comprehensive and correct knowledge about symptoms, causes and measures for prevention of Hepatitis B. …

Sci-Tech Book News Reviews, Susan Fingerman

Sci-Tech News

This section consists of 100 book reviews selected from Sci-Tech Book News, reprinted with the permission of Book News, Inc.

Surgical Site Infection: A Review, Olatilewa Awe, James Harrop

JHN Journal

Infection of the spine may occur spontaneously, by direct hematogenous or contiguous spread from an area of infection, or secondarily to an inciting event such as trauma or spine operation. The overall rate of spine surgery has increased steadily over the last decade. Medicare spending on inpatient spine surgery has doubled over the same period with lumbar fusion representing the greatest percentage of spending.1 Surgical site infection (SSI) after spinal surgery is not uncommon, leading to increased morbidity and mortality. The incidence of surgical site infection after spine surgery varies and depends on several factors including immune status of patient, …

Fever And Infection In The Neurosurgical Intensive Care Unit, Craig Laws, Jack Jallo

JHN Journal

Fever is an adaptive response to a variety of infectious, inflammatory, and foreign stimuli. The “febrile response” confers an immunological advantage to the host over invading microorganisms – bacterial, fungal and viral. Fever results from a cytokine-mediated reaction that results in the generation of acute phase reactants and controlled elevation of core body temperature. The anterior hypothalamus coordinates the “febrile response” in reaction to the release of endogenous pyrogenes and subsequent up-regulation of prostaglandin synthesis. An ensuing change in the hypothalamic set point for temperature regulation advances a synchronized physiologic response from CNS to periphery, on a microscopic and macroscopic …

Development And Evaluation Of Therapeutics In The Setting Of Radiation Injury, Karin Emmons Thompson

Theses and Dissertations (ETD)

The possibility of an incident involving radiation exposure is at the forefront of public attention in the current global environment. With a greater number of entities possessing nuclear weapons and increased demand for nuclear power, the concern for uncontained exposure to radiation is increasing. In light of these developments, the need for treatments that may be easily stored and administered to large numbers of people who have been exposed to high doses of total body irradiation (TBI) is more urgent than ever before.

Our goal was to identify and develop novel, drug-like small molecules that would exhibit radiomitigating activity for …

Antimicrobial-Resistant Bacteria In A General Intensive Care Unit In Saudi Arabia, Nermin K. Saeed, Abdulmageed M. Kambal, Noura A. El-Khizzi

Saudi Medical Journal

OBJECTIVE: To assess the prevalence of multi-drug resistant (MDR) bacteria causing infections in patients at the intensive care units (ICUs) of Riyadh Military Hospital (RMH), as well as their antimicrobial resistance patterns for one year. METHODS: A retrospective, cohort investigation was performed. Laboratory records from January to December 2009 were studied for the prevalence of MDR Gram-negative and Gram-positive bacteria and their antimicrobial resistance in ICU patients from RMH, Riyadh, Kingdom of Saudi Arabia. RESULTS: A total of 1210 isolates were collected from various specimens such as: respiratory (469), blood (400), wound/tissue (235), urinary (56), nasal swabs (35), and cerebro-spinal …

Lords Of The Manor: Fighting California Slumlords With Private Multi-Plaintiff Implied Warranty Of Habitability Litigation., Christina Sosa

The Scholar: St. Mary's Law Review on Race and Social Justice

Abstract Forthcoming.

The Effects Of Two Insecticides On California Anurans (Rana Sierrae And Pseudacris Sierra) And The Implications For Declining Amphibian Populations., David Dimitrie

Theses

Evidence is growing that agrochemicals are playing a role in the decline of amphibians in California. An area of concern is the Sierra Nevada Mountains, where insecticides used in the Central Valley are aerially transported to amphibian habitats. I examined the effects of two of these insecticides, endosulfan and chlorpyrifos, in two experiments on anuran larvae. For the first experiment I exposed Sierra Mountain yellow-legged frog (Rana sierrae) larvae starting at Gosner stage 25 to each insecticide for 63 d to determine median lethal concentrations (LC50) and sublethal effects on growth and development. In the second experiment Sierran treefrog (Pseudacris …

Screening For Influenza Viruses In 7804 Patients With Influenza-Like Symptoms, Xuehui Li, Nan Lv, Chen Hangwei, Lanhua You, Huimin Wang

Saudi Medical Journal

OBJECTIVE: To screen a large number of patients with influenza-like symptoms by using the gold-immunochromatographic assay kit. METHODS: All patients with influenza-like symptoms visiting the outpatient department of the General Hospital of Beijing Military Region, Beijing, China between May 2009 and January 2010 were enrolled in the study. Nasopharyngeal swabs were collected immediately after the patient visited, then a gold-immunochromatographic assay was performed for screening of influenza A and B viruses according to the kit protocol. RESULTS: Among the 7804 patients enrolled in this study, 202 patients were influenza virus-positive; the positive cases accounted for 2.6% of all cases detected. …

Management Of Infected Abdominal Aortic Aneurysm Associated With Vertebral Destruction Due To Chronic Leak, Khalid A. Brekeit, Mirza A. Baig, Abdullah A. Al-Massod, Saleem A. Dahduli

Saudi Medical Journal

We report a case of a patient with an infected abdominal aortic aneurysm due to Staphylococcus versus Brucellar spine infection complicated by aortic aneurysm with chronic contained leak. A 75-year-old patient who had a history of Brucellosis 4 years ago presented one year later with 4.5 cm infra renal abdominal aortic aneurysm (AAA). He presented with aggravated acute abdominal pain radiating to the back and right hip, loss of weight, anorexia, and malaise. The CT-scan showed an AAA of size 6.5 cm involving infra-renal abdominal aorta with erosion of the body of lumbar vertebrae L3 and L4, and stretching of …

Pandemic H1n1 Influenza, Viroj Wiwanitkit, Emin E. Tutuncu

Saudi Medical Journal

No abstract provided.

Core Genome Components And Lineage Specific Expansions In Malaria Parasites Plasmodium, Hong Cai, Jianying Gu, Yufeng Wang

Publications and Research

Background The increasing resistance of Plasmodium, the malaria parasites, to multiple commonly used drugs has underscored the urgent need to develop effective antimalarial drugs and vaccines. The new direction of genomics-driven target discovery has become possible with the completion of parasite genome sequencing, which can lead us to a better understanding of how the parasites develop the genetic variability that is associated with their response to environmental challenges and other adaptive phenotypes. Results We present the results of a comprehensive analysis of the genomes of six Plasmodium species, including two species that infect humans, one that infects monkeys, and three …

The Immune Inhibitor A1 Protease Of Bacillus Anthracis, Kathryn Pflughoeft

Dissertations and Theses (Open Access)

Bacillus anthracis, an organism ubiquitous in the soil and the causative agent of anthrax, utilizes multiple mechanisms to regulate secreted factors; one example is the activity of secreted proteases. One of the most abundant proteins in the culture supernates of B. anthracis is the Immune Inhibitor A1 (InhA1) protease. Here, I demonstrate that InhA1 modulates the abundance of approximately half of the proteins secreted into the culture supernates, including substrates that are known to contribute to the ability of the organism to cause virulence. For example, InhA1 cleaves the anthrax toxin proteins, PA, LF, and EF. InhA1 also targets …

Plasmacytoid Dendritic Cells Sense Skin Injury And Promote Wound Healing Through Type I Interferons, Josh D. Gregorio

Dissertations and Theses (Open Access)

Plasmacytoid dendritic cells (pDCs) are a rare population of circulating cells, which selectively express intracellular Toll-like receptors (TLR)-7 and TLR-9 and have the capacity to produce large amounts of type I IFNs (IFN-a/b) in response to viruses or host derived nucleic acid containing complexes. pDCs are normally absent in skin but accumulate in the skin of psoriasis patients where their chronic activation to produce IFN-a/b drives the disease formation. Whether pDCs and their activation to produce IFN-a/b play a functional role in healthy skin is unknown. Here we show that pDCs are rapidly and transiently recruited into healthy human and …

Novel Neomycin Conjugates For Multi-Recognition Of Nucleic Acids, Albert Willis

All Dissertations

Neomycin is an aminoglycoside antibiotic known for its high affinity for RNA duplex structures. Recent developments from our labs have indicated that aminoglycoside binding is not limited to RNA, but to nucleic acids that, like RNA, adopt conformations similar to A-form. Our group sought to further expand the utility of aminoglycoside binding to B-DNA structures by conjugating neomycin, an aminoglycoside antibiotic, with the B-DNA minor groove binding ligand Hoechst 33258. Envisioning a dual groove-binding mode, we have extended the potential recognition process to include a third, intercalative moiety. Furthermore, we observe remarkable recognition of such conjugates with RNA duplex. Spectroscopic …

Development And Characterization Of Novel Sub-Coatings With Polymorphic Brookite Titania Nanoparticles: Enhanced Uv/Vis Photocatalytic Antibacterial And Anticancer Properties, Donna Weinbrenner

All Dissertations

ABSTRACT
Nosocomial and community infections and biofilm formation from bacteria has increased significantly through adaptation combined with overuse of broad spectrum antibiotics. Because the world population continues to escalate, hospitals and long-term managed care will also escalate, thereby increasing transmission of infections, lowering patients' quality of health. Another disease on the rise throughout the world is skin cancer. A treatment modality that would cause less deleterious effects on the patient would be ideal. These two seemingly different issues could be solved with one product. First an inexpensive, safe, and non-selective antimicrobial surface coating would enhance the hospital arena and a …

The Epidemiology Of Bacterial Vaginosis In Relation To Sexual Behaviour, Hans Verstraelen, Rita Verhelst, Mario Vaneechoutte, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

Background: Bacterial vaginosis (BV) has been most consistently linked to sexual behaviour, and the epidemiological profile of BV mirrors that of established sexually transmitted infections (STIs). It remains a matter of debate however whether BV pathogenesis does actually involve sexual transmission of pathogenic microorganisms from men to women. We therefore made a critical appraisal of the literature on BV in relation to sexual behaviour.

Discussion: G. vaginalis carriage and BV occurs rarely with children, but has been observed among adolescent, even sexually non-experienced girls, contradicting that sexual transmission is a necessary prerequisite to disease acquisition. G. vaginalis carriage is enhanced …

Mother And Daughter Communication About Sexual Health In Rural Kenya, Jessica Velcoff

College of Liberal Arts & Social Sciences Theses and Dissertations

The present study focused on young women, and the manner in which communication with their mothers may facilitate decreased sexual risk behaviors in rural Kenya. With regard to sexual behaviors, Hutchinson and Wood (2007) developed the parent-based expansion of the theory of planned behavior (PETPB). The PETPB is a theoretical framework that builds upon the theory of planned behavior, to include the influence of parents in understanding adolescent sexual risk behavior. The present study was guided by the PETPB and explored communication, knowledge of sexuality and sexual health, and preventative behaviors among rural secondary school aged Kenyan young women (15 …

Spatial Epidemiology Of Birth Defects In The United States And The State Of Utah Using Geographic Information Systems And Spatial Statistics, Samson Y. Gebreab

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Oral clefts are the most common form of birth defects in the United States (US) and the State of Utah has among the highest prevalence of oral clefts in the nation. The overall objective of this dissertation was to examine the spatial distribution of oral clefts and their linkage with a broad range of demographic, behavioral, social, economic, and environmental risk factors through the application of Geographic Information Systems (GIS) and spatial statistics. Using innovative linked micromaps plots, we investigated the geographic patterns of oral clefts occurrence from 1998 to 2002 and their relationships with maternal smoking rates and proportion …