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Mechanism And Inhibition Of Bacterial Enoyl-Acp Reductases: Towards Novel Antibacterial Drugs, Hao Lu

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Resistance to existing antimicrobial agents is a global threat to human health care, and new drugs with novel mechanisms of action are required in order to keep pace with the emergence of drug resistant pathogens. The bacterial fatty acid biosynthesis (FAS-II) pathway represents a validated yet relatively unexploited target for new antibiotic development and consequently there is significant interest in developing potent inhibitors of FAS-II enzymes. In this work we have focused on the FAS-II enoyl-ACP reductase enzyme which is known to be essential for bacterial survival. We cloned, expressed and purified the enoyl-ACP reductase from Francisella tularensis (ftuFabI). The …

Memento, Sarah Rollman

Interior Design Program: Terminal Projects

Executive Statement

The focus of this project will be the tattoo parlor and bringing a new identity to the industry. The business is an artistic and creative one that will work well in the historic district among architecture and design firms, graphic design and branding firms, art galleries, and advertising firms.

Tattooing was widely practiced by many cultures in the ancient world, and was associated with a high level of artistic endeavor. The imagery of ancient tattooing is very similar to that of modern tattooing, and throughout history tattooing, like other forms of body decoration, has been related to the …

Indiana Wildlife Disease News, Vol 5, Issue 2 -- May 2010, Joe N. Caudill, Dean Zimmerman

Indiana Wildlife Disease News

Botulism in wildlife

White-nose syndrome (WNS) Spreads into Midwestern United States

Publication on Tularemia Now Available from the USGS National Wildlife Health Center

BOAH in New Location and New Contact Information

Midwest Wildlife Disease Update: No TB Found in Indiana Deer Sampled; New BOAH Contact Information; Indiana Cervid Testing; Indiana Man Dies of Rabies; Missouri Has CWD Positive in Captive Herd; A bat from a cave in northwest Oklahoma has tested positive for the fun-gus associated with WNS; Indiana Continues To Be CWD Free; Illinois CWD Positives in Decline

Interaction Of Francisella Asiatica With Tilapia (Oreochromis Niloticus) Innate Immunity, Esteban Soto, Denise Fernandez, Ronald Thune, John P. Hawke

Faculty Publications

Members of the genus Francisella are facultative intracellular bacteria that cause important diseases in a wide variety of animals worldwide, including humans and fish. Several genes that are important for intramacrophage survival have been identified, including the iglC gene, which is found in the iglABCD operon in the Francisella sp. pathogenicity island (FPI). In the present study, we examined the interaction of wild-type Francisella asiatica and a ΔiglC mutant strain with fish serum and head kidney-derived macrophages (HKDM). Both the wild-type and the mutant strains were resistant to killing by normal and heat-inactivated sera. The wild-type F. asiatica is able …

Enhanced Psychosocial Well-Being Following Participation In A Mindfulness-Based Stress Reduction Program Is Associated With Increased Natural Killer Cell Activity., Carolyn Y Fang, Diane K Reibel, Margaret L Longacre, Steven Rosenzweig, Donald E Campbell, Steven D Douglas

Marcus Institute of Integrative Health Faculty Papers

BACKGROUND: Mindfulness-based stress reduction (MBSR) programs have consistently been shown to enhance the psychosocial well-being of participants. Given the well-established association between psychosocial factors and immunologic functioning, it has been hypothesized that enhanced psychosocial well-being among MBSR participants would be associated with corresponding changes in markers of immune activity.

OBJECTIVES: The objectives of this study were to examine changes in psychosocial and immunologic measures in a heterogeneous patient sample following participation in a MBSR program.

DESIGN: A single-group, pretest/post-test design was utilized.

SETTING: The intervention was conducted at an academic health center.

SUBJECTS: This pilot study involved 24 participants (aged …

The Senior Resident - Beginning The Journey - Richard Donlick, Do, Justin Guthier

Voices from the Floor

No abstract provided.

Checkup, Lehigh Valley Health Network

Checkup

No abstract provided.

Automated Extraction Of Structures From Sketches Of Biological Specimens, Jamie Joseph Schirf

School of Computing: Dissertations, Theses, and Student Research

The goal of this study was to develop automated techniques to extract biological structures from sketches of biological specimens. This will form the basis for a searchable database of information about the specimens. Having such a database enables researchers to efficiently search for specimens with particular qualities or identify unknown specimens. After some preprocessing of the images, the important internal organs of the specimen are extracted using image analysis techniques. The shape, size, and organization of the organs are used to categorize and then to reorganize them in the image. Results using a large database of sketches of trematodes, in …

Voices From The Floor (May 2010), Pcom

Voices from the Floor

No abstract provided.

Immunomodulatory Properties Of Noni (Morinda Citrifolia), Madhukar Lohani

All Theses

Noni (Morinda citrifolia) is a popular medicinal plant of family Rubiaceae. Its fruit is rich in various phytochemicals and polysaccharides. Anecdotal evidence indicates that it was used to stimulate the immune system and, thus, to fight various infections. Limited in vitro studies also support the immunomodulatory role of Noni, however only one study utilized an animal model. The purpose of this study was to examine the immunomodulatory properties of Noni fruit the broiler chicken.
Different concentrations of dietary Noni were added to diets and fed to day-old broiler chickens for 3 to 6 weeks. Gut tissue and blood were sampled …

Exploring Health Through The Lens Of Homelessness, Faith T. Adewusi

Senior Honors Projects

Homelessness is a serious economic, social and public health problem. Approximately 2.3 to 3.5 million people are estimated to be homeless nationwide and with the current recession, these numbers are expected to rise. Due to the lack of permanent living accommodations and limited access to healthcare, homeless people are more likely than domiciled people to suffer from a wide range of chronic health problem, ranging from diabetes to tuberculosis to mental illness. Healthcare problems can be seen as both the cause and the effect of homelessness.

The purpose of this study was to learn about the living conditions of the …

The Molecular Analysis Of Hemoparasite Burdens Of Free-Ranging Lions (Panthera Leo) In The Kruger National Park, South Africa, Jamie R. Sherman

Renée Crown University Honors Thesis Projects - All

Hemoparasites, or parasites of the blood transmitted by arthropod vectors, are commonly found in domestic animals and wildlife all over the world. Although hemoparasites can cause serious illness in domestic species, they often persist at low levels in wildlife without compromising general health. Current reports on wildlife parasitemia, specifically in lions (Panthera leo) are obtained from zoological parks and managed game reserves. However, few studies have examined parasitic burdens of free ranging lion populations. This study aims to semi quantitatively evaluate the presence of four representative hemoparasites including Babesia sp., Theileria sp., Cytauxzoon sp., and …

Urban Farming Mumbai, Ankur Patel

Renée Crown University Honors Thesis Projects - All

Abstract not included.

Preventing The Sixth Plague: Microbial Forensics In The War Against Terrorism, Amanda Mickley

Honors College Theses

Bioterrorism utilizes viruses, bacteria, fungi and toxins to cause mass sickness or death in people, animals, or agriculture. The use of bioterrorism may be ideal for terrorists, because these agents are difficult to detect, and people may not become sick for a few hours or even days, allowing for the ability to cover their trail. Microbial Forensics is an up and coming field which utilizes the basic concepts of forensic biology in the application of pathogens. Some of the current technologies include rapid response hand-held bioassays, and genomic sequencing of the pathogens. Advanced technologies in the field are currently being …

La Enfermedad Respiratoriaen Los Terneros Lecheros, Alvaro Garcia, Russ Daly

SDSU Extension Extra Archives

La enfermedad respiratoria es la segunda causa de muerte (diarrea es la primera) en las terneras lecheras no destetadas. Los problemas respiratorios han aumentado en un 34 por ciento en los últimos 20 años, causando cerca de 21 por ciento de la mortandad de los terneros (NAHMS 2007). Las terneras que sobreviven continúan con un des¬empeño pobre al convertirse en vacas adultas. Para prevenir este problema, es importante tener en cuenta tanto causas predisponentes como determinantes.

Use Of An Animal Model To Explore Prenatal Predictors Of Insulin And Glucose Metabolism In Southwestern Alaskan Yupiit, Julie Jo Kachinski

UNLV Theses, Dissertations, Professional Papers, and Capstones

Compared to other North American indigenous populations, Southwest Alaskan Yupiit exhibit very low rates of type 2 diabetes despite the occurrence of common risk factors. Contemporary Yupiit obtain a substantial portion of their calories from traditional foods, which contain high amounts of omega-3 polyunsaturated fatty acids. Epidemiological and experimental animal research has linked glucose and insulin homeostasis with a diet high in omega-3s. This study used an experimental animal model to explore potential diabetes protective effects (for adult offspring) of prenatal maternal nutrition modeled on traditional locally-obtained Yupiit diets. The results of this study showed that the adult offspring whose …

Health Status Of Infants And Children From The Bronze Age Tomb At Tell Abraq, United Arab Emirates, Kathryn Mary Baustian

UNLV Theses, Dissertations, Professional Papers, and Capstones

Tell Abraq is significant because it is the largest prehistoric site on the southern coast of the Arabian Gulf. It was strategically important as an ancient port, regionally surrounded by large political centers. Commingled remains were located in a small tomb (6 m) used for a 200 year period (2200-2000 BC). The site was continually occupied from the 3rd millennium BC up to the 1st century AD. In the tomb were minimally 286 adults and 127 subadults. What is extraordinary is the number of pre-term (3rd trimester) infants (n=28, 22%), neonates (n=12, 9%), and infants under 2 years (n=46, 36%). …

Latin America And The Caribbean: Assessment Of The Advances In Public Health For The Achievement Of The Millennium Development Goals, Amal K. Mitra, Gisela Rodriguez-Fernandez

Faculty Publications

To improve health and economy of the world population, the United Nations has set up eight international goals, known as Millennium Development Goals (MDGs), that 192 United Nations member states and at least 23 international organizations have agreed to achieve by the year 2015. The goals include: (1) eradicating extreme poverty and hunger; (2) achieving universal primary education; (3) promoting gender equality; (4) reducing child mortality; (5) improving maternal health; (6) combating HIV/AIDS, malaria and other diseases; (7) ensuring environmental sustainability; and (8) developing a global partnership for development. Having been in the midway from the 2015 deadline, the UN …

Impacts On Maternal Diet In A Transitional Community In Rural Costa Rica: Potential Implications For The Developmental Origins Of Obesity-Related Disorders, Allison Cantor

UNLV Theses, Dissertations, Professional Papers, and Capstones

This thesis examines maternal diet in a rural, transitional community in Costa Rica. Using cross-cultural categories recognized in the ethnographic literature (i.e. dietary taboos, dietary prescriptions, food cravings and the acknowledgment of a special post-partum period diet), maternal dietary practices were identified in the local community through surveys (n=45) and participant-observation (n=5), and to reflect the actual consumption patterns of pregnant and nursing women in the area, 24-hour diet recalls were administered to 5 pregnant or nursing women. In light of the recent changes that increased tourism has brought to the Monteverde Zone, focus groups were employed to determine impacts …

Colono Wares In The Western Spanish Borderlands: A Ceramic Technological Study, Jennifer Boyd Dyer

Anthropology ETDs

The appearance of hybrid ceramics, also known as colono wares, signals Spanish contact across the Empire and materially represents syncretism between Native American and European traditions. Because colono wares are low-fired, locally produced ceramics that take on European shapes, they are used in this study to investigate how Pueblo groups in New Mexico responded to Spanish contact during the early colonial period, defined as initial contact to the Pueblo Revolt of 1680. I build a model that compares colono wares to traditional forms using technological variables to determine if cultural resilience, disruption, or innovation best characterize early colonial period interactions …

Comparison Of E-Test And Disc Diffusion Methods For The In Vitro Evaluation Of The Antimicrobial Activity Of Colistin In Multi-Drug Resistant Gram-Negative Bacilli, Ali M. Somily

Saudi Medical Journal

OBJECTIVE: To study susceptibility of clinical isolates of multi-drug resistant (MDR) Gram-negative bacilli to colistin by minimum inhibitory concentration (MIC) determination using Etest, and compare this with their susceptibility measured by the disc diffusion (DD) method. METHODS: A total of 224 of MDR organisms (147 Acinetobacter baumannii [A. baumannii], 49 Acinetobacter species, 24 Stenotrophomonas maltophilia [S. maltophilia], and 43 Pseudomonas aeruginosa [P. aeruginosa]) were tested between January 2007 and August 2008 at King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia. They were identified by standard microbiological methods. Susceptibility by DD and MIC by Etest were interpreted according to the …

A Counter-Wmd Strategy For The Future, Albert J. Mauroni

The US Army War College Quarterly: Parameters

No abstract provided.

Efficacy And Mechanism Of Â-Defensin2 Fused Antigen Protein Vaccines, Hyun J. Park

Dissertations and Theses (Open Access)

Vaccines which use the strategy of fusing adjuvant murine â-defensin2 (mBD2) to an antigen in order to elicit stronger anti-antigen immune responses are referred to as murine â-defensin2 (mBD2) vaccines. Previous studies have validated the potential of mBD2 vaccines, thus in this study we focus on increasing vaccine efficacy as well as mechanism elucidation. Initially, we demonstrate superior IFN-ã release levels by antigen specific effector T cells when antigen is crosspresented by dendritic cells (DC) which absorbed mBD2 vaccine (mBD2 fused antigen protein) over antigen alone. We move unto an in vivo model and note significant increases in the expansion …

Immunizations And Autism: Educating The Public, Lori L. Slaubaugh

Theses and Dissertations

Research has shown that the avoidance or delay of immunizations can lead to significant outbreaks of diseases previously thought eradicated. Recent outbreaks of diseases, such as measles, have emphasized the need for immunizations to protect each child, which in turn protects the population as a whole. Although research has not substantiated a link between the occurrence of autism and thimerosal , a preservative used in many vaccines since 1930, many parents continue to avoid immunizations out of fear that those containing thimerosal may cause autism in their child. Educating parents on the evidence related to thimerosal as a preservative in …

Tactics For Identifying And Eliminating Tritrichomonas Foetus From Infected Beef Herds, Jeff D. Ondrak

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

The protozoan, Tritrichomonas foetus (TF), has been recognized as a cause of bovine infertility for more than 100 years (Skirrow and BonDurant, 1988). As an obligate parasite of the bovine reproductive tract its control and eradication seems achievable (Harding, 1950). However, this disease continues to trouble United States cattle producers and a recent epidemic in the Western US has lead to increased interest in research and regulatory efforts (Cima, 2009). Outbreak investigations were carried out on three Nebraska ranches to assess the efficiency of currently available diagnostic tests, culture, gel polymerase chain reaction (PCR), and real time PCR (rtPCR), in …

Sci-Tech Book News Reviews, Susan Fingerman

Sci-Tech News

This section consists of 100 book reviews selected from Sci-Tech Book News, reprinted with the permission of Book News, Inc.

Simulation-Based Metrics Analysis Of An Outpatient Center., Elvin Webb

Electronic Theses and Dissertations

With more and more attention surrounding healthcare, Industrial Engineers have championed the task to help hospitals and outpatient centers operate as efficiently as possible. Simulation is often used to analyze hospital performance measures. The University of Louisville Health Care Outpatient Center is a relatively new building occupying 169,000 ft2 and opened in October of 2008. The clinic is experiencing uneven workloads, over scheduling of Medical Assistants, and highly variable patient waiting times. The Arena Simulation package has been used to develop a model of the outpatient center's current state. Using the data from July 2009 the model has been validated …

An Updated History Of The Teratology Society., Thomas H Shepard, Mason Barr, Robert L Brent, Andrew Hendrickx, Devendra Kochhar, Godfrey Oakley, William J Scott, John M Rogers

Department of Pediatrics Faculty Papers

BACKGROUND: The 49-year history of the Teratology Society is reviewed. An abbreviated history is outlined in table form, with listings of the Warkany Lectures, the Continuing Education Courses, and officers of the society. The original article was updated to include the years 2000 to 2010.

METHODS: A year-by-year description of the events is given, including the scientific and social content of the annual meetings and changes in the business of the society, in many cases using comments from the past presidents. The valuable and unique diversity of the members is discussed and illustrated, presenting the disciplines and main research areas …

Systems Biology Approach To Identifying Host Interactive Pathways Modulating The Severity Of Streptococcal Sepsis, Nourtan Fatthy Abdeltawab

Theses and Dissertations (ETD)

Clinical outcomes of infectious diseases are controlled by complex interactions between the host and the pathogen. Epidemiological, genetic and molecular studies in my mentor’s laboratory provided evidence that in invasive Group A streptococcal (GAS) infections, genetic variations in both bacteria and patients influenced the severity of GAS sepsis. Allelic variations in class II human leukocyte antigens (HLA) contributed significantly to differences in the severity of group A streptococcal sepsis caused by the same virulent strain of the bacteria. HLA class II molecules present streptococcal superantigens (SAgs) to T cells, and variations in HLA class II molecules can strongly influence SAg …

The Design And Synthesis Of Novel Antimicrobial Agents For Use In The Battle Against Bacterial Resistance, Joshua Randal Brown

Theses and Dissertations (ETD)

There is an ever increasing need to develop new antimicrobial agents with novel mechanisms of action. These new agents will help to combat the steady rise of antibiotic-resistant bacteria which are becoming more and more difficult to treat due to the dwindling number of antibiotics available to treat such organisms. This body of work brings to light the many ways in which medicinal chemistry plays a vital role in the discovery of novel antimicrobial agents. Chapter 1 is an introduction into antimicrobial agents. It provides a brief history of the discovery of antimicrobial agents, and delves into reasons why new …