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Socioeconomic And Environmental Causes For Respiratory Infection Death In Alaska Native Villages, Sarah Mcbeth

Master of Public Health Program Student Publications

Objectives. This ecological study evaluates the association between community characteristics and death rates from pneumonia/influenza, tuberculosis, and infectious diseases in 196 Alaska Native villages.

Methods. Ecological variables studied included percentage of Natives in the population, age distribution, latitude, average household size, socioeconomic status, percentage of homes with complete plumbing and/or kitchens, type of heating fuel used, community alcohol restrictions, level of healthcare access, and residence in specific regions of Alaska. These data come from the 2000 U.S. Census, the Alaska Alcohol Beverage Control Board, and the Alaska Native Tribal Health Consortium. A stepwise analysis of variance using the Proc GLM …

Zoonotic Disease In Ohio: Surveillance, Preparation, And Response, Erik B. Balster

Master of Public Health Program Student Publications

This paper examines the state of public health preparation and response capacity to zoonotic infectious disease in the state of Ohio. A comprehensive literature review of zoonotic disease emergence and re-emergence, the National Veterinary Stockpile (NVS), the One Health Initiative, emergency response, and Ohio policy was performed in conjunction with telephone interviews. This study shows that responsibilities and systems integral to disease preparedness, such as sentinel surveillance and reporting, vary significantly between two key departments: the Ohio Department of Health (ODH) and the Ohio Department of Agriculture (ODA). Consistency and standardization of agency, mirroring the One Health Initiative, must be …

Obesity, Poverty, And The Built Environment: Challenges And Opportunity, Wendy Collins Perdue

Law Faculty Publications

Obesity and its associated chronic diseases have become a major health concern in the United States.... Approximately two thirds of adults in the United States are either overweight or obese, and the condition is linked to diabetes, high blood pressure and other chronic conditions requiring ongoing medical supervision. Obesity is a particular health concern for the poor. Not only are obesity rates generally higher among those with lower socioeconomic status, but the chronic conditions caused by obesity may present a particular challenge for the poor who often lack access to necessary ongoing medical supervision.

Mitigation/Adaptation And Health: Health Policymaking In The Global Response To Climate Change And Implications For Other Upstream Determinants, Lindsay Wiley

Scholarly Articles in Law Reviews & Journals

No abstract provided.

Adaptation To The Health Consequences Of Climate Change As A Potential Influence On Public Health Law And Policy: From Preparedness To Resilience, Lindsay Wiley

Scholarly Articles in Law Reviews & Journals

Because the health effects of climate change are likely to be significant and far-reaching, a key component of climate change adaptation will be our public health infrastructure. Perhaps counter-intuitively, recent emphasis in public health law on preparedness for extraordinary events may be to the detriment of our ability to cope with the health impacts of climate change. While existing emergency preparedness law will necessarily be an important backdrop for health-focused climate change adaptation efforts (especially with regard to natural disasters and infectious disease outbreaks), the focus on emergency preparedness in recent years does not necessarily situate us well for handling …

Cannabinoid Conditioned Reward And Aversion: Behavioral And Neural Processes, Jennifer E. Murray, Rick A. Bevins

Department of Psychology: Faculty Publications

The discovery that delta-9-tetrahydrocannabinol

(Δ⁹-THC) is the primary psychoactive ingredient in

marijuana prompted research that helped elucidate

the endogenous cannabinoid system of the brain.

Δ⁹-THC and other cannabinoid ligands with agonist

action (CP 55,940, HU210, and WIN 55,212-2)

increase firing of dopamine neurons and increase

synaptic dopamine in brain regions associated with

reward and drug addiction. Such changes in cellular

processes have prompted investigators to examine

the conditioned rewarding effects of the cannabinoid

ligands using the place conditioning task with rats and

mice. As reviewed here, these cannabinoid ligands

can condition place preferences (evidence for rewarding …

The Social Determinants Of ‘Health’ Of Embryos: Practices, Purposes, And Implications, Roxanne Mykitiuk, Jeff Nisker

Articles & Book Chapters

An increasing focus on the biomedical determinants of the health of embryos and fetuses is resulting from new technical possibilities, clinical considerations and research purposes (Nisker and White, 2005), but also from social factors, and for a variety of reasons. An exploration of the determinants of health of embryos, just as an exploration of the determinants of child or adult health, must take into consideration traditional social determinants, including those related to the consequences of poverty, such as poor nutrition and toxic environments (World Health Organization, 1948; Wilkinson and Marmot, 2003; Raphael, 2004), but also laws, policies and institutions, which …

African American Caregiver Resiliency: Resources, Vulnerabilities, Coping, And Well-Being Among Caregivers Of Persons With Chronic Illness, Kimberly Carter

All Theses and Dissertations (ETDs)

Using a sample of African American family members from the National Survey of Families and Households: NSFH), this study explored the experience of caring for a family member with chronic illness. Guided by the Model of Family Stress, Adaptation, and Resiliency the study looked at the role that family stress and coping factors: specifically, resources, vulnerabilities, and coping behaviors) have on caregiver well-being. T-tests and chi-square analyses of the entire sample, both the caregivers and non-caregivers: N = 2390) revealed no significant differences, other than gender, between caregivers and non-caregivers across demographic, stressor, and coping factors. Caregivers were more likely …

Psychosocial Problems Of Homeless Sexual Minority Youths And Their Heterosexual Counterparts, Maurice Gattis

All Theses and Dissertations (ETDs)

Abstract The purpose of this dissertation was to better understand the psychosocial problems: mental health problems, substance use problems, and sexual risk behaviors) and the associated contextual risk factors by comparing homeless sexual minority youths with their heterosexual counterparts. This study used an ecological perspective: Bronfenbrenner, 1989) and a risk and protective factors framework: Hawkins, Catalano, & Miller, 1992) to identify contextual risk factors at the microsystem, mesosystem, and macrosystem levels that are associated with the psychosocial problems of homeless sexual minority and homeless heterosexual youths. Individuals aged 16-24 were recruited from three drop-in programs serving homeless youths in downtown …

The Impact Of Conservation On The Status Of The World's Vertebrates, Michael Hoffmann, Craig Hilton-Taylor, Ariadne Angulo, Monika Böhm, Thomas M. Brooks, Stuart H. M. Butchart, Kent E. Carpenter, Janice Chanson, Beth A. Polidoro, Jonnell C. Sanciangco

Biological Sciences Faculty Publications

Using data for 25,780 species categorized on the International Union for Conservation of Nature Red List, we present an assessment of the status of the world's vertebrates. One-fifth of species are classified as Threatened, and we show that this figure is increasing: On average, 52 species of mammals, birds, and amphibians move one category closer to extinction each year. However, this overall pattern conceals the impact of conservation successes, and we show that the rate of deterioration would have been at least one-fifth again as much in the absence of these. Nonetheless, current conservation efforts remain insufficient to offset the …

E Pluribus Unum: Data And Operations Integration In The California Criminal Justice System, W. David Ball

Faculty Publications

This Article reflects some of the insights from the Stanford Criminal Justice Center's (SCJC's) year-long project on data and operations integration in California's criminal justice system. Part I lays out some of the benefits of an integrated system as a means of illustrating why law enforcement agencies across the state are actively pursuing data integration. Part II discusses three organizational and political obstacles to creating an integrated system: defining what we mean by  the criminal justice "system," drawing boundaries of relevant networks, and resolving tensions among state and local agencies with concurrent jurisdiction. Part III then discusses three ways in …

Attenuated Response Of Aged Mice To Respiratory Francisella Novicida Is Characterized By Reduced Cell Death And Absence Of Subsequent Hypercytokinemia, Chris A. Mares, J. Sharma, S. S. Ojeda, Q. Li, J. A. Campos, E. G. Morris, J. J. Coalson, J. M. Teale

Biology Faculty Publications (Archived)

Background: Pneumonia and pulmonary infections are major causes of mortality among the growing elderly population. Age associated attenuations of various immune parameters, involved with both innate and adaptive responses are collectively known as immune senescence. These changes are likely to be involved with differences in host susceptibility to disease between young and aged individuals. Methodology/Principal Findings: The objective of this study was to assess potential age related differences in the pulmonary host response in mice to the Gram-negative respiratory pathogen, Francisella novicida. We intranasally infected mice with F. novicida and compared various immune and pathological parameters of the pulmonary host …

S-Nitrosothiols: Formation, Decomposition, Reactivity And Possible Physiological Effects, Moshood Kayode Morakinyo

Dissertations and Theses

Three biologically-active aminothiols cysteamine (CA), DL-cysteine (CYSH) and DL-homocysteine, were studied in this thesis. These aminothiols react with nitrous acid (HNO₂), prepared in situ, to produce S-nitrosothiols (RSNOs): S-nitrosocyteamine (CANO), S-nitrosocysteine (CYSNO) and S-nitrosohomocysteine (HCYSNO). They also react with S-nitrosoglutathione (GSNO) and S-nitroso-N-acetylpenicillamine (SNAP) through a transnitrosation reaction to produce their corresponding RSNOs. A detailed kinetics and mechanistic study on the formation of these RSNOs and their subsequent decomposition to release nitric oxide (NO) were studied.

For all three aminothiols the stoichiometry of their reaction with nitrous acid is strictly 1:1 with the formation of one mole …

Functional Genomic Examinations Of Interactions Between Common Members Of The Human Gut Microbiota, Michael Mahowald

All Theses and Dissertations (ETDs)

The adult human gut microbiota consists of hundreds to thousands of bacterial species, the majority belonging to the Bacteroidetes and the Firmicutes. Differences in the balance between these phyla has been linked to obesity in mice and humans. However, little is known about their interactions in vivo. I have used comparative and functional genomics, proteomics and biochemical assays to identify the ways they marshal their genomic resources to adapt to life together in the distal gut. I first annotated the complete genome sequences of two human gut Bacteroidetes (Bacteroides vulgatus and Parabacteroides distasonis) and two Firmicutes (Eubacterium rectale and E. …

The Impact Of Interferon Regulatory Factor 3 On The Immune Response To Herpes Simplex Virus Type I Infection, Vineet Menachery

All Theses and Dissertations (ETDs)

The type I interferon: IFN) cascade is critical in control of herpes simplex virus type I: HSV-1) infection and relies on specific recognition molecules to rapidly signal viral infection via interferon regulatory factor-3: IRF-3) -dependent pathways. The absence of these recognition molecules or the loss of IRF-3 would be predicted to render early recognition pathways inoperative and thus impact viral infection. However, previous results had produced contradictory results in terms of the role of IRF-3 during HSV-1 infection. In this study, infected IRF-3-/- immune cells were found to support increased HSV-1 replication compared to control cells. In addition, IRF-3 deficient …

Knowledge And Awareness About H1n1 Influenza (Swine Flu) Among University Students, Suneel Kumar Parvathareddy

All Graduate Theses, Dissertations, and Other Capstone Projects

H1N1 influenza (Swine influenza or Swine flu) is a respiratory disease of pigs caused by type A influenza virus that regularly causes outbreaks of influenza in pigs. Worldwide, as of October 17, 2009, there have been more than 414,000 laboratory confirmed cases of pandemic influenza H1N1 2009 and nearly 5000 deaths. The 2009 flu pandemic is a global outbreak of a new strain of influenza A virus subtype H1N1 and was first identified April 2009 in Mexico. On June 11, 2009, WHO declared the H1N1 outbreak as a pandemic. Worldwide, as of April 11, 2010, more than 214 countries and …

Discovery: The Student Journal Of Dale Bumpers College Of Agricultural, Food And Life Sciences - Volume 11 2010, Several Authors

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

No abstract provided.

Washington University School Of Medicine Bulletin, 2010

Washington University School of Medicine Bulletins

No abstract provided.

Donna Whitney V. Division Of Juvenile Justice, Utah Department Of Human Services, State Of Utah, Quest Youth Services, Kyle Lancaster, Dan Maldanado, Jason Kaufusi, Huy Nguyen, And Berry Howard : Brief Of Appellee, Utah Court Of Appeals

Utah Court of Appeals Briefs (2007– 2019)

CERTIFICATION OF QUESTION OF STATE LAW TO THE UTAH SUPREME COURT BY THE UNITED STATES COURT OF APPEALS FOR THE TENTH CIRCUIT

The Impact Of Pre-Operative Mupirocin Prophylaxis On Surgical Site Infections In Same-Day Admission Open Heart Patients, Joanna Gerry

Electronic Theses and Dissertations

The CDC estimates that one in 20 patients admitted to the hospital is a carrier of methicillin-resistant Staphylococcus aureus (MRSA). Staphylococci are commonly found on the skin and mucous membranes within the anterior nares, which provides the principle reservoir for this organism. These organisms can go on to cause surgical site infections in hospitalized patients. Mupirocin is an effective topical medication used to eliminate nasal carriage of Staphylococcus aureus (S. aureus). Based on Level A evidence, the 2007 Society of Thoracic Surgeons has made a Class I recommendation for the use of mupirocin for all patients undergoing cardiac surgery in …

Robustness Of The Healthcare Utilization Results From The Rotavirus Efficacy And Safety Trial (Rest) Evaluating The Human-Bovine (Wc3) Reassortant Pentavalent Rotavirus Vaccine (Rv5), Robbin Itzler, Gary Koch, David O. Matson, Leif Gothefors, Pierre Van Damme, Mark J. Dinubile, Penny M. Heaton

Community & Environmental Health Faculty Publications

Background: The Rotavirus Efficacy and Safety Trial was a placebo-controlled Phase III study that evaluated the safety and efficacy of a three-dose pentavalent rotavirus vaccine (RV5) including its effect on healthcare utilization for rotavirus gastroenteritis (RVGE). The per-protocol (PP) analyses, which counted events occurring 14 days after dose 3 among infants without protocol violations, have already been published. This paper evaluates the consistency of the healthcare utilization results based on the modified intention to treat (MITT) analyses with the PP analyses. The MITT analyses include all infants receiving at least one dose of vaccine or placebo and follow-up begins after …

Female Competition And The Role Of Testosterone In A Polygynous System, Lars Stefan Ekernas

Graduate Student Theses, Dissertations, & Professional Papers

Testosterone plays an important role in male competitive ability, and it may play a similar function in females. Female-female competition for resources is often associated with high testosterone, both within females and in comparison to males. Positive associations between testosterone and competition are most likely to be seen in systems with high female-female competition. Resource defense polygyny may be one such system since females congregate on high-quality nutrient sources, leading to substantial opportunities for interference competition. I studied female Grant’s gazelle (Nanger granti), a classic resource defense polygynous species, to investigate female competition and its relationship to testosterone. I found …

Chloroquine Susceptibility And Reversibility In A Plasmodium Falciparum Genetic Cross, Jigar J. Patel, Drew Thacker, John C. Tan, Perri Pleeter, Lisa Checkley, Joseph M. Gonzales, Bingbing Deng, Paul D. Roepe, Roland A. Cooper, Michael T. Ferdig

Biological Sciences Faculty Publications

Mutations in the Plasmodium falciparum chloroquine (CQ) resistance transporter (PfCRT) are major determinants of verapamil (VP)-reversible CQ resistance (CQR). In the presence of mutant PfCRT, additional genes contribute to the wide range of CQ susceptibilities observed. It is not known if these genes influence mechanisms of chemosensitization by CQR reversal agents. Using quantitative trait locus (QTL) mapping of progeny clones from the HB3 x Dd2 cross, we show that the P. falciparum multidrug resistance gene 1 (pfmdr1) interacts with the South-East Asia-derived mutant pfcrt haplotype to modulate CQR levels. A novel chromosome 7 locus is predicted to contribute …

Lyme Disease: The Surprising Debate In The 2010 Virginia House Of Delegates, Gerald C. Canaan Ii, Karah L. Gunther

Richmond Journal of Law and the Public Interest

In most every General Assembly session, there are those bills that while on the surface appear fairly innocuous-quickly take on a life of their own, generating an audible buzz in and around the General Assembly Building. The 2010 Virginia General Assembly session was no different. Amidst hallway discussions concerning the budget, gun rights, and abortion, one could also hear the distinct murmur of a completely novel topic: Lyme disease. Often associated with a small, pesky insect known as the black-legged tick, until this year, Lyme disease had not been the subject of any controversial legislation proposed in the Commonwealth of …

A Behavioral Approach To Human Rights, Andrew K. Woods

Law Faculty Scholarly Articles

For the last sixty years, scholars and practitioners of international human rights have paid insufficient attention to the ground level social contexts in which human rights norms are imbued with or deprived of social meaning. During the same time period, social science insights have shown that social conditions can have a significant impact on human behavior. This Article is the first to investigate the far-ranging implications of behavioralism—especially behavioral insights about social influence—for the international human rights regime. It explores design implications for three broad components of the regime: the content, adjudication, and implementation of human rights. In addition, the …

Rowan County Historical Society Newsletters, 2004-2010, Rowan County Historical Society.

Rowan County Histories Collection

The Rowan County (Kentucky) Historical Society newsletters from 2004 to 2010.

Using Modeling And Simulation To Evaluate Disease Control Measures, Tracy Atkins

Electronic Theses and Dissertations

This dissertation introduced several issues concerning the analysis of diseases by showing how modeling and simulation could be used to assist in creating health policy by estimating the effects of such policies. The first question posed was how would education, vaccination and a combination of these two programs effect the possible outbreak of meningitis on a college campus. After creating a model representative of the transmission dynamics of meningitis and establishing parameter values characteristic of the University of Central Florida main campus, the results of a deterministic model were presented in several forms. The result of this model was the …

Critical Role For The Host Gtpase-Activating Protein Arap2 In Inlb-Mediated Entry Of Listeria Monocytogenes, Balramakrishna Gavicherla, Lisa Ritchey, Antonella Gianfelice, Andrey A. Kolokoltsov, Robert A. Davey, Keith Ireton

Faculty Bibliography 2010s

The bacterial pathogen Listeria monocytogenes causes food-borne illnesses culminating in gastroenteritis, meningitis, or abortion. Listeria induces its internalization into some mammalian cells through binding of the bacterial surface protein InlB to the host receptor tyrosine kinase Met. Interaction of InlB with the Met receptor elicits host downstream signaling pathways that promote F-actin cytoskeletal changes responsible for pathogen engulfment. Here we show that the mammalian signaling protein ARAP2 plays a critical role in cytoskeletal remodeling and internalization of Listeria. Depletion of ARAP2 through RNA interference (RNAi) caused a marked inhibition of InlB-mediated F-actin rearrangements and bacterial entry. ARAP2 contains multiple functional …

Phylogenetic Analysis Of Chlamydia Trachomatis Tarp And Correlation With Clinical Phenotype, Erika I. Lutter, Christine Bonner, Martin J. Holland, Robert J. Suchland, Walter E. Stamm, Travis J. Jewett, Grant Mcclarty, Ted Hackstadt

Faculty Bibliography 2010s

Chlamydia trachomatis is the leading cause of infectious blindness worldwide and is the most commonly reported pathogen causing sexually transmitted infections. Tarp (translocated actin recruiting phosphoprotein), a type III secreted effector that mediates actin nucleation, is central to C. trachomatis infection. The phylogenetic analysis of tarP from reference strains as well as ocular, genital, and lymphogranuloma venereum (LGV) clinical isolates demonstrated an evolutionary relationship with disease phenotype, with LGV and ocular isolates branched into clades that were separate from the urogenital isolates. The sequence analysis of Tarp indicated a high degree of variability and identified trends within clinical groupings. Tarps …

The Formulated Microbicide Rc-101 Was Safe And Antivirally Active Following Intravaginal Application In Pigtailed Macaques, Alexander M. Cole, Dorothy L. Patton, Lisa C. Rohan, Amy L. Cole, Yvonne Cosgrove-Sweeney, Nicole A. Rogers, Deena Ratner, Alexandra B. Sassi, Carol Lackman-Smith, Patrick Tarwater, Bharat Ramratnam, Piotr Ruchala, Robert I. Lehrer, Alan J. Waring, Phalguni Gupta

Faculty Bibliography 2010s

Background: RC-101 is a congener of the antiretroviral peptide retrocyclin, which we and others have reported is active against clinical HIV-1 isolates from all major clades, does not hemagglutinate, and is non-toxic and non-inflammatory in cervicovaginal cell culture. Herein, film-formulated RC-101 was assessed for its antiviral activity in vitro, safety in vivo, retention in the cervix and vagina, and ability to remain active against HIV-1 and SHIV after intravaginal application in macaques. Methodology/Principal Findings: RC-101 was formulated as a quick-dissolving film (2000 mu g/film), retained complete activity in vitro as compared to unformulated peptide, and was applied intravaginally in six …