Digital Commons Network^™

Barriers To Computer Use And Internet Competency Among Homeless Women And Low-Income Women At Risk Of Becoming Homeless, Sondra L. Wildman

Communication & Leadership Dissertations and Theses

As our society relies more and more on digital communication methods, the consequences of not having access to computers and the internet will further erode the ability of homeless women to effectively navigate mainstream venues for social and economic interaction. This study strives to explore the barriers that prevent homeless women, and low-income women at risk of becoming homeless, from optimizing their access to computer and internet resources. A group of fifty homeless women was observed using a computer lab at a daytime shelter, and of this group, five women were interviewed. The theoretical framework of the study utilizes Pierre …

Performing Impressionistic Autoethnographic Narrative In Text And Pixels To Explore Fear Of Death In End-Of-Life Care-Giving Contexts, Dena M. Rosko

Communication & Leadership Dissertations and Theses

This study explores fear of death in end-of-life caregiving contexts via impressionistic autoethnographic narrative as performed on a blog with photographs and poems. This study relies on ethical assumptions for communicating dialogue, confirmation, and a performance narrative ethos in end of life. This study employs Terror Management Theory to identify a gap in existing empirical fear and death studies, and fills that gap by embedding its framework and method in the psychotherapeutic tradition to foster creative freedom and psychological safety and so break the cultural silence shrouding grief. Key findings show that the blog coordinated a therapeutic process to assuage …

Early Childhood Abuse And Neglect: Exploring The Consequences, Effects, And Treatment, Kimberly Friedman

Psychology and Child Development

With the prevalence of child abuse and neglect in our nation and around the world, the theories of why these types of maltreatment occur are a relevant topic for all to explore. Researchers are interested in how child abuse and neglect affect the individuals who were victims as well as the use and efficacy of treatment procedures. In this project, significant research is examined, detailing the various models of abuse and neglect and how the models are perpetuated through development, as a result of exposure to various environments or social relationships. The consequences of experiencing these forms of maltreatment are …

What Motivates People To Volunteer: A Case Study Using Coastal Cleanup Day In San Luis Obispo, California, Kristine M. Liddie

Social Sciences

No abstract provided.

Global Demographic Challenges: Case Study Women, Madeline Fox

Social Sciences

Half of the world lives on less than $2 a day. Everywhere men, women and children live in extreme poverty and suffer. Anthropogenic climate change has intensified famines, droughts, floods, hurricanes and other natural disasters. Modern civilization has altered nature and nature has responded to these alterations. Every year approximately 80 million people are added to the
planet, increasing pressure on the land. These added numbers of people require increased food and land resources and produce more pollution. While populations grow, arable lands with high yields do not. It is essential to reduce global consumption of all commodities and reduce …

Prevalence And Predictors Of Weight-Loss Maintenance In A Biracial Cohort: Results From The Coronary Artery Risk Development In Young Adults Study, Suzanne Phelan, Rena R. Wing, Catherine M. Loria, Yongin Kim, Cora E. Lewis

Kinesiology and Public Health

Background: Few population-based studies have examined the behavioral and psychosocial predictors of long-term weight-loss maintenance.
Purpose: The goal of this study was to determine the prevalence and predictors of weight-loss maintenance in a biracial cohort of younger adults.
Methods: This study examined a population-based sample of overweight/obese African-American and white men and women who had 5% weight loss between 1995 and 2000. Subsequent changes in weight, physical activity, and behavioral and psychosocial factors were examined between 2000 and 2005. Analyses were conducted in 2008 –2009.
Results: Among the 1869 overweight/obese individuals without major disease in 1995, …

Development And Validation Of A Light Weight, Energy Dense, Ready To Eat (Rte) Bar, Jacob Wilhelm-Maria Heick

Master's Theses

DEVELOPMENT AND VALIDATION OF A LIGHT WEIGHT, ENERGY DENSE, READY TO EAT (RTE) BAR

Jacob Wilhelm-Maria Heick

Providing additional calories in the form of an RTE bar to endurance athletes will increase performance and muscle re-synthesis, reduce muscle breakdown, and shorten recovery time. An RTE bar containing a blend of dairy proteins and carbohydrates will create a product with superior functionality, including bioactive and immunity enhancing properties from dairy derived ingredients. The protein will provide benefits in the form of easily digestible calories, essential amino acids and physical satiate.

A formulation was developed and optimized, resulting in a final product …

Digital And Printed Magazines’ Effects On The Environment, Jeannie Nguyen

Graphic Communication

The purpose of this study was to show how printed magazines affect the environment with their use of paper and how digital magazines affect their environment with their electricity use from servers hosting the digital magazines. It is also to find how the printed magazine industry is reducing their paper use and how digital magazines are reducing the amount of electricity used by servers hosting the digital magazines.

Results show that printed magazines use a massive amount of paper to produce millions of magazines and that the process of getting paper produces a large amount of carbon dioxide which is …

Magazines And The Tablet Interface, Kevin Black

Graphic Communication

No abstract provided.

China’S Out Of Area Naval Operations: Case Studies, Trajectories, Obstacles, And Potential Solutions, Christopher D. Yung, Ross Rustici, Isaac Kardon, Joshua Wiseman

China Strategic Perspectives

This study seeks to understand the future direction of the People’s Liberation Army Navy (PLAN) with regard to out of area deployments and power projection. The assessment is based on the history of past PLAN out of area deployments and an analysis of out of area operations of other military forces. Both short- and long-term lenses are employed to understand the scope and direction of China’s defense planning and strategic decisions.

The study’s assessment of the PLAN’s short-term (1- to 5-year) trajectory is based on:

• operational patterns of behavior observed in China’s out of area deployments
• analysis of information about …

The Deda Protein Family In Selected Bacterial Species, James Cox

Honors Capstones

No abstract provided.

Lsuhsc Facilities Daily Update: December 2010, Lsuhsc Property And Facilities Management

LSUHSC Facilities Daily Updates: 2010

LSUHSC Facilities Daily Updates from December 2010.

On the original documents, the daily update for Thursday, December 2, 2010 is misdated as Thursday, November 2, 2010; and the daily update for Thursday, December 9, 2010 is misdated as Thursday, December 10, 2010.

These updates describe damage and a timeline of repairs at the LSU Health Sciences Center - New Orleans campus due to Hurricane Katrina which made landfall August 29, 2005.

Lsuhsc Facilities Biweekly Update: December 2010, Lsuhsc Property And Facilities Management

LSUHSC Facilities Biweekly Updates: 2010

LSUHSC Facilities Biweekly Updates from December 3 and 17, 2010.

These updates describe damage and a timeline of repairs at the LSU Health Sciences Center - New Orleans campus due to Hurricane Katrina which made landfall August 29, 2005.

Elucidating Functional Roles For Myogenin In Adult Skeletal Muscle Metabolism, Exercise Capacity, And Regeneration, Jesse Flynn

Dissertations and Theses (Open Access)

The four basic helix-loop-helix myogenic transcription factors, myogenin, Myf5, MRF4, and MyoD are critical for embryonic skeletal muscle development. Myogenin is necessary for the terminal differentiation of myoblasts into myofibers during embryogenesis, but little is known about the roles played by myogenin in adult skeletal muscle function and metabolism. Furthermore, while metabolism is a well-studied physiological process, how it is regulated at the transcriptional level remains poorly understood. In this study, my aim was to determine the function of myogenin in adult skeletal muscle metabolism, exercise capacity, and regeneration. To investigate this, I utilized a mouse strain harboring the Myogflox …

The Immune Inhibitor A1 Protease Of Bacillus Anthracis, Kathryn Pflughoeft

Dissertations and Theses (Open Access)

Bacillus anthracis, an organism ubiquitous in the soil and the causative agent of anthrax, utilizes multiple mechanisms to regulate secreted factors; one example is the activity of secreted proteases. One of the most abundant proteins in the culture supernates of B. anthracis is the Immune Inhibitor A1 (InhA1) protease. Here, I demonstrate that InhA1 modulates the abundance of approximately half of the proteins secreted into the culture supernates, including substrates that are known to contribute to the ability of the organism to cause virulence. For example, InhA1 cleaves the anthrax toxin proteins, PA, LF, and EF. InhA1 also targets …

Stress-Induced Targeting Of Molecular Chaperones In The Yeast Saccharomyces Cerevisiae, Hugo Tapia

Dissertations and Theses (Open Access)

The eukaryotic stress response is an essential mechanism that helps protect cells from a variety of environmental stresses. Cell death can result if cells are not able to properly adapt and protect themselves against adverse stress conditions. Failure to properly deal with stress has implications in human diseases including neurodegenerative disorders and distinct cancers, emphasizing the importance of understanding the eukaryotic stress response in detail. As part of this response, expression of a battery of heat shock proteins (HSP) is induced, which act as molecular chaperones to assist in the repair or triage of unfolded proteins. The 90-kDa HSP (Hsp90) …

Plasmacytoid Dendritic Cells Sense Skin Injury And Promote Wound Healing Through Type I Interferons, Josh D. Gregorio

Dissertations and Theses (Open Access)

Plasmacytoid dendritic cells (pDCs) are a rare population of circulating cells, which selectively express intracellular Toll-like receptors (TLR)-7 and TLR-9 and have the capacity to produce large amounts of type I IFNs (IFN-a/b) in response to viruses or host derived nucleic acid containing complexes. pDCs are normally absent in skin but accumulate in the skin of psoriasis patients where their chronic activation to produce IFN-a/b drives the disease formation. Whether pDCs and their activation to produce IFN-a/b play a functional role in healthy skin is unknown. Here we show that pDCs are rapidly and transiently recruited into healthy human and …

Tracking The Flow Of Information Through The Hippocampal Formation In The Rat, Joshua P. Neunuebel

Dissertations and Theses (Open Access)

The hippocampus receives input from upper levels of the association cortex and is implicated in many mnemonic processes, but the exact mechanisms by which it codes and stores information is an unresolved topic. This work examines the flow of information through the hippocampal formation while attempting to determine the computations that each of the hippocampal subfields performs in learning and memory. The formation, storage, and recall of hippocampal-dependent memories theoretically utilize an autoassociative attractor network that functions by implementing two competitive, yet complementary, processes. Pattern separation, hypothesized to occur in the dentate gyrus (DG), refers to the ability to decrease …

The Role Of Post-Translation Regulation Of Twist Expression In The Tumor Progression Of Squamous Cell Carcinoma Of Head And Neck, Ying-Wen Su

Dissertations and Theses (Open Access)

Squamous cell carcinoma of head and neck (SCCHN) is the tenth most common cancer in the world. Unfortunately, the survival of patients with SCCHN has not improved in the last 40 years. Therefore new targets for therapy are needed, and to this end we are studying signaling pathways activated by IL-6 which we have found stimulates cell migration and soft agar growth in SCCHN. Our data show that IL-6 increases TWIST expression in a transcription-independent mechanism in many SCCHN cell lines. Further investigation reveals TWIST can be phosphorylated upon IL-6 treatment. By computation prediction (http://scansite.mit.edu/motifscan_seq.phtml ), we found that TWIST …

Characterization Of The Agrobacterium Tumefaciens Virb2 Pilin Of The Virb/D4 Type Iv Secretion System, Jennifer Kerr

Dissertations and Theses (Open Access)

The Agrobacterium tumefaciens VirB/D4 type IV secretion system (T4SS) delivers oncogenic T-DNA and effector proteins to susceptible plant cells. This leads to the formation of tumors termed Crown Galls. The VirB/D4 T4SS is comprised of 12 subunits (VirB1 to VirB11 and VirD4), which assemble to form two structures, a secretion channel spanning the cell envelope and a T-pilus extending from the cell surface. In A. tumefaciens, the VirB2 pilin subunit is required for assembly of the secretion channel and is the main subunit of the T-pilus. The focus of this thesis is to define key reactions associated with the T4SS …

Agrobacterium Virb10 Contributions To Type Iv Substrate Secretion, T-Pilus Biogenesis, And Outer Membrane Pore Formation, Isaac Garza

Dissertations and Theses (Open Access)

The VirB/D4 type IV secretion system (T4SS) of Agrobacterium tumefaciens functions to transfer substrates to infected plant cells through assembly of a translocation channel and a surface structure termed a T-pilus. This thesis is focused on identifying contributions of VirB10 to substrate transfer and T-pilus formation through a mutational analysis. VirB10 is a bitopic protein with several domains, including a: (i) cytoplasmic N-terminus, (ii) single transmembrane (TM) α-helix, (iii) proline-rich region (PRR), and (iv) large C-terminal modified β-barrel. I introduced cysteine insertion and substitution mutations throughout the length of VirB10 in order to: (i) test a predicted transmembrane topology, (ii) …

Analyzing The Role Of Αvβ8 Integrin In Glioma-Induced Angiogenesis, Jeremy H. Tchaicha

Dissertations and Theses (Open Access)

In this study we aimed to determine the functional roles for αvβ8 integrin in astrocytoma-induced angiogenesis. These studies originate from our analyses of αvβ8 integrin in developmental brain angiogenesis. αv and β8 knockout (KO) mice develop brain-specific vascular phenotypes that resemble vascular pathologies observed in the malignant astrocytoma, glioblastoma multiforme (GBM). Indeed, a murine xenograft model of astrocytoma suggested a role for the integrin in glioma-induced angiogenesis. Primary mouse astroglia were cultured from wild type (WT) and β8 KO neonates and were immortalized (HPV:E6/E7) and transformed (HRas:G12V). WT and β8 KO transformed astroglia were intracranially injected into athymic mice. WT …

Elucidating The Role Of Cd44 Expression On Mesenchymal Stem Cells Within The Tumor Microenvironment, Erika L. Spaeth

Dissertations and Theses (Open Access)

The tumor microenvironment is comprised of a vast array of heterogeneous cells including both normal and neoplastic cells. The tumor stroma recruitment process has been exploited for an effective gene delivery technique using bone marrow derived MSC. Targeted migration of the MSC toward the tumor microenvironment, while successful, is not yet fully understood. This study was designed to assess the role of CD44 in the migration of MSC toward the tumor microenvironment and to determine the implications of CD44-deficient MSC within the tumor stroma. Inhibition of MSC migration was evaluated through a variety of methods in vitro and in vivo …

14-3-3sigma Negatively Regulates The Stability And Subcellular Localization Of Cop1, Chun-Hui Su

Dissertations and Theses (Open Access)

Mammalian constitutive photomorphogenic 1 (COP1), a p53 E3 ubiquitin ligase, is a key negative regulator for p53. DNA damage leads to the translocation of COP1 to the cytoplasm, but the underlying mechanism remains unknown. We discovered that 14-3-3σ controlled COP1 subcellular localization and protein stability. Investigation of the underlying mechanism suggested that, upon DNA damage, 14-3-3σ bound to phosphorylated COP1 at S387, resulting in COP1 translocation to the cytoplasm and cytoplasmic COP1 ubiquitination and proteasomal degradation. 14-3-3σ targeted COP1 for degradation to prevent COP1-mediated p53 degradation, p53 ubiquitination, and p53 transcription repression. COP1 expression promoted cell proliferation, cell transformation, and …

Dynamic Remodeling Of The Stressed Heart: Role Of Protein Degradation Pathways, Deborah Vela

Dissertations and Theses (Open Access)

The heart is a remarkable organ. In order to maintain its function, it remodels in response to a variety of environmental stresses, including pressure overload, volume overload, mechanical or pharmacological unloading and hormonal or metabolic disturbances. All these responses are linked to the inherent capacity of the heart to rebuild itself. Particularly, cardiac pressure overload activates signaling pathways of both protein synthesis and degradation. While much is known about regulators of protein synthesis, little is known about regulators of protein degradation in hypertrophy. The ubiquitin-proteasome system (UPS) selectively degrades unused and abnormal intracellular proteins. I speculated that the UPS may …

Effects Of Combined Bevacizumab And Paclitaxel On Tumor Interstitial Fluid Pressure In A Preclinical Breast Cancer Model, Ricardo Hugo Alvarez

Dissertations and Theses (Open Access)

Effects of Combined Bevacizumab and Paclitaxel on Tumor Interstitial Fluid Pressure in a Preclinical Breast Cancer Model by Ricardo H. Alvarez Several mechanisms of cell resistance are often accountable for unsuccessful chemotherapy against cancer. Another reason, which has received increased attention, is the inefficient transport of anticancer drugs into tumor tissue. These impaired transports of chemotherapy into the tumor have been attributed to abnormal microvasculature and to pathologically increased tumor hypertension also called: interstitial fluid pressure (IFP). The pathophysiological processes leading to elevated tumor IFP are poorly understood. Here, in a preclinical breast cancer model, it is argued that a …

Temozolomide And Bevacizumab Therapy In Advanced Hemangiopericytoma/ Solitary Fibrous Tumor, Min S. Park

Dissertations and Theses (Open Access)

Tumors comprising the spectrum of hemangiopericytoma/ malignant solitary fibrous tumor (HPC/SFT) are thought to arise from fibroblasts and represent a small subset of soft tissue sarcomas. Surgery is typically the treatment of choice for localized disease, with reported 10-year overall survival rates of 54-89% after complete surgical resection. However, for the approximately 20% of HPC/SFT patients who eventually develop local recurrences and/or distant metastases, options for effective treatment are limited and are poorly defined. Alternative therapeutic options are therefore needed for improved palliation and disease control. We hypothesize that HPC/SFT are a spectrum of soft tissue tumors with unique clinical, …

Mcam/Muc18 Regulates Melanoma Progression By Modulating The Expression Of Id-1, Maya Zigler

Dissertations and Theses (Open Access)

The acquisition of the metastatic melanoma phenotype is associated with increased expression of the melanoma cell adhesion molecule MCAM/MUC18 (CD146). However, the mechanism by which MUC18 contributes to melanoma metastasis remains unclear. Herein, we stably silenced MUC18 expression utilizing lentivirus-incorporated small hairpin RNA, in two metastatic melanoma cell lines, A375SM and C8161, and conducted cDNA microarray analysis. We identified and validated that the transcriptional regulator, Inhibitor of DNA Binding-1 (Id-1), previously shown to function as an oncogene in several malignancies, was downregulated by 5.6-fold following MUC18 silencing. Additionally, we found that MUC18 regulated Id-1 expression at the transcriptional level via …

Policy Relevant Heterogeneity In The Value Of Statistical Life: New Evidence From Panel Data Quantile Regressions, W. Kip Viscusi, Thomas J. Kniesner, James P. Ziliak

Vanderbilt Law School Faculty Publications

We examine differences in the value of statistical life (VSL) across potential wage levels in panel data using quantile regressions with intercept heterogeneity. Latent heterogeneity is econometrically important and affects the estimated VSL. Our findings indicate that a reasonable average cost per expected life saved cut-off for health and safety regulations is $7 million to $8 million per life saved, but the VSL varies considerably across the labor force. Our results reconcile the previous discrepancies between hedonic VSL estimates and the values implied by theories linked to the coefficient of relative risk aversion. Because the VSL varies elastically with income, …

The Determinants Of Entrepreneurial Income In South Carolina, Devin Swindall

All Theses

Supporters claim that entrepreneurship is critical to building and sustaining the economy of urban and rural areas across the nation. Proponents argue that economic development practices that enhance and support entrepreneurship are essential because they cultivate innovation which, in turn, provides the area with new jobs, new wealth, and a better quality of life. However, self-employment income growth in South Carolina in particular and in the United States in general has lagged growth in income from other sources. This fact raises the need to study the determinants of self-employed income. Using the literature as a guide, a conceptual model was …