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Changes In Iron-Regulatory Gene Expression Occur In Human Cell Culture Models Of Pd, Cb Carroll, Ml Zeissler, N Chadborn, K Gibson, Gj Williams, Ke Morrison, Jp Zajicek, Co Hanemann

Peninsula Medical School

No abstract provided.

Boldness And Intermittent Locomotion In The Bluegill Sunfish, Lepomis Macrochirus, Alexander D.M. Wilson, Jean Guy J. Godin

School of Biological and Marine Sciences

No abstract provided.

Cannabinoids Are Neuroprotective In A Human Cell Culture Model Of Parkinson's Disease, Cb Carroll, Ml Zeissler, V Stone, Co Hanemann, Jp Zajicek

Peninsula Medical School

No abstract provided.

Perfluorodecalin Enhances In Vivo Confocal Microscopy Resolution Of Arabidopsis Thaliana Mesophyll, George R. Littlejohn, João D. Gouveia, Christoph Edner, Nicholas Smirnoff, John Love

School of Biological and Marine Sciences

No abstract provided.

Neuronal Network Pharmacodynamics Of Gabaergic Modulation In The Human Cortex Determined Using Pharmaco-Magnetoencephalography., Stephen D. Hall, Gareth R. Barnes, Paul L. Furlong, Stefano Seri, Arjan Hillebrand

School of Psychology

Neuronal network oscillations are a unifying phenomenon in neuroscience research, with comparable measurements across scales and species. Cortical oscillations are of central importance in the characterization of neuronal network function in health and disease and are influential in effective drug development. Whilst animal in vitro and in vivo electrophysiology is able to characterize pharmacologically induced modulations in neuronal activity, present human counterparts have spatial and temporal limitations. Consequently, the potential applications for a human equivalent are extensive. Here, we demonstrate a novel implementation of contemporary neuroimaging methods called pharmaco-magnetoencephalography. This approach determines the spatial profile of neuronal network oscillatory power …

When Not Thinking Leads To Being And Doing: Stereotype Suppression And The Self, Na Wyer, G Mazzoni, Tj Perfect, G Calvini, Hl Neilens

School of Psychology

Suppressing stereotypes often results in more stereotype use, an effect attributed to heightened stereotype activation. The authors report two experiments examining the consequences of suppression on two self-relevant outcomes: the active self-concept and overt behavior. Participants who suppressed stereotypes incorporated stereotypic traits into their self-concepts and demonstrated stereotype-congruent behavior compared to those who were exposed to the same stereotypes but did not suppress them. These findings address issues emerging from current theories of suppression, priming, and the active self.

Enhancing The Learning Experience In Undergraduate Geoscience Fieldwork Through The Use Of Hand-Held Technologies, Meriel Fitzpatrick, Jason Truscott

School of Geography, Earth and Environmental Sciences

Aims of projectTo evaluate the effectiveness of electronic and lab-based exercises in preparing students to use PDAs in the field; To investigate the pedagogic impact of PDAs during fieldwork; To enhance the learning material delivered through PDAs to support learning in the field. Background to project (or context)The idea for this project emerged from a development project which evaluated the use of learning technologies during Stage 1 and 2 geoscience fieldwork located in Kingsand/Cawsand, (FitzPatrick, 2009). This previous project provided significant insight into the student experience of using PDAs (Personal Digital Assistants) during fieldwork, and raised some interesting questions about …

A Review Of Bast Fibres And Their Composites. Part 2 - Composites, John Summerscales, Nilmini Dissanayake, Amandeep Virk, Wayne Hall

School of Engineering, Computing and Mathematics

Bast fibres are defined as those obtained from the outer cell layers of the stems of various plants. The fibres find use in textile applications and are increasingly being considered as reinforcements for polymer matrix composites as they are perceived to be "sustainable". The fibres are composed primarily of cellulose which potentially has a Young's modulus of similar to 140 GPa (being a value comparable with man-made aramid [Kevlar/Twaron] fibres). The plants which are currently attracting most interest are flax and hemp (in temperate climates) or jute and kenaf (in tropical climates). Part 2 of this review will consider the …

Context-Dependent Partitioning Of Motor Learning In Bimanual Movements, Ian S. Howard, James N. Ingram, Daniel M. Wolpert

School of Engineering, Computing and Mathematics

No abstract provided.

Erbb/Her Receptor Activation And Preclinical Efficacy Of Lapatinib In Vestibular Schwannoma, Sylwia Ammoun, Clare H. Cunliffe, Jeffrey C. Allen, Luis Chiriboga, Filippo G. Giancotti, David Zagzag, C. Oliver Hanemann, Matthias A. Karajannis

Peninsula Medical School

Vestibular schwannomas (VS) arising sporadically or in patients with neurofibromatosis type 2 (NF2) consistently lack expression of Merlin, a tumor suppressor. Conventional treatment options include surgery and radiotherapy but there is no validated medical option. Recent evidence suggests that Merlin deficiency may result in abnormal activation of receptor tyrosine kinases (RTKs) and downstream signaling, promoting tumor growth. Although small-molecule RTK inhibitors are widely available for clinical use, no such therapy has been validated in patients with VS. To screen for RTK activation, surgical VS specimens from patients with and without NF2 were analyzed by phospho-RTK profiling arrays. Downstream signaling pathway …

Gesturing Meaning: Non-Action Words Activate The Motor System, P Bach, D Griffiths, M Weigelt, Sp Tipper

School of Psychology

Across cultures, speakers produce iconic gestures, which add - through the movement of the speakers' hands - a pictorial dimension to the speakers' message. These gestures capture not only the motor content but also the visuospatial content of the message. Here, we provide first evidence for a direct link between the representation of perceptual information and the motor system that can account for these observations. Across four experiments, participants' hand movements captured both shapes that were directly perceived, and shapes that were only implicitly activated by unrelated semantic judgments of object words. These results were obtained even though the objects …

Cognitive Distortions As Social Practices: An Examination Of Cognitive Distortions In Sex Offender Treatment Froma Discursive Psychology Perpective, Tc Auburn

School of Psychology

This article presents a critique of the concept of cognitive distortion as it has been developed within the domain of sex-offender treatment programme theory and practice. Drawing upon a discursive psychology perspective, it is argued that cognitive distortions should not be considered as mental entities but as social practices. This argument is illustrated by closely examining how offenders’ accounts of their offences during sex offender treatment sessions were organised. Recordings and transcriptions of treatment group sessions were analysed for the occurrence of regular patterns of talk and interaction. This analysis focused on how minimisation was achieved through well documented rhetorical …

What Does Doodling Do?, Jackie Andrade

School of Psychology

No abstract provided.

Bio-Informatics Analysis Of A Gene Co-Expression Module In Adipose Tissue Containing The Diet-Responsive Gene Nnat., X Li.X, Pa Thomason, Dj Withers, J Scott

Peninsula Medical School

Obesity causes insulin resistance in target tissues - skeletal muscle, adipose tissue, liver and the brain. Insulin resistance predisposes to type-2 diabetes (T2D) and cardiovascular disease (CVD). Adipose tissue inflammation is an essential characteristic of obesity and insulin resistance. Neuronatin (Nnat) expression has been found to be altered in a number of conditions related to inflammatory or metabolic disturbance, but its physiological roles and regulatory mechanisms in adipose tissue, brain, pancreatic islets and other tissues are not understood.

Comparison And Consolidation Of Microarray Data Sets Of Human Tissue Expression, Jenny Russ, Matthias E. Futschik

School of Biomedical Sciences

No abstract provided.

Inferring Modules From Human Protein Interactome Classes, Elisabetta Marras, Antonella Travaglione, Gautam Chaurasia, Matthias Futschik, Enrico Capobianco

School of Biomedical Sciences

Abstract Background The integration of protein-protein interaction networks derived from high-throughput screening approaches and complementary sources is a key topic in systems biology. Although integration of protein interaction data is conventionally performed, the effects of this procedure on the result of network analyses has not been examined yet. In particular, in order to optimize the fusion of heterogeneous interaction datasets, it is crucial to consider not only their degree of coverage and accuracy, but also their mutual dependencies and additional salient features. Results We examined this issue based on the analysis of modules detected by network clustering methods applied to …

Models Of Faith And Reason, Peter Holmes

Theses

In his excellent work The Assurance of things Hoped For ¹ surveying the development of the understanding of “faith” in the context of the Christian religion, Avery Dulles provides a concise sketch of the historical development and current manifestation of seven 'models' of faith which still have some contemporary influence. This thesis takes each of the models of faith Dulles presents and gives a brief description of the model; offers some preliminary observations about the relationship between faith and reason in the respective models; and, by examining the Church's teaching on faith and reason in Fides et Ratio, discusses …

Examining The Relationship Between Trust And Culture In The Consultant-Client Relationship, Stephanos Avakian, Timothy Clark, Joanne Roberts

Research Collection Lee Kong Chian School Of Business

This chapter examines the dimensions of inter-organizational and interpersonal trust as they are manifested in the consultant–client interaction, viewed within the ‘cultural spheres’ framework (Schneider and Barsoux, 2003). The chapter argues that the alignment or misalignment of culture(s) helps foster or hinder the presence of trust in the consultant–client relationship. We support our argument by demonstrating how culture becomes an important informative resource from which consultants and clients manage their expectations and risk taking. In inter-organizational contexts, trust is developed through artifacts and formal procedures that are shared by both parties. In interpersonal contexts, trust is developed through the mutual …

The Legal Ecology Of Resistance: The Role Of Antibiotic Resistance In Pharmaceutical Innovation, Kevin Outterson

Cardozo Law Review

Antibiotic effectiveness is a common pool resource that can be prematurely depleted through resistance. Some experts warn that we may face a global ecological collapse in antibiotic effectiveness.

Conventional wisdom argues for more intellectual property rights to speed the creation of new antibiotics. Recent theoretical literature suggests that conservation-based approaches may yield superior results. This Article describes a novel typology for organizing these emerging theories and provides an early empirical test of these models using proprietary data on the sales of vancomycin, an important hospital antibiotic for the last three decades.

The results challenge the assumptions in several models and …

Behavioral Decision Theory And Implications For The Supreme Court's Campaign Finance Jurisprudence, Molly J. Walker Wilson

Cardozo Law Review

America stands at a moment in history when advances in the understanding of human decision-making are increasing the strategic efficacy of political strategy. As campaign spending for the presidential race reaches hundreds of millions of dollars, the potential for harnessing the power of psychological tactics becomes considerable. Meanwhile, the Supreme Court has characterized campaign money as "speech" and has required evidence of corruption or the appearance of corruption in order to uphold restrictions on campaign expenditures. Ultimately, the Court has rejected virtually all restrictions on campaign spending on the ground that expenditures, unlike contributions, do not contribute to corruption or …

The Bankruptcy Hegemon: Section 524(A) And Its Effect On State And Federal Comity, Benjamin Margulis

Cardozo Law Review

No abstract provided.

The Geography Of Criminal Law, Adam Benforado

Cardozo Law Review

When Westerners explain the causes of actions or outcomes in the criminal law context, they demonstrate a strong tendency to overestimate the importance of dispositional factors, like thinking, preferring, and willing, and underestimate the impact of interior and exterior situational factors, including environmental, historical, and social forces, as well as affective states, knowledge structures, motives, and other unseen aspects of our cognitive frameworks and processes. One of the situational factors that we are particularly likely to overlook is physical space - that is, landscapes, places, natures, boundaries, and spatialities. Our shortsightedness comes at a great cost. Spatial concerns shape legal …

Learning A Foreign Language With A Collaborative Web-Based Task, Processes And Performances. Apprendre Une Langue Étrangère À Partir D'Une Tâche Collaborative Sur Internet : Processus Et Performances, Frédérique Penilla

Theses: Doctorates and Masters

Within language teaching and learning, tasks have been advocated for use as they are thought to set up ideal conditions for language acquisition to occur. With the emergence of the Internet in the last decade, and the deployment of technology in schools, Web-based tasks, referred to as Computer-assisted Language Learning (CALL) are being used by an increasing number of teachers. Teachers who employ Web-based tasks in their classrooms, commonly set these up so that learners complete them in a collaborative mode. This requires learners engaging in a process of task negotiation and, at times, task redefinition, which in turn requires …

Is Regime Switching In Stock Returns Important In Asset Allocations?, Jun Tu

Research Collection Lee Kong Chian School Of Business

The stock market displays regime switching between upturns and downturns. This paper provides a Bayesian framework for making portfolio decisions that takes this regime switching into account, together with asset pricing model uncertainty and parameter uncertainty. The findings reveal that the economic value of accounting for regimes is substantially independent of whether or not model and parameter uncertainties are incorporated: the certainty-equivalent losses associated with ignoring regime switching are generally above 2% per year, and can be as high as 10%. These results suggest that the more realistic regime switching model is fundamentally different from the commonly used single-state model, …

The Effect Of Visfatin And Adiponectin On Metabolic Parameters Of An Animal Model Of Type 2 Diabetes, Thuraya Saeed Ali Alshamisi

Theses

Background: Diabetes mellitus (DM) is one of the most common exocrine disorders affecting more than 6% of the world’s population. The incidence and prevalence of this chronic disease are on the rise in many parts of the world including the Middle East. DM is caused by defective Insulin production, release and/or function. The causes and nature of abnormal insulin metabolism is less than clear. While defective insulin secretion is observed in type 1 diabetes, insulin resistance is predominant in type 2 diabetes, which affects more than 94% of the diabetic patients.

Materials and Methods: Rats between the age of two …

Performance Of Reinforced Concrete Columns Strengthened With Fiber Reinforced Polymers Under Various Loading Conditions, Mohamed Gamal Mohamed El Sayed

Theses

Strengthening of reinforced concrete (RC) structures with Carbon Fiber Reinforced Polymer (CFRP) composites has been a popular subject that attracted considerable attention from researchers for the last two decades. The high specific strength, stiffness, environmental resistance, and ease of application make CFRP composites highly desirable for strengthening and rehabilitation of RC structural components.

For concentrically loaded RC members with a circular cross-section, the lateral CFRP-confinement of concrete results in a substantial increase in load capacity and ductility. CFRP-confinement is less effective for RC compression members with square and rectangular cross-sections due to stress concentration at the corners and lack of …

The Stability Of Time Versus Money Valuations, Leonard Lee, Michelle P. Lee, Gal Zauberman

Research Collection Lee Kong Chian School Of Business

In this work, we propose that the stability of consumer preferences in decision making differs depending on whether the resource in question is time or money. Two competing hypotheses are tested: whereas prior research has demonstrated greater ambiguity in the value of time (vs. money) thus pointing to less consistency in time valuation, a separate stream of research suggests that money (vs. time) lacks emotional tags and is more difficult to process, pointing to less consistency in money valuation. Our experimental results demonstrate that preferences based on money (vs. time) valuations are less transitive and consistent, supporting the emotion-based account.

The Influence Of Hydrogen Peroxide On The Static And Fatigue Properties Of Palacos-R Bone Cement, John M. Guerin

Theses

Aseptic loosening is a very costly complication of joint arthroplasty, both in terms of patient quality of life and financially. One potential contributing factor in its development - namely the use of hydrogen peroxide as an effervescent haemostatic agent - was investigated in this study. Clean bone cement samples and samples contaminated with 6% hydrogen peroxide were manufactured and stored either in room air or normal saline prior to testing. Thus four sample types were tested (clean stored wet or dry and contaminated stored wet or dry). Static (tension to failure) and fatigue testing was performed. Analysis was carried out …

Enhanced Pervaporation Using A Novel Pump Configuration, Donough Patrick Shanahan

Theses

The pervaporation process is investigated in this work under the guises of process design improvements and process performance. Several avenues of research were investigated.

The main aim of the project was to investigate the use of liquid ring vacuum pumps for permeate recovery at laboratory and industrial scales. Due to technical and economical issues, these pumps were deemed unsuitable. This analysis then had to be extended further. Previous work investigated the use of dry vacuum pump systems on a lab scale and this work was extended to industrial scale simulations. Results from the lab scale process particularly those relating to …

Nested Coloured Timed Petri Nets For Production Configuration Of Product Families, Lianfeng Zhang, Brian Rodrigues

Research Collection Lee Kong Chian School Of Business

Production configuration is as an effective technique to deal with product variety while maintaining production stability and efficiency. It involves a diverse set of process elements (e.g., machines, operations), a high variety of component parts and assemblies and many constraints arising from product and process variety. Production configuration entails the selection and subsequent arrangement of process elements into complete production processes and the final evaluation of configured multiple alternatives. To better understand production configuration and its implementation, we study the underlying logic for configuring production processes using a dynamic modelling and visualisation approach. This is accomplished by developing a new …