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An Impaired 20s Proteasome Contributes To The Accumulation Of Oxidized Proteins In Multiple Sclerosis And Its Animal Model, Jianzheng Zheng

Biomedical Sciences ETDs

Carbonylated (oxidized) proteins are known to accumulate in the brain of patients with multiple sclerosis (MS) and in the spinal cord of rats with acute experimental autoimmune encephalomyelitis (EAE). Yet, our knowledge regarding mechanism(s) underlying the build-up of protein carbonyls in these inflammatory demyelinating disorders is quite limited. The objectives of this dissertation were (1) to measure the changes in protein carbonylation during disease progression, and to identify the target cells and modified proteins in the cerebellum of EAE animals, prepared by active immunization of C57/BL6 mice with MOG35-55 peptide, (2) to determine if the accumulation of carbonylated proteins in …

Singular Value Decomposition Metrics Show Limitations Of Detector Design In Diffuse Fluorescence Tomography, Frederic Leblond, Kenneth M. Tichauer, Brian W. Pogue

Dartmouth Scholarship

The spatial resolution and recovered contrast of images reconstructed from diffuse fluorescence tomography data are limited by the high scattering properties of light propagation in biological tissue. As a result, the image reconstruction process can be exceedingly vulnerable to inaccurate prior knowledge of tissue optical properties and stochastic noise. In light of these limitations, the optimal source-detector geometry for a fluorescence tomography system is non-trivial, requiring analytical methods to guide design. Analysis of the singular value decomposition of the matrix to be inverted for image reconstruction is one potential approach, providing key quantitative metrics, such as singular image mode spatial …

Colony Breeding System Influences Cuticular Bacterial Load Of Formosan Subterranean Termite (Isoptera: Rhinotermitidae) Workers, Claudia Husseneder, Dawn M. Simms, Gabriel K. Aluko, Jennifer Delatte

Faculty Publications

The goal of this study was to test whether the breeding system and/or the degree of inbreeding of field colonies of the Formosan subterranean termite, Coptotermes formosanus, Shiraki (Isoptera: Rhinotermitidae) influences bacterial load on the cuticle of foraging workers. We enumerated bacterial load on the cuticle of groups of workers foraging in 20 inground monitoring stations surrounding the French Market in New Orleans, LA, and identified bacteria species using 16S rRNA gene sequencing. We used microsatellite genotyping to assign the 20 worker groups to seven simple family colonies (headed by a single pair of reproductives) and four extended family colonies …

Population Forecasting Model Of Nilaparvata Lugens And Sogatella Furcifera (Homoptera: Delphacidae) Based On Markov Chain Theory, Xiang Hui Yan, Huai Liu, Jin Jun Wang, Zhi Mo Zhao, Fangneng Huang, Deng Fa Cheng

Faculty Publications

Nilaparvata lugens (Stål) and Sogatella furcifera (Horváth) are the two most important long-distance migratory insect pests that cause great yield losses to rice in China. Accurate long-term population forecast is needed to implement effective management strategies for these two rice pests. In this paper, a transition probability matrix of 5-yr steps of Markov chain theory was constructed based on 31-yr light-trapping data of the two pests from 1977 to 2007 in Jiangkou County, Guizhou, China. The weight of each step for the transition probability matrix was calculated according to its prediction accuracy. Insect occurrence levels in the sixth year were …

Special Report, Celebrating The Tenth Anniversary Of State Wildlife Grants In Tennessee, Tennessee. Wildlife Resources Agency.

Strategic and Management Plans

No abstract provided.

An Analysis Of Psycho-Educational Profiles Of Elementary Students Referred For Special Education Consideration Due To Literacy Difficulties, Amy M. Bowers

Masters Theses and Doctoral Dissertations

This study examined the results of a uniquely constructed literacy assessment technique, combining Dehn’s (2006) interpretation of psychological processing assessment and the Reading Rockets (Greater Washington Educational Telecommunications Association, Inc., 2005) interpretation of academic achievement. The study employed a quantitative descriptive research design using ex post facto data. The population was selected from one northwest Georgia school district and consisted of 54 elementary school students (first through fifth grades). Participants in the population met the following criteria: 1) received three tiers of reading intervention in the RTI process, 2) were referred for initial special education consideration, 3) were from either …

Factors That Influence The Adoption Of Agricultural Conservation Programs In Northwest Arkansas, Edison Anthony Froelich

Graduate Theses and Dissertations

A survey was developed and administered to agricultural producers in Northwest Arkansas in order to better understand producer awareness of, application for and participation in six federal and state conservation programs available in Arkansas: the Environmental Quality Incentives Program, the Conservation Reserve Enhancement Program, the Arkansas Revolving Loan Program, the Arkansas Nonpoint Pollution Management Program , the Arkansas Soil Nutrient and Poultry Litter Application and Management Program, and the Surplus Poultry Litter Removal Incentives Cost Share Program. Survey results found that less than half of the sample was aware of any one of the programs. A logit model was developed …

Personality And Politics: Introduction To The Special Issue, Lauren E. Duncan, Bill E. Peterson, Eileen L. Zurbriggen

Psychology: Faculty Publications

This special issue of Journal of Personality brings together 10 original articles addressing the intersection of personality and politics. Articles build on classic traditions in political psychology by presenting both idiographic and nomothetic work on the motivational, cognitive, ideological, attitudinal, and identity correlates of many different aspects of political behavior. This work is used to understand political activism and leadership as well as everyday political behavior. We hope this collection of articles will inspire our readers to explore new investigations in personality and political psychology.

Leadership In Building Communities: Old North Dayton And Mccook Field Neighborhoods, Fitz Center For Leadership In Community, University Of Dayton

Dayton Neighborhood Studies

No abstract provided.

Iota-Carrageenan Hydrolysis By Pseudoalteromonas Carrageenovora Ifo12985, Bernadette M. Henares, Erwin P. Enriquez, Fabian M. Dayrit, Nina Rosario L. Rojas

Chemistry Faculty Publications

We report iota-carrageenan hydrolysis by Pseudoalteromonas carrageenovora IFO 12985. Kappa-carrageenase and lambda-carrageenase were previously isolated from this organism, but iota-carrageenase activity had not been reported in the literature. P. carrageenovora was grown in iota-carrageenan-based liquid medium. Using the zone of depression assay, transfer of aliquots of the culture to solid medium with 2% iota- and kappa-carrageenan showed extensive hydrolysis of iota-carrageenan. Analysis of the hydrolysates by C-13 Nuclear Magnetic Resonance spectroscopy confirmed degradation of the iota-carrageenan. Hydrolytic activity of P. carrageenovora grown in iota-carrageenan was compared with that of the same organism grown in kappa-carrageenan. Cell-free supernatants from each yielded …

Development And Validation Of A Rapid Multi-Class Method For The Confirmation Of Fourteen Prohibited Medicinal Additives In Pig And Poultry Compound Feed By Liquid Chromatography Tandem Mass Spectrometry, Mark Cronly, Patrice Behan, Barry Foley, Liam Regan, Marella Gallagher, Sean Earley, Paula Shearan, Edward Malone

Articles

A confirmatory method has been developed to allow for the analysis of fourteen prohibited medicinal additives in pig and poultry compound feed. These compounds are prohibited for use as feed additives although some are still authorised for use in medicated feed. Feed samples are extracted by acetonitrile with addition of sodium sulphate. The extracts undergo a hexane wash to aid with sample purification. The extracts are then evaporated to dryness and reconstituted in initial mobile phase. The samples undergo an ultracentrifugation step prior to injection onto the LC-MS/MS system and are analysed in a run time of 26 minutes. The …

Volume 48, Number 15: December 01, 2010, University Of North Dakota

University Letter Archive

No abstract provided.

Comparative Conservation Genetics Of Two Endangered Darters, Percina Rex And Percina Jenkinsi, Anna L. George, David A. Neely, Richard L. Mayden

Southeastern Fishes Council Proceedings

No abstract provided.

Number 52 (December 2010), Southern Fishes Council

Southeastern Fishes Council Proceedings

(December 2010) - Comparative Conservation Genetics of Two Endangered Darters, Percina rex and Percina jenkinsi By Anna L. George, David Neely, and Richard Mayden

Invasion of Gulf Menhaden in the Alabama River By T. Heath Haley, R. Kyle Bolton, and Carol E. Johnston

Southeastern Fishes Council State Reports

Minutes, Business Meeting, 35th Annual Meeting, Southeastern Fishes Council

2009 Treasurer's Report for the Southeastern Fishes Council

Southern Alumni, Siu Alumni Association

SIU Alumni Magazine

No abstract provided.

The Changing Patterns Of Internet Usage, Christopher S. Yoo

Federal Communications Law Journal

Symposium: Essays from Time Warner Cable's Research Program on Digital Communications.

The Lumberjack, December 01, 2010

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

Minnie Evans: Art Of The Gatekeeper, Michelle Dawn Williams

Electronic Theses and Dissertations Archive

Minnie Evans: Art of the Gatekeeper focuses on African American early to mid-twentieth-century social and cultural issues that were experienced by the self-taught artist Minnie Evans (1892-1987). Evans was the gatekeeper at Airlie Gardens in Wilmington, North Carolina and is known for having experienced visions and dreams, which she attributed to her deep Christian faith. This study provides an extensive overview of past scholarship and offers previously undocumented oral histories and photographs that were acquired while visiting Airlie Gardens and St. Matthew African Methodist Episcopal Church in Wilmington. The subjects discussed include the Airlie Gardens gate, gates to dreams, African …

Not Quite Natural: Stories From The Edges Of Humanity, Patrick Walters

Electronic Theses and Dissertations Archive

This thesis, entitled “Not Quite Natural: Stories From the Edges of Humanity,” is a collection of creative nonfiction essays. It features stories about people who exist on the fringes of the human experience, from a man who infects himself with hookworms in an effort to cure his severe allergies to a woman who discovers a deaf man who has no language. It also features stories about groups of people on the edges of the human experience, including a community that refuses to leave its town, even though a fire is burning a hundred and fifty feet beneath it and a …

The Chestershaw: The Views And Ideas That Shaped The Friendly Rivalry Of G.K. Chesterton And George Bernard Shaw, Jonathan Vowell

Electronic Theses and Dissertations Archive

G.K. Chesterton and George Bernard Shaw both lived at the turn of the twentieth century, which was a time of incredible social and philosophic change and upheaval. In reaction to the social chaos and uncertainty, both men sought to change the world through their artistic and polemical works and thus were friends, yet both men wanted to change the world into different things for different reasons and thus were enemies. Their intellectual, friendly rivalry was a hallmark of early twentieth-century public discourse and English letters. Unfortunately, while their artistic contributions remain, most of their intellectual contributions have been either misunderstood …

"The Young Blood Hungers": Mapping Young Black Manhood In Marita Bonner's Frye Street Fiction, Rachel Leigh Smith

Electronic Theses and Dissertations Archive

Marita O. Bonner, early twentieth century African American public intellectual and creative writer, wrote particularly about the experiences of blacks in Chicago. Though most Bonner scholarship focuses primarily on her working class female characters, this study provides close readings of the young male figures in the short stories, "One Boy's Story," "The Makin's," "The Whipping," "There Were Three," "Tin Can," and "Nothing New." I analyze how these texts confront notions of family, personal identity, and violence, and how Bonner configures young life as a volatile liminal space of human development. As seen in Bonner's short stories and in her essay …

Signal Conditioning And Feature Estimation For Profiling Sensor Systems, Jeremy Benjamin Brown

Electronic Theses and Dissertations Archive

This paper presents techniques for signal conditioning and feature estimation to be used for profiling sensors which perform broad scale classifications. Methods for improving existing feature estimation techniques for linear array profiling systems are provided. A 360 profiling system and the accompanying algorithms used for signal conditioning and feature estimation are presented. The algorithms are validated by demonstrating classification results for the broad scale human, animal, and vehicle three class problem for the linear array, and the human and animal two class problem for the 360 profiling sensor.

Modeling Light-Dark Cycle Memory In The Mammalian Scn, Benjamin L. Coffey

Electronic Theses and Dissertations Archive

The suprachiasmatic nuclei (SCN), the principal mammalian circadian oscillator, contain several thousand clock neurons that oscillate spontaneously with ~24-hour periods in its ventrolateral region. Without light, this network synchronizes through action potentials releasing VIP, compromising on a free-running period near 24 hours. We entrained Siberian hamsters to various light-dark cycles and tracked their activity into constant darkness showing that they retain memory for a particular light-dark cycle to which they were entrained before returning to their own free-running period. Using Leloup-Goldbeter mammalian clock neurons, we model the ventrolateral SCN network and show that light acting weakly upon a strongly rhythmic …

Stochastic Simulation Of Human Pulmonary Blood Flow Based On Anatomic And Elasticity Data, Jun Shi

Electronic Theses and Dissertations Archive

In order to fully understand the function of the lungs, it is important to determine the transit time of the pulmonary circulation. However, a practical model to estimate the transit time is difficult to be found in literature, because of the high complexity of the whole pulmonary circulation system. This study developed a computing model of steady blood flow in human lungs based on detailed morphology and elasticity data by Huang et al (1996) [5], which incorporated a Diameter-Defined Strahler System to simulate a human lung branching system. A stochastic simulation approach was introduced. Considering Huang’s connectivity data between different …

Efficient Separation And Sensitive Detection Of Listeria Monocytogenes Using Magnetic Nanoparticles, Microfluidics And Interdigitated Microelectrode Based Impedance Immunosensor, Damira Ashimkhanovna Kanayeva

Graduate Theses and Dissertations

Listeria monocytogenes continues to be a major foodborne pathogen that causes food poisoning and sometimes death in immunosuppressed people and abortion in pregnant women. Nanoparticles have recently drawn attentions for use in immunomagnetic separation techniques due to their greater surface area/volume ratio and better stability against sedimentation in the absence of a magnetic field. Interdigitated microelectrodes and microfluidics make material transfer more efficient and biological/chemical interaction between the surface and solution phase much quicker. Magnetic nanoparticles (Fe3O4) with a 30 nm diameter were functionalized with rabbit anti-L. monocytogenes antibodies via biotin-streptavidin bonds and then amalgamated with target bacterial cells …

Violence Transformed 2010, Jonathan Shirland

Bridgewater Review

Violence Transformed is an annual series of exhibitions, performances and collaborative art-making events that are held in the greater Boston area. Since its beginnings five years ago, Violence Transformed has been composed of professionals from a wide range of backgrounds and disciplines, including art historians, studio artists, and specialists from the museum world.

The Central Bank Of Nigeria Partnership With Alliance For A Green Revolution In Africa (Agra): Conceptual Issues, Operations And Prospects For Food Security In Nigeria, Paul N. Eluhaiwe

Economic and Financial Review

The paper discusses the effort of the Central Bank of Nigeria in collaboration with Alliance for a Green Revolution in Africa (AGRA) towards ensuring food security in Nigeria

Applications Of Site-Specific Recombination Systems In Transgene Expression And Marker Gene Removal, Mehmet Aydin Akbudak

Graduate Theses and Dissertations

Site Specific Recombination systems, such as FLP-FRT and Cre-lox, have been successfully used for site-specific gene integration and marker-gene deletion in plant systems. They are very useful tools in the integration of single-copy full-length transgene cassettes into the genome because the transgene integration via conventional methods often generate multi-copy locus. Such complex locus containing direct and inverted repeats of full-length and truncated copies of the transgene cassette generate aberrant RNA resulting in gene silencing. Therefore, for stable gene expression, a single copy transgene locus is preferred. However, even single copy locus sometimes succumbs to gene silencing. Although the mechanism is …

Characterization Of Neuronal Groups Regulating Sexual And Agonistic Behavior In Male Chicken (Gallus Gallus), Jingjing Xie

Graduate Theses and Dissertations

The study aimed to understand the neuronal regulation of male sexual and agonistic behavior in broiler breeders. First, brain structures associated with sexual and agonistic behavior were identified by mapping Fos expression. The ventromedial subnucleus of medial portion of bed nucleus of the stria teriminalis (BSTM2) was specifically activated by male courtship behavior. The medial preoptic nucleus (POM) and lateral septum (SL) were associated with both sexual and agonistic behaviors. The bed nucleus of the pallial commissure (NCPa) and the paraventricular nucleus (PVN) were closely related to stress. Second, Fos-ir neurons were phenotyped by double labeling Fos with aromatase (ARO) …

Cognitive Frameworks That Enable South Carolina High School Principals To Implement Smaller Learning Communities, Leslie Jr. Gamble

College of Graduate Studies: Theses & Dissertations

The demands of an ever-changing technological and diverse global society contribute to the need for systemic change in today's secondary schools. Faced with these realities, American high schools must set course on a new mission for education. Not only must high schools require differentiated instructions to accommodate students' needs, high school personnel must also be held accountable for student learning by producing a high quality education. Because of the variety of these diverse issues, high school principals are faced with overcoming the challenges and obstacles that confront high school reforms. The research regarding smaller learning communities is well-documented and encouraging. …