Digital Commons Network^™

Osteoclast-Mediated Cell Therapy As An Attempt To Treat Elastin-Specific Vascular Calcification, Chartrisa Simpson

All Dissertations

Vascular calcification occurs during physiological aging and is clinically recognized as a major risk factor for myocardial infarction, systolic hypertension, heart failure and coronary insufficiency caused by loss of aortic recoil. Medial arterial calcification is an active remodeling process that involves the deposition of bone-specific matrix in close association with elastic fibers. Elastin, a major structural protein in the extracellular matrix of arterial walls, provides elastic recoil to the arteries. Increasing evidence suggests that vascular calcification share features with skeletal bone formation such as bone matrix deposition and bone resorption. Bone morphogenetic proteins and bone cells have been found in …

Mayh2010, Robert Kelly

Robert Kelly Manuscripts

Robert Kelly Archive May 2010

Mayb2010, Robert Kelly

Robert Kelly Manuscripts

Robert Kelly Archive May 2010

Mayf2010, Robert Kelly

Robert Kelly Manuscripts

Robert Kelly Archive May 2010

Echo, Summer/Fall 2010, Columbia College Chicago

Echo

Student-produced magazine formerly published as Chicago Arts and Communication, changed to Echo magazine in 1997. Cover Articles: Triumph over trauma: rise up; Community cursade: group living returns; Step up to the plate: women at bat; Underground gallery: home is where the art is. 72 pages.

Weed Control In Pasture And Range: 2010, Darrell L. Deneke, Mike Moechnig, Leon J. Wrage

SDSU Extension Fact Sheets

No abstract provided.

Tamoxifen: Mechanisms Of Resistance, Cyrus Mccoy Adams

Theses and Dissertations (ETD)

The role of estrogen in breast cancer has been recognized for decades. The selective estrogen receptor modulator tamoxifen was the first targeted therapy for the treatment of breast cancer. It was also the first drug approved by the FDA for the reduction of breast cancer risk. While tamoxifen has extended the lives of countless patients with breast cancer, resistance to tamoxifen remains a significant clinical problem. Work over the last two decades has greatly enhanced our understanding of the molecular mechanisms by which breast cancer cells may become resistant to tamoxifen treatment. Here I review our current understanding of the …

Systems Biology Approach To Identifying Host Interactive Pathways Modulating The Severity Of Streptococcal Sepsis, Nourtan Fatthy Abdeltawab

Theses and Dissertations (ETD)

Clinical outcomes of infectious diseases are controlled by complex interactions between the host and the pathogen. Epidemiological, genetic and molecular studies in my mentor’s laboratory provided evidence that in invasive Group A streptococcal (GAS) infections, genetic variations in both bacteria and patients influenced the severity of GAS sepsis. Allelic variations in class II human leukocyte antigens (HLA) contributed significantly to differences in the severity of group A streptococcal sepsis caused by the same virulent strain of the bacteria. HLA class II molecules present streptococcal superantigens (SAgs) to T cells, and variations in HLA class II molecules can strongly influence SAg …

Characterizing Purkinje Cell Responses And Cerebellar Influence On Fluid Licking In The Mouse, Jeri Lonece Bryant

Theses and Dissertations (ETD)

Rodents consume water by performing stereotypical, rhythmic licking movements which are believed to be driven by central pattern generating circuits located in the brainstem. Temporal aspects of rhythmic licking behavior have been shown to be represented in the olivo-cerebellar system in the form of population complex spike activity. These findings suggest that the olivo-cerebellar system is involved in the generating circuitry responsible for licking rhythm in rodents. However, the representation of licking in the simple spike activity of Purkinje cells and the consequences of loss of cerebellar function on licking behavior has not been quantified. I investigated the influence of …

Transcriptional Regulation Of Azole Antifungal Resistance And Tolerance In Candida Glabrata, Kelly E. Caudle

Theses and Dissertations (ETD)

Azole antifungal resistance has emerged as a significant problem in the management of infections caused by fungi including Candida species. In recent years, Candida glabrata has become the second most common cause of mucosal and invasive fungal infections in humans second to Candida albicans. Not only are systemic C. glabrata infections characterized by high mortality rates, treatment failures to the azole class of antifungals, the most widely used antifungal for treatment of Candida infections, have been reported. Contributing to this problem, C. glabrata exhibits intrinsic reduced susceptibility to the azole antifungals, and the development of high-level azole resistance …

Tetrahydroisoquinoline Neurotoxins In Parkinson Disease, Michael G. Decuypere

Theses and Dissertations (ETD)

The goal of this dissertation work was to (1) determine the distribution of several tetrahydroisoquinoline (TIQ) derivatives in rodent, normal human and Parkinson disease (PD) brain, (2) quantify the levels of these TIQ derivatives in common food sources in an effort to link specific food intake patterns with the development of PD and (3) examine the neurotoxicity of select TIQ derivatives in human dopaminergic cell culture. The TIQs are a family of monoamine alkaloids that share structural homology with 1-methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (MPTP), can be formed from dopamine or its oxidized metabolites and may be involved in the pathogenesis of monoaminergic cell …

Synthesis Of Novel Cannabinoid Ligands And Their Use As Anti-Glioma And Anti-Inflammatory Agents, Steven Neal Gurley

Theses and Dissertations (ETD)

Following the discovery of the cannabinoid receptors, research in the field of cannabinoids has grown exponentially over the last two decades. Cannabinoids have been shown to have tremendous therapeutic potential in the treatment of several pathological conditions ranging from inflammation to asthma, multiple sclerosis, Parkinson’s disease, epilepsy, glaucoma, septic shock, hemorrhagic shock, and cancer. Our research has focused on two major conditions for which cannabinoids hold great promise for drug development, namely, cancer and inflammation.

Our focus in the field of cancer has been on the devastatingly lethal brain tumor glioblastoma multiforme. Due to the high expression of the CB2 …

H5n1 Influenza Virus Induces A Parkinsonian Pathology, Haeman Jang

Theses and Dissertations (ETD)

The greatest threat for an influenza pandemic at this time is posed by the highly pathogenic H5N1 avian influenza virus. To date, 63% of the 436 known human cases of H5N1 infection have proven fatal. Animals infected by H5N1 viruses have demonstrated acute neurological signs ranging from mild encephalitis to motor disturbances and coma. However, no studies have examined the longer-term neurologic consequences of H5N1 infection. We show that this virus travels from the peripheral nervous system into the central nervous system (CNS) to higher levels of the neuroaxis, using C57BL/6J mice that are infected by the A/VN/1203/04 H5N1 virus …

T-Cell Receptor Cdr3 Sequence But Not Recognition Characteristics Distinguish Autoreactive Effector And Foxp3+ Regulatory T-Cells, Xin Liu

Theses and Dissertations (ETD)

Regulatory T-cells (Treg) play an important role in maintaining immune tolerance to self-antigens and in suppressing excessive immune responses in the host. The source, specificity, and plasticity of the forkhead box transcription factor 3 (Foxp3⁺) Treg and conventional T (Tconv) cell populations active at sites of autoimmune pathology are not well characterized. To evaluate this, we combined global repertoire analyses and functional assessments of isolated T-cell receptors (TCR) from TCRa retrogenic mice with autoimmune encephalomyelitis (EAE). Treg and Tconv cell TCR repertoires were distinct, and autoantigen-specific Treg and Tconv cells were enriched in diseased tissue. Autoantigen sensitivity and …

The Use Of Preclinical Models To Improve The Treatment Of Retinoblastoma, Katie Marie Nemeth

Theses and Dissertations (ETD)

Rodent models play an essential role in the development of new chemotherapeutics and dosing regimes. It is often difficult to carryout a clinical study for pediatric cancers due to the small patient population. Retinoblastoma, a pediatric cancer of the eye, is one example of a pediatric cancer that can benefit from preclinical studies. Over the years various retinoblastoma rodent models have been developed used to test various combination of broad-spectrum systemic chemotherapy. It was found form these studies that the combination of topotecan and carboplatin was effective. However both drugs cause myelosuppression and therefore administrating both of these drugs systemically …

The Effect Of L-Proline On Two Recombinant Ampa Glutamate Receptors, Adetutu Abiose Oyelami

Theses and Dissertations (ETD)

L-proline is a non-essential amino acid and one of the major amino acid constituents of extracellular fluid. Specific mutations in genes that control proline metabolism lead to hyperprolinemia which is characterized by an increase in the level of blood and cerebrospinal fluid concentration of l-proline. In fact, deletion or mutation of the PRODH gene which codes for proline oxidase (POX) / proline dehydrogenase which is critical for proline metabolism leads to Type I hyperprolinemia and is strongly associated with schizophrenia, autism and mental retardation. Proline has previously been shown to be a low affinity agonist at glutamate and glycine receptors. …

Development And Application Of Computational Tools For The Study And Optimization Of Variable Resolution X-Ray (Vrx) Computed Tomography Scanners, David Alejandro Rendon

Theses and Dissertations (ETD)

The overall goal of this project was to develop and apply important computerized aids for the design and implementation of Variable Resolution X-ray (VRX) CT scanners developed at the University of Tennessee, Memphis. VRX scanners take advantage of the “projective compression” principle that allows the same device to image objects of very different sizes with the same level of detail by adjusting the field of view and the reconstruction resolution.

The first part of this project aimed to develop a set of computational tools specifically tailored for the design, implementation and study of VRX scanners. This included creating a reconstruction …

Glycan Shielding Of The Influenza Virus Hemagglutinin Elicits Evasion Of The Adaptive Immune Response And T-Cell-Driven Pathology, Keith C. Wanzeck

Theses and Dissertations (ETD)

Three separate influenza pandemics have emerged in the human population since 1918, each characterized by viruses that lack N-linked glycosylation sites on the globular head of the hemagglutinin protein. In contrast, recent non-pandemic isolates have acquired such sites. Here we constructed isogenic viruses containing differing numbers of additional N-linked glycosylation sites to assess the impact on the host immune response. These studies show that mice infected with a glycosylated virus remain susceptible to challenge with a non-glycosylated virus, glycosylated viruses elicit an inferior immune response, and in this context T-cell pathology and death may occur. We conclude from these data …

Tdiscovery And Development Of Novel Therapeutic Agents For Advanced Melanoma, Zhao Wang

Theses and Dissertations (ETD)

Malignant melanoma is the most dangerous form of skin cancer and accounts for about 75% of skin cancer deaths. Once diagnosed at the metastatic stage, it has a very poor prognosis with a median survival rate of 6 months and a 5-year survival rate of less than 5%. In addition, melanoma has become an important public health hazard owing to its rising incidence, which has been well documented over the past 50 years. Currently there is no effective way to treat melanoma. It is highly resistant to existing chemotherapy, radiotherapy, and immunotherapy. Over the past 30 years, only two drugs …

Discovery Of Quinic Acid Derivatives As Oral Anti-Inflammatory Agents, Kui Zeng

Theses and Dissertations (ETD)

Quinic acid (QA) esters found in hot water extracts of Uncaria tomentosa (a.k.a. Cat’s claw) exert anti-inflammatory activity through mechanisms involving inhibition of the pro-inflammatory transcription factor nuclear factor kappa B (NF-κB). Herein, we described the synthesis and biological testing of novel QA derivatives. Inhibition of NF-κB was assessed using A549 (Type II alveolar epithelial-like) cells that stably express a secreted alkaline phosphatase (SEAP) reporter driven by an NF-κB response element. A549- NF-κB cells were stimulated with TNF-α (10 ng/mL) in the presence or absence of QA derivative for 18 hours followed by measurement of SEAP activity. Amide substitution at …

Ns1 Of H5n1 Interacts With Sap-97 In A Pdz-Dependent Manner To Disrupt Epithelial Barrier Integrity, Veronica Garcia Conoley

Theses and Dissertations (ETD)

The ability of influenza A virus to cause global pandemics has been a great concern throughout history and poses a serious health risk worldwide. Pandemic outbreaks throughout history, such as the Spanish flu of 1918, have claimed the lives of millions of people worldwide. The current outbreak of avian influenza (H5N1) that began in 1997 is still claiming lives, and therefore efforts to understand the mechanisms of pathogenesis in this highly virulent virus are of the utmost importance. According to the World Health Organization, there have been 447 reported H5N1 human cases, resulting in 263 deaths. The pathology of H5N1 …

Practical Impediments To Structural Reform And The Promise Of Third Branch Analytic Methods: A Reply To Professors Baum And Legomsky, Russell R. Wheeler

Duke Law Journal

No abstract provided.

Neural Networks And The Natural Gradient, Michael R. Bastian

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Neural network training algorithms have always suffered from the problem of local minima. The advent of natural gradient algorithms promised to overcome this shortcoming by finding better local minima. However, they require additional training parameters and computational overhead. By using a new formulation for the natural gradient, an algorithm is described that uses less memory and processing time than previous algorithms with comparable performance.

Learning Ability And Factors Influencing Nest Establishment Of The Solitary Bees Osmia Lignaria And Megachile Rotundata (Hymenoptera: Megachilidae), Cory A. Vorel

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Over the last several decades, the use of solitary bees as an alternative to honey bees (Apis mellifera L.) for pollination of commercial crops has increased, in part as a response to ongoing problems faced by commercial honey bee populations. Two solitary bee species have exhibited great commercial potential: the blue orchard bee, Osmia lignaria Say, and the alfalfa leafcutting bee, Megachile rotundata Fabricius (Hymenoptera: Megachilidae). However, growth of O. lignaria and M. rotundata populations is limited in commercial systems, mainly due to low establishment of females at provided nesting sites, possibly due to mortality, dispersal, or other causes. …

Full Issue, No Author

Verbum

This is the full issue of Volume 7, Issue 2 of Verbum, published in Spring 2010 by the REST Club at St. John Fisher College. Articles from this issue are available as separate PDFs at http://fisherpub.sjfc.edu/verbum/vol7/iss2/

The Study Of Teachers’ Task Values And Self-Efficacy On Their Commitment And Effectiveness For Technology-Instruction Integration, Chia-Jung Lin, Mei-Yan Lu

Faculty Publications

The city of Taipei has been considered as a leading role of information technology education in Taiwan. However, many questions have been waited to be answered. The purpose of this study was to investigate the current situations and problems of primary school teachers’ technology-instruction integration. By implementing the approach of cognitive motivators and the human performance technology (HPT) theory, this study also investigated the relationships among teachers’ cognitive motivators (self-efficacy and task values) and their commitment and effort on technology-instruction integration. The researchers delivered 2,952 questionnaires via Internet, e-mail and airmail in January 2008. Finally, 1,549 questionnaires replied back and …

Premature Judgment, Todd Landman

Human Rights & Human Welfare

Just as Mark Twain said in 1897, “The report of my death was an exaggeration,” many commentators have prematurely reported the death of human rights. For example, in 1999, in The Theory and Reality of the Protection of International Human Rights , J. Shand Watson sees human rights as a “mere fiction” in light of a century of state-sponsored killing. One year later, Costas Douzinas, through an appeal to history, philosophy, and psychoanalysis proclaimed the “end of human rights.” It is thus no surprise that the article by Joshua Kurlantzick is yet another attempt to warn us that human rights …

Diabolical Ventriloquism: A Case Study In Rhetorical Transcendence With C. S. Lewis’S Infamous Imp Screwtape, Daniel J. Coyle

UNLV Theses, Dissertations, Professional Papers, and Capstones

Most religious discourse is predicated on the assumption that our choices in life have eternal implications. For those who subscribe to a belief in an afterlife, rhetoric which exploits eternity to form attitudes and induce actions can be especially persuasive. This study performs a detailed analysis of a particularly compelling case of the rhetoric of eternity during the twentieth century: C.S. Lewis‘s fictional demon Screwtape. In The Screwtape Letters and ―Screwtape Proposes a Toast,‖ Lewis offers readers an eternal, though diabolical, perspective of the ―modern‖ intellectual climate during the twentieth century. By puppeteering a demon in prose, Lewis satirically lampoons …

Transmitter Localization Using Autonomous Robotic Swarms, Joshua S. Adams

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The purpose of this research is to design a proof of concept system that is capable of locating a hidden radio transmitter and to investigate methods of multi-agent formation control with a specific interest in the effectiveness of these methods on the overall objective of locating this transmitter. A system is proposed and developed in which autonomous agents work together to locate this transmitter and their responsiveness is analyzed while using formations based both on a behavioral system and a system derived from centroidal Voronoi tessellations. Many software adaptations to the existing MASnet program are required, as well as some …

Stormwater Monitoring And Resident Behavior In A Semi-Arid Region, Jennifer Abraham

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The combined effect of land-use alterations and introduced diffuse anthropogenic pollutants to the earth's surface in suburban/urban zones often sparks a decrease in stormwater quality in the area, and contributes to nonpoint source pollution in receiving waters. The ponds at the Utah Botanical Center (UBC) located in Kaysville, UT, regularly experience algal blooms, which in turn cause low dissolved oxygen levels in the waters, indicating high concentrations of inflowing pollutants. The goal of this thesis paper was to describe the findings from the water quality monitoring implemented at both the inlet and outlet of the UBC ponds in order to …