Digital Commons Network^™

Alteration Of Micrornas Regulated By C-Myc In Burkitt Lymphoma, Anna Onnis1, Giulia De Falco, Giuseppina Antonicelli, Monica Onorati, Cristiana Bellan, Omar Sherman, Shahin Sayed, Lorenzo Leoncini

Pathology, East Africa

Background: Burkitt lymphoma (BL) is an aggressive B-cell lymphoma, with a characteristic clinical presentation, morphology and immunophenotype. Over the past years, the typical translocation t(8;14) and its variants have been considered the molecular hallmark of this tumor. However, BL cases with no detectable MYC rearrangement have been identified. Intriguingly, these cases express MYC at levels comparable with cases carrying the translocation. In normal cells c-Myc expression is tightly regulated through a complex feedback loop mechanism. In cancer, MYC is often dysregulated, commonly due to genomic abnormalities. It has recently emerged that this phenomenon may rely on an alteration of post-transcriptional …

The Regulation Of The Alternative Splicing Of Caspase 9, Rachel Goehe

Theses and Dissertations

The pro-apoptotic, caspase 9a, and the anti-apoptotic, caspase 9b, are derived from the caspase 9 gene by alternative splicing. This study demonstrates that the alternative splicing of caspase 9 is dysregulated in a large percentage of non-small cell lung cancer (NSCLC) tumors of the adenocarcinoma type. Furthermore, modulation of the levels of splice variants of caspase 9 had dramatic effects on the anchorage-independent growth and tumorigenic capacity of NSCLC cells. Due to these findings, the molecular mechanisms regulating the post-transcriptional processing of caspase 9 were therefore examined and an exonic splicing silencer (ESS) regulating the pre-mRNA processing of caspase 9 …

2010-09-24 Undergraduate Committee Meeting Minutes, Morehead State University. Faculty Senate.

Faculty Senate Records

Undergraduate Committee Meeting Minutes for September 24, 2010.

The Daily Egyptian, September 23, 2010, Daily Egyptian Staff

September 2010

No abstract provided.

The Pacifican September 23, 2010, University Of The Pacific

All Issues - Student Newspaper, The Pacifican, Pacific Weekly

No abstract provided.

Eastern Progress - 23 Sep 2010, Eastern Kentucky University

Eastern Progress 2010-2011

No abstract provided.

Assessing Plasticity : The Populations Responsible For The Epithelial Engraftment On Marrow-Derived Cells, Justin Brent Cohen

Yale Medicine Thesis Digital Library

Bone marrow-derived cells (BMDCs) have significant plasticity allowing them to give rise to various non-hematopoietic cell types including epithelial cells of the lung, liver, gut, and skin. These findings offer tremendous possibilities for the use of cell therapy to treat tissue injury and disease. However, the specific populations of cells responsible for this phenomenon are still unclear with considerable controversy over the mechanism of this transformation. In this study, we sought to compare the epithelial engraftment ability of two populations enriched for hematopoietic stem cells (HSCs), specifically the fractionated, lineage-depleted, and homed subset (FLH) and the lineage-Sca-1+c-Kit+ sorted population (LSK), …

The Setonian, September 23, 2010, Seton Hall University

2010

No abstract provided.

Jet Lag, Office Of Arts + Cultural Programming, Peak Performances At Montclair State University

2010-2011 PEAK Explores the Answer: Experiments in Arts & Technology

In 1998 Marianne Weems and The Builders Association, in collaboration with the architects/media artists Elizabeth Diller and Ricardo Scofidio, presented JET LAG, a cross-media project that was ahead of its time. JET LAG is based on two overlapping true stories about eccentric individuals who manipulated time and space, turning their travels into a new kind of escape. In 1969 an ambitious sailor set out on a round-the-world sailboat race only to discover that he could “win” by simply sending radio reports of his false travel times while sailing in circles off the coast of South America. Then, over the course …

Orally Active Mmp-1 Sparing Α-Tetrahydropyranyl And Α-Piperidinyl Sulfone Matrix Metalloproteinase (Mmp) Inhibitors With Efficacy In Cancer, Arthritis, And Cardiovascular Disease, Daniel P. Becker, Thomas E. Barta, Louis J. Bedell, Terri L. Boehm

Chemistry: Faculty Publications and Other Works

α-Sulfone-α-piperidine and α-tetrahydropyranyl hydroxamates were explored that are potent inhibitors of MMP’s-2, -9, and -13 that spare MMP-1, with oral efficacy in inhibiting tumor growth in mice and left-ventricular hypertrophy in rats and in the bovine cartilage degradation ex vivo explant system. α-Piperidine 19v (SC-78080/SD-2590) was selected for development toward the initial indication of cancer, while α-piperidine and α-tetrahydropyranyl hydroxamates 19w (SC-77964) and 9i (SC-77774), respectively, were identified as backup compounds.

2010-09-23 Unm News Minute, University Of New Mexico Communication And Marketing Department

UNM News Minute 2010

No abstract provided.

The Missouri Miner, September 23, 2010

The Missouri Miner Newspaper

No abstract provided.

The Advocate, September 23, 2010, Minnesota State University Moorhead

The Advocate

No abstract provided.

Exponent, Vol. 42, Iss. 4, 2010-09-23, University Of Alabama In Huntsville

2010

No abstract provided.

Daily Eastern News: September 23, 2010, Eastern Illinois University

September

No abstract provided.

The Pan American (2010-09-23), Kristen Cabrera

UTPA Archives - The Pan American Newspaper

Vol. 67, No. 4

Microrna-21 Dysregulates The Expression Of Mef2c In Neurons In Monkey And Human Siv/Hiv Neurological Disease., Sowmya V. Yelamanchili, A Datta Chaudhuri, L N. Chen, Huangui Xiong, Howard S. Fox

Journal Articles: Pharmacology & Experimental Neuroscience

MicroRNAs (miRNAs) play important roles in regulating a plethora of physiological and pathophysiogical processes including neurodegeneration. In both HIV associated dementia in humans and its monkey model SIV encephalitis we find miR-21, a miRNA largely known for its link to oncogenesis, to be significantly upregulated in the brain. In situ hybridization of the diseased brain sections revealed induction of miR-21 in neurons. MiR-21 can be induced in neurons by prolonged N-methyl-D-aspartic acid receptor stimulation, an excitotoxic process active in HIV and other neurodegenerative diseases. Introduction of miR-21 into human neurons leads to pathological functional defects. Furthermore, we show that miR-21 …

The George-Anne, Georgia Southern University

The George-Anne

• Carville, Matalin Make Politics Look Easy
• Keel Provides Update On Statewide Budget Cuts
• 10th Annual Fries Lecture Tonight
• Do You, Democrat, Take This Republican?
• Images Are a Politician's Best Friend
• Letters To the Editor
• Examining Religion
• Police Beat
• Rally Is Welcome Home for the Eagles
• Alcohol Study Does Not Excuse Common Sense
• GSU's Game Design Program Ranked Among Top In U.S.
• Weekend Wrap
• Uniting Against Adversity
• Weekly Buzz
• Fall With More Dyverzion
• Reviews
• Classifieds
• Gameday Mayday
• Asking "Who Is the Real GSU?" Is Irrelevant

The Bg News September 23, 2010, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. September 23, 2010. Volume 101-Issue 24.

The Armadillo Repeat Protein Pf16 Is Essential For Flagellar Structure And Function In Plasmodium Male Gametes, Ursula Straschil, Arthur M. Talman, David J. P. Ferguson, Karen A. Bunting, Zhengyao Xu, Elizabeth Bailes, Robert E. Sinden, Anthony A. Holder, Elizabeth F. Smith

Dartmouth Scholarship

Malaria, caused by the apicomplexan parasite Plasmodium, threatens 40% of the world's population. Transmission between vertebrate and insect hosts depends on the sexual stages of the life-cycle. The male gamete of Plasmodium parasite is the only developmental stage that possesses a flagellum. Very little is known about the identity or function of proteins in the parasite's flagellar biology. Here, we characterise a Plasmodium PF16 homologue using reverse genetics in the mouse malaria parasite Plasmodium berghei. PF16 is a conserved Armadillo-repeat protein that regulates flagellar structure and motility in organisms as diverse as green algae and mice. We show that …

The Montclarion, September 23, 2010, The Montclarion

The Montclarion

Student Newspaper of Montclair State University

The East Texan, 2010-09-23, Texas A&M University-Commerce

All Issues

Volume XCV, number 4 of The East Texan, a student newspaper published at Texas A&M University-Commerce.

Beyond The Plate: September Soup & Substance Looks Into Food Ethics, University Relations

Campus News Archive

The discussion group will delve into topics such as locally versus nonlocally grown food, consumption and waste, and organic versus nonorganic.

The Cowl - V. 75 - N. 3 - Sept 23, 2010

The Cowl

The Cowl - student newspaper of Providence College. Volume 75 - Number 3 - September 23, 2010. 32 pages.

Vista: September 23, 2010, University Of San Diego

USD Vista (1965-)

No abstract provided.

September 23, 2010, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Extent And Limits Of The Matching Concept In Cebus Apella: A Matter Of Experimental Control?, Olavo De Faria Galvao, Romariz Da Silva Barros, Jose Ricardo Dos Santos, Ana Leda De Faria Brino, Sandra Brandao, Cintia Mara Lavratti, William V. Dube, Willilam J. Mcilvane

The Psychological Record

The capacity to exhibit generalized sameness-difference judgments is a hallmark of cognition that is regularly exhibited by humans. As yet, that capacity has not been well documented in New World monkeys such as the capuchin (Cebus apel/a). This article presents data obtained with 6 capuchin monkeys with a variety of procedures that might lead to gEmeralized identity matching-to-sample (MTS) in this species, reporting part of a research program conducted to evaluate methods for assessing the species' relational learning capacity. Our working hypothesis is that past failures to demonstrate relational learning have been caused by procedural insufficiency rather than a lack …

Spartan Daily September 22, 2010, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 135, Issue 13

Suffolk Journal, Vol. 71, No. 2, 9/22/2010, Suffolk Journal

Suffolk Journal

No abstract provided.

The Winonan, Winona State University

The Winonan - 2010s

No abstract provided.