Digital Commons Network^™

Poxvirus Complement Control Proteins Are Expressed On The Cell Surface Through An Intermolecular Disulfide Bridge With The Viral A56 Protein, Brian Dehaven

Biology Faculty Scholarship

The vaccinia virus (VACV) complement control protein (VCP) is an immunomodulatory protein that is both secreted from and expressed on the surface of infected cells. Surface expression of VCP occurs though an interaction with the viral transmembrane protein A56 and is dependent on a free N-terminal cysteine of VCP. Although A56 and VCP have been shown to interact in infected cells, the mechanism remains unclear. To investigate if A56 is sufficient for surface expression, we transiently expressed VCP and A56 in eukaryotic cell lines and found that they interact on the cell surface in the absence of other viral proteins. …

Supremacy Clause Textualism, Henry Paul Monaghan

Faculty Scholarship

Whatever its status in the statutory interpretation "wars," originalism-driven textualism has assumed an increasingly prominent role in constitutional interpretation, at least within the academy. The focus of this Article is on one such form, namely, "Supremacy Clause textualism", that is, recent textualist claims about the implications of the Supremacy Clause of Article VI. This Article addresses two such claims.

First, in important articles, Professor Bradford Clark argues that the clause is "at the epicenter of [our] constitutional structure" and it "recognizes only the 'Constitution,' 'Laws,' and 'Treaties' of the United States as 'the supreme Law of the Land."' Displacement of …

Guns, Originalism, And Cultural Cognition, Jamal Greene

Faculty Scholarship

In a legal regime whose canonical text is Marbury v. Madison, it should be unremarkable that the Supreme Court's actions are bounded rather severely by public opinion. What makes the proposition remarkable – enough to be well worth Barry Friedman's time – is also what makes Marbury remarkable: namely, that judges so often go out of their way to deny it. Though not unheard of, it is rare for a judge to advertise that the content of a constitutional rule she is announcing is motivated by public opinion. Such an admission would be self-defeating, since it invites the charge …

The Contradictions Of Juvenile Crime & Punishment, Jeffery Fagan

Faculty Scholarship

Juvenile incarceration in the United States is, at first glance, distinctly different from its adult counterpart. While some juvenile facilities retain the iconic aesthetic of adult incarceration – orange jumpsuits, large cellblocks, uniformed guards, barbed wire, and similar heavy security measures – others have trappings and atmospherics more reminiscent of boarding schools, therapeutic communities, or small college campuses. These compact, benign settings avoid the physical stigmata of institutional life and accord some autonomy of movement and intimacy in relations with staff. They also give primacy to developmentally appropriate and therapeutic interventions.

Implications Of The Internet For Quasi-Legislative Instruments Of Regulation, Peter L. Strauss

Faculty Scholarship

It is a quarter century since I began telling my Administrative Law students that they had better be watching the Internet and how agencies of interest to them were using it, as they entered an Information Age career. The changes since then have been remarkable. Rulemaking, where the pace has perhaps been slowest, is now accelerating into the Internet, driven by a President committed to openness and consultation. This paper seeks little more than to point the reader toward the places where she can find the changes and watch them for herself.

The Vaccinia Virus Complement Control Protein Modulates Adaptive Immune Responses During Infection, N. M. Girgis, Brian Dehaven

Biology Faculty Scholarship

Complement activation is an important component of the innate immune response against viral infection and also shapes adaptive immune responses. Despite compelling evidence that complement activation enhances T cell and antibody (Ab) responses during viral infection, it is unknown whether inhibition of complement by pathogens alters these responses. Vaccinia virus (VACV) modulates complement activation by encoding a complement regulatory protein called the vaccinia virus complement control protein (VCP). Although VCP has been described as a virulence factor, the mechanisms by which VCP enhances VACV pathogenesis have not been fully defined. Since complement is necessary for optimal adaptive immune responses to …

Summers With My Bapuji: Opening Up A World Of What-Ifs, Amit Patel

Neureuther Book Collection Essay Competition

Graduate Winner: 2nd Place, 2010. 23rd Annual Carl Neureuther Student Book Collection Competition

Reconciling Fair Use And Trademark Use, Margreth Barrett

Faculty Scholarship

No abstract provided.

The So-Called Right To Privacy, Jamal Greene

Faculty Scholarship

The constitutional right to privacy has been a conservative bugaboo ever since Justice Douglas introduced it into the United States Reports in Griswold v. Connecticut. Reference to the "so-called" right to privacy has become code for the view that the right is doctrinally recognized but not in fact constitutionally enshrined. This Article argues that the constitutional right to privacy is no more. The two rights most associated historically with the right to privacy are abortion and intimate sexual conduct, yet Gonzales v. Carhart and Lawrence v. Texas made clear that neither of these rights is presently justified by its …

Above All Else Stop Digging: Local Government Law As A (Partial) Cause Of (And Solution To) The Current Housing Crisis, Darien Shanske

Faculty Scholarship

No abstract provided.

Quasi-Preemption: Nervous Breakdown In Our Constitutional System, Geoffrey C. Hazard Jr.

Faculty Scholarship

No abstract provided.

Wyeth V. Levine And Agency Preemption More Muddle Or Creeping To Clarity?, Ashutosh Bhagwat

Faculty Scholarship

No abstract provided.

The Intellectual Property Landscape For Ips Cells, Robin Feldman, Deborah Furth

Faculty Scholarship

No abstract provided.

Federal Lands In The Twenty-First Century, John D. Leshy

Faculty Scholarship

A destabilized climate will change everything, including federal lands policies. The nation's large federal land base will be enlisted both in "avoiding the unmanageable"-helping control or mitigate greenhouse gas (GHG) emissions that contribute to a destabilized climate-and "managing the unavoidable"-helping adapt to climate instability that cannot be avoided. Green industry requests for access to federal lands to help control GHGs can pose challenging policy issues, such as how much to encourage the use of federal lands to control GHGs at the expense of other goals. Adapting to a destabilized climate will be even more challenging, requiring considerable investment of public …

Vigorous Currents, Painful Archives: The Production Of Affect And History In Poe's "Tale Of The Ragged Mountains", Christina Zwarg

English Faculty Scholarship

First delivered as a paper at the Poe conference in Philadelphia in 2009, this extended version reveals how Poe's mesmeric tale can help us rethink trauma theory before Freud. Poe's strategic use of archival materials concerning an 18th-century insurrection in India provides compelling insight into the transmission of affect in the construction of global histories. --author-supplied description

Contract Interpretation Redux, Alan Schwartz, Robert E. Scott

Faculty Scholarship

Contract interpretation remains the largest single source of contract litigation between business firms. In part this is because contract interpretation issues are difficult, but it also reflects a deep divide between textualist and contextualist theories of interpretation. While a strong majority of U.S. courts continue to follow the traditional, "formalist" approach to contract interpretation, some courts and most commentators prefer the "contextualist" interpretive principles that are reflected in the Uniform Commercial Code and the Second Restatement. In 2003, we published an article that set out a formalist theory of contract interpretation to govern agreements between business firms. We argued that, …

The Disposing Power Of The Legislature, Thomas W. Merrill

Faculty Scholarship

The Constitution as we understand it includes principles that have emerged over time in a common law fashion. One such principle is the disposing power of the legislature – the understanding that only the legislature has the power to arrange, order, and distribute the power to act with the force of law among the different institutions of society. This Essay illustrates the gradual emergence of the disposing power in criminal, civil, and administrative law, and offers some reasons why it is appropriate that the legislature be given this exclusive authority. One implication of the disposing power is that another type …

The Politics Of Nature: Climate Change, Environmental Law, And Democracy, Jedediah S. Purdy

Faculty Scholarship

Legal scholars’ discussions of climate change assume that the issue is one mainly of engineering incentives, and that “environmental values” are too weak, vague, or both to spur political action to address the emerging crisis. This Article gives reason to believe otherwise. The major natural resource and environmental statutes, from the acts creating national forests and parks to the Clean Air and Clean Water Acts, have emerged from precisely the activity that discussions of climate change neglect: democratic argument over the value of the natural world and its role in competing ideas of citizenship, national purpose, and the role and …

Historic And Modern Social Movements For Reparations: The National Coalition Of Blacks For Reparations In America (N’Cobra) And Its Antecedents, Adrienne D. Davis, Adjoa A. Aiyetoro

Scholarship@WashULaw

Most of the legal scholarship on reparations for Blacks in America focuses on its legal or political viability. This literature has considered both procedural obstacles, such as statutes of limitations and sovereign immunity, as well as the substantive conception of a defensible cause of action. Indeed, Congressman John Conyers introduced H.R. 40, a bill to study reparations, in 1989 and every Congressional session since, and there have been three law suits that have received national attention. This Essay takes a different approach, considering reparations as a social movement with a rich and under-explored history. As Robin Kelley explains, such an …

Susan Wolf On The Meaning Of Life: A Review, Joseph Raz

Faculty Scholarship

The book comprises the two Tanner Lectures given by Susan Wolf at Princeton in 2007; helpful comments by John Koethe, Robert M. Adams, Nomy Arpaly, and Jonathan Haidt;Wolf ’s replies; and a brief introduction by Stephen Macedo. Wolf writes elegantly and thoughtfully, and the book, which seems to preserve in length and style its origins as two lectures, is full of sensible, suggestive ideas. The Tanner Lectures are meant to reach a nonspecialist audience, and some specialist readers may wish to have more on less, a desire likely to affect especially those who, like myself, share Wolf ’s basic approach …

Justice Souter And The Civil Rules, Scott Dodson

Faculty Scholarship

No abstract provided.

Professor Frederick C. Moss, Or, The Education Of A Junior Colleague, Jeffrey D. Kahn

SMU Law Review

No abstract provided.

Review: Electric Salome, Loie Fuller's Performance Of Modernism, Tim Scholl

Faculty & Staff Scholarship

No abstract provided.

Dopamine D1 Receptor-Mediated Enhancement Of Nmda Receptor Trafficking Requires Rapid Pkc-Dependent Synaptic Insertion In The Prefrontal Neurons, Yan-Chun Li, Gang Liu, Jian-Li Hu, Wen-Jun Gao, Yueqiao Huang

PCOM Scholarly Works

Understanding the interaction between dopamine and glutamate, particularly the interaction of dopamine and NMDA receptors, may enable a more rational approach to the treatment of schizophrenia, drug addiction, and other psychiatric disorders. We show that, in prefrontal cortical neurons, dopamine D1-induced enhancement of NMDA receptor function depends on rapid insertion of new NMDA receptor 2B subunits on the synaptic surface. Protein kinase A (PKA) inhibitor, but not protein kinase C (PKC) inhibitor, completely blocked dopamine D1 agonist SKF-81297-induced increase of the total expression of NMDA receptors. Furthermore, SKF-81297 failed to alter the surface expression and synaptic insertion of NMDA receptors …

Environmental Law, Travis M. Trimble

Scholarly Works

In this survey period, the United States Court of Appeals for the Eleventh Circuit decided two cases addressing the scope of agency discretion to interpret statutes. In Friends of the Everglades v. South Florida Water Management District, the Eleventh Circuit held that the Environmental Protection Agency’s adoption of the “unitary waters” definition of navigable waters under the Clean Water Act was reasonable even though that approach had been universally rejected by the courts as an interpretation of the statute prior to the agency’s rule. In Miccosukee Tribe of Indians of Florida v. United States, the Eleventh

Circuit upheld …

The Constructive Trust In Singapore: Five Persistent Puzzles, Hang Wu Tang

Research Collection Yong Pung How School Of Law

This paper investigates some persistent difficulties surrounding the constructive trust. The five persistent puzzles relating to the constructive trust that are considered in this paper are: the terminology puzzle, the institutional and remedial puzzle, the explanatory puzzle, the bankruptcy puzzle and the Torrens puzzle. It is the author’s thesis that these five enduring puzzles must be addressed and ultimately unravelled in order to ensure the coherent development of the law in this area.

Moving Authority Control From Manual To Automated, Shannon Hoffman

Faculty Publications

Authority control is very expensive; however, a controlled vocabulary is important for the users of a library catalog. Ways must be found to do authority control faster, cheaper, and better if we are to maintain a high-quality library catalog.

Phase-Linking And The Perceived Motion During Off-Vertical Axis Rotation, Jan Holly, Scott Wood, Gin Mccollum

Mathematics and Statistics Faculty Publications and Presentations

Human off-vertical axis rotation (OVAR) in the dark typically produces perceived motion about a cone, the amplitude of which changes as a function of frequency. This perception is commonly attributed to the fact that both the OVAR and the conical motion have a gravity vector that rotates about the subject. Little-known, however, is that this rotating-gravity explanation for perceived conical motion is inconsistent with basic observations about self-motion perception: (a) that the perceived vertical moves toward alignment with the gravito-inertial acceleration (GIA) and (b) that perceived translation arises from perceived linear acceleration, as derived from the portion of the GIA …

Asia Pacific Perspectives Vol. 9 No. 2, June 2010, University Of San Francisco, University Of San Francisco

Asia Pacific Perspectives

Contents:

The Sea Otter Islands: Geopolitics and Environment in the East Asian Fur Trade by Richard Ravalli

The origins of the sea otter trade can be traced to inter-Asian fur markets that developed centuries prior to the well-chronicled journeys of Vitus Bering and James Cook in the North Pacific. Japanese merchants and Ainu hunters traded for otter pelts as part of a larger system of exchanges in the Western Pacific. Russian entry to the trade by the early eighteenth century intensified territorial disputes in the Kuril Islands. A series of Russo-Japanese showdowns in the region helped forge an international borderland …

Brief Of Amici Curiae Of Professors Of History, Political Science, And Law In Support Of Petitioner, Kerry Abrams

Faculty Scholarship

No abstract provided.