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Gymnochromes E And F, Cytotoxic Phenanthroperylenequinones From A Deep-Water Crinoid, Holopus Rangii., H. V. K. Wangun, A. Wood, C. Fiorilla, John K. Reed, Peter J. Mccarthy, Amy E. Wright

Faculty Scholarship

Bioactivity-guided fractionation of metabolites from the crinoid Holopus rangii led to the discovery of two new phenanthroperylenequinone derivatives, gymnochromes E (1) and F (2). Gymnochrome E showed cytotoxic activity toward the NCI/ADR-Res with an IC50 of 3.5 μM. It also inhibited histone deacetylase-1 with an IC50 of 3.3 μM. Gymnochrome F was a moderate inhibitor of myeloid cell leukemia sequence 1 (MCL-1) binding to Bak. Two anthraquinone metabolites, emodic acid (4) and its new bromo derivative (5), were also isolated from the crinoid and show remarkable similarity to the phenanthroperylenequinone …

Self Fish, Douglas E. Rogers

Theses

Without the pursuit of love and happiness, breath is simply the sand of an hourglass pouring away to our time of passing. Love is the reason we are alive. To spend even a moment in misery is a moment wasted. Love is the goal of humanity. Everyone has or will experience love in its many forms over the course of a lifetime. Many, out of ignorance, habit, or sheer desperation, will fall in love with the wrong person. Most of us have or will have that one failed relationship, the one we reflect on as the relationship that taught us …

Polarimetric Remote Sensing System Analysis: Digital Imaging And Remote Sensing Image Generation (Dirsig) Model Validation And Impact Of Polarization Phenomenology On Material Discriminability, Chabitha Devaraj

Theses

In addition to spectral information acquired by traditional multi/hyperspectral systems, passive electro optical and infrared (EO/IR) polarimetric sensors also measure the polarization response of different materials in the scene. Such an imaging modality can be useful in improving surface characterization; however, the characteristics of polarimetric systems have not been completely explored by the remote sensing community. Therefore, the main objective of this research was to advance our knowledge in polarimetric remote sensing by investigating the impact of polarization phenomenology on material discriminability. The first part of this research focuses on system validation, where the major goal was to assess the …

A New Framework For An Electrophotographic Printer Model, Fermín A. Colón-López

Theses

Digital halftoning is a printing technology that creates the illusion of continuous tone images for printing devices such as electrophotographic printers that can only produce a limited number of tone levels. Digital halftoning works because the human visual system has limited spatial resolution which blurs the printed dots of the halftone image, creating the gray sensation of a continuous tone image. Because the printing process is imperfect it introduces distortions to the halftone image. The quality of the printed image depends, among other factors, on the complex interactions between the halftone image, the printer characteristics, the colorant, and the printing …

Driver Knowledge, Beliefs, And Attitudes About Deer–Vehicle Collisions In Southern Michigan, Alix Marcoux, Shawn J. Riley

Human–Wildlife Interactions

Deer–vehicle collisions (DVCs) are one of the most frequent and costly human– wildlife conflict throughout the range of white-tailed deer (Odocoileus virginianus). We conducted a self-administered, mail-back survey of Michigan drivers to determine: (1) driver attitudes and knowledge about DVCs; (2) reporting rates of DVCs; and (3) effects of being in a DVC on attitudes toward desired deer population levels. From a sample of 3,600 randomly selected licensed drivers >18 years of age in southeast Michigan, we obtained 1,653 completed questionnaires (48% response rate). Although 18% of respondents reported experiencing >1 DVC within 5 years of the survey …

El Centro Comercial: Connecting Commercial Opportunities To Community Needs, 2010, Todd Campbell, Madeline Carroll, Adrian Desilva, Candaco Dorsey, Saba Hamidi, John Mccarthy, Adam Noga, Ruemel Panglao, Luis Ramirez

Monteverde Institute: Sustainable Design, Planning and Community Development

This final report focuses on the creation of plans for Centro Comercial Monteverde, including the economic benefits of incorporating strategies to meet the needs of the local community along with sustainable measures to enhance the local ecology. Maps and architectural drawings are included in the report.

Blending Rudists With Technology; Non-Destructive Examination Of The Internal And External Structures Of Rudists Using High Quality Scanning And Digital Imagery, Ann Molineux, Robert W. Scott, Jessie Maisano, Richard Ketcham, Louis Zachos

Turkish Journal of Earth Sciences

Certain formations within the Cretaceous of Texas include zones of silicified rudists. Such diagenetic alteration, combined with the timing of alteration, has preserved many structural features of the rudist suitable for computed tomography (CT scanning). The excellent density differences between those skeletal structures (silica) and the internal sediment (calcitic mud) or later crystallization (calcite), fulfill a fundamental requirement for such analysis. The Jackson School of Geosciences at The University of Texas provides access to a high resolution computed tomography scanning system. This equipment, not identical to medical scanners, provides higher resolution and sophisticated software to analyze the imagery. Several rudist …

Cyber-Communication : Can Virtual Server Technologies Serve As Effective Media Delivery Tools For Human Performance Enhancement?, James E. Dorris

Graduate Research Papers

This project involved exploring whether or not virtual server technologies are viable and effective tools for human performance enhancement. The goal of this project was to conduct a comparative analysis of three specific virtual servers (i.e., YouTube, TeacherTube, and iTunesU) to determine whether or not either of these would serve as effective assets for improving the media development and delivery capabilities of the staff and faculty members at Hawkeye Community College. Four collaborative multimedia development projects were produced, monitored and evaluated to determine the levels of consistency, reliability, and user-friendliness in departmental media delivery processes. The research team of Hawkeye's …

Virtual Field Trips, Jill R. Stannard

Graduate Research Papers

This review focuses on the advantages and disadvantages of virtual field trips and the lack of hands-on experience vs. traveling virtually through the World Wide Web. This study concentrates on the use of virtual field trips for students inside the classroom. Several descriptions of advantages and disadvantages are reflected in this review to provide a credible implementation in exploring the world. This can be done without even going outside or spending a lot of money, through virtual field trips which can be materialized inside the classroom without going farther from the school. This paper defines the qualities of an effective …

Hidden Alphabet On The Farm: Can You Find It? : A Research Project, Sandra Greufe

Graduate Research Papers

The purpose of this research project was to introduce young children to agriculture and provide a new and interesting way of looking at the alphabet. Researching the use of alphabet books to introduce children to agriculture shows that presenting the alphabet in a new and exciting way is beneficial to teaching children the alphabet (Norton, 2007). Studies show the movement of people to urban areas corresponds with decreased knowledge of agriculture ( AFBF A, 2006c). Hidden Alphabet on the Farm: Can You Find It? presents the alphabet to young children in a new and exciting way and teaches children about …

Laughter And Tears: A Qualitative Content Analysis, Apra Loomis

Graduate Research Papers

Young adult literature often focuses on different problems associated with adolescence. Humor may provide a strategy for alleviating the tension associated with such problems in realistic fiction. The purpose of this study was to describe the use of humor in current, positively reviewed young adult literature in dark topics such as depression, death and suicide. Themes that emerged included humor as a coping device, self-defeating humor, and affiliative humor. Humor as a coping device was shown to increase with age as a way to deal with stressful situations in a study by Fuhr (2002). In a study by Erickson & …

Promoting A Desire To Read With Graphic Novels, Alexis Woodward

Graduate Research Papers

The purpose of this research project was to create a graphic novel to encourage reluctant 4th grade boys to become interested in reading. This research questioned the graphics in graphic novels that appeal to reluctant readers, the type of content that would appeal particularly to boys who lack interest in reading, and the method of balance needed between text and graphics to capture the interest of boys who lack motivation to read. The researcher focused on graphic novels and their use in the classroom, different ways graphic novels can motivate reluctant readers to become interested in reading, the concept of …

Deontology, Political Morality, And The State Symposium: Political Theory And Criminal Punishment, Youngjae Lee

Faculty Scholarship

Sometimes the government makes a policy choice, and, as a result, innocent persons die. How should we morally assess such deaths? For instance, is the government’s choice of the reasonable doubt standard or its decision to restrict the death penalty to certain narrow categories responsible for deaths of innocents? If so, does the deontological norm against harming people dictate that the government loosen the evidentiary standard for conviction or widen the availability of capital punishment? This Article argues that the traditional distinctions between intending and foreseeing harm and between causing harm and allowing harm to occur are insufficient to absolve …

Drug Policy In Context: Rhetoric And Practice In The United States And The United Kingdom, Richard C. Boldt

South Carolina Law Review

No abstract provided.

Revisions To Realist Representation In Far From The Madding Crowd And Heart Of Darkness., Paul Robertson Stephens

The Oswald Review: An International Journal of Undergraduate Research and Criticism in the Discipline of English

No abstract provided.

The Oswald Review Undergraduate Research And Criticism In The Discipline Of English: Volume 12 Fall 2010

The Oswald Review: An International Journal of Undergraduate Research and Criticism in the Discipline of English

No abstract provided.

Klebsiella Pneumoniae Induces Dna Damage In Lung Cells And The Potential Role Of Dna Repair Pathways In Klebsiella Pneumonia, Huang Huang

Theses and Dissertations

No abstract provided.

Woo You, Amy Woodward Evans

Electronic Theses and Dissertations

No abstract provided.

A Fractal Analysis Of The Binding And Dissociation Kinetics Of Analyte-Receptor Systems On Biosensor Surfaces, Ifejesu Eni-Olorunda

Electronic Theses and Dissertations

No abstract provided.

Meal Parameters And Vagal Gastrointestinal Afferents In Mice That Experienced Early Postnatal Overnutrition, Jessica Biddinger, Edward A. Fox

Department of Psychological Sciences Faculty Publications

Early postnatal overnutrition disrupts satiety without altering vagal gastrointestinal afferents. PHYSIOL BEHAV 00(0) 000-000, 2010. Early postnatal overnutrition results in a predisposition to develop obesity due in part to hypothalamic and sympathetic dysfunction. Potential involvement of another major regulatory system component - the vagus nerve - has not been examined. Moreover, feeding disturbances have rarely been investigated prior to development of obesity when confounds due to obesity are minimized. To examine these issues, litters were culled on the day of birth to create small litters (SL; overnutrition), or normal-size litters (NL; normal nutrition). Body weight, fat pad weight, meal patterns, …

Use Of Web-Based Lessons Of Statistical Concepts With Graphics And Animation To Enhance The Effectiveness Of Learning, Lavanya Pillala

Browse all Theses and Dissertations

Statistics is of critical importance to engineers. However, many engineering students struggle to grasp the meaning of statistical concepts and the idiosyncrasies of statistical methodologies. Because of this problem, instructors of statistics are constantly searching for better ways to help students understand statistical concepts. The goal of this project is to design and develop web-based lessons that use graphics and animations to enhance the effectiveness of students' learning of statistical concepts.

Lessons of three important statistical concepts have been developed for this thesis - normal distribution, central limit theorem and confidence & tolerance intervals - following well-recognized instructional design development …

Sensitization Of Behavioral Response To Maternal Separation: Persistence Of The Effect And Role Of Proinflammatory Activity, Jessie Caraway

Browse all Theses and Dissertations

Maternal separation in guinea pigs produces a biphasic response consisting of an active behavior phase followed by a phase of passive behavior (crouched stance, piloerection, and eye closure). Previous studies suggest that pro-inflammatory cytokines mediate passive behavior during the passive phase. It is also known that guinea pig pups separated on two consecutive days show a significant increase (sensitization) in full passive behavior on the second day. The current study examined the persistence and role of pro-inflammatory activity in the sensitization of passive behavior in maternally separated guinea pigs. Guinea pig pups were assigned to one of four groups differing …

You Do Have To Keep Your Promises: A Disgorgement Theory Of Contract Remedies, Steve Thel, Peter Siegelman

Faculty Scholarship

Contract law is generally understood to require no more of a person who breaches a contract than to give the injured promisee the "benefit of the bargain." The law is thus assumed to permit a promise-breaker to keep any profit remaining from breach, after putting the victim in the position he would have been in had the promise been performed. This conventional description is radically wrong: across a wide range of circumstances, standard contract doctrines actually do require people to keep their promises, or to disgorge their entire profit from breach if they do not. Rather than protecting the expectation …

2,3,7,8-Tetrachlordibenzo-P-Dioxin Mediated Immune Suppression Through Interactions At The 3'Immunoglobulin Heavy Chain Regulatory Region Enhancers, David Harold Ellis

Browse all Theses and Dissertations

2,3,7,8-Tetrachlordibenzo-p-dioxin (TCDD) is a potent toxin which inhibits the antibody response of B cells. The 3'IgHRR which is involved in transcriptional regulation of the heavy-chain polypeptide of antibodies is inhibited by TCDD. The hs1,2 enhancer region, isolated from the 3'IgHRR, is also inhibited while the isolated hs4 is activated by TCDD. This project sought to determine if that dichotomy in effects results from interactions at enhancer-specific binding sites for AhR, thought to mediate transcriptional effects of TCDD, and NFκB, a transcription factor involved in B cell activation. Here, I report a difference in the effect of TCDD on transcriptional activity …

Revision Of The Genus Erythromelana Townsend, 1919 (Diptera: Tachinidae) With Notes On Their Phylogeny And Diversification, Diego Javier Inclan Luna

Browse all Theses and Dissertations

The neotropics harbor an enormous diversity of tachinid flies, yet the fauna remains poorly known. The tribe Blondeliini is particularly diverse in this region and desperately needs taxonomic attention. Here, I present a revision of the neotropical genus Erythromelana Townsend including the redescription of three previously described species and the description of 11 new species. Two species previously assigned into this genus, are resurrected as distinct genera. Erythromelana species are widely distributed from southern Mexico to northern Argentina, with the Andes being a hotspot of diversity. Erythromelana are specialized on geometrids in the genus Eois, which mainly feed on plants …

An Assessment Of White-Tailed Deer (Odocoileus Virginianus) Dynamics, Management, And Impacts In Highly Fragmented Landscapes, Bambi Shafer

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Habitat and forage selection by deer can cause local extinction of plant species. In my research, I asked: 1) How do deer population growth rates in urban parks change through time? 2) Are culling rates and deer densities correlated? 3) Are browse rates on Trillium spp. and deer densities correlated? I used FLIR deer census data from Davis Aviation and culling data from Five Rivers MetroParks (Montgomery County, Ohio). I found that deer population growth rates generally declined from 2003 to 2008. The number of deer culled was positively correlated to the deer densities. The browse rates of Trillium spp. …

Reflexivity In Pigeons, Mary M. Sweeney, Peter J. Urcuioli

Department of Psychological Sciences Faculty Publications

A recent theory of pigeons’ equivalence-class formation (Urcuioli, 2008) predicts that reflexivity, an untrained ability to match a stimulus to itself, should be observed after training on two “mirror-image” symbolic successive matching tasks plus identity successive matching using some of the symbolic matching stimuli. One group of pigeons was trained in this fashion; a second group was trained similarly but with successive oddity (rather than identity). Subsequently, comparison-response rates on novel matching versus mismatching sequences with the remaining symbolic matching stimuli were measured on non-reinforced probe trials. Higher rates were observed on matching than on mismatching probes in the former …

Associative Symmetry And Stimulus-Class Formation By Pigeons: The Role Of Non-Reinforced Baseline Relations, Peter J. Urcuioli

Department of Psychological Sciences Faculty Publications

Two experiments tested the assumption of Urcuioli’s (2008) theory of pigeons’ equivalence-class formation that consistent non-reinforcement of certain stimulus combinations in successive matching juxtaposed with consistent reinforcement of other combinations generates stimulus classes containing the elements of the reinforced combinations. In Experiment 1, pigeons were concurrently trained on symbolic (AB) and two identity (AA and BB) successive tasks in which half of all identity trials ended in non-reinforcement but all AB trials were reinforced, contingent upon either responding or not-responding to the comparisons. Subsequent symmetry (BA) probe trials showed evidence of symmetry in one of four pigeons. In Experiment 2, …

Smooth Muscle-Specific Expression Of Neurotrophin-3 In The Embryonic And Neonatal Gastrointestinal Tract Of The Mouse, Jennifer Mcadams, Edward A. Fox

Department of Psychological Sciences Faculty Publications

Neurotrophin-3 (NT-3), which is essential for the survival of a large proportion of vagal sensory neurons, is expressed in the developing gastrointestinal (GI) tract where it could contribute to this survival, to other aspects of vagal afferent development, and to the development of spinal afferents, postganglionic sympathetic neurons and intrinsic neurons. Identifying the functions of this peripheral NT-3 requires a detailed understanding of the localization and timing of its expression in the developing GI tract. Therefore, X-gal staining of embryos and neonates expressing the lacZ reporter gene from the NT-3 locus was used to characterize the spatiotemporal pattern of NT-3 …

Effects Of The Novel Endocannabinoid Uptake Inhibitor, Ly2183240, On Fear-Potentiated Startle And Alcohol-Seeking Behaviors In Mice Selectively Bred For High Alcohol Preference, Matthew S. Powers, G. D. Barrenha, N. S. Mlinac, Eric L. Barker, Julia Chester

Department of Psychological Sciences Faculty Publications

Rationale Alcohol-use disorders often occur together with anxiety disorders in humans which may be partly due to common inherited genetic factors. Evidence suggests that the endocannabinoid system (ECS) is a promising therapeutic target for the treatment of individuals with anxiety and/or alcohol-use disorders. Objectives The present study assessed the effects of a novel endocannabinoid uptake inhibitor, LY2183240, on anxiety- and alcohol-seeking behaviors in a unique animal model that may represent increased genetic risk to develop co-morbid anxiety and alcohol-use disorders in humans. Mice selectively bred for high alcohol preference (HAP) show greater fear-potentiated startle (FPS) than mice selectively bred for …