Digital Commons Network^™

Extended Papers From The 2009 Sketch-Based Interfaces And Modeling Conference (Foreword), Cindy Grimm, Joseph J/ Laviola Jr.

Faculty Bibliography 2010s

No abstract provided.

Investigation Of The Behavior Of Serum And Plasma In A Microfluidics System, J. Caroline Henderson, Michele Yacopucci, Chang Ju Chun, Keith Lenghaus, Frank Sommerhage, James J. Hickman

Faculty Bibliography 2010s

There are common problems with adsorption of analytes on the surfaces of microfluidic systems with physiological samples such as blood serum, plasma, and urine. The authors' investigation involves the interaction of serum components with fused-silica surfaces under various flow regimes in microcapillaries. Their focus will include the individual components of serum as well as fresh whole serum. The authors studied the whole serum components in our microfluidic system to uncover the responses of proteins in capillary and microchannel surfaces when influenced by the highly variable serum constituents. They have observed the whole serum with a total protein assay by using …

Structural Morphology Of Acoustically Levitated And Heated Nanosilica Droplet, Ranganathan Kumar, Erick Tijerino, Abhishek Saha, Saptarshi Basu

Faculty Bibliography 2010s

We study the vaporization and precipitation dynamics of a nanosilica encapsulated water droplet by levitating it acoustically and heating it with a CO(2) laser. For all concentrations, we observe three phases: solvent evaporation, surface agglomeration, and precipitation leading to bowl or ring shaped structures. At higher concentrations, ring reorientation and rotation are seen consistently. The surface temperature from an infrared camera is seen to be dependent on the final geometrical shape of the droplet and its rotation induced by the acoustic field of the levitator. With nonuniform particle distribution, these structures can experience rupture which modifies the droplet rotational speed.

Mcp-Induced Protein 1 Deubiquitinates Traf Proteins And Negatively Regulates Jnk And Nf-Kappa B Signaling, Jian Liang, Yasser Saad, Tianhua Lei, Jing Wang, Dongfei Qi, Qinglin Yang, Pappachan E. Kolattukudy, Mingui Fu

Faculty Bibliography 2010s

The intensity and duration of macrophage-mediated inflammatory responses are controlled by proteins that modulate inflammatory signaling pathways. MCPIP1 (monocyte chemotactic protein-induced protein 1), a recently identified CCCH Zn finger-containing protein, plays an essential role in controlling macrophage-mediated inflammatory responses. However, its mechanism of action is poorly understood. In this study, we show that MCPIP1 negatively regulates c-Jun N-terminal kinase (JNK) and NF-kappa B activity by removing ubiquitin moieties from proteins, including TRAF2, TRAF3, and TRAF6. MCPIP1-deficient mice spontaneously developed fatal inflammatory syndrome. Macrophages and splenocytes from MCPIP1(-/-) mice showed elevated expression of inflammatory gene expression, increased JNK and I. B …

Reduction Of Sympathetic Activity Via Adrenal-Targeted Grk2 Gene Deletion Attenuates Heart Failure Progression And Improves Cardiac Function After Myocardial Infarction, Anastasios Lymperopoulos, Giuseppe Rengo, Erhe Gao, Steven N. Ebert, Gerald W. Dorn Ii, Walter J. Koch

Faculty Bibliography 2010s

Chronic heart failure (HF) is characterized by sympathetic over-activity and enhanced circulating catecholamines (CAs), which significantly increase HF morbidity and mortality. We recently reported that adrenal G protein-coupled receptor kinase 2 (GRK2) is up-regulated in chronic HF, leading to enhanced CA release via desensitization/down-regulation of the chromaffin cell alpha(2)-adrenergic receptors that normally inhibit CA secretion. We also showed that adrenal GRK2 inhibition decreases circulating CAs and improves cardiac inotropic reserve and function. Herein, we hypothesized that adrenal-targeted GRK2 gene deletion before the onset of HF might be beneficial by reducing sympathetic activation. To specifically delete GRK2 in the chromaffin cells …

Doppler Imaging With Dual-Detection Full-Range Frequency Domain Optical Coherence Tomography, Panomsak Meemon, Kye-Sung Lee, Jannick P. Rolland

Faculty Bibliography 2010s

Most of full-range techniques for Frequency Domain Optical Coherence Tomography (FD-OCT) reported to date utilize the phase relation between consecutive axial lines to reconstruct a complex interference signal and hence may exhibit degradation in either mirror image suppression performance or detectable velocity dynamic range or both when monitoring a moving sample such as flow activity. We have previously reported a technique of mirror image removal by simultaneous detection of the quadrature components of a complex spectral interference called a Dual-Detection Frequency Domain OCT (DD-FD-OCT) [Opt. Lett. 35, 1058-1060 (2010)]. The technique enables full range imaging without any loss of acquisition …

Host-Toxin Interactions Involving Espc And Pet, Two Serine Protease Autotransporters Of The Enterobacteriaceae, Fernando Navarro-Garcia, Michael Sonnested, Ken Teter

Faculty Bibliography 2010s

EspC and Pet are toxins secreted by the diarrheagenic enteropathogenic and enteroaggregative Escherichia coli pathotypes, respectively. Both toxins have a molecular mass around 110 kDa and belong to the same protein family called Serine Protease Autotransporters of the Enterobacteriaceae (SPATE). Furthermore, both toxins act within the cytosol of intoxicated epithelial cells to disrupt the architecture of the actin cytoskeleton. This cytopathic and enterotoxic effect results from toxin cleavage of the actin-binding protein fodrin, although the two toxins recognize different cleavage sites on fodrin. EspC and Pet also have dramatically different mechanisms of entering the target cell which appear dependent upon …

A Novel Multiprotein Complex Is Required To Generate The Prechylomicron Transport Vesicle From Intestinal Er, Shahzad Siddiqi, Umair Saleem, Nada A. Abumrad, Nicholas O. Davidson, Judith Storch, Shadab A. Siddiqi, Charles M. Mansbach Ii

Faculty Bibliography 2010s

Dietary lipid absorption is dependent on chylomicron production whose rate-limiting step across the intestinal absorptive cell is the exit of chylomicrons from the endoplasmic reticulum (ER) in its ER-to-Golgi transport vesicle, the prechylomicron transport vesicle (PCTV). This study addresses the composition of the budding complex for PCTV. Immunoprecipitation (IP) studies from rat intestinal ER solubilized in Triton X-100 suggested that vesicle-associated membrane protein 7 (VAMP7), apolipoprotein B48 (apoB48), liver fatty acid-binding protein (L-FABP), CD36, and the COPII proteins were associated on incubation of the ER with cytosol and ATP. This association was confirmed by chromatography of the solubilized ER over …

Sec24c Is Required For Docking The Prechylomicron Transport Vesicle With The Golgi, Shahzad Siddiqi, Shadab A. Siddiqi, Charles M. Mansbach Ii

Faculty Bibliography 2010s

The rate-limiting step in the transit of dietary fat across the intestinal absorptive cell is its exit from the endoplasmic reticulum (ER) in a specialized ER-to-Golgi transport vesicle, the prechylomicron transport vesicle (PCTV). PCTV bud off from the ER membranes and have unique features; they are the largest ER-derived vesicles (average diameter 250 nm), do not require GTP and COPII proteins for their formation, and utilize VAMP7 as a v-N-ethylmaleimide sensitive factor attachment protein receptor (SNARE). However, PCTV require COPII proteins for their fusion with the Golgi, suggesting a role for them in Golgi target recognition. In support of this, …

Techniques Of Nerve-Sparing And Potency Outcomes Following Robot-Assisted Laparoscopic Prostatectomy, Sanket Chauhan, Rafael F. Coelho, Bernardo Rocco, Kenneth J. Palmer, Marcelo A. Orvieto, Vipul R. Patel

Faculty Bibliography 2010s

Purpose: Nerve sparing radical prostatectomy is the gold standard for the treatment of prostate cancer. Over the past decade, more and more surgeons and patients are opting for a robot-assisted procedure. The purpose of this paper is to briefly review different techniques and outcomes of nerve sparing robot assisted laparoscopic prostatectomy (RALP). Materials and Methods: We performed a MEDLINE search from 2001 to 2009 using the keywords "robotic prostatectomy", "cavernosal nerve", "pelvic neuroanatomy", "potency", "outcomes" and "comparison". Extended search was also performed using the references from these articles. Results: Several techniques of nerve sparing are available in literature for RALP, …

Regulation Of The Matriptase-Prostasin Cell Surface Proteolytic Cascade By Hepatocyte Growth Factor Activator Inhibitor-1 During Epidermal Differentiation, Ya-Wen Chen, Jehng-Kang Wang, Feng-Pai Chou, Chiu-Yuan Chen, Ellen A. Rorke, Li-Mei Chen, Karl X. Chai, Richard L. Eckert, Michael D. Johnson, Chen-Yong Lin

Faculty Bibliography 2010s

Matriptase, a membrane-tethered serine protease, plays essential roles in epidermal differentiation and barrier function, largely mediated via its activation of prostasin, a glycosylphosphatidylinositol-anchored serine protease. Matriptase activity is tightly regulated by its inhibitor hepatocyte growth factor activator inhibitor-1 (HAI-1) such that free active matriptase is only briefly available to act on its substrates. In the current study we provide evidence for how matriptase activates prostasin under this tight control by HAI-1. When primary human keratinocytes are induced to differentiate in a skin organotypic culture model, both matriptase and prostasin are constitutively activated and then inhibited by HAI-1. These processes also …

A Synthetic Uric Acid Analog Accelerates Cutaneous Wound Healing In Mice, Srinivasulu Chigurupati, Mohamed R. Mughal, Sic L. Chan, Thiruma V. Arumugam, Akanksha Baharani, Sung-Chun Tang, Qian-Sheng Yu, Harold W. Holloway, Ross Wheeler, Suresh Poosala, Nigel H. Greig, Mark P. Mattson

Faculty Bibliography 2010s

Wound healing is a complex process involving intrinsic dermal and epidermal cells, and infiltrating macrophages and leukocytes. Excessive oxidative stress and associated inflammatory processes can impair wound healing, and antioxidants have been reported to improve wound healing in animal models and human subjects. Uric acid (UA) is an efficient free radical scavenger, but has a very low solubility and poor tissue penetrability. We recently developed novel UA analogs with increased solubility and excellent free radical-scavenging properties and demonstrated their ability to protect neural cells against oxidative damage. Here we show that the uric acid analog (6, 8 dithio-UA, but not …

The Formulated Microbicide Rc-101 Was Safe And Antivirally Active Following Intravaginal Application In Pigtailed Macaques, Alexander M. Cole, Dorothy L. Patton, Lisa C. Rohan, Amy L. Cole, Yvonne Cosgrove-Sweeney, Nicole A. Rogers, Deena Ratner, Alexandra B. Sassi, Carol Lackman-Smith, Patrick Tarwater, Bharat Ramratnam, Piotr Ruchala, Robert I. Lehrer, Alan J. Waring, Phalguni Gupta

Faculty Bibliography 2010s

Background: RC-101 is a congener of the antiretroviral peptide retrocyclin, which we and others have reported is active against clinical HIV-1 isolates from all major clades, does not hemagglutinate, and is non-toxic and non-inflammatory in cervicovaginal cell culture. Herein, film-formulated RC-101 was assessed for its antiviral activity in vitro, safety in vivo, retention in the cervix and vagina, and ability to remain active against HIV-1 and SHIV after intravaginal application in macaques. Methodology/Principal Findings: RC-101 was formulated as a quick-dissolving film (2000 mu g/film), retained complete activity in vitro as compared to unformulated peptide, and was applied intravaginally in six …

Stem Cells For The Treatment Of Neurodegenerative Diseases, Elise Dantuma, Stephanie Merchant, Kiminobu Sugaya

Faculty Bibliography 2010s

Stem cells off er an enormous pool of resources for the understanding of the human body. One proposed use of stem cells has been as an autologous therapy. The use of stem cells for neurodegenerative diseases has become of interest. Clinical applications of stem cells for Alzheimer disease, Parkinson disease, amyotrophic lateral sclerosis, and multiple sclerosis will increase in the coming years, and although great care will need to be taken when moving forward with prospective treatments, the application of stem cells is highly promising.

Chloroplast-Derived Vaccine Antigens Confer Dual Immunity Against Cholera And Malaria By Oral Or Injectable Delivery, Abdoreza Davoodi-Semiromi, Melissa Schreiber, Samson Nalapalli, Dheeraj Verma, Nameirakpam D. Singh, Robert K. Banks, Debopam Chakrabarti, Hnery Daniell

Faculty Bibliography 2010s

Cholera and malaria are major diseases causing high mortality The only licensed cholera vaccine is expensive, immunity is lost in children within 3 years and adults are not fully protected No vaccine is yet available for malaria Therefore, in this study, the cholera toxin-B subunit (CTB) of Vibrio cholerae fused to malarial vaccine antigens apical membrane antigen-1 (AMA1) and merozoite surface protein-1 (MSP1) was expressed in lettuce and tobacco chloroplasts Southern blot analysis confirmed homoplasmy and stable integration of transgenes CTB-AMA1 and CTB-MSP1 fusion proteins accumulated up to 13 17% and 10 11% (total soluble protein, TSP) in tobacco and …

Stat3-Mediated Metabolic Switch Is Involved In Tumour Transformation And Stat3 Addiction, Marco Demaria, Carlotta Giorgi, Magdalena Lebiedzinska, Giovanna Esposito, Luca D'Angeli, Antonietta Bartoli, Daniel J. Gough, James Turkson, David E. Levy, Christine J. Watson, Mariusz R. Wieckowski, Paolo Provero, Paolo Pinton, Valeria Poli

Faculty Bibliography 2010s

The pro-oncogenic transcription factor STAT3 is constitutively activated in a wide variety of tumours that often become addicted to its activity, but no unifying view of a core function determining this widespread STAT3-dependence has yet emerged. We show here that constitutively active STAT3 acts as a master regulator of cell metabolism, inducing aerobic glycolysis and down-regulating mitochondrial activity both in primary fibroblasts and in STAT3-dependent tumour cell lines. As a result, cells are protected from apoptosis and senescence while becoming highly sensitive to glucose deprivation. We show that enhanced glycolysis is dependent on HIF-1a up-regulation, while reduced mitochondrial activity is …

Deceptive Cultural Practices That Sabotage Hiv/Aids Education In Tanzania And Kenya, Mary Oluga, Susan Kiragu, Mussa K. Mohamed, Shelina Walli

Institute for Educational Development, East Africa

In spite of numerous HIV/AIDS‐prevention education efforts, the HIV infection rates in Sub‐Saharan Africa remain high. Exploring and understanding the reasons behind these infection rates is imperative in a bid to offer life skills and moral education that address the root causes of the pandemic. In a recent study concerning effective HIV/AIDS‐prevention education, conducted in Tanzania and Kenya among teacher trainees and their tutors, the notion of mila potofu (defined by educators as ‘deceptive’ cultural practices) emerged as a key reason for educators’ difficulties in teaching HIV/AIDS prevention education in schools and for high HIV infection rates. Since these cultural …

Reality Hackers: The Next Wave Of Media Revolutionaries, Aaron A. Delwiche, Evan Barnett, Andrew Coe, Patrick Crim, Kendra Doshier, Christopher Dudley, Ender Ergun, Ashley Funkhouser, Cole Gray, Sarah Hellman, John Key, Christopher Kradle, Patrick Lynch, Shepherd Mcallister, Mark Mccullough, Justin Michaelson, Alyson Miller, Robin Murdoch, Aaron Passer, Maricela Rios, Laura Schluckebier, Raelle Smiley, Andrew Truelove, Richard Bartle, Annalee Newitz, Ekaterina Sedia, Steven Shaviro, R.U. Sirius

Faculty Authored and Edited Books & CDs

Just as the printing press gave rise to the nation-state, emerging technologies are reshaping collective identities and challenging our understanding of what it means to be human.

Should citizens have the right to be truly anonymous on-line? Should we be concerned about the fact that so many people are choosing to migrate to virtual worlds? Are injectible microscopic radio-frequency ID chips a blessing or a curse? Is the use of cognitive enhancing nootropics a human right or an unforgivable transgression? Should genomic data about human beings be hidden away with commercial patents or open-sourced like software? Should hobbyists known as …

Catalysts For Clarification: Modern Twists On The Insurable Interest Requirement For Life Insurance, Robert S. Bloink

Connecticut Insurance Law Journal

No abstract provided.

Fronting Arrangements: Industry Practices And Regulatory Concerns, Esteban Carranza-Kopper

Connecticut Insurance Law Journal

No abstract provided.

Annuity Coeptis: Is There A Way To Avoid American Equity Investment Life Insurance Co. V. Sec Becoming A Herald For The Sec Gaining Regulatory Control Over All Securities-Related Insurance Products?, Russell Hasan

Connecticut Insurance Law Journal

No abstract provided.

2010-2011 Graduate Catalog, Armstrong Atlantic State University

Armstrong Office of the Registrar: Graduate Catalogs (Archived)

Academic catalog for Armstrong Atlantic State University.

The Rise And Fall Of The American Institute Of Criminal Law And Criminology, Jennifer Devroye

Journal of Criminal Law and Criminology

No abstract provided.

Opening Remarks, Ronald J. Allen

Journal of Criminal Law and Criminology

No abstract provided.

Capital Punishment: A Century Of Discontinuous Debate, Carol S. Steiker, Jordan M. Steiker

Journal of Criminal Law and Criminology

No abstract provided.

One Hundred Years Of Race And Crime, Paul Butler

Journal of Criminal Law and Criminology

No abstract provided.

(Trans)Forming The Provocation Defense, Morgan Tilleman

Journal of Criminal Law and Criminology

No abstract provided.

Petals And Mortar, Amanda Rose Bramley

Theses

The stories in this collection focus on the little, almost insignificant symbols that appear in our daily lives. People, in general, don't notice how certain objects gravitate toward us. The symbols in my life and in my writing appear in places and forms unexpected: a bird outside of a windowsill, flowers that grow by themselves in our backyards, a scarf purchased at a discount store, domino tiles in a common game. How easy it is to take pieces of our lives for granted. They can, for many, hold an almost transcendental power. They provide landmarks for the steps we choose …

The Understudy, Linda Denise Harris

Theses

This story is a first person true account of love and loss between two sisters. The sisters are separated by seven years and other siblings, yet the bond formed in childhood is strengthened through the trials and tribulations of life. When the older sibling learns that she has terminal cancer she wants her sister by her side.

From the perspective of the younger sister, the story weaves from past to present, back and forth, as each substantial scene unfolds. Through her eyes, the younger sibling sheds light on the early years and the reader learns what it was like growing …

Imagining The Imaginary: Finding Mr. Marmalade, Brian Kappler

Theses

Unavailable.