Digital Commons Network^™

Emerging Vaccine Informatics, Yongqun He, Rino Rappuoli, Anne S. De Groot, Robert T. Chen

Institute for Immunology and Informatics Faculty Publications

Vaccine informatics is an emerging research area that focuses on development and applications of bioinformatics methods that can be used to facilitate every aspect of the preclinical, clinical, and postlicensure vaccine enterprises. Many immunoinformatics algorithms and resources have been developed to predict T- and B-cell immune epitopes for epitope vaccine development and protective immunity analysis. Vaccine protein candidates are predictable in silico from genome sequences using reverse vaccinology. Systematic transcriptomics and proteomics gene expression analyses facilitate rational vaccine design and identification of gene responses that are correlates of protection in vivo. Mathematical simulations have been used to model host-pathogen interactions …

Financialization Of The Asian Game Industry: A New Business Model, Dal Young Jin

Iowa Journal of Communication

This study is a historical documentation of the recent trends of financialization, mainly to ascertain whether these trends are confirmation that financialization plays a pivotal role in the game market in the midst of the global economic crisis in the early 21st century. The major focus will not only be on capital flow but also on financing, which means that the paper is to map out the way in which the Asian game industry has been part of the transnationalization process in order to fully understand the nature of globalization. Eventually, it examines whether the financialization of the online game …

Setting The Rules Of Play: Network Video Game Policies And Regulations In China, Zixue Tai

Iowa Journal of Communication

By situating online game regulations against the backdrop of the grand scheme of Internet information control, this paper offers a comprehensive, in-depth overview of the regulatory framework wherein the Chinese online video game industry operates. The topics analyzed include the bureaucratic regulatory structure, the ground rules for Web cafes operations, the complicated set of controversial market entry conditions and qualifications for online game distribution services as well as the multitude of concerted official measures and state-centered initiatives with the intent to foster particular genres of patriotic, morally-uplifting game titles and to build a core list of national production clusters.

Dysrhythmia Monitoring Practices Of Nurses On A Telemetry Unit, Susan Jane Schultz

UNF Graduate Theses and Dissertations

Standards of practice for hospital electrocardiogram monitoring were recommended in 2004 by the American Heart Association; however they are not widely followed. Many nurses monitor in a single lead regardless of diagnosis and are unable to differentiate wide QRS complex tachycardias. The purpose of this project was to evaluate the effectiveness of an interactive web-based education program combined with unit-based collaborative learning activities on both telemetry staff nurses‘ knowledge of dysrhythmias and their monitoring practices for patients at risk for wide QRS complex tachycardias. This interventional, one group before-and-after cohort study design consisted of four components: interactive web-based educational program …

Arthropod Biodiversity In Response To The Restoration Of Former Pine Plantations, John Curtis Burkhalter

UNF Graduate Theses and Dissertations

The goal of ecological restoration is to return degraded or altered ecosystems to their pre-disturbed state with respect to ecosystem structure, function, and composition. In the current study the research objective was to reestablish high levels of biodiversity on two restored pine plantations as well as restore a native pine flatwoods ecosystem. Managed, even-aged pine flatwoods are now the most extensive ecosystem in North Florida, comprising approximately 70% of the forested landscape. Slash pine trees were thinned in the experimental plots to restore the natural slash pine density of native ecosystems. In addition to the thinning treatments, experimental plots have …

Seeking Generalities In Salt Stress Effects On Herbivores: A Multi-Species Approach, Christy Marie Foust

UNF Graduate Theses and Dissertations

Stress has been identified as one of the primary factors influencing the structure of food webs, but few conclusions about the effects of stress on community dynamics have emerged. This study examined generalities that exist between salt stress and insect herbivore responses. Ambient salinity was artificially increased by adding 1.3 kg/m2 of salt to six different plant species: Avicennia germinans, Baccharis halimifolia, Batis maritima, Borrichia frutescens, Iva frutescens, and Spartina alterniflora. By performing a multiple species examination, stress responses were examined to determine if consistencies within and between plant type, ambient salinity conditions, and host plant species (among other criteria) …

Policy Implications Of Changes In Illinois Hog Production, Neil Probst

Research Papers

This paper analyzes the rapid changes of the hog industry in the state of Illinois, with a focus on the impact of increasing scale on local communities and environments. Theory on externalities, regional economics, and efficiencies is explored. A literature review looks at past studies on effects to local environments, health, land values, and economic vitality and explores potential solutions. A regression model is used to determine the impact of increased hog concentration on local Illinois employment rates to see if local economies are strengthened or weakened by large hog operations. Results show Illinois counties that had hog farm loss …

Whole Genome Wide Expression Profiles Of Vitis Amurensis Grape Responding To Downy Mildew By Using Solexa Sequencing Technology, Jiao Wu, Yali Zhang, Huiqin Zhang, Hong Huang, Kevin M. Folta, Jiang Lu

School of Information Faculty Publications

Background: Downy mildew (DM), caused by pathogen Plasmopara viticola (PV) is the single most damaging disease of grapes (Vitis L.) worldwide. However, the mechanisms of the disease development in grapes are poorly understood. A method for estimating gene expression levels using Solexa sequencing of Type I restriction-endonuclease-generated cDNA fragments was used for deep sequencing the transcriptomes resulting from PV infected leaves of Vitis amurensis Rupr. cv. Zuoshan-1. Our goal is to identify genes that are involved in resistance to grape DM disease.

Results: Approximately 8.5 million (M) 21-nt cDNA tags were sequenced in the cDNA library derived from PV pathogen-infected …

Plausible Methods For Populating Virtual Scenes, Catherine Ennis, Anton Gerdelan, Carol O'Sullivan

Research Outputs: 2025-Present

No abstract provided.

Review Of Understanding Labor And Employment Law In China, By Ronald C.Brown, Nicholas C. Howson

Reviews

Any attempt to analyze China’s comprehensive labor reform over the past three decades faces at least two dilemmas. First, the analyst must confront the task of describing how the Chinese state has dismantled the “work unit” (or danwei)- based “iron rice bowl” employment and entitlements system, replacing that comforting but low-production employment and social security scheme with formally-proclaimed legal rights and institutions apparently designed to protect employees in a functioning labor market. Second, the analyst must track how the state’s commitment (at all levels of government) to implementation of proclaimed legal and institutional protections has waxed and waned, based upon …

Book Review: What's Left? A Review Of International Law On The Left: Re-Examining Marxist Legacies By Susan Marks, Barbara Stark

Hofstra Law Faculty Scholarship

In response to the American invasion of Iraq, a group of prominent European legal scholars convened a symposium to explore the causes of the “material economic woes of international society.” A revised and expanded version of that Symposium, including five new essays, was published by Cambridge, International Law on the Left: Re-examining the Marxist Legacies (Susan Marks, ed. 2008).

In What’s Left? I review the provocative, scholarly, and occasionally electrifying essays in this volume in two parts, each addressing a version of the question, “What’s Left?” Part I asks, “What‘s ‘Left?” That is, is there a coherent Left in international …

Transepithelial D-Glucose And D-Fructose Transport Across Lobster Intestine, Ijeoma Ebelechukwu Obi

UNF Graduate Theses and Dissertations

The mechanisms of transepithelial absorption of dietary D-glucose and D-fructose in the American lobster, Homarus americanus, were investigated in this study in order to determine whether sugar transport proteins have been conserved throughout evolution. Whole lobster intestine was isolated and mounted in a perfusion chamber to determine transepithelial mucosal to serosal (MS) and serosal to mucosal (SM) mechanisms of ³H-D-glucose and ³H-D-fructose transport across the intestine. Unidirectional MS and SM fluxes were measured by adding variable concentrations of ³H-D-glucose and ³H-D-fructose (2.5 to 50uM) to either the perfusate or the bath respectively and sampling the …

Albany’S Dysfunction Denies Due Process, Eric Lane, Laura Seago

Hofstra Law Faculty Scholarship

The coup that shut down the New York State Senate for over a month last summer brought the State Legislature's dysfunction to the forefront of public consciousness. As the public waited for the approval of several critical budget bills and action on a long list of substantive legislation, two members of the newly elected Democratic majority deserted to the Republican side and then switched back again to caucus with the Democrats, destabilizing the already listing New York ship of state and spreading disgust among their colleagues and the public at large. These events were, unfortunately, not anomalous. The process by …

World Of Viruses: The Frozen Horror, Martin Powell, Tom Floyd, Angie Fox, Anisa Angeletti, Peter Angeletti, Judy Diamond, Kristin Watkins, Charles Wood

Books: College of Public Health

No abstract provided.

Making It Happily Ever After: Rectifying The Inherent Contradiction Between Suicide And Hollywood Endings, Mitchell Zoelzer

Iowa Journal of Communication

Hollywood movies often struggle to present depressing ideas realistically. This rhetorical analysis, using narrative criticism, analyzes the presentation of suicide in five Hollywood films: Thelma and Louise, Seven Pounds, Milk, What Dreams May Come, and Dead Poet's Society. This analysis suggests a test to tell how Hollywood will present the suicide by simply knowing when the suicide is committed or by whom. If the suicide is presented at the end of the film or committed by the protagonist, Hollywood will be forced to portray it as positive and unrealistic. The only exception to this rule …

The Genomic Research And Accessibility Act: More Science Fiction Than Fact, James Degiulio

Northwestern Journal of Technology and Intellectual Property

No abstract provided.

The Combined Influence Of The Local Environment Andregional Enrichment On Bird Species Richness, Ethan P. White, A. H. Hurlbert

Biology Faculty Publications

It is generally accepted that local species richness at a site reflects the combined influence of local and regional processes. However, most empirical studies evaluate the influence of either local environmental variables or regional enrichment but not both simultaneously. Here we demonstrate the importance of combining these processes to understand continental scale richness patterns in breeding birds. We show that neither regional enrichment nor the local environment in isolation is sufficient to characterize observed patterns of species richness. Combining both sets of variables into a single model results in improved model fit and the removal of residual spatial autocorrelation. At …

Loss Of Foundation Species Increases Population Growth Of Exotic Forbs In Sagebrush Steppe, J S. Prevey, M J. Germino, Nancy J. Huntly

Biology Faculty Publications

The invasion and spread of exotic plants following land disturbance threatens semiarid ecosystems. In sagebrush steppe, soil water is scarce and is partitioned between deeprooted perennial shrubs and shallower-rooted native forbs and grasses. Disturbances commonly remove shrubs, leaving grass-dominated communities, and may allow for the exploitation of water resources by the many species of invasive, tap-rooted forbs that are increasingly successful in this habitat. We hypothesized that exotic forb populations would benefit from increased soil water made available by removal of sagebrush, a foundation species capable of deep-rooting, in semiarid shrub-steppe ecosystems. To test this hypothesis, we used periodic matrix …

When Work Culture And Ministry Collide, Brett C. Hoover

Theological Studies Faculty Works

The article offers information on the implication of collision between the work culture and ministry. It informs that the parish leadership has been negatively affected by the work culture of the U.S. It explores the leadership renewal process called INSPIRE (Identify, Nurture and Sustain Pastoral Imagination through Resources for Excellence) and offers remedies for the culture of work of parishes and schools of ministry.

All Dogs Go To Heaven... Or Divorce Court: New Jersey Unleashes A Subjective Value Consideration To Resolve Pet Custody Litigation In Houseman V. Dare, Eric Kotloff

Villanova Law Review (1956 - )

No abstract provided.

Symposium Introduction, Various Editors

Villanova Law Review (1956 - )

No abstract provided.

Educating The United States Supreme Court At Summers' School: A Lesson On The "Special Character Of The Animal", Rafael Gely, Ramona L. Paetzold, Leonard Bierman

Faculty Publications

In this article, we explore the implications that Professor Summers' insights regarding public employment have for the Garcetti and Davenport decisions. In particular, we focus on the extent to which the political nature of public employment affects public employees' rights to freedom of speech as well as matters regarding the representational functions of public employee unions.

The Role Of Toll-Like Receptors 2 And 4 In Helicobacter Felis Infections And Asthma, Carolyn Durham

All ETDs from UAB

The inverse correlation between the industrialization and disease prevalence is termed the "hygiene hypothesis." Supporting this, immunological studies show Th1 cytokines modulate Th2 immune responses. Because the mucosa is essential in antigenic exposure, understanding bacterial sensing here is critical to addressing three foundations of this hypothesis: the role of bacterial exposure, relevance of noninvasive bacterial exposure, and influence of these exposures on immune responses. Key components of antigen sensing in the mucosa are toll-like receptors (TLRs) 2 and 4, which have been implicated in disease. The hypothesis of this thesis is, by globally knocking out one or both of these …

Cellular Mechanisms Involved In Host Responses To Porphyromonas Gingivalis And Its Virulence Factor Hemagglutinin B, Dalia Emil Gaddis

All ETDs from UAB

Porphyromonas gingivalis is a main causative agent for adult chronic periodontitis and immunization with its virulence factor Hemagglutinin B (HagB) provides protection against infection. Toll-like receptors (TLRs) recognize various microbial products and are crucial in eliciting and regulating the innate and adaptive immune responses to infections. The objective of this dissertation was to investigate the cellular mechanisms that influence the innate and adaptive immune response to HagB and P. gingivalis, focusing on the role of TLR signaling in the response. We started with investigating the ability of HagB to activate dendritic cells (DC), the most efficient antigen-presenting cell in priming …

Characterization Of The Oligosaccharides Of B. Anthracis Exosporium, Shengli Dong

All ETDs from UAB

Fatal systemic anthrax is caused by exposure to spores of Bacillus anthracis. The outermost layer of the B. anthracis spore is called the exosporium. It consists of a paracrystalline basal layer and an external hair-like nap. The filaments of the hair-like nap are primarily composed of the glycoprotein BclA. Our previous studies showed that a 715-Da tetrasaccharide and a 324-Da disaccharide are attached to BclA through GalNAc. We named the novel nonreducing terminal sugar of the 715-Da tetrasaccharide anthrose. We subsequently proposed a plausible anthrose biosynthetic pathway and identified a gene cluster of four continuous genes that appeared to encode …

Lens Cataract: Biochemical Analysis Of The Alpha Crystallins, David Ray Stella

All ETDs from UAB

The cataract is a common ailment affecting the aged population. It appears over time and affects the quality of one’s life by the eventual loss of vision. Currently, there is no effective strategy to prevent or treatment to reverse the development of a cataract. As well, there is no consensus on one particular mechanism or sequence of events that contributes to its formation. In order to better understand the possible etiology of the cataract, it is necessary to define the biochemical changes that occur to lens proteins as one ages, as these are the key players in the prevention of …

One Of Us Is Gay, Timothy Alan Tipton

All ETDs from UAB

This is an original work of creative nonfiction centered on the challenges of living a gay lifestyle during the early years of the AIDS crisis. This work is primarily a memoir, engaging real life events and people, crafted into a chronicle of everyday life in the deep South of the mid 1980s and early 1990s. Aspects of gay life are exposed through the lense of the author's relationship with his first partner. One of Us is Gay provides a graphic exposé of the journey that a young man takes through the vulnerable and innocent awareness of his homosexuality, to the …

Tragic Consequences Of Deadly Dilemmas: A Response To Allen And Laudan, D. Michael Risinger

Seton Hall Law Review

No abstract provided.

Immigration As Invasion: Sovereignty, Security, And The Origins Of The Federal Immigration Power, Matthew Lindsay

All Faculty Scholarship

This Article offers a new interpretation of the modern federal immigration power. At the end of the nineteenth century, the Supreme Court and Congress fundamentally transformed the federal government’s authority to regulate immigration, from a species of commercial regulation firmly grounded in Congress’ commerce authority, into a power that was unmoored from the Constitution, derived from the nation’s “inherent sovereignty,” and subject to extraordinary judicial deference. This framework, which is commonly referred to as the “plenary power doctrine,” has stood for more than a century as an anomaly within American public law. The principal legal and rhetorical rationale for the …

The Harmony Way: Integrating Indigenous Values Within Native North American Theology And Mission, Randy Stephen Woodley

ATS Dissertations

No abstract provided.