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2009

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Substrate Induced Structural And Dynamics Changes In Human Phosphomevalonate Iinase And Implications For Mechanism, Andrew Lawrence Olson, Huili Yao, Timothy J. Herdendorf, Henry M. Miziorko, Supa Hannongbua, Patchareenat Saparpakom, Sheng Cai, Daniel S. Sem Jan 2009

Substrate Induced Structural And Dynamics Changes In Human Phosphomevalonate Iinase And Implications For Mechanism, Andrew Lawrence Olson, Huili Yao, Timothy J. Herdendorf, Henry M. Miziorko, Supa Hannongbua, Patchareenat Saparpakom, Sheng Cai, Daniel S. Sem

Chemistry Faculty Research and Publications

Phosphomevalonate kinase (PMK) catalyzes an essential step in the mevalonate pathway, which is the only pathway for synthesis of isoprenoids and steroids in humans. PMK catalyzes transfer of the γ-phosphate of ATP to mevalonate 5-phosphate (M5P) to form mevalonate 5-diphosphate. Bringing these phosphate groups in proximity to react is especially challenging, given the high negative charge density on the four phosphate groups in the active site. As such, conformational and dynamics changes needed to form the Michaelis complex are of mechanistic interest. Herein, we report the characterization of substrate induced changes (Mg-ADP, M5P, and the ternary complex) in PMK using …

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The Debt Financing Of Parenthood, Melissa B. Jacoby Jan 2009

The Debt Financing Of Parenthood, Melissa B. Jacoby

Faculty Publications

No abstract provided.

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The Continuing Search For A Meaningful Model Of Judicial Rankings And Why It (Unfortunately) Matters, Scott Baker, Adam Feibelman, William P. Marshall Jan 2009

The Continuing Search For A Meaningful Model Of Judicial Rankings And Why It (Unfortunately) Matters, Scott Baker, Adam Feibelman, William P. Marshall

Faculty Publications

No abstract provided.

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The Special Threat Of Informants To The Innocent Who Are Not Innocents: Producing "First Drafts," Recording Incentives, And Taking A Fresh Look At The Evidence, Robert P. Mosteller Jan 2009

The Special Threat Of Informants To The Innocent Who Are Not Innocents: Producing "First Drafts," Recording Incentives, And Taking A Fresh Look At The Evidence, Robert P. Mosteller

Faculty Publications

No abstract provided.

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At The End Of The Clinical Trial: Does Access To Investigational Technology End As Well?, Richard S. Saver Jan 2009

At The End Of The Clinical Trial: Does Access To Investigational Technology End As Well?, Richard S. Saver

Faculty Publications

No abstract provided.

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Escheat: Is The State The Last Heir?, John V. Orth Jan 2009

Escheat: Is The State The Last Heir?, John V. Orth

Faculty Publications

No abstract provided.

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Gene Patents And The Product Of Nature Doctrine, John M. Conley Jan 2009

Gene Patents And The Product Of Nature Doctrine, John M. Conley

Faculty Publications

No abstract provided.

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Structuring A Us Federal Vat, Reuven S. Avi-Yonah Jan 2009

Structuring A Us Federal Vat, Reuven S. Avi-Yonah

Articles

On 18 and 19 February 2009, the American Tax Policy Institute (ATPI) sponsored a conference in Washington, DC, on “Structuring a Federal VAT: Design and Coordination Issues.” The purpose of the conference was to lay the ground for a potential future adoption of a federalVAT in the United States by discussing some of the technical issues related to two broad topics: firstly, how should such a US federal VAT be designed and, secondly, how should it be coordinated with the existing state retail sales taxes (RST). In this article, the author summarized the conference presentations.

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Prosecuting Worker Endangerment: The Need For Stronger Criminal Penalties For Violations Of The Occupational Safety And Health Act, David M. Uhlmann Jan 2009

Prosecuting Worker Endangerment: The Need For Stronger Criminal Penalties For Violations Of The Occupational Safety And Health Act, David M. Uhlmann

Articles

A recent spate of construction deaths in New York City, similar incidents in Las Vegas, and scores of fatalities in recent years at mines and industrial facilities across the country have highlighted the need for greater commitment to worker safety in the United States and stronger penalties for violators of the worker safety laws. Approximately 6,000 workers are killed on the job each year1—and thousands more suffer grievous injuries—yet penalties for worker safety violations remain appallingly small, and criminal prosecutions are almost non-existent. In recent years, most of the criminal prosecutions for worker safety violations have been brought by the …

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Kaikobase: An Integrated Silkworm Genome Database And Data Mining Tool, Michihiko Shimomura, Hiroshi Minami, Yoshitaka Suetsugu, Hajime Ohyanagi, Chikatada Satoh, Baltazar Antonio, Yoshiaki Nagamura, Keiko Kadono-Okuda, Hideyuki Kajiwara, Hideki Sezutsu, Javaregowda Nagaraju, Marian R. Goldsmith, Qingyou Xia, Kimiko Yamamoto, Kazuei Mita Jan 2009

Kaikobase: An Integrated Silkworm Genome Database And Data Mining Tool, Michihiko Shimomura, Hiroshi Minami, Yoshitaka Suetsugu, Hajime Ohyanagi, Chikatada Satoh, Baltazar Antonio, Yoshiaki Nagamura, Keiko Kadono-Okuda, Hideyuki Kajiwara, Hideki Sezutsu, Javaregowda Nagaraju, Marian R. Goldsmith, Qingyou Xia, Kimiko Yamamoto, Kazuei Mita

Biological Sciences Faculty Publications

Background: The silkworm, Bombyx mori, is one of the most economically important insects in many developing countries owing to its large-scale cultivation for silk production. With the development of genomic and biotechnological tools, B. mori has also become an important bioreactor for production of various recombinant proteins of biomedical interest. In 2004, two genome sequencing projects for B. mori were reported independently by Chinese and Japanese teams; however, the datasets were insufficient for building long genomic scaffolds which are essential for unambiguous annotation of the genome. Now, both the datasets have been merged and assembled through a joint collaboration …

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Epitope-Based Vaccination Against Pneumonic Tularemia, Stephen H. Gregory, Stephanie Mott, Jennifer Phung, Jinhee Lee, Leonard Moise, Julie A. Mcmurry, William Martin, Anne S. De Groot Jan 2009

Epitope-Based Vaccination Against Pneumonic Tularemia, Stephen H. Gregory, Stephanie Mott, Jennifer Phung, Jinhee Lee, Leonard Moise, Julie A. Mcmurry, William Martin, Anne S. De Groot

Institute for Immunology and Informatics Faculty Publications

Francisella tularensis, the etiological agent of tularemia, is one of the most infectious bacterial pathogens known. No vaccine is currently approved for public use. Previously, we identified epitopes recognized specifically by T cells obtained from individuals following infection with F. tularensis. Here, we report that a subunit vaccine constructed based upon these epitopes elicited protective immunity in “humanized” HLA class II (DRB1*0401) transgenic mice. Vaccinated mice challenged intratracheally with a lethal dose of F. tularensis (Live Vaccine Strain) exhibited a rapid increase in pro-inflammatory cytokine production and diminished number of organisms in the lungs, and a concurrent increased …

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Learning Resources Classroom Schedules Jan 2009

Learning Resources Classroom Schedules

Learning Resources

No abstract provided.

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From Bush V. Gore To Namudno: A Response To Professor Amar, Ellen D. Katz Jan 2009

From Bush V. Gore To Namudno: A Response To Professor Amar, Ellen D. Katz

Articles

In his Dunwody Lecture, Professor Akhil Amar invites us to revisit the Bush v. Gore controversy and consider what went wrong. This short essay responds to Professor Amar by taking up his invitation and looking at the decision through a seemingly improbable lens, the U.S. Supreme Court’s decision last June in Northwest Austin Municipal Utility District No. One (NAMUDNO) v. Holder. Among its many surprises, NAMUDNO helps illuminate the Court’s fundamental error nine years ago. Professor Amar forcefully argues that the mistrust with which the Justices in the Bush v. Gore majority viewed the Florida Supreme Court was both unjustified …

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Domestic Effects Of The Foreign Activities Of U.S. Multinationals, Mihir A. Desai, C. Fritz Foley, James R. Hines Jr. Jan 2009

Domestic Effects Of The Foreign Activities Of U.S. Multinationals, Mihir A. Desai, C. Fritz Foley, James R. Hines Jr.

Articles

Do firms investing abroad simultaneously reduce their domestic activity? This paper analyzes the relationship between the domestic and foreign operations of US manufacturing firms between 1982 and 2004 by instrumenting for changes in foreign operations with GDP growth rates of the foreign countries in which they invest. Estimates produced using this instrument indicate that 10 percent greater foreign investment is associated with 2.6 percent greater domestic investment, and 10 percent greater foreign employee compensation is associated with 3.7 percent greater domestic employee compensation. These results do not support the popular notion that expansions abroad reduce a firm’s domestic activity, instead …

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Intellectual Liability, Daniel A. Crane Jan 2009

Intellectual Liability, Daniel A. Crane

Articles

Intellectual property is increasingly a misnomer since the right to exclude is the defining characteristic of property and incentives to engage in inventive and creative activity are increasingly being granted in the form of liability rights (which allow the holder of the right to collect a royalty from users) rather than property rights (which allow the holder of the right to exclude others from using the invention or creation). Much of this recent reorientation in the direction of liability rules arises from a concern over holdout or monopoly power in intellectual property. The debate over whether liability rules or property …

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Who We Were And Who We Are: How Michigan Law Students Have Changed Since The 1950s: Findings From 40 Years Of Alumni Surveys, David L. Chambers, Terry K. Adams Jan 2009

Who We Were And Who We Are: How Michigan Law Students Have Changed Since The 1950s: Findings From 40 Years Of Alumni Surveys, David L. Chambers, Terry K. Adams

Articles

For 40 consecutive years, from 1967 to 2006, the Law School surveyed its alumni regarding their lives and careers. The project began in 1967 with the mailing of a questionnaire to the class of 1952 shortly before their 15th reunion. The results proved interesting enough that surveys were sent each year thereafter to the class 15 years out. In 1973, the classes 5 years out were added to the survey.

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Laryngeal Level Amplitude Modulation In Vibrato, Christopher Dromey, Lorie Reese, J. Arden Hopkin Jan 2009

Laryngeal Level Amplitude Modulation In Vibrato, Christopher Dromey, Lorie Reese, J. Arden Hopkin

Faculty Publications

Objectives: The goal of this investigation was to test a new methodology for measuring amplitude modulation (AM) at the level of the vocal folds during vibrato in trained singers, because previous research has suggested that AM arises in large part as an acoustic epiphenomenon through an interaction of the harmonics in the laryngeal source with the resonances of the vocal tract as the fundamental frequency oscillates.
Study Design: A within-subjects model was used to compare vocal activity across three pitch and three loudness conditions.
Methods: Seventeen female singers with a range of training and experience were recorded with a microphone …

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Intra-Speaker Variability In Palatometric Measures Of Consonant Articulation, Christopher Dromey, Marybeth Sanders Jan 2009

Intra-Speaker Variability In Palatometric Measures Of Consonant Articulation, Christopher Dromey, Marybeth Sanders

Faculty Publications

Electropalatometry is a useful clinical and research tool for measuring linguapalatal contact. The goal of this study was to examine intra-speaker variability in performance. Twenty individuals spoke VCV nonsense words using a schwa in the initial position, the 15 palatal consonants, and three corner vowels, /ɑ/, /i/, /u/. A variability index was created to examine speaker consistency.
Different aspects of articulation (i.e. place, manner, voicing, coarticulation) were compared. Significant differences for variability were found for place of articulation in the /i/ vowel context and for manner of articulation in the /ɑ/ vowel context. Also for the /ɑ/ vowel, significant differences …

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Comment On "Generation Of Cold Low Divergent Atomic Beam Of Indium By Laser Ablation", A. Denning, A. Booth, S. Lee, M. Amonson, Scott D. Bergeson Jan 2009

Comment On "Generation Of Cold Low Divergent Atomic Beam Of Indium By Laser Ablation", A. Denning, A. Booth, S. Lee, M. Amonson, Scott D. Bergeson

Faculty Publications

We present measurements of the velocity distribution of calcium atoms in an atomic beam generated using a dual-stage laser back-ablation apparatus. Distributions are measured using a velocity selective Doppler time-of-flight technique. They are Boltzmann-like with rms velocities corresponding to temperatures above the melting point for calcium. Contrary to a recent report in the literature, this method does not generate a subthermal atomic beam.

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Spin Dynamics For Wave Packets In Rashba Systems, Bailey C. Hsu, Jean F. Van Huele Jan 2009

Spin Dynamics For Wave Packets In Rashba Systems, Bailey C. Hsu, Jean F. Van Huele

Faculty Publications

We explore spin dynamics for localized wave packets in Rashba systems using spin quantum propagators. We derive exact (one-dimensional) and approximate (two-dimensional) analytic expressions for the propagators and apply them to Gaussian wave packets to obtain localized solutions of systems manifesting Rashba interactions. We observe and describe the evolution of the wave packets. We identify characteristic structures in the wave-packet evolution and look for features with specific spintronics applications such as spin separation and spin accumulation. We discuss the relative importance of those features as a function of the Rashba coupling strength α and the width of the wave packet …

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The Teaching-Learning Process: A Set Of Instructional Strategies And Tactics Through Analysis Of Mosston's "Spectrum Of Teaching Styles", Robert S. Christenson, David C. Barney Jan 2009

The Teaching-Learning Process: A Set Of Instructional Strategies And Tactics Through Analysis Of Mosston's "Spectrum Of Teaching Styles", Robert S. Christenson, David C. Barney

Faculty Publications

This analysis of teaching is comprised of a series of articles that are intended to introduce the reader or provide for a refocusing for those familiar to Mosston's eleven styles along the spectrum of teaching styles. Mosston developed them as a result of his work at Pennsylvania's Temple University and East Stroudsburg University and then at Rutgers University and the Center on Teaching. Since the first publication of Teaching Physical Education, which introduced The Spectrum of Teaching Styles, Mosston demonstrated his love for the teaching-learning process in physical education by challenging other professionals to expand their instructional repertoires in an …

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The Spectrum Of Teaching Styles: Style D – The Self-Check Style, Robert S. Christenson, David C. Barney Jan 2009

The Spectrum Of Teaching Styles: Style D – The Self-Check Style, Robert S. Christenson, David C. Barney

Faculty Publications

Muska Mosston (1964) created, and Mosston and Ashworth (1994) revised the Spectrum of Teaching Styles in an effort to identify several of the more profound instructional episodes in the teaching-learning process. While developed with physical education as a focal point, the eleven teaching styles included in the teaching spectrum are based upon the countless instructional decisions that are made prior to (PRE-IMPACT), during (IMPACT) and following an instructional episode (POST IMPACT). Based upon who is making the decisions, styles A to E are grouped into a first cluster representing reproduction styles. Styles F to K represent a discovery style of …

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The Teaching/Learning Process Through Mosston's "Spectrum Of Teaching Styles: The Reciprocal Style", David C. Barney, Robert S. Christenson Jan 2009

The Teaching/Learning Process Through Mosston's "Spectrum Of Teaching Styles: The Reciprocal Style", David C. Barney, Robert S. Christenson

Faculty Publications

Mosston (1994) created the Spectrum of Teaching Styles to identify the various alternatives that exist to design as well as present instructional episodes. As there are most likely as many ways to define the styles of teaching as there are learners, Mosston's original seven teaching styles have evolved into eleven. As identified by Mosston, each of the styles is differentiated by the decisions that are made by teacher or learner. The sequence of decisions that are made by either the teacher of learner during each of the three specified phases of instruction, before (pre-impact), during (impact) or after (post-impact) helps …

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Cultural Competence: Developing And Assessing Multicultural Proficiency For Teachers And School Personnel In Hawaii, Caryl H. Hitchcock, Mary Anne Prater, Chuan Chang Jan 2009

Cultural Competence: Developing And Assessing Multicultural Proficiency For Teachers And School Personnel In Hawaii, Caryl H. Hitchcock, Mary Anne Prater, Chuan Chang

Faculty Publications

Teachers were recruited from the mainland of the United States to work in rural areas in the State of Hawaii to meet the high demand for personnel. But often there is a mismatch between the culture of the island residents and that of the new teachers. To alleviate this mismatch, a workshop was developed to promote multicultural proficiency of school personnel focusing on Asian/Pacific cultures. One hundred teachers, administrators and staff (including custodians and cafeteria workers) from four rural elementary schools participated in a three hour workshop. The workshop consisted of three activities: (a) self-awareness, (b) awareness of Asian/Pacific Island …

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Backlog 2009, Lipscomb University Jan 2009

Backlog 2009, Lipscomb University

Backlogs and Other Yearbooks

The 2009 Lipscomb University Backlog yearbook.

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Investigating The Effects Of Marriage And Relationship Education On Couples' Communication Skills: A Meta-Analytic Study, Victoria L. Blanchard, Alan J. Hawkins, Scott A. Baldwin, Elizabeth B. Fawcett Jan 2009

Investigating The Effects Of Marriage And Relationship Education On Couples' Communication Skills: A Meta-Analytic Study, Victoria L. Blanchard, Alan J. Hawkins, Scott A. Baldwin, Elizabeth B. Fawcett

Faculty Publications

This meta-analysis probes into previous research substantiating the positive effects of marriage and relationship education (MRE) on couples' communication skills. We reviewed 97 MRE research reports that yielded 143 distinct evaluation studies. We found modest evidence that MRE functions both as a universal prevention and as a selective or indicated prevention. That is, MRE demonstrates program effects at longer term follow-ups for more distressed couples. In addition, we found that observational assessments produced larger effects than self-report assessments, although interpreting the meaning of this difference is difficult.

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A Comparison Of The Communal Lament Psalms And The Treaty-Covenant Formula, Dan Belnap, Daniel L. Belnap Jan 2009

A Comparison Of The Communal Lament Psalms And The Treaty-Covenant Formula, Dan Belnap, Daniel L. Belnap

Faculty Publications

Within the corpus of psalms in the Hebrew Bible is a group known as the communal laments. Characterized by their use of the first person common plural pronoun, some type of calamity experienced by the community, and a petition to God, these psalms incorporate similar imagery, terminology, and structure. This study explores these psalms and suggests that they relate closely to the Hittite treaty-covenant formula found elsewhere in the Hebrew Bible, yet differ in that they reflect an ongoing covenantal relationship rather than the establishment of such. Thus, these psalms emphasize Israel’s expectation that God, as the senior covenantal party, …

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Ten Scalability Factors In Distance Education, R. Dwight Laws, Scott L. Howell, Nathan K. Lindsay Jan 2009

Ten Scalability Factors In Distance Education, R. Dwight Laws, Scott L. Howell, Nathan K. Lindsay

Faculty Publications

The institutional decision about how much technology should be used to scale distance education enrollments, reduce costs, maximize profits, and protect course and program quality is both institutional specific and complex. Guri-Rosenblit (1999) noted that “many conventional universities worldwide operate as large-scale universities and are in a continuous search to find the right balance between massification trends, quality education, and the catering to the individual needs of students” (p. 289). This research is an outgrowth of the authors’ own efforts to identify relevant scalability factors and their interrelationship one to another in a traditional university’s distance education program.

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Christ's Interpretation Of Isaiah's 52'S "My Servant" In 3 Nephi, Gaye Strathearn, Jacob Moody Jan 2009

Christ's Interpretation Of Isaiah's 52'S "My Servant" In 3 Nephi, Gaye Strathearn, Jacob Moody

Faculty Publications

When the Savior appeared to the “more righteous” of the Nephites and Lamanites, he used many teachings that modern readers readily recognize from the Old and New Testaments. Some critics have suggested that Joseph Smith merely lifted these teachings from his copy of the Bible.1 While some of these quotations are very similar to the accounts in the King James Bible, there are some significant differences that strongly suggest that the process was more complex and nuanced than these critics allow.

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Biblical Naming Reports With, Dana M. Pike Jan 2009

Biblical Naming Reports With, Dana M. Pike

Faculty Publications

This study reviews the naming reports in the MT r that contain the phrase [Hebrew text] () in order to analyze the current practice of regularly rendering the subjects of these reports as indefinite. Though this is understandable in some cases, I contend that many of these subjects can just as well be understood as definite. Whereas the difference may seem insignificant in some passages, rendering the subject as definite is productive in others. A complete examination of all biblical naming reports is a large and complex undertaking, well beyond the limitations of the present study. This review of the …

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