Digital Commons Network^™

Natural Resource News, Vol. 09, No. 1 (June 2009), N/A N/A

Natural Resource News

No abstract provided.

The Bg News June 17, 2009, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. June 17, 2009. Volume 99-Issue 155.

Reactive Oxygen Species Mediate Tnfr1 Increase After Trpv1 Activation In Mouse Drg Neurons, Fei Ma, Liping Zhang, Karin N. Westlund

Physiology Faculty Publications

Background: Transient receptor potential vanilloid subtype 1 (TRPV1) is activated by low pH/protons and is well known to be involved in hyperalgesia during inflammation. Tumor necrosis factor α (TNF-α), a proinflammatory cytokine, is involved in nociceptive responses causing hyperalgesia through TNF receptor type 1 (TNFR1) activation. Reactive oxygen species (ROS) production is also prominently increased in inflamed tissue. The present study investigated TNFR1 receptors in primary cultured mouse dorsal root ganglion (DRG) neurons after TRPV1 activation and the involvement of ROS. C57BL/6 mice, both TRPV1 knockout and wild type, were used for immunofluorescent and live cell imaging. The L4 and …

Missoula Students Receive Um Scholarships, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Biophysical Analysis Of The Ap1-Dna Interaction, Kenneth L. Seldeen

Open Access Dissertations

Jun and Fos are components of the AP1 family of transcription factors that bind to the promoters of a diverse multitude of genes involved in critical cellular responses such as cell growth and proliferation, cell cycle regulation, embryonic development and cancer. The specific protein-DNA interactions are driven by the binding of basic zipper (bZIP) domains of Jun and Fos to TPA response element (TRE) and cAMP response element (CRE) within the promoters of target genes. Here, using a diverse array of biophysical techniques, including in particular isothermal titration calorimetry in conjunction with molecular modeling and semi-empirical analysis, I characterize AP1-DNA …

Physicochemical Studies Of The Grb2-Sos1 Interaction, Caleb B. Mcdonald

Open Access Dissertations

Grb2, a modular protein comprised of a central SH2 domain flanked between a N-terminal SH3 (nSH3) domain and a C-terminal SH3 (cSH3) domain, is a component of cell signaling networks involved in the transmission of extracellular information in the form of growth factors and cytokines to downstream targets such as transcription factors within the nucleus. The Grb2-Sos1 interaction is mediated through the combinatorial binding of nSH3 and cSH3 domains of Grb2 to various sites - designated S1, S2, S3, and S4 - containing PXpsiPXR motifs within Sos1. Here, using a diverse array of biophysical techniques, including in particular isothermal titration …

A Novel Role For The Trafs As Co-Activators And Co-Repressors Of Transcriptional Activity, George C. Brittain, Iv

Open Access Dissertations

The tumor necrosis factor (TNF) receptor-associated factors (TRAFs) were initially discovered as proteins that inducibly interact with the intracellular region of TNF receptors (TNFRs). Because the TNFRs lack intrinsic catalytic activity, the TRAFs are hypothesized to orchestrate signaling activation downstream of the TNFR superfamily, however their mechanism of activation remains unclear (Inoue et al., 2000; Bishop, 2004). Originally, the TRAFs were compared to the signal transducers and activators of transcription (STAT) protein family, due to their sequence homology, and the presence of multiple RING- and zinc-finger domains, suggesting that their function may be to regulate transcriptional activity (Rothe et al., …

Allometry Of The Duration Of Flight Feather Molt In Birds, Sievert Rohwer, Robert Ricklefs, Vanya Rohwer, Michelle Copple

Biology Department Faculty Works

No abstract provided.

Nutrient Limitation On Phytoplankton Growth In The Upper Barataria Basin, Louisiana: Microcosm Bioassays, Ling Ren, Nancy N. Rabalais, R. Eugene Turner, Wendy Morrison, Warren Mendenhall

Faculty Publications

The Davis Pond Diversion (DPD) was constructed to divert Mississippi River (MR) water into the Barataria Basin to reduce the salinity in support of wetland restoration on the Louisiana coast. To assess the phytoplankton nutrient limitation in adjacent water systems and potential impacts of DPD, 12 seasonal nutrient-phytoplankton bioassay experiments were conducted from October 2003 to July 2004 using the natural phytoplankton assemblages from freshwater and brackish-water lakes, Cataouatche and Salvador, LA (USA), which receive Mississippi River water from the DPD, and from a nearby freshwater lake, Lac des Allemands, that does not. Dissolved inorganic nitrogen (N), phosphorus (P), and …

Um Awards Scholarships To Incoming Missoula Students, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Novel Cinchona Alkoloid Derived Ammonium Salts As Phase-Transfer Catalysts For The Asymmetric Synthesis Of Beta-Hydroxy Alpha-Amino Acids Via Aldol Reactions And Total Synthesis Of Celogentin C., Bing Ma

Theses and Dissertations

Project I. Cinchona alkaloid-derived quaternary ammonium salts have been successfully used as phase-transfer catalysts, particularly in asymmetric alkylations. Our group applied this type of catalyst in the synthesis of β-hydroxy α-amino acids via aldol reactions and discovered that the Park-Jew catalyst afforded good yields and good enantiomeric excess of the syn diasteromers, but negligible diastereoselectivity. This project was therefore focused on the synthesis of novel cinchonidine-derived catalysts with the Park-Jew catalyst as the lead structure. The C3 position of cinchonidine nucleus was modified to achieve dimers and catalysts possessing electron-deficient alkyne and alkene moieties. Synthesized catalysts were tested in the …

Methods To Identify Plant Metabolites, Deane L. Falcone, John M. Littleton

Plant and Soil Sciences Faculty Patents

This invention provides materials and methods to manipulate the plant genome at the level of single plant cells in culture resulting in the ability to assign metabolic functionality to plant genes involved in the production of biologically active molecules and to create a means of product discovery based on the biosynthetic capacity of plants. The materials to create an activation mutagenesis include incorporation of enhancer sequences from a plant viral promoter at random places in the plant genome via Agrobacterium mediated DNA transfer (T-DNA). The usefulness is that genes in the immediate vicinity of the incorporation were activated which allows …

New Study Focuses On Mercury Cycling In Great Bay Ecosystem, Rebecca Zeiber

Media Relations

No abstract provided.

Florida Sentinel Bulletin, June 16, 2009, Gwen Hayes

Florida Sentinel Bulletin Collection

The June 16, 2009, issue of the Florida Sentinel Bulletin.

Soundings 2009-06, N/A N/A

Soundings

No abstract provided.

The Eagleville Times,Volume 7, Issue 12, Debbie Ryan

Eagleville Times

No abstract provided.

Kailua-Kona Student Receives Um Scholarship, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Cancer Institute Selects Chemistry Professor To Receive Three-Year Grant, Winthrop University

Winthrop News 2009

• The three-year grant will build on Sumter's associated with the initiation and progression of cancer.
• Sumter and other faculty members have have been awarded five major grants totaling more than $1 million in funding for Winthrop undergraduate research.

A Context-Aware Approach Based On Self-Organizing Maps To Study Web-Users' Tendencies From Their Behaviour, Luca Longo, Stephen Barrett

Conference papers

In the context of a highly volatile web of uneven quality, the identification of content deemed valuable by end users is of paramount importance. Where page content undergoes rapid change, this issue is particularly challenging. Web browsing activity represents a unique source of context by which the value of web pages can be determined via an assessment of individual user interactions, such as scrolling, clicking, saving and so forth. Over time, this data set forms a pattern of activity which can be mined for meaning. In this paper we present an approach to web content, based on Kohonen mapping, used …

06-15-2009 High School Students Attend Swosu Science & Math Academy, Southwestern Oklahoma State University

THE BARK ARCHIVE 2009

Twenty-one high school juniors and seniors attended the Summer Science and Mathematics Academy June 1-12 at Southwestern Oklahoma State University in Weatherford.

Departing Moments, Judith Pokras

Westview

No abstract provided.

A Unique Group I Intron In Coxiella Burnetii Is A Natural Splice Mutant, Rahul Raghavan, Linda D. Hicks, Michael F. Minnick

Biological Sciences Faculty Publications

Cbu.L1917, a group I intron present in the 23S rRNA gene of Coxiella burnetii, possesses a unique 3'-terminal adenine in place of a conserved guanine. Here, we show that, unlike all other group I introns, Cbu.L1917 utilizes a different cofactor for each splicing step and has a decreased self-splicing rate in vitro.

Role Of Inn1 And Its Interactions With Hof1 And Cyk3 In Promoting Cleavage Furrow And Septum Formation In S. Cerevisiae, R. Nishihama, J. H. Schreiter, M. Onishi, Elizabeth A. Vallen, J. Hanna, K. Moravcevic, Margaret Flynn Lippincott , '01, Haesun Han , '08, M. A. Lemmon, J. R. Pringle, E. Bi

Biology Faculty Works

Cytokinesis requires coordination of actomyosin ring (AMR) contraction with rearrangements of the plasma membrane and extracellular matrix. In Saccharomyces cerevisiae, new membrane, the chitin synthase Chs2 (which forms the primary septum [PS]), and the protein Inn1 are all delivered to the division site upon mitotic exit even when the AMR is absent. Inn1 is essential for PS formation but not for Chs2 localization. The Inn1 C-terminal region is necessary for localization, and distinct PXXP motifs in this region mediate functionally important interactions with SH3 domains in the cytokinesis proteins Hof1 (an F-BAR protein) and Cyk3 (whose overexpression can restore PS …

Central Florida Future, Vol. 41 No. 52, June 15, 2009

Central Florida Future

Students views vary as parents join site; The energy drink crisis; Caffeine effects; Parking conflict sparks protest; Author's book captivates audience.

A Cox-2 Inhibitor Nimesulide Analog Selectively Induces Apoptosis In Her2 Overexpressing Breast Cancer Cells Via Cytochrome C Dependent Mechanisms, Bin Chen, Bin Su, Shiuan Chen

Chemistry Faculty Publications

Epidemiological and animal model studies have suggested that non-steroidal anti-inflammatory drugs (NSAIDs) can act as chemopreventive agents. The cyclooxygenase-2 (COX-2) inhibitor nimesulide shows anti-cancer effect in different type of cancers. In the current study, five breast carcinoma cell lines were used to explore the anti-cancer mechanisms of a nimesulide derivative compound 76. The compound dose dependently suppressed SKBR-3, BT474 and MDA-MB-453 breast cancer cell proliferation with IC50 of 0.9 μM, 2.2 μM and 4.0 μM, respectively. However, it needs much higher concentrations to inhibit MCF-7 and MDA-MB-231 breast cancer cell growth with IC50 at 22.1 μM and 19.6 μM, respectively. …

Isca/Sufa Paralogues Are Required For The [4fe-4s] Cluster Assembly In Enzymes Of Multiple Physiological Pathways In Escherichia Coli Under Aerobic Growth Conditions, Guoqiang Tan, Jianxin Lu, Jacob P. Bitoun, Hao Huang, Huangen Ding

Faculty Publications

IscA/SufA paralogues are the members of the iron-sulfur cluster assembly machinery in Escherichia coli. Whereas deletion of either IscA or SufA has only a mild effect on cell growth, deletion of both IscA and SufA results in a null-growth phenotype in minimal medium under aerobic growth conditions. Here we report that cell growth of the iscA/sufA double mutant (E. coli strain in which both iscA and sufA had been in-frame-deleted) can be partially restored by supplementing with BCAAs (branched-chain amino acids) and thiamin. We further demonstrate that deletion of IscA/SufA paralogues blocks the [4Fe-4S] cluster assembly in IlvD (dihydroxyacid dehydratase) …

June 15, 2009 Reporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Behavior Of Chemically Dispersed Oil In Marine Sediment, Jian Hua

Journal of Marine Science and Technology–Taiwan

This laboratory study was to describe properties of four chemically dispersed oils within natural beach sands. The influence of temperature on the adsorption characteristics of dispersed oil to marine sediment was almost negligible, within 10 to 30°C. With certain amount of oil and varied dispersant/oil ratio, oil in top sediments following flushing was not affected by the increase in dispersant application. The application dosage of dispersant had no more influence on releasing oil to deeper sediment or water than the amount of oil applied. When the outflow rate of flushing water doubled, the amounts of oil retained in surface sediment …

Kalman Filter Effective To Hydrologic Routing?, Yang-Liang Jeng, Rong-Che Chen, Chao-He Chang

Journal of Marine Science and Technology–Taiwan

Intake-generated tumbling motion has been recently proposed to enhance the turbulence level during compression stroke to promote the combustion rate and reduce operation variations. This study is to investigate the quality of the tumbling motion, especially for the engine with a bowl-in-piston. To overcome the difficulties on the flow visualization caused by the high-speed motion of a real engine, a transparent water-analogy-simulation system is designed based on similarity analysis and fabricated to model the operation of an actual engine. Benchmark tests including the qualitative flow visualization and quantitative full-field measurements using a high-speed PIA system have been conducted to study …

Monitor Newsletter June 15, 2009, Bowling Green State University

Monitor

Official Publication of Bowling Green State University for Faculty and Staff