Digital Commons Network^™

Classification And Energetics Of The Base-Phosphate Interactions In Rna, Craig L. Zirbel, Judit E. Šponer, Jiri Šponer, Jesse Stombaugh, Neocles B. Leontis

Chemistry Faculty Publications

Structured RNA molecules form complex 3D architectures stabilized by multiple interactions involving the nucleotide base, sugar and phosphate moieties. A significant percentage of the bases in structured RNA molecules in the Protein Data Bank (PDB) hydrogen-bond with phosphates of other nucleotides. By extracting and superimposing base-phosphate (BPh) interactions from a reduced-redundancy subset of 3D structures from the PDB, we identified recurrent phosphate-binding sites on the RNA bases. Quantum chemical calculations were carried out on model systems representing each BPh interaction. The calculations show that the centers of each cluster obtained from the structure superpositions correspond to energy minima on the …

Grieving Together And Apart: Bereaved Parents’ Contradictions Of Marital Interaction, Paige W. Toller, Dawn O. Braithwaite

Communication Faculty Publications

The researchers adopted relational dialectics theory (Baxter & Montgomery, 1996) to examine the discourse of 37 bereaved parents. Research questions guiding the study were what dialectical contradictions do bereaved parents experience when communicating with their marital partner after their child’s death and how do bereaved parents and their marital partners communicatively negotiate the dialectical contradictions they experience? Our analysis revealed that bereaved parents experienced a dialectical contradiction between trying to grieve their child’s death together as a couple and apart as individuals. Likewise, parents experienced a contradiction between being both open and closed when talking with one another about their …

Nonlinear Analysis Of Sitting Postural Sway Indicates Developmental Delay In Infants, Joan E. Deffeyes, Regina T. Harbourne, Anastasia Kyvelidou, Wayne A. Stuberg, Nikolaos Stergiou

Journal Articles

Background

Upright sitting is one of the first developmental motor milestones achieved by infants, and sitting postural sway provides a window into the developing motor control system. A variety of posture sway measures can be used, but the optimal measures for infant development have not been identified.

Methods

We have collected sitting postural sway data from two groups of infants, one with typical development (n = 33), and one with delayed development and either diagnosed with or at risk for cerebral palsy (n = 26), when the infants had developed to the point where they could just maintain …

"Individually, And On Behalf Of All Others Similarly Situated", Dolores Frese

Medieval Feminist Forum: A Journal of Gender and Sexuality

No abstract provided.

The Mineralization Front Of The Eastern Oyster Is Cellular, Andrew S. Mount, Neeraj V. Gohad, Mary Beth Johnstone, Karolyn Hansen, Douglas C. Hansen

Biology Faculty Publications

Abstract of Technical Paper Presented at the 101^st Annual Meeting National Shellfisheries Association Savannah, Georgia March 22–26, 2009

Cardioprotective Effect Of Adiponectin Is Partially Mediated By Its Ampk-Independent Antinitrative Action., Yajing Wang, Ling Tao, Yuexing Yuan, Wayne Bond Lau, Rong Li, Bernard L. Lopez, Theodore A. Christopher, Rong Tian, Xin-Liang Ma

Department of Emergency Medicine Faculty Papers

Adiponectin (APN) exerts its metabolic regulation largely through AMP-dependent protein kinase (AMPK). However, the role of AMPK in APN's antiapoptotic effect in ischemic-reperfused (I/R) adult cardiomyocytes remains incompletely understood. The present study was designed to determine the involvement of AMPK in the antiapoptotic signaling of APN. Cardiomyocytes from adult male mice overexpressing a dominant-negative alpha(2)-subunit of AMPK (AMPK-DN) or wild-type (WT) littermates were subjected to simulated I/R (SI/R) and pretreated with 2 microg/ml globular domain of APN (gAPN) or vehicle. SI/R-induced cardiomyocyte apoptosis was modestly increased in AMPK-DN cardiomyocytes (P < 0.05). Treatment with gAPN significantly reduced SI/R-induced apoptosis in WT cardiomyocytes as well as in AMPK-DN cardiomyocytes, indicating that the antiapoptotic effect of gAPN is partially AMPK independent. Furthermore, gAPN-induced endothelial nitric oxide synthase (eNOS) phosphorylation was significantly reduced in AMPK-DN cardiomyocytes, suggesting that the APN-eNOS signaling axis is impaired in AMPK-DN cardiomyocytes. Additional experiments demonstrated that treatment of AMPK-DN cardiomyocytes with gAPN reduced SI/R-induced NADPH oxidase overexpression, decreased superoxide generation, and blocked peroxynitrite formation to the same extent as that observed in WT cardiomyocytes. Collectively, our present study demonstrated that although the metabolic and eNOS activation effect of APN is largely mediated by AMPK, the superoxide-suppressing effect of APN is not mediated by AMPK, and this AMPK-independent antioxidant property of APN increased nitric oxide bioavailability and exerted significant antiapoptotic effect.

The Relationship Between Multiple Indicators Of Wellness And Parental Stress In Foster Parents, Sarah Gillingham

Dissertations

No abstract provided.

A Conceptual Integration Analysis Of Multiple Instructional Metaphors, Robert Johnson

Dissertations

The present study was conducted to investigate some of the practical implications of conceptual integration theory for educators. This research was a mixed-methods study exploring how improvements in understanding—learning—(as measured by a selectedresponse assessment) are reflected in changes in learner language (described in terms of conceptual integration patterns). After a pretest with open-response and selected-response prompts, two groups of young adult participants viewed different videos of a slightly different review lesson in genes, genetics, and heredity, the difference lying in two different metaphor conditions: the experimental group was shown a more “metaphorrich” version of the lesson using two classic metaphors …

2009 August Newsletter, Nancy Rockey

Human Subject Research Archive

No abstract provided.

August 2009 Commencement Program, Bowling Green State University

Commencement Programs

No abstract provided.

The Inner Experience Of Older Individuals, Todd Michael Seibert

UNLV Theses, Dissertations, Professional Papers, and Capstones

Older individuals are susceptible to the development of numerous age-related neurodegenerative disorders including Alzheimer’s Disease and Vascular Dementia. This is continuing to become a more serious social, financial, medical, and psychological problem as the average life span continues to increase across the world. Nevertheless, very little is known about the inner experience of older individuals. This study used Descriptive Experience Sampling (DES) to investigate the inner experience of twelve older individuals with and without cognitive impairment. Five of six unimpaired individuals were able to engage successfully in DES compared to only one individual with cognitive impairment. The findings suggest that …

Morphological Deformities As Biomarkers In Fish From Contaminated Rivers In Taiwan, Peter Lin Sun, William E. Hawkins, Robin M. Overstreet, Nancy J. Brown-Peterson

Faculty Publications

Tilapia (Oreochromis spp.) were collected seasonally from four contaminated rivers in southwestern Taiwan for studies of morphological deformities that could be used as biomarkers of contamination. Morphological deformities found in tilapia were separated into 15 categories. Overall, the prevalence of deformities such as split fins, lower lip extension and gill deformities were significantly related to various water quality parameters, including low DO and high ammonium, lead and zinc concentrations. The persistence of tilapia in polluted waters and the development of a suite of morphological deformities suggest that tilapia can be used as sentinels of non-point source pollution in rivers.

A Discrete Impulsive Model For Random Heating And Brownian Motion, John D. Ramshaw

Physics Faculty Publications and Presentations

The energy of a mechanical system subjected to a random force with zero mean increases irreversibly and diverges with time in the absence of friction or dissipation. This random heating effect is usually encountered in phenomenological theories formulated in terms of stochastic differential equations, the epitome of which is the Langevin equation of Brownian motion. We discuss a simple discrete impulsive model that captures the essence of random heating and Brownian motion. The model may be regarded as a discrete analog of the Langevin equation, although it is developed ab initio. Its analysis requires only simple algebraic manipulations and elementary …

Pandemic Flu Planning In Africa: Thoughts From A Nigerian Case Study, Cheryl Loeb, Lynn Mcgrath, Sudhir Devalia

Defense and Technology Papers

This paper discusses the Avian Influenza/Pandemic Influenza Policy Planning workshop held in Nigeria in June 2007, the objective of which was assisting selected Nigerian officials in evaluating their nation’s pandemic response plan.

Does Change In Timbre Alter Stereotypy Movements Exhibited By Three Persons With Diagnoses Of Mental Retardation And Autism Spectrum Disorder: Three Case Studies, Kathy Wade Webb

Dissertations

The purpose of this study was to observe and collect data while monitoring the responses of three individuals to recorded presentations of four folk songs. The individuals, or participants, were all residents of a state-run facility in the southern region of the United States. The participants were females diagnosed with mental retardation and autism spectrum disorder, and they all exhibited one or more stereotypy behaviors in some form or another. The primary purpose of the study was to see if change in timbre of the songs would alter the stereotypy movements exhibited by these participants as the songs were presented …

Optimizing Vitamin D Status To Reduce Colorectal Cancer Risk: An Evidentiary Review., Guiyun Zhou, Jill Stoitzfus, Beth A. Swan

College of Nursing Faculty Papers & Presentations

Vitamin D deficiency is common in the general public and in patients with cancer. Optimizing vitamin D intake is increasingly recognized in cancer risk reduction, particularly in decreasing colorectal cancer risk. Therefore, summarizing the current evidence to promote best practices related to vitamin D intake and colorectal cancer risk reduction is important. The objectives of this article are to examine the current evidence regarding the impact of vitamin D on colorectal cancer risk reduction and provide practice recommendations for clinicians. Relevant research articles from 2002-2008 were retrieved from multiple electronic databases. Reference lists of relevant articles also were searched manually. …

Exposure To Ultraviolet Radiation Causes Proteomic Changes In Embryos Of The Purple Sea Urchin, Strongylocentrotus Purpuratus, Joseph Paul Campanale

Master's Theses

The amount of solar ultraviolet radiation (UVR, 290-400 nm) reaching Earth’s surface is increasing due to ozone depletion and global climate change. Embryos of the purple sea urchin, Strongylocentrotus purpuratus, provide an ideal system for examining how UVR affects developing marine organisms and cells in general. To model the protein-mediated cell cycle response to UV-irradiation, six batches of S. purpuratus embryos were exposed to UVR, monitored for delays in the first mitotic division and examined for global proteomic changes. Embryos from each batch were exposed to or protected from artificial UVR for 25 or 60 min. Embryos treated with …

Scarred Images: Using Appearance As A Motivator To Reduce Driving Under The Influence Of Alcohol, Mary-Theresa Mcnabb

Dissertations

In response to continued driving under the influence of alcohol (DUI) amongst young adults and increased drinking and driving amongst females, the current study aimed to decrease such risky behavior using threats to appearance as a deterrent. One hundred and thirty-three undergraduates at the University of Southern Mississippi completed a threepart study after sequential assignment to one of three groups, a no-photo group, a crash scene photo group, or a personalized-photo group. Baseline measures were taken concerning participants' alcohol-related behaviors. One week later all groups were given statistical information commonly available in DUI prevention pamphlets together with strategies to avoid …

Inferring Gene Regulatory Networks From Time Series Microarray Data, Peng Li

Dissertations

The innovations and improvements in high-throughput genomic technologies, such as DNA microarray, make it possible for biologists to simultaneously measure dependencies and regulations among genes on a genome-wide scale and provide us genetic information. An important objective of the functional genomics is to understand the controlling mechanism of the expression of these genes and encode the knowledge into gene regulatory network (GRN). To achieve this, computational and statistical algorithms are especially needed.

Inference of GRN is a very challenging task for computational biologists because the degree of freedom of the parameters is redundant. Various computational approaches have been proposed for …

Classroom Management: Teacher Training, Attitudes And Beliefs, And Intervention Practices, Margaret Catherine Davis Ladner

Dissertations

This study examined the factors that are associated with teacher classroom management with regard to training, attitudes and beliefs, and intervention practices of general and special education teachers in dealing with classroom control. These factors were examined in general and special education classrooms. The participants for this study were teachers of kindergarten, 1st grade, 2nd grade and 3r grade students in three public school districts in a southeastern state. Participants were recruited through a convenience or voluntary sample selection.

The school districts chosen for this sample provide a good cross-section of schools; they were representative of buildings with different percentages …

Associations Of The Plasticity Region Ofh. Pyloriin Patients With Gastroduodenal Diseases, Javed Yakoob, Z Abbas, Shagufta Naz, Shahab Abid, Wasim Jafri

Section of Gastroenterology

No abstract provided.

Indications, Complications, And Techniques For Emergent Rapid Sequence Intubation Outside The Operating Room, Nicole Underdahl

Theses and Dissertations

Airway is the initial and single most important step in any Advanced Cardiac Life Support (ACLS), airway rescue, or trauma resuscitative algorithm. Without a patent airway, further resuscitative measures are futile. Rapid sequence intubation (RSD is a technique used by Certified Registered Nurse Anesthetists (CRNA) and other appropriately trained healthcare providers to secDre the airway in an attempt to regain physiological homeostasis in ihe failing patient. This procedure, however, is associated with substantial ri sks. A.dditional l.y, those oati.ents r-ec1uirin r2: RSI are often the most ..i. J ,_. critically ill with a multitude of other injuries or pathology. A …

Depression Symptom Changes As A Function Of Increased Creative Behavior Over A Two-Week Recording Period, Julie M. Grieves

Theses and Dissertations

Research in the area of creativity suggested that mild, but not severe, mood elevation may sometimes enhance creativity. While depression has been thought by some to reduce creativity, empirical support for this hypothesis has been elusive and the relationship between creativity and depression now seems more complex than previously considered. Conversely, there has been speculation that creative activity itself may have differential effects on mood, depending on the individual. Maladaptive perfectionism, theorized to be one of the intervening variables between depression and creativity, has been associated with higher levels of categorical thinking which may mitigate against the constructive reasoning thought …

Photoionization Of Rare Gas Clusters, Huaizhen Zhang

Dissertations

This thesis concentrates on the study of photoionization of van der Waals clusters with different cluster sizes. The goal of the experimental investigation is to understand the electronic structure of van der Waals clusters and the electronic dynamics. These studies are fundamental to understand the interaction between UV-X rays and clusters. The experiments were performed at the Advanced Light Source at Lawrence Berkeley National Laboratory. The experimental method employs angle-resolved time-of-flight photoelectron spectrometry, one of the most powerful methods for probing the electronic structure of atoms, molecules, clusters and solids.

The van der Waals cluster photoionization studies are focused on …

Exploring The Relationships Between White Racial Consciousness, Feminist Identity Development And Family Environment For White Undergraduate Women, Kara E. Wolff

Dissertations

Although the literature has emphasized the importance of understanding between White racial consciousness, feminist identity development and family environment. Based on the relationships described by the canonical functions considered noteworthy in the analyses three main findings appeared to emerge. First, family environments that were perceived by White undergraduate women to promote engagement with a variety of outside perspectives were related to more actively antiracist worldviews and well-developed feminist identities; while family environments perceived to reflect a more insular focus (i.e. less exposure to divergent opinions) were related to more prejudicial racial attitudes and less feminist identity development. Second, the more …

Functional State Following The Fontan Procedure., Ismee A. Williams, Lynn A. Sleeper, Steven D. Colan, Minmin Lu, Elizabeth A. Stephenson, Jane W. Newburger, Welton M. Gersony, Meryl S. Cohen, James F. Cnota, Andrew M. Atz, Richard V. Williams, Renee Margossian, Andrew J. Powell, Mario P. Stylianou, Daphne T. Hsu, Pediatric Heart Network Investigators, Girish S. Shirali

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Despite improvements in outcomes after completion of the Fontan circulation, long-term functional state varies. We sought to identify pre- and postoperative characteristics associated with overall function.

METHODS AND RESULTS: We analyzed data from 476 survivors with the Fontan circulation enrolled in the Pediatric Heart Network Fontan Cross-sectional Study. Mean age at creation of the Fontan circulation was 3.4 plus or minus 2.1 years, with a range from 0.7 to 17.5 years, and time since completion was 8.7 plus or minus 3.4 years, the range being from 1.1 to 17.3 years. We calculated a functional score for the survivors by …

The Troxel Aftermath: A Proposed Solution For State Courts And Legislatures, Sonya C. Garza

Louisiana Law Review

No abstract provided.

The Current Volume 20 : Issue 1, Nova Southeastern University

Student Newspapers

No abstract provided.

Rapid Evolution Of Sex-Pheromone-Producing Enzyme In Drosophila, Troy R. Shirangi, Héloïse D. Dufour, Thomas M. Williams, Sean B. Carroll

Biology Faculty Publications

A wide range of organisms use sex pheromones to communicate with each other and to identify appropriate mating partners. While the evolution of chemical communication has been suggested to cause sexual isolation and speciation, the mechanisms that govern evolutionary transitions in sex pheromone production are poorly understood. Here, we decipher the molecular mechanisms underlying the rapid evolution in the expression of a gene involved in sex pheromone production in Drosophilid flies. Long-chain cuticular hydrocarbons (e.g., dienes) are produced female-specifically, notably via the activity of the desaturase DESAT-F, and are potent pheromones for male courtship behavior in Drosophila melanogaster. We …

Towards Biomimetic Ceramic Coatings: Cellular Aspects Of Oyster Shell Biomineralization, Mary Beth Johnstone, Karolyn Hansen, Neeraj V. Gohad, Douglas C. Hansen, Andrew S. Mount

Biology Faculty Publications

Abstract of Technical Paper Presented at the 101^st Annual Meeting National Shellfisheries Association Savannah, Georgia March 22–26, 2009