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Transcriptional Regulation Of Cytokine Function In Airway Smooth Muscle Cells., Deborah Clarke, Gautam Damera, Maria B. Sukkar, Omar Tliba

College of Pharmacy Faculty Papers

The immuno-modulatory properties of airway smooth muscle have become of increasing importance in our understanding of the mechanisms underlying chronic inflammation and structural remodeling of the airway wall in asthma and chronic obstructive pulmonary disease (COPD). ASM cells respond to many cytokines, growth factors and lipid mediators to produce a wide array of immuno-modulatory molecules which may in turn orchestrate and perpetuate the disease process in asthma and COPD. Despite numerous studies of the cellular effects of cytokines on cultured ASM, few have identified intracellular signaling pathways by which cytokines modulate or induce these cellular responses. In this review we …

Mining Globally Distributed Frequent Subgraphs In A Single Labeled Graph, Xing Jiang, Hui Xiong, Chen Wang, Ah-Hwee Tan

Research Collection School Of Computing and Information Systems

Recent years have observed increasing efforts on graph mining and many algorithms have been developed for this purpose. However, most of the existing algorithms are designed for discovering frequent subgraphs in a set of labeled graphs only. Also, the few algorithms that find frequent subgraphs in a single labeled graph typically identify subgraphs appearing regionally in the input graph. In contrast, for real-world applications, it is commonly required that the identified frequent subgraphs in a single labeled graph should also be globally distributed. This paper thus fills this crucial void by proposing a new measure, termed G-Measure, to find globally …

Google Earth Dissemination Of Soil Survey Derived Interpretations For Land Use Planning, Nj Hamilton, B Mijatovic, Tg Mueller, Bd Lee, B. W. Kew, Cetin Haluk, Anastasios D. Karathanasis

Journal of Extension

The Cooperative Extension Service could help individuals and communities make more informed decisions regarding residential development by providing soil survey-derived land use assessment data through Google Earth, a popular Web-based map viewer. This article describes how existing data sets can be more readily visualized with commercially available Internet software and provides examples of how these maps can be interpreted for land use assessment. Finally, the opportunities and constraints of using Google Earth as a tool for disseminating land use planning information are described.

Ecological Principles—A Unifying Theme In Environmental Education, Michael T. Mengak, Holly E. Rutledge, Barbara Mcdonald

Journal of Extension

Using ecological principles to form the basis of a succinct list of general environmental education (EE) standards will bring unity and strength to EE. Environmental education literature supports the importance of understanding general ecological principles, and general ecological concepts are prevalent in both widely used and locally adapted EE programs. In addition, an understanding of general ecological principles is included in both NSES (National Science Education Standards) and NAAEE Guidelines for Excellence. This article presents an analysis of the frequency of ecological references in several EE programs and discusses the implications of general ecological principles as a common thread in …

Identifying Farmers' Interest In Growing Switchgrass For Bioenergy In Southern Virginia, Zhiyou Wen, John Ignosh, David Parrish, Jamie Stowe

Journal of Extension

Several factors are generating interest in growing switchgrass for energy. To understand farmers' perspectives on possible switchgrass cultivation, Cooperative Extension conducted a survey in south-central and southwestern Virginia. The survey found that 66% of respondents had heard of using switchgrass for bioenergy, yet only 43% indicated they would be interested in cultivating switchgrass even if the enterprise were profitable. Reluctance to consider growing a potentially profitable crop is likely due to an underdeveloped market and lack of familiarity with switchgrass culture. The results indicate an important role for Extension in conveying technical information to producers as biofuel markets develop.

Revolutionary Decision, Meredith Jones-Gray

Faculty Publications

No abstract provided.

Deep Rationality: The Evolutionary Economics Of Decision Making, Douglas T. Kenrick, Vladas Griskevicius, Jill M. Sundie, Norman P. Li, Jessica Yexin Li, Steven L. Neuberg

Research Collection School of Social Sciences

What is a “rational” decision? Economists traditionally viewed rationality as maximizing expected satisfaction. This view has been useful in modeling basic microeconomic concepts, but falls short in accounting for many everyday human decisions. It leaves unanswered why some things reliably make people more satisfied than others, and why people frequently act to make others happy at a cost to themselves. Drawing on an evolutionary perspective, we propose that people make decisions according to a set of principles that may not appear to make sense at the superficial level, but that demonstrate rationality at a deeper evolutionary level. By this, we …

Sharing Mobile Multimedia Annotations To Support Inquiry-Based Learning Using Mobitop, Khasfariyati Razikin, Dion Hoe-Lian Goh, Yin-Leng Theng, Quang Minh Nguyen, Thi Nhu Quynh Kim, Ee Peng Lim, Chew-Hung Chang, Kalyani Chatterjea, Aixin Sun

Research Collection School Of Computing and Information Systems

Mobile devices used in educational settings are usually employed within a collaborative learning activity in which learning takes place in the form of social interactions between team members while performing a shared task. We introduce MobiTOP (Mobile Tagging of Objects and People), a geospatial digital library system which allows users to contribute and share multimedia annotations via mobile devices. A key feature of MobiTOP that is well suited for collaborative learning is that annotations are hierarchical, allowing annotations to be annotated by other users to an arbitrary depth. A group of student-teachers involved in an inquiry-based learning activity in geography …

Lake Mead National Recreation Area Vegetation Monitoring And Analysis: Quarterly Progress Report, July 1, 2009 To September 30, 2009, Margaret N. Rees

Vegetation Monitoring

Executive Summary

• Weed Sentry staff surveyed over 55 miles and 311 acres (most of which was conducted by foot) this quarter.
• Planning for future Brassica tournefortii research projects has been implemented through collaboration between PLI and NPS staff.
• Preliminary results from ongoing Brassica tournefortii projects indicate little effect of disturbance on abundance of the species, but, as expected, the species benefitted with increased water availability
• Rare plant data monitoring and data entry for this season is complete.
• Pre-planning activities for the upcoming Northshore Road restoration plantings and evaluation were initiated.
• Gypsum restoration research is ongoing, data are being analyzed and …

Heat And Smoke Effects On Red Brome Soil Seed Banks, Scott R. Abella, E. Cayenne Engel

Public Policy and Leadership Faculty Research

Management of exotic plants that are annuals entails understanding and managing their soil seed banks. We completed a study of the influences of heat and liquid smoke on red brome (Bromus rubens) soil seed banks collected from Red Rock Canyon in southern Nevada as part of a collaborative fire effects monitoring effort with Bureau of Land Management - Las Vegas. We collected the samples from the 2005 Loop Fire, where we observed in a monitoring field study that exotic grasses such as red brome were relatively sparse in the first 2-3 years (which were during a dry period) following the …

Apollonius Of Perga: Historical Background And Conic Sections, Ashley Allen

Senior Honors Theses

Apollonius of Perga greatly contributed to geometry, specifically in the area of conics. Through the study of the “Golden Age” of Greek mathematics from about 300 to 200 B.C., Apollonius, who lived from about 262 to 190 B.C., is seen as an innovative geometer whose theories were eventually proved factual. By investigating his theorems on how the different kinds of conic sections are formed, the standard equations for each conic will be better understood. The achievements that have been made as a result of conics include flashlights to whispering galleries.

Antibiotic And Disinfectant Resistance Of Methicillin-Resistant Staphylococcus Aureus, Christopher Justin Steed

Senior Honors Theses

Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium that has developed an increasing resistance to antibiotic drugs. This bacterium is very prevalent in hospitals but is becoming more prevalent in community-based settings. The goals of this research are to test the antibiotic sensitivity of two strains of MRSA, discover the proper disinfectants to use in households and hospital settings, and develop and test antibiotic derivatives to determine the future of antibiotic use against this bacterium. Research indicated that each strain was resistant to β-lactam antibiotics as well as other antibiotics. Each strain tested was unique in its resistance against antibiotics, thus …

Mojave Applied Ecology Notes Fall 2009, Tom Monaco, Scott R. Abella, Amber Lee, James E. Deacon

Mojave Applied Ecology Notes

USDA working to manage invasive annual grasses, effects of heat and smoke on red brome soil seed bank, how burial depth and substrate affect germination of Sahara mustard and red brome, environmental effects of the southern Nevada groundwater project

Sparticus: Small Particles In Cirrus Science And Operations Plan, J. Mace, E. Jensen, G. Mcfarquhar, J. Comstock, T. Ackerman, David L. Mitchell, X. Liu, T. Garrett

Publications (E)

From a mass-weighted perspective, cirrus clouds exert an enormous influence on the radiative energy budget of the earth?s climate system. Owing to their location in the cold upper troposphere, cirrus can significantly reduce the outgoing longwave radiation while, at the same time, remaining relatively transmissive to solar energy. Thus, cirrus clouds are the only cloud genre that can exert a direct radiative warming influence on the climate system (Ackerman et al. 1988). It is not surprising, therefore, that general circulation models (GCMs) are especially sensitive to the presence of cirrus in the model atmosphere. Lohmann and Roeckner (1995), for instance, …

Unlv Magazine, Matthew K. Jacobsen, Holly Ivy De Vore, Lisa Arth, Cate Weeks, Greg Lacour, Tony Allen, Afsha Bawany, Barbara Cloud, Gian Galassi, Phil Hagen, Karyn S. Hollingsworth, Michelle Mouton, Erin O'Donnell

UNLV Magazine

No abstract provided.

Migration Dynamics Of The Northern Saw-Whet Owl In The Piedmont, Mountain, And Coastal Plain Provinces Of Virginia, Kyle E. Van Althuis

Senior Honors Theses

The Northern Saw-whet Owl (Aegolius acadicus) is a small common owl of which little is known. The saw-whet’s migration dynamics are particularly shrouded in mystery due to the secretive nature of this owl. This study examined data obtained by capturing owls with mist nets in order to better understand volume, timing, sex differences and age differences in migration in the Piedmont province of Virginia for 2002-2007. Comparative owl capture data from two other physiographic regions (Mountain and Coastal Plain) were also examined.

Migration flight volume was highest in the Mountain province and lowest in the Coastal Plain, while movements were …

Use Of Artificial Sweeteners And Fat-Modified Foods In Weight Loss Maintainers And Always-Normal Weight Individuals, Suzanne Phelan, W. Lang, D. Jordan, Rena R. Wing

Kinesiology and Public Health

Objective: The purpose of this study was to compare the dietary strategies, and use of fat- and sugar-modified foods and beverages in a weight loss maintainer group (WLM) and an always-normal weight group (NW).
Subjects: WLM (N=172) had maintained ≥10% weight loss for 11.5 years, and had a body mass index (BMI) of 22.0 kg m-2. NW (N=131) had a BMI of 21.3 kg m-2 and no history of being overweight. Three, 24-h recalls on random, non-consecutive days were used to assess dietary intake.
Results: WLM reported consuming a diet that was lower in fat (28.7 vs 32.6%, PConclusions: …

Analyzing The Effects Of Two Response To Intervention Tools, Oral Reading Fluency And Maze Assessments, In The Language Arts Classrooms Of Middle School Students, Donna Lyerly Jones

Doctoral Dissertations and Projects

This quantitative study analyzed data to find a valid and reliable assessment for progress monitoring also having predictive power of a student's future reading performance on a state-mandated standardized reading achievement evaluation. The Response to Intervention (RTI) model was implemented in the language arts classrooms of a rural middle school in northeast Georgia to study the effectiveness of instruction for all students, the at-risk, general, and advanced population. This study used Oral Reading Fluency (ORF) and Maze fluency assessments to monitor student progress and to analyze data to drive instruction. The data were gathered weekly over a 23 week period, …

Identification Of The [Fefe]-Hydrogenase Responsible For Hydrogen Generation In Thermoanaerobacterium Saccharolyticum And Demonstration Of Increased Ethanol Yield Via Hydrogenase Knockout, A. Joe Shaw, David A. Hogsett, Lee R. Lynd

Dartmouth Scholarship

Three putative hydrogenase enzyme systems in Thermoanaerobacterium saccharolyticum were investigated at the genetic, mRNA, enzymatic, and phenotypic levels. A four-gene operon containing two [FeFe]-hydrogenase genes, provisionally termed hfs (hydrogenase-Fe-S), was found to be the main enzymatic catalyst of hydrogen production. hfsB, perhaps the most interesting gene of the operon, contains an [FeFe]-hydrogenase and a PAS sensory domain and has several conserved homologues among clostridial saccharolytic, cellulolytic, and pathogenic bacteria. A second hydrogenase gene cluster, hyd, exhibited methyl viologen-linked hydrogenase enzymatic activity, but hyd gene knockouts did not influence the hydrogen yield of …

The George-Anne, Georgia Southern University

The George-Anne

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How The New Economics Can Improve Employment Discrimination Law, And How Economics Can Survive The Demise Of The "Rational Actor", Scott A. Moss, Peter H. Huang

William & Mary Law Review

Much employment discrimination law is premised on a purely money-focused "reasonable" employee, the sort who can be made whole with damages equal to lost wages, and who does not hesitate to challenge workplace discrimination. This type of "rational" actor populated older economic models but has been since modified by behavioral economics and research on happiness. Behavioral and traditional economists alike have analyzed broad employment policies, such as the wisdom of discrimination statutes, but the devil is in the details of employment law. On the critical damages-and liability issues the Supreme Court and litigators face regularly, the law essentially ignores the …

Creating A Category V: Conservation Perceptions And Cultural Changes In The Anjozorobe-Angavo Forest Corridor, Kate Wright

Independent Study Project (ISP) Collection

Local communities have long played an integral role in the realization of conservation goals and the success of protected areas in Madagascar. Since the appearance of human civilizations approximately 2,000 years ago (Brown 1995), the physical landscape of the island has undergone processes of adaptation to the practices of Malagasy people, while Malagasy cultures have in turn molded to fit their surroundings. The coevolution of nature and culture has produced a delicate environmental situation where human practices exploit but also conserve important natural resources, a situation that has been historically misinterpreted as intentional environmental destruction on the part of local …

Full Issue Fall 2009

Inscape

No abstract provided.

The Classic, Fall 2009, Public Relations

The Classic, 2000-2009

Zwemer View: Don't Keep It Secret; In Box; Executive Decisions; Campus Enhancements; Spanglish Hoops; Of Course: You in Context; Mission Minor; Teaching Leader; First-Year Faculty: Weston Cutter, Yin Lam (Nicole) Lee, Jonathan Sabo, Richard Sowienski; Courses Online; Compiling Kudos; Face Value: Dave Nonnemacher; On Board; Music Maker: Kimberly Utke Svanoe retires after three decades at NWC; 1000 Words: Class Pride; Class Warfare; Funding Northwestern's Mission: 2008-09 giving spurred by $250,000 gift; Family Tree: Families who branch out through adoption grow in more ways than one; Red Ties; Class Notes; New Arrivals; Marriages; In Memoriam; Pen Pal; Wildlife Lover; Cities by …

When What You Don’T Know Can Hurt You: Third Party Liability For Fraudulent Misrepresentation In Non-Commercial Settings After Doe V. Dilling, 888 N.E.2d 24 (Ill. 2008), Laura Barke

Southern Illinois University Law Journal

Fraudulent misrepresentation actions most commonly arise in the commercial context. In Doe v. Dilling, however, the plaintiff attempted to expand the tort’s usage to an extremely personal context and hold the parents of her fiancée liable for fraudulently misrepresenting her fiancée’s HIV status. Although this Casenote agrees that the Illinois Supreme Court reached the correct result in denying the plaintiff’s claim, it argues that the court failed to provide a clear framework for future cases. Because this case is susceptible to misinterpretation and could potentially bar all claims for fraudulent misrepresentation within non-commercial settings, this Casenote sets forth a test …

Jefferson Alumni Bulletin – Volume 58, Number 3, Fall 2009

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 58, Number 3, Fall 2009 Dean’s Message, page 2 Findings--Researchers Counter Allergy to Plavix with Steroids and Antihistamines, page 4 Why in the World Would You Go into Medicine Today?, page 6 Philadelphia 1918: The Flu Pandemic Hits Home, page 14 New Movie Underscores Healthcare Conflicts, page 20 Faculty Profile: Vincenzo Berghella, MD ’90, page 22 On Campus, page 24 Class Notes, page 28 Looking at Scholarships from Both Sides, page 36 Alumni Giving, page 38 In Memoriam, page 50 By the Numbers, page 53

Pathways To The Aviation Professoriate: An Investigation Into The Attributes And Backgrounds Of Professional Pilot Education Faculty, David Carl Ison

Applied Aerospace Science

"The purpose of this study was to identify the pathways professional pilot program faculty take to reach their positions. Data were collected through a survey that was distributed via the internet using Survey Monkey. Pathways were defined by investigations into the occupational and educational histories of the faculty. Also, demographic attributes of the faculty were collected to create a comprehensive picture of the faculty. Statistical analysis of the survey data was conducted using SPSS Graduate Pack software. The findings of the study indicate that professional pilot faculty take a range of occupational and educational pathways to reach their positions in …

2009 October, Office Of Communications & Marketing, Morehead State University.

Morehead State Press Release Archive, 1961 to the Present

Press releases for October of 2009.

High Content Screening Identifies Decaprenyl-Phosphoribose 2’ Epimerase As A Target For Intracellular Antimycobacterial Inhibitors, Thierry Christophe, Mary Jackson, Hee Kyoung Jeon, Denis Fenistein, Monica Contreras-Dominguez, Jaeseung Kim, Auguste Genovesio, Jean-Philippe Carralot, Fanny Ewann, Eun Hye Kim, Sae Yeon Lee, Sunhee Kang, Min Jung Seo, Eun Jung Park, Henrieta Skovierová, Ha Pham, Giovanna Riccardi, Ji Youn Nam, Laurent Marsollier, Marie Kempf, Marie-Laure Joly-Guillou, Taegwon Oh, Won Kyung Shin, Zaesung No, Ulf Nehrbass, Roland Brosch, Stewart T. Cole

Faculty and Staff Publications

A critical feature of Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB), is its ability to survive and multiply within macrophages, making these host cells an ideal niche for persisting microbes. Killing the intracellular tubercle bacilli is a key requirement for efficient tuberculosis treatment, yet identifying potent inhibitors has been hampered by labor-intensive techniques and lack of validated targets. Here, we present the development of a phenotypic cell-based assay that uses automated confocal fluorescence microscopy for high throughput screening of chemicals that interfere with the replication of M. tuberculosis within macrophages. Screening a library of 57,000 small molecules led …

Patrick Lee And Robert P. George, Body-Self Dualism In Contemporary Ethics And Politics, Daniel N. Robinson

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.