Digital Commons Network^™

Oct-1 As An Oncoprotein And Use Of Nucleic Acid Inhibitors Of Oct-1 For Cancer Treatment, George Blanck, Kimberly Palubin, Aaron Osborne

USF Patents

Oct-1 is shown to be an oncoprotein because of its known role as an activator of the histone H2B gene and the importance of this gene during DNA synthesis. To determine the role of Oct-1 as an oncoprotein, the cell line 5637 (ATCC HTB9) was transfected with the vector pcDNA3 containing full length, antisense Oct-1 cDNA. This cell line is Rb-defective and has been shown to have increased Oct-1 binding activity as compared to Rb reconstituted clones. After transfection, Oct-1 antisense clones were grown and assayed for the loss of oncogenic characteristics as compared to control transformants.

Targeting Of Long Chain Triacylglycerol Hydrolase Gene For Tuberculosis Treatment, Pappachan Kolattukudy, Jaiyanth Daniel, Chirajyoti Deb

UCF Patents

Tuberculosis, caused by the organism Mycobacterium tuberculosis, is one of the major public health threats in the world. The emergence of multidrug resistant strains poses serious threats to the control of this disease due to the complex nature of second-line drug treatment. Upon infection, the bacterium goes through an initial replication phase after which it enters a nonreplicative, drug-resistant state of dormancy. The bacterium is able to survive in this dormant state for decades until the hosts immune system is weakened when it reactivates and causes the infectious disease.

2009 University Of Alaska Southeast Comprehensive Self Study Report, The Office Of The Provost

Accreditation Documents

No abstract provided.

A Full-Scale Evaluation Committee Report, University Of Alaska Southeast Juneau, Sitka, Ketchikan, October 6-9, 2009, Northwest Association Of Schools And Colleges

Accreditation Documents

A Confidential Report Prepared for the Commission on Colleges that Represents the Views of the Evaluation Committee

The Current Volume 20 : Issue 9, Nova Southeastern University

Student Newspapers

No abstract provided.

Inhibition Of Rna Recruitment And Replication Of An Rna Virus By Acridine Derivatives With Known Anti-Prion Activities, Zsuzsanna Sasvari, Stéphane Bach, Marc Blondel, Peter D. Nagy

Plant Pathology Faculty Publications

BACKGROUND: Small molecule inhibitors of RNA virus replication are potent antiviral drugs and useful to dissect selected steps in the replication process. To identify antiviral compounds against Tomato bushy stunt virus (TBSV), a model positive stranded RNA virus, we tested acridine derivatives, such as chlorpromazine (CPZ) and quinacrine (QC), which are active against prion-based diseases.

METHODOLOGY/PRINCIPAL FINDINGS: Here, we report that CPZ and QC compounds inhibited TBSV RNA accumulation in plants and in protoplasts. In vitro assays revealed that the inhibitory effects of these compounds were manifested at different steps of TBSV replication. QC was shown to have an effect …

Harnessing Gene Expression To Identify The Genetic Basis Of Drug Resistance, Bo-Juen Chen, Helen C. Causton, Denesy Mancenido, Noel L. Goddard, Ethan O. Perlstein, Dana Pe'er

Publications and Research

The advent of cost-effective genotyping and sequencing methods have recently made it possible to ask questions that address the genetic basis of phenotypic diversity and how natural variants interact with the environment. We developed Camelot (CAusal Modelling with Expression Linkage for cOmplex Traits), a statistical method that integrates genotype, gene expression and phenotype data to automatically build models that both predict complex quantitative phenotypes and identify genes that actively influence these traits. Camelot integrates genotype and gene expression data, both generated under a reference condition, to predict the response to entirely different conditions. We systematically applied our algorithm to data …

Spartan Daily October 13, 2009, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 133, Issue 24

October 13, 2009, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Monitoring Early Season Mosquito And Bird Populations: Implications For West Nile Virus In Lancaster County, Nebraska, Jason Thiele, Trevor Hefley, Lindsay Beck-Johnson, Emily Matthews

RURALS: Review of Undergraduate Research in Agricultural and Life Sciences

West Nile virus (WNV) surveillance efforts in Nebraska focus on the late summer and early fall months. We studied mosquito and bird populations in Lancaster County, Nebraska to evaluate the potential for WNV transmission in the late spring and early summer, prior to occurrences of human WNV infections. Culex tarsalis is the most important vector of WNV in Nebraska and was the focal species for the study. Mosquitoes were trapped at six locations representing three habitat types from May 14 to July 11, 2007. The C. tarsalis population, as estimated by the number of individuals caught in the traps each …

Mustang Daily, October 12, 2009

Cal Poly Student Newspaper

Student newspaper of California Polytechnic State University, San Luis Obispo, CA.

The Chanticleer, 2009-10-12, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

Insertion Sequence Content Reflects Genome Plasticity In Strains Of The Root Nodule Actinobacterium Frankia, Derek M. Bickhart, Johann P. Gogarten, Pascal Lapierre, Louis S. Tisa, Philippe Normand, David R. Benson

Molecular, Cellular & Biomedical Sciences

Background: Genome analysis of three Frankia sp. strains has revealed a high number of transposable elements in two of the strains. Twelve out of the 20 major families of bacterial Insertion Sequence (IS) elements are represented in the 148 annotated transposases of Frankia strain HFPCcI3 (CcI3) comprising 3% of its total coding sequences (CDS). EAN1pec (EAN) has 183 transposase ORFs from 13 IS families comprising 2.2% of its CDS. Strain ACN14a (ACN) differs significantly from the other strains with only 33 transposase ORFs (0.5% of the total CDS) from 9 IS families. Results: Insertion sequences in the Frankia genomes were …

October 12, 2009, James Madison University

The Breeze, 2000-2009

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Spartan Daily October 12, 2009, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 133, Issue 23

Current, October 12, 2009, University Of Missouri-St. Louis

Current (2000s)

No abstract provided.

The Statesman, V. 53, I. 11, Stony Brook University

Stony Brook Statesman-Sucolian

v. 53, i. 11

This Week At Sbs, V.4, N.07 | This Week At Stony Brook Southampton/In The News, Darren Johnson

Southampton Announcements and News

No abstract provided.

Nutrient Removal & Greenhouse Gas Abatement With Co2 Supplemented Algal High Rate Ponds, Ian Woertz, Laura Fulton, Tryg Lundquist

Civil and Environmental Engineering

High rate algae ponds fed clarified domestic wastewater and CO₂-rich flue gas are expected to remove nutrients to concentrations similar to those achieved in mechanical treatment technologies, such as activated sludge. However, the energy intensity of wastewater treatment with CO₂-supplemented high rate ponds (HRPs) would be less than that of mechanical treatments. In conjunction with anaerobic digestion of algal biomass and co-substrates, the algae-based system would produce a substantial excess of electricity. Greenhouse gas abatement from such CO₂-HRP/digestion systems would stem mainly from energy conservation and the offset of fossil fuel electricity with biogas-derived …

Grand Valley Forum, Volume 034, Number 07, October 12, 2009, Grand Valley State University

2009-2010, Volume 34

Grand Valley Forum is Grand Valley State's faculty and staff newsletter, published from 1976 to the present.

Monitor Newsletter October 12, 2009, Bowling Green State University

Monitor

Official Publication of Bowling Green State University for Faculty and Staff

The Collegian (2009-10-12), Julianna Sosa

UTB/TSC Archives - The Collegian [Newspaper]

Vol. 62, No. 8

Crow's Nest, October 12, 2009, Crow's Nest Staff

Crow's Nest

The October 12, 2009, issue of the Crow's Nest.

The Daily Gamecock, Monday, October 12, 2009, University Of South Carolina, Office Of Student Media

October

No abstract provided.

October 12th 2009, Csusb

Coyote Chronicle (1984-)

No abstract provided.

Post Partum Anxiety And Depression In Peri-Urban Communities Of Karachi, Pakistan: A Quasi-Experimental Study, Niloufer Sultan Ali, Badar S. Ali, Iqbal Azam Syed

Department of Family Medicine

Background: Postpartum anxiety and depression is a major public health concern because of its adverse effects on the cognitive and social development of the infant. Globally postpartum depression has been widely investigated but as anxiety is a more prominent feature of postpartum depression we assessed the prevalence of anxiety and depression and their associated factors in post partum women.
Methods: A quasi-experimental study investigating the impact of postpartum anxiety and depression on child growth and development was conducted in two peri-urban, multiethnic, communities of Karachi, a mega city of Pakistan. A house to house questionnaire based survey was done by …

Biogas Production From Algae Biomass Harvested At Wastewater Treatment Ponds, Michael Salerno, Yakup Nurdogan, Tryg J. Lundquist

Civil and Environmental Engineering

Waste-grown microalgae are a potentially important biomass for biofuel production. However, most of the 7,000 wastewater treatment ponds systems in the US do not use algae harvesting. Those that do, typically return the biomass to the ponds, where it decomposes on the pond floor, releasing methane to the atmosphere and degrading water quality. Instead, the algae biomass could be processed in anaerobic digesters. Algae typically yield less methane than wastewater sludge (~0.3 vs. 0.40 L CH4/g volatile solids introduced). Ammonia toxicity and recalcitrant cell walls are commonly cited causes of the lower yields. Ammonia toxicity might be counteracted by co-digesting …

Altruistic Task Allocation Despite Unbalanced Relationships Within Multi-Robot Communities, Ryan Morton, George A. Bekey, Christopher M. Clark

Computer Science and Software Engineering

Typical Multi-Robot Systems consist of robots cooperating to maximize global fitness functions. However, in some scenarios, the set of interacting robots may not share common goals and thus the concept of a global fitness function becomes invalid. This work examines Multi-Robot Communities(MRC), in which individual robots have independent goals. Within the MRC context, we present a task allocation architecture that optimizes individual robot fitness functions over long time horizons using reciprocal altruism.

Previous work has shown that reciprocating altruistic relationships can evolve between two willing robots, using market-based task auctions, while still protecting against selfish robots aiming to exploit …

Trophic Structure Of The Northwest Hawaiian Islands And Resident Monk Seals (Monachus Schaundslandi) During The Twentieth Century, Nina M. Thompson, Amy Hirons, Charles W. Potter, Charles Littnan

Marine & Environmental Sciences Faculty Proceedings, Presentations, Speeches, Lectures

The Hawaiian monk seal (Monachus schauinslandi) is an endangered species only found within the Hawaiian Archipelago. The majority of the breeding population for this seal is located around six islands in the Northwest Hawaiian Island chain (NWHI). Overall, both juvenile and adult seals have a wide range in δ¹³C and δ¹⁵N from 1912-2006 (δ¹³C: -12.5‰; δ¹⁵N: 12.6‰). Seals in the northern NWHI were enriched in δ¹³C by nearly 2‰ and depleted in δ¹⁵N by nearly 6‰ during the 96 years. Meanwhile, seals within the middle and …

Protection Against Mucosal Shiv Challenge By Peptide And Helper-Dependent Adenovirus Vaccines, Eric A. Weaver, Pramod N. Nehete, Bharti P. Nehete, Stephanie J. Buchl, Donna Palmer, David C. Montefiori, Philip Ng, K. Jagannadha Sastry, Michael A. Barry

Nebraska Center for Virology: Faculty Publications

Groups of rhesus macaques that had previously been immunized with HIV-1 envelope (env) peptides and first generation adenovirus serotype 5 (FG-Ad5) vaccines expressing the same peptides were immunized intramuscularly three times with helperdependent adenovirus (HD-Ad) vaccines expressing only the HIV-1 envelope from JRFL. No gag, pol, or other SHIV genes were used for vaccination. One group of the FG-Ad5- immune animals was immunized three times with HD-Ad5 expressing env. One group was immunized by serotype-switching with HD-Ad6, HD-Ad1, and HD-Ad2 expressing env. Previous work demonstrated that serum antibody levels against env were significantly higher in the serotype-switched group than in …