Digital Commons Network^™

The Interaction Of Hab18g/Cd147 With Integrin Alpha6beta1 And Its Implications For The Invasion Potential Of Human Hepatoma Cells., Jing-Yao Dai, Ke-Feng Dou, Cong-Hua Wang, Pu Zhao, Wayne Bond Lau, Ling Tao, Ya-Mei Wu, Juan Tang, Jian-Li Jiang, Zhi-Nan Chen

Department of Emergency Medicine Faculty Papers

BACKGROUND: HAb18G/CD147 plays pivotal roles in invasion by hepatoma cells, but the underlying mechanism remains unclear. Our previous study demonstrated that overexpression of HAb18G/CD147 promotes invasion by interacting with integrin alpha3beta1. However, it has never been investigated whether alpha3beta1 is solely responsible for this process or if other integrin family members also interact with HAb18G/CD147 in human hepatoma cells. METHODS: Human SMMC-7721 and FHCC98 cells were cultured and transfected with siRNA fragments against HAb18G/CD147. The expression levels of HAb18G/CD147 and integrin alpha6beta1 were determined by immunofluorescent double-staining and confocal imaging analysis. Co-immunoprecipitation and Western blot analyses were performed to examine …

The Political Economy Of Patent Policy Reform In The United States, F. M. Scherer

Colorado Technology Law Journal

No abstract provided.

The New "Emergence Economics" Of Innovation And Growth, And What It Means For Communications Policy, Richard S. Whitt, Stephen J. Schultze

Colorado Technology Law Journal

No abstract provided.

Don't Send A Lawyer To Do An Engineer's Job: How Advancing Technology Changes The Software Monoculture Debate, John Bergmayer

Colorado Technology Law Journal

No abstract provided.

Evaluation Of The Effectiveness Of The Senior Year Plus Program In Iowa, Andrew Q. Morse

Honors Program Theses

Iowa’s public institutions graduate students with the sixth highest student loan debt in the nation (Project on Student Debt, 2008). As a result, Iowa Governor Chet Culver has proposed the Senior Year Plus Program, which is a state-funded dual-enrollment program. This program’s purpose is to help alleviate the debts students incur while attending college. However, there are no examinations to this point that focus on the financial, as well as the personal and professional developmental benefits of the program, particularly in comparison to the four-year institution. The current research utilized a qualitative research design. Ten (5 Dual-Enrollers/5 Non-Dual Enrollers) participants …

Microscopic Investigation Of Reversible Nanoscale Surface Size Dependent Protein Conjugation, Kazushige Yokoyama, Hyunah Cho, Sean P. Cullen, Matthew Kowalik, Nicole M. Briglio, Harold Hoops, Zhouying Zhao, Michael A. Carpenter

Biology

Aβ1-40 coated 20 nm gold colloidal nanoparticles exhibit a reversible color change as pH is externally altered between pH 4 and 10. This reversible process may contain important information on the initial reversible step reported for the fibrillogenesis of Aβa hallmark of Alzheimer's disease). We examined this reversible color change by microscopic investigations. AFM images on graphite surfaces revealed the morphology of Aβ aggregates with gold colloids. TEM images clearly demonstrate the correspondence between spectroscopic features and conformational changes of the gold colloid. © 2009 by the authors.

De Novo Assembly Using Low-Coverage Short Read Sequence Data From The Rice Pathogen Pseudomonas Syringae Pv. Oryzae, Josephine A. Reinhardt, David A. Baltrus, Marc T. Nishimura, William R. Jeck, Corbin D. Jones, Jeffery L. Dangl

Biology

We developed a novel approach for de novo genome assembly using only sequence data from high-throughput short read sequencing technologies. By combining data generated from 454 Life Sciences (Roche) and Illumina (formerly known as Solexa sequencing) sequencing platforms, we reliably assembled genomes into large scaffolds at a fraction of the traditional cost and without use of a reference sequence. We applied this method to two isolates of the phytopathogenic bacteria Pseudomonas syringae. Sequencing and reassembly of the well-studied tomato and Arabidopsis pathogen, PtoDC3000, facilitated development and testing of our method. Sequencing of a distantly related rice pathogen, Por1-6, demonstrated our …

Transcriptional Profiling And Functional Analysis Of Heterokaryon Incompatibility In Neurospora Crassa Reveals That Reactive Oxygen Species, But Not Metacaspases, Are Associated With Programmed Cell Death, Elizabeth Hutchison

Biology

Heterokaryon incompatibility (HI) is a nonself recognition phenomenon occurring in filamentous fungi that is important for limiting resource plundering and restricting viral transfer between strains. Nonself recognition and HI occurs during hyphal fusion between strains that differ at het loci. If two strains undergo hyphal fusion, but differ in allelic specificity at a het locus, the fusion cell is compartmentalized and undergoes a rapid programmed cell death (PCD). Incompatible heterokaryons show a macroscopic phenotype of slow growth and diminished conidiation, and a microscopic phenotype of hyphal compartmentation and cell death. To understand processes associated with HI and PCD, we used …

Using Wisconsin Fast Plants To Incorporate Inquiry Into The General Biology Curriculum At Linn-Mar High School, Steven R. Meeker

Graduate Research Papers

This creative component is a culmination of what has been learned throughout the coursework of the Masters of Arts in Science Education Degree at the University of Northern Iowa. The curriculum that has been developed for this project is a series of three learning cycles that allow long-term inquiry labs to be incorporated directly into the existing General Biology curriculum at Linn-Mar High School. The inquiry lab use Wisconsin Fast Plants™ to teach about plant life cycles, ecology and the scientific method. It is expected that the inclusion of these learning cycles will infuse a constructivist framework into the curriculum …

Trends In Asthma Health Care Utilization At University Medical Center (Umc) Of Southern Nevada In Las Vegas, 2000-2007, Aishia Tennille Henderson

UNLV Theses, Dissertations, Professional Papers, and Capstones

Lifetime asthma prevalence is the physician diagnosis of asthma while current asthma prevalence is the existing asthma symptoms. In Nevada, the pediatric current and lifetime asthma prevalence rates were 7.1% and 11.8% in 2006. Similarly, the adult current and lifetime asthma prevalence rates were 6.9% and 13.4% in 2007.

Characterization studies examining trends of asthma health care utilization for children and adults are not well studied for Las Vegas, Nevada. This project determined if trends in asthma admissions at UMC hospital of Southern Nevada in Las Vegas have increased longitudinally across years and characterizes which demographic subgroups are disproportionately affected …

Mutation I810n In The Α3 Isoform Of Na+,K +-Atpase Causes Impairments In The Sodium Pump And Hyperexcitability In The Cns, Steven J. Clapcote, Steven Duffy, Gang Xie, Greer Kirshenbaum, Allison R. Bechard, Vivien Rodacker Schack, Janne Petersen, Laleh Sinai, Bechara J. Saab, Jason P. Lerch, Berge A. Minassian, Cameron A. Ackerley, John G. Sled, Miguel A. Cortez, Jeffrey T. Henderson, Bente Vilsen, John C. Roder

Psychology

In a mouse mutagenesis screen,weisolated a mutant, Myshkin (Myk), with autosomal dominant complex partial and secondarily generalized seizures, a greatly reduced threshold for hippocampal seizures in vitro, posttetanic hyperexcitability of the CA3-CA1 hippocampal pathway, and neuronal degeneration in the hippocampus. Positional cloning and functional analysis revealed that Myk/+ mice carry a mutation (I810N) which renders the normally expressed Na +,K+-. ATPase α3 isoform inactive. Total Na +,K+-ATPase activity was reduced by 42% in Myk/+ brain. The epilepsy in Myk/+ mice and in vitro hyperexcitability could be prevented by delivery of additional copies of wild-type Na+,K+-ATPase α3 by transgenesis, which also …

Computational Analysis Of Ultraviolet Reactors, Xiang Li

Theses

Disinfection of water treatment using ultraviolet (UV) light has received wide recognition as an important contribution to the protection of public health. To ensure a UV disinfection system that can deliver the required UV dose, analytical and numerical methods have been used to evaluate the flow field of the UV reactor. A Multiple Point Source Summation (MPSS) method was used to estimate the radiation intensity field, with the utilization of Computational Fluid Dynamics (CFD) technique. To couple the analytical model with numerical simulations, a user friendly interface software was developed to calculate the UV dosage distribution. In addition a UV …

16s Rrna Gene-Based Analysis Of Fecal Microbiota From Preterm Infants With And Without Necrotizing Enterocolitis, Yunwei Wang, Jeanette D. Hoenig, Kathryn J. Malin, Sanaa Qamar, Elaine O. Petrof, Jun Sun, Dionysios A. Antonopoulos, Eugene B. Chang, Erika C. Claud

College of Nursing Faculty Research and Publications

Neonatal necrotizing enterocolitis (NEC) is an inflammatory intestinal disorder affecting preterm infants. Intestinal bacteria play a key role; however no causative pathogen has been identified. The purpose of this study was to determine if there are differences in microbial patterns which may be critical to the development of this disease. Fecal samples from twenty preterm infants, ten with NEC and ten matched controls (including four twin pairs) were obtained from patients in a single site Level III neonatal intensive care unit. Bacterial DNA from individual fecal samples were PCR amplified and subjected to terminal restriction fragment length polymorphism analysis and …

Second-Stage Labor Care: Challenges In Spontaneous Bearing Down, Lisa Hanson

College of Nursing Faculty Research and Publications

Substantial scientific evidence supports spontaneous maternal bearing down for its associated maternal and fetal physiologic benefits. Imposing specific directions for Valsalva pushing does not result in optimal outcomes but continues to be widely used, particularly when labor progress is less than optimal. However, there are numerous evidence-based approaches that can be used to avoid reverting to directed, prolonged Valsalva bearing down. Nursing care challenges may be encountered when using physiologic approaches; therefore, strategies are detailed to alleviate a variety of problems including ways to promote physiological descent and effectively support women's spontaneous efforts. For example, maternal postural interventions are suggested …

A New Way Forward: A Response To Judge Weinstein, Elizabeth Chamblee Burch

Scholarly Works

This short essay responds to Judge Jack Weinstein's essay, Preliminary Reflections on Administration of Complex Litigations, 2009 Cardozo De Novo 1. In so doing, it also provides a condensed version of my earlier article, Litigating Groups, which analyzes group dynamics within nonclass aggregation. By drawing on the literature of moral and political philosophy as well as social psychology, I contend that, in the face of hard cases, of instability and disunity, plaintiffs who have made promises and assurances to one another can invoke social norms of promise-keeping, social agglomeration, compatibility, and the desire for means-end coherence to achieve consensus, mitigate …

Marine Protected Areas: Legal Framework For The Gully Off The Coast Of Nova Scotia (Canada), Paul Mcnab, David Vanderzwaag

Articles, Book Chapters, & Popular Press

The Gully, a submarine canyon hosting a rich diversity of marine life off Nova Scotia, was designated in 2004 under Canada’s Oceans Act 1996 as a marine protected area (MPA). This case study reviews the Gully MPA legal and management framework through a five-part discussion. First described is the overall Canadian law and policy context for establishing MPAs. Next, specific legislative and regulatory provisions governing the Gully MPA are summarized including the three types of management zones adopted, ranging from strict preservation to multi-use. Management approaches to control human activities in and around the MPA are then described, with a …

Safety First: Recognizing And Managing The Risks To Child Participants In Magnetic Resonance Imaging Research, Matthias Schmidt, Jocelyn Downie

Articles, Book Chapters, & Popular Press

Specialized and up-to-date knowledge is required to identify and manage the risks associated with advanced biomedical research. Additional complexities need to be considered when the research involves infants or young children. In this article, we focus on recent information about the physical risks of pediatric magnetic resonance imaging research and highlight information gaps. With an eye to assisting institutional review boards and researchers, we consider strategies for the management of these risks and formulate key questions aimed at exposing hidden hazards. Institutional review boards should ask these questions, and researchers should bear them in mind as they develop research protocols.

Sotl In Chemistry: How To Make The Learning Meaningful, Liberato Cardellini

International Journal for the Scholarship of Teaching & Learning

No abstract provided.

Click Or Clique? Using Educational Technology To Address Students’ Anxieties About Peer Evaluation, Ruth Walker, Graham Barwell

International Journal for the Scholarship of Teaching & Learning

Peer bias is recognised as a primary factor in negative student perceptions of peer assessment strategies. This study trialled the use of classroom response systems, widely known as clickers, in small seminar classes in order to actively engage students in their subject’s assessment process while providing the anonymity that would lessen the impact of peer pressure. Focus group reflection on the students’ impressions of the peer evaluation process, the use of clickers, and their anxieties about potential peer bias were analysed in the light of the results of teacher and class evaluations of each individual student presentation. The findings revealed …

(Re)Considering The Scholarship Of Learning: Inviting The Elephant In The Room To Tea, Ashlee Cunsolo Willox, Dale Lackeyram

International Journal for the Scholarship of Teaching & Learning

This essay argues that the SoT(L) field has mistakenly equated learning solely to teaching and the teaching classroom, and has systematically ignored the other moments and opportunities within higher education institutes where learning and scholarly learning occurs—particularly within academic support and development programming. Therefore, we endeavour to discuss what we see as the elephant in the SoT(L) living room—learning, scholarly learning, and the Scholarship of Learning—and examine the ways in which learning and the Scholarship of Learning can be brought back into the SoT(L) discussion through an examination of academic support and development programming. Through the creation of a new …

How Do Management Students Prefer To Learn? Why Should We Care?, Ednilson Bernardes, Mark Hanna

International Journal for the Scholarship of Teaching & Learning

This paper reports the findings of a study of the learning styles of students in the operations management class at a regional comprehensive university in southeastern United States. Extant learning styles are found to be highly diverse and differ by student gender. However, in contrast to at least one prior study, the learning styles of our respondents did not differ by student major. Five areas of opportunity for future research arising from the results of this study are identified in the paper’s conclusion.

Sustaining Student And Faculty Success: A Model For Student Learning And Faculty Development, David Concepción, Mellisa Holtzman, Paul Ranieri

International Journal for the Scholarship of Teaching & Learning

We begin this essay with a brief description of the four-year multidisciplinary faculty development project in which we participated. After describing some of the successes of the project, we argue that three elements of our approach were integral to the increases in student learning that were facilitated by project participants: (1) The Learning Question, Disciplinary Expertise, and Foundational Learning Theory, (2) Collaboration and Evaluation, and (3) Public Support and Professional Acknowledgement.

Glass Houses: The Power Of Money In Bioethics Research, Jocelyn Downie

Articles, Book Chapters, & Popular Press

In this paper I explore the power of money in bioethics research and ask whether, while casting stones regarding financial conflicts of interest in health research, bioethics researchers are in fact living in glass houses. I first review the need for money in bioethics research, the sources of money, and key features of the money (specifically, the amount of money involved and the fact that the money often is embedded, encumbered, and required to be matched). Next, I explore a range of possible objectives for the money transfer. I then examine the effects of this transfer and raise some questions …

A Citizen's Guide To Protecting Sandown's Wetlands And Water Resources, Sandown Conservation Commission

PREP Reports & Publications

No abstract provided.

Eighteenth Year Of The Gulf Of Maine Environmental Monitoring Program, Lawrence A. Leblanc, Christian Krahforst, Jamie Aube, Shawn Roach, Guy Brun, Gareth Harding, Peter Hennigar, David Page, Stephen H. Jones, Susan Shaw, James Stahlnecker, Jack Schwartz, Darrell Taylor, Bruce Thorpe, Peter Wells

PREP Reports & Publications

This report summarizes the metals and organic contaminant data associated with the collection and analyses of blue mussel (Mytilus edulis) tissue from selected sites along the Gulf of Maine coast during the 2008 sampling season. Contaminant monitoring is conducted by the Gulfwatch Program for the Gulf of Maine Council on the Marine Environment (GOMC). A subset of these data is compared with analytical results from earlier Gulfwatch monitoring (2001-2007). Statistical analyses are limited to descriptive measures of replicates from selected sampling sites and include: arithmetic means, and appropriate measures of variance. The primary purpose of this report is to present …

Healthy Planet, Healthy People: Integrating Global Health Into The International Response To Climate Change, Lindsay Wiley

Scholarly Articles in Law Reviews & Journals

The potentially groundbreaking negotiations currently underway on the international response to climate change and national implementation of commitments under the United Nations Framework Convention on Climate Change (UNFCCC) include a number of hotly contested issues: (1) what degree of climate change is acceptable as a basis for emissions targets, (2) to what extent and in what ways climate change mitigation should incorporate emissions reductions or increased sinks for developing countries, (3) whether the legal regime governing mitigation can take advantage of the huge mitigation potential of changed practices in the land use and agricultural sectors, (4) how adaptation should be …

An Economic Justification For Open Access To Essential Medicine Patents In Developing Countries, Sean Flynn, Aidan Hollis, Mike Palmedo

Scholarly Articles in Law Reviews & Journals

This paper offers an economic rationale for compulsory licensing of needed medicines in developing countries. The patent system is based on a trade-off between the “deadweight losses” caused by market power and the incentive to innovate created by increased profits from monopoly pricing during the period of the patent. However, markets for essential medicines under patent in developing countries with high income inequality are characterized by highly convex demand curves, producing large deadweight losses relative to potential profits when monopoly firms exercise profit-maximizing pricing strategies. As a result, these markets are systematically ill-suited to exclusive marketing rights, a problem which …

Law That Values All Families: Beyond (Straight And Gay) Marriage, Nancy Polikoff

Scholarly Articles in Law Reviews & Journals

No abstract provided.

Multiple Families, Multiple Goals, Multiple Failures: The Need For “Limited Equalization” As A Theory Of Child Support, Adrienne Jennings Lockie

Scholarly Articles in Law Reviews & Journals

Current child support laws are based on flawed assumptions about families that fail to reflect family complexity and the realities of parenting. Further, there has been little reevaluation of the stated goals of child support law since they were first implemented thirty years ago. The stated goals — fiscal savings, children’s economic well-being, and parental involvement — have not been achieved and are increasingly unlikely to be achieved because they ignore the way that children in multiple families — families in which at least one parent has had another child with a different partner —compete for the limited resources of …

Offspring And Bodies: Dependency And Vulnerability In The Constitutional Jurisprudence Of Reproductive Rights, Ann Shalleck

Scholarly Articles in Law Reviews & Journals

In this article, the author responds to Sherry Colb’s argument in "To Whom Do We Refer When We Speak of Obligations to “Future Generations”? Reproductive Rights and the Intergenerational Community," (77 GEO. WASH. L. REV. 1582 (2009)). Colb offered a new way to consider reproductive rights by delineating two distinct and not always overlapping interests at stake in giving meaning to and shaping the contours of the rights implicated in reproductive decisions. Through differentiating interests in bodily integrity and offspring selection, Colb disentangled underlying justifications for legal advocacy and judicial decisions and offered an interpretive frame through which to consider …