Digital Commons Network^™

Washington University Record, February 19, 2009

Washington University Record

No abstract provided.

Plants Used As Medicine By Paliyar Tribes Of Shenbagathope In Virudhunagar District Of Tamilnadu, India, S. Shanmugam, N. Gayathri, B. Sakthivel, S. Ramar, K. Rajendran

Ethnobotanical Leaflets

The traditional medicinal uses of 58 angiospermic plant species belonging to 54 genera of 31 families for various diseases and ailments like wounds, cuts, stomach pain, diabetes, fever, cold, poisonous bites etc., by the Paliyar tribes of Shenbagathope in Virudhunagar district of Tamilnadu, India, are mentioned. Generally, fresh part of the plant is used for the preparation of medicine. When fresh plant parts are not available, dried parts are also used. Attention should be made on proper exploitation and utilization of these ethnomedicinally important plant species.

Characterization Of Putative Self-Resistance Genes In The Biosynthetic Gene Cluster Of Hygromycin A From Streptomyces Hygroscopicus Nrrl 2388, Vidya Dhote

Dissertations and Theses

Streptomyces hygroscopicus NRRL 2388 produces an aminocyclitol antibiotic called hygromycin A (HA), which targets bacterial protein synthesis by inhibiting the peptidyl transferase reaction. The hyg6, hygl9, hyg21, hyg28, and hyg29 genes in the biosynthetic gene cluster of HA are predicted to confer self-resistance to the producer strain by different mechanisms. Targeted gene disruptions and in vitro characterization of recombinant proteins were carried out to elucidate the functions of these genes. The hyg21 gene encodes an O-phosphotransferase with a proposed role in HA inactivation by phosphorylation. Disruption of hyg21 led to a significant decrease in HA production but did not …

Bovine Spongiform Encephalopathy: European Union’S Reactions To The Crisis In The Uk, Alice Wieduwilt

ESSAI

No abstract provided.

The Lumberjack, February 11, 2009

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

Three Heroic Journeys, Brian Flanagan

Features

No abstract provided.

Bjc Today

BJC Today

No abstract provided.

Richard Whitley Appointed Distinguished Professor, Staff

Browse All News

No abstract provided.

Submicroscopic Gametocytes And The Transmission Of Antifolate-Resistant Plasmodium Falciparum In Western Kenya, Mayke J.A.M. Oesterholt, Michael Alifrangis, Colin J. Sutherland, Sabah A. Omar, Patrick Sawa, Christina Howitt, Louis C. Gouagna, Robert W. Sauerwein, Teun Bousema

All Peer-Reviewed Publications

Background: Single nucleotide polymorphisms (SNPs) in the dhfr and dhps genes are associated with sulphadoxine-pyrimethamine (SP) treatment failure and gametocyte carriage. This may result in enhanced transmission of mutant malaria parasites, as previously shown for chloroquine resistant parasites. In the present study, we determine the association between parasite mutations, submicroscopic P. falciparum gametocytemia and malaria transmission to mosquitoes. Methodology/Principal Findings: Samples from children treated with SP alone or in combination with artesunate (AS) or amodiaquine were genotyped for SNPs in the dhfr and dhps genes. Gametocytemia was determined by microscopy and Pfs25 RNA-based quantitative nucleic acid sequence-based amplification (Pfs25 QT-NASBA). …

Interconnections Between Sigma B, Agr, And Proteolytic Activity In Staphylococcus Aureus Biofilm Maturation, Katherine J. Lauderdale, Blaise R. Boles, Ambrose L. Cheung, Alexander R. Horswill

Dartmouth Scholarship

Staphylococcus aureus is a proficient biofilm former on host tissues and medical implants. We mutagenized S. aureus strain SH1000 to identify loci essential for ica-independent mechanisms of biofilm maturation and identified multiple insertions in the rsbUVW-sigB operon. Following construction and characterization of a sigB deletion, we determined that the biofilm phenotype was due to a lack of sigma factor B (SigB) activity. The phenotype was conserved in a sigB mutant of USA300 strain LAC, a well-studied community-associated methicillin-resistant S. aureus isolate. We determined that agr RNAIII levels were elevated in the sigB mutants, and high levels of RNAIII expression are …

Free-Range Farming And The Optimal Public And Private Responses To A Possible Epidemic, Sajal Lahiri, Basharat A. Pitafi

Economics Discussion Papers

We develop an optimizing model of a farm that is subject to invasion by an infectious disease such as bird flu, where the probability of invasion depends on the degree of free- ranging on the farm and post-invasion rate of spread on the farm depends on the farm size, the farmer's surveillance efforts, and the degree of free-ranging. We examine optimal policies for the farm and for the government, and analyze how these policies are affected by the degree of free-ranging. We find, inter alia, that when the farm size is endogenous fining an infected farm is superior as …

Progress Notes, Lehigh Valley Health Network

Progress Notes

No abstract provided.

Health Professionals’ Roles In Animal Agriculture, Climate Change, And Human Health, Aysha Z. Akhtar, Michael Greger, Hope Ferdowsian, Erica Frank

Human Health Collection

What we eat is rapidly becoming an issue of global concern. With food shortages, the rise in chronic disease, and global warming, the impact of our dietary choices seems more relevant today than ever. Globally, a transition is taking place toward greater consumption of foods of animal origin, in lieu of plantbased diets. With this transition comes intensification of animal agriculture that in turn is associated with the emergence of zoonotic infectious diseases, environmental degradation, and the epidemics of chronic disease and obesity. Health professionals should be aware of these trends and consider them as they promote healthier and more …

Synthesis: Evolutionary Ecology Of Microbial Wars: Within-Host Competition And (Incidental) Virulence, Sam Brown, Fredrik Inglis, François Taddei

Biology Department Faculty Works

Invading an occupied niche is a formidable ecological challenge, and one of particular human importance in the context of food-borne microbial pathogens. We discuss distinct categories of invader-triggered environmental change that facilitate invasion by emptying their niche of competitors. Evidence is reviewed that gut bacteria use such strategies to manipulate their environment (via bacteriocins, temperate phage viruses or immuno-manipulation) at the expense of their competitors are reviewed. The possible virulence implications of microbial warfare among multiple co-infecting strains are diverse. Killing competitors can reduce virulence by reducing overall microbial densities, or increase virulence if for example the allelopathic mechanism involves …

Evolutionary Ecology Of Microbial Wars: Within-Host Competition And (Incidental) Virulence, Sam Brown, R Inglis, François Taddei

Biology Department Faculty Works

Invading an occupied niche is a formidable ecological challenge, and one of particular human importance in the context of food-borne microbial pathogens. We discuss distinct categories of invader-triggered environmental change that facilitate invasion by emptying their niche of competitors. Evidence is reviewed that gut bacteria use such strategies to manipulate their environment (via bacteriocins, temperate phage viruses or immuno-manipulation) at the expense of their competitors are reviewed. The possible virulence implications of microbial warfare among multiple co-infecting strains are diverse. Killing competitors can reduce virulence by reducing overall microbial densities, or increase virulence if for example the allelopathic mechanism involves …

Benchmarks 2009, February 20, The Rockefeller University

BenchMarks 2009

BenchMarks. Friday, February 20, 2009

The community newsletter of The Rockefeller University

BenchMarks is published monthly and is distributed on the campus of The Rockefeller University. It produced by the Office of Communications and Public Affairs

Extensive Phylogenetic Analysis Of A Soil Bacterial Community Illustrates Extreme Taxon Evenness And The Effects Of Amplicon Length, Degree Of Coverage, And Dna Fractionation On Classification And Ecological Parameters, Sergio E. Morales, Theodore F. Cosart, Jesse Johnson, William Holben

Computer Science Faculty Publications

To thoroughly investigate the bacterial community diversity present in a single composite sample from an agricultural soil and to examine potential biases resulting from data acquisition and analytical approaches, we examined the effects of percent G+C DNA fractionation, sequence length, and degree of coverage of bacterial diversity on several commonly used ecological parameters (species estimation, diversity indices, and evenness). We also examined variation in phylogenetic placement based on multiple commonly used approaches (ARB alignments and multiple RDP tools). The results demonstrate that this soil bacterial community is highly diverse, with 1,714 operational taxonomic units demonstrated and 3,555 estimated (based on …

Helicobacter Pylori Infection Rate Decreases In Symptomatic Children: A Retrospective Analysis Of 13 Years (1993-2005) From A Gastroenterology Clinic In West Virginia, Yoram Elitsur, Yulia Dementieva, Mary Rewalt, Zanda Lawrence

Pediatrics

Background: The rate of Helicobacter pylori is decreasing in the developed countries, but few long-term studies are available from the United States. We retrospectively assessed the annual H. pylori infection rate in symptomatic children seen in our clinic over a 13-year study period.

Study: A retrospective analysis of all children who had histologic diagnosis of H. pylori infection between January 1993 and December 2005 in our pediatric gastroenterology clinic was performed. The annual infection rate and the overall infection rate were calculated.

Results: A total of 1743 upper endoscopy reports were reviewed, of which 212 (12.1%) were diagnosed with H. …

Pubh 595.52: The Practice Of International Health, Lisa Pascopella, Craig A. Molgaard

University of Montana Course Syllabi, 1990-2010

No abstract provided.

Phar 452.01: Therapeutics Ii: Clinical Use Of Antimicrobials, Doug Allington

University of Montana Course Syllabi, 1990-2010

No abstract provided.

Management Of Merino Weaners For Optimum Production, Patricia Harper, Keith Croker, Danny Roberts

Bulletins 4000 -

Sheep mortality during the first year of life is a large problem on many farms and poses a significant animal welfare issue for Australian agriculture. Post weaning mortality is estimated to cost the Australian sheep industry more than $89 million annually through reduced income, poor productivity and increased management expenses (Sackett et al. 2006).

A high mortality rate among weaners reduces the number of surplus animals available for sale and the number of potential breeding replacements. This, in turn, affects the selection intensity for desirable traits and the flock’s rate of genetic improvement.

Ill thrift and poor growth of weaner …

Leptospira Interrogans Induces Apoptosis In Macrophages Via Caspase-8- And -3-Dependent Pathways, Dandan Jin, David M. Ojcius, Dexter Sun, Haiyan Dong, Yihui Luo, Yafei Mao, Jie Yan

All Dugoni School of Dentistry Faculty Articles

Apoptosis of host cells plays an important role in modulating the pathogenesis of many infectious diseases. It has been reported that Leptospira interrogans, the causal agent of leptospirosis, induces apoptosis in macrophages and hepatocytes. However, the molecular mechanisms responsible for host cell death remained largely unknown. Here we demonstrate that L. interrogans induced apoptosis in a macrophage-like cell line, J774A.1, and primary murine macrophages in a time- and dose-dependent manner. Apoptosis was associated with the activation of cysteine aspartic acid-specific proteases (caspase-3, caspase-6, and caspase-8), the increased expression of Fas-associated death domain (FADD), and the cleavage of the caspase substrates …

Seasonal Variation Of Ectosymbiotic Ciliates On Farmed And Wild Shrimps From Coastal Yucatan, Mexico, Norma A. López-Téllez, Victor M. Vidal-Martínez, Robin M. Overstreet

Harold W. Manter Laboratory of Parasitology: Faculty Publications

High levels of ciliate infestation can affect respiration, feed intake, and locomotion in farmed shrimps in the tropics. Information on seasonal variation of the infestation parameters of ciliates is scarce, but it would be useful for determining the suitability of preventive measures or therapeutic treatment if necessary. This study aimed to describe the prevalence and mean intensity of infestation (MII) of ciliates on wild native shrimps Penaeus (Farfantepenaeus) brasiliensis and P. (Farfantepenaeus) duorarum and farm-cultured juvenile shrimp Penaeus (Litopenaeus) vannamei over an annual cycle and to determine whether an association existed among physicochemical factors …

Leishmaniasis Resembling Hematological Malignancies. The Concern Of Differential Diagnosis, Pasquale Niscola, Massimiliano Palombi, Stefano Fratoni, Malgorzata M. Trawinska, Laura Scaramucci, Barbara Tolu, Alessio P. Perrotti, Paolo De Fabritiis

Saudi Medical Journal

No abstract provided.

Eimeria Spp. In Brazilian Water Buffalo, Antonio Carlos F. De Noronha, Jr., Wilma A. Starke-Buzetti, Donald W. Duszynski

Harold W. Manter Laboratory of Parasitology: Faculty Publications

Eimeria species are frequently found in water buffalo (Bubalus bubalis) in Brazil. Here, we report those Eimeria spp. that infect buffalos during their first year of life. Fresh fecal samples were examined from 2 groups (1 group/yr for 2 yr, 2000-2002), each with 18 water buffalo calves (both sexes), from birth through 12 months of age, in Selvíria, MS, Brazil. Five oocyst morphotypes were observed, i.e., Eimeria ellipsoidalis and Eimeria zuernii, both previously described from water buffalo, and 3 other morphotypes consistent with descriptions of known Eimeria spp. from Artiodactyla hosts, but originally described from other …

The Health Seeking Behaviour Of Elderly Population In A Poor-Urban Community Of Karachi, Pakistan, Abdullah Ladha, Romaisa Shamim Khan, Awais Amjad Malik, Sana Farooq Khan, Beenish Khan, Irum Nawaz Khan, Samiullah, Waleed Tallat Kayani, Sarah Saleem

Community Health Sciences

OBJECTIVES: To presents socio-demographic characteristics and health seeking behaviour of elderly and to determine frequency of Diabetes Mellitus and Hypertension in elderly population of a poor peri-urban community in Karachi, Pakistan.

METHODS: A cross-sectional study was conducted, targeting population aged 65 or above. A total of 438 respondents were interviewed after taking informed consent, between November 2005 and December 2005. Frequencies and Chi square values were calculated for different variables using SPSS 13.0.

RESULTS: Total population surveyed comprised of 438 elderly, 158 (36%) women and 280 (63.9%) men. Mean age for the population was 71.44 +/- 7.74. A total of …

Molecular Coevolution Of Pacific Northwest Hantaviruses And Their Host, The Deer Mouse, Peromyscus Maniculatus, Philip Darren Jones

Dissertations and Theses

Sin Nombre virus (SNV, family Bunyaviridae, genus Hantavirus), hosted by the deer mouse, Peromyscus maniculatus (family Cricetidae, Subfamily Neotominae), is the primary etiological agent of Hantavirus pulmonary syndrome (HPS) in the western United States. HPS, with known pathogenicity only to humans and for which there is no cure or prophylaxis, affects the epithelium of the lungs by making the capillaries leaky, thereby resulting in bilateral infiltrates, and eventually leading to respiratory failure and death by drowning in approximately 38% of hospitalized patients.

In the Americas, Peromyscus has been co-evolving with hantaviruses for approximately 12–20 million years, since the first …

Reducing The Spread Of Infectious Disease Through Hand Washing, Marcus M. Comer, Mohammad Ibrahim, Valerie Jarvis Mcmillan, Geissler G. Baker, Sonya G. Patterson

Journal of Extension

According to the Centers for Disease Control (2002), hand washing is the simplest, most effective measure for preventing the spread of bacteria, pathogens, and viruses. Recent studies by the American Society for Microbiology (2005) indicate that Americans do not wash their hands after going to the bathroom and before handling or eating food. The study reported here sought to determine the presence of publications encouraging the public to wash hands in two North Carolina counties. Public restrooms located in rest areas, convenience stores, restaurants, and childcare facilities were examined. Findings indicate that literature encouraging hand washing is not present.

Dual Parametric Sensors For Highly Sensitive Nucleic Acid Detection, Manu Sebastian Mannoor

Theses

The primary focus of this research work was on the design and development of a molecular scale (nano-scale) capacitive sensing mechanism for the highly sensitive and label-free detection of Nucleic Acid hybridization. These novel capacitive sensors with nano-scale electrode spacing offer solutions to many problems suffered by the conventional signal transduction mechanisms, thereby immensely improving the sensitivity of the biomolecular detection processes. Reducing the separation between the capacitive electrodes to the same scale as the Debye length of the sample solution, results in the overlapping of the electrical double layers of the two electrodes, thereby confining them to occupy a …

Studies On Hepatoprotective Properties Of Leaf Extracts Of Azadirachta Indica A. Juss (Meliaceae), T. Kalaivani, E. Meignanam, N. Premkumar, R. Siva, V. Vijayakumar, C. Rajasekaran, S. Ramya, R. Jayakumararaj

Ethnobotanical Leaflets

The present study was carried out to evaluate the hepatoprotective role of leaf extracts of Azadirachta indica A. Juss. Hepatoprotective activities of ethanolic and aqueous extracts of A. indica were examined against carbon tetrachloride induced liver damage in mice using silymarin as control. Enzyme activities of Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT) and Alkaline Phosphatase (ALP) were analyzed. Phytochemical leaf extracts of A. indica exhibited significant hepatoprotective activity. Ethanolic and aqueous leaf extracts of A. indica exhibited moderate activity over carbon tetrachloride treated animals. Results confirm the traditional - ethnomedicinal use of A. indica as a …