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Rationale And Design Of A Trial Of Angiotensin-Converting Enzyme Inhibition In Infants With Single Ventricle., Daphne T. Hsu, Seema Mital, Chitra Ravishankar, Renee Margossian, Jennifer S. Li, Lynn A. Sleeper, Richard V. Williams, Jami C. Levine, Brian W. Mccrindle, Andrew M. Atz, Darlene Servedio, Lynn Mahony, Pediatric Heart Network Investigators, Girish S. Shirali

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Angiotensin converting enzyme (ACE) inhibitors are known to improve clinical outcome and ventricular function in adults with heart failure. Infants with single-ventricle physiology show abnormalities in ventricular function as well as poor growth. The ability of an ACE inhibitor to preserve ventricular function and improve growth in these infants is unknown.

METHODS: The Pediatric Heart Network designed a randomized, double-blind trial to compare outcomes in infants with single-ventricle physiology receiving enalapril or placebo. Neonates < or =45 days old were eligible. The primary outcome is weight-for-age Z-score at 14 months of age. Secondary outcomes include other measures of somatic growth, laboratory and functional measures of heart failure, developmental indices, measures of ventricular size and function, and the relationship of the renin-angiotensin-aldosterone system genotype to the response to enalapril. The incidence and spectrum of adverse events will also be compared between treatment groups.

RESULTS: A total of 1,245 neonates were screened and 533 (43%) were eligible. The consent rate was 43%; 230 subjects were enrolled. Parental reluctance to …

Closing The Achievement Gap: A Social Justice Imperative For School Counseling, Alan W. Burkard, Michael J. Martinez, Casey A. Holtz

College of Education Faculty Research and Publications

No abstract provided.

Positive Psychology Within A Cultural Context, Jennifer Teramoto Pedrotti, Lisa M. Edwards, Shane J. Lopez

College of Education Faculty Research and Publications

As our capacity for communication with nations across the globe increases through the advances of technology, our interactions with others with different worldviews also become more frequent. This exposure to diversity on so many levels requires a better understanding of the multiple contexts in which people from different cultural backgrounds live and the strengths they possess that help them experience well-being. In order to define the characteristics that my be viewed as strengths in different groups, we must make efforts to remember that cultural rules and norms often dictate what can be called a strength versus a weakness. It is …

Lori Laitman And Sara Teasdale: A Performer's Guide To The Metropolitan Tower And Other Songs, Mystery, And The Years, Andrea Mueller

LSU Doctoral Dissertations

American composer, Lori Laitman, has published over fifty works for solo voice and piano. She has become an important contributor to contemporary art song composition, the genre in which she primarily focused her compositional efforts. Laitman may, at any time, be working on a variety of projects, predominately commissions. Though not an extensive amount of information has been published about her creative life, over the past eight years much interest has arisen in her repertoire, both artistically and scholastically. This paper will focus on Laitman’s settings of the Sara Teasdale poetry including three song sets: The Metropolitan Tower and Other …

Examining Successful Recuritment Strategies Utilized By Volunteer Alumni, James Eric Prudhomme

LSU Doctoral Dissertations

The purpose of this phenomenological qualitative study was to describe the manner in which volunteer alumni recruiters at a flagship institution were able to recruit prospective students both in and out of the formal recruitment setting. Due to the challenges facing Louisiana State University with out-of-state recruitment, volunteer alumni recruiters provide a cost-effective alternative to assist this effort. Findings of this study can be used to expand the current alumni volunteer recruitment effort by providing insight into the strategies that result in success in the recruitment process, all the while encouraging fellow alumni to assist their effort. The methodology for …

Single-Molecule Detection Of Unique Genome Signatures: Applications In Molecular Diagnostics And Homeland Security, Jason M. Emory

LSU Doctoral Dissertations

Single-molecule detection (SMD) offers an attractive approach for identifying the presence of certain markers that can be used for in vitro molecular diagnostics in a near real-time format. The ability to eliminate sample processing steps afforded by the ultra-high sensitivity associated with SMD yields an increased sampling pipeline. When SMD and microfluidics are used in conjunction with nucleic acid-based assays such as the ligase detection reaction coupled with single-pair fluorescent resonance energy transfer (LDR-spFRET), complete molecular profiling and screening of certain cancers, pathogenic bacteria, and other biomarkers becomes possible at remarkable speeds and sensitivities with high specificity. The merging of …

Numerical Modeling For Long Term Performance Of Soil-Bentonite Cut-Off Walls In Unsaturated Soil Zone, Sukanta Chakraborty

LSU Master's Theses

ABSTRACT The construction practices of containment walls are extremely important in this competitive economic market, but development is limited. Unsaturated zone is an integral part of the geotechnical problems, as it affects on any kind of soils structures. The unsaturated zone plays significant role in many aspects of water flow and contaminant transport, including containment system such as: cut-off walls, infiltration, soil moisture storage, evaporation, plant water uptake, ground water recharge, erosion, and runoff. This research focuses on the hydraulic sustainability and performance of soil-bentonite cutoff walls (Britton et al, 2004) models showing hydraulic behavior of barrier walls. The cutoff …

An Analysis Of The Impact Of The Eu Sugar Policy Reform On Acp Countries: A Quota Market Framework, Liliane Kiswendsida Zoungrana

LSU Doctoral Dissertations

The pressures for reform within the World Trade Organization have led to the European Union (EU) reforming its sugar policy with a price cut phased from 2006 and scheduled to end in 2009. The reform will have an impact on the sugar protocol African Caribbean and Pacific (ACP) countries that have a preferential market access to the European Union with a protected price. This study investigates the effect of EU sugar policy reform has on these ACP sugar countries. First, it examines how the protocol countries’ sugar supply and demand determinants. While the determinants of supply in some countries performed …

Modification Of Rice Starch Properties By Addition Of Amino Acids At Various Ph Levels, Rosaly Vallejo Manaois

LSU Master's Theses

Amino acids were previously found to modify starch functionalities and potentially increase starch utilization. The effect of amino acids at different pH levels on the pasting properties, thermal characteristics, and resistant starch (RS) formation of rice starch was investigated. Prior to the analyses, pretreatment of starch was done by adding amino acid (aspartic acid, leucine, lysine and tyrosine) at 6% dry weight basis and dispersing the mixture in distilled water, solutions adjusted with HCl and NaOH to pH 4, 7 and 10, and buffers of acetate, phosphate and carbonate at the same pH levels, respectively. Samples in HCl/NaOH solutions were …

Testicular Toxicity And The Potential For 1, 2 -Ethlyene Dichloride (Edc) To Initiate Epigenetic Disruption Of The Paternal Genome, Harold J. Daigle

LSU Doctoral Dissertations

Our genetic inheritance begins with one genome copy from each parent. The presence of one or more errors in either the maternal or the paternal genome can lead to genetic disease or disruption of the embryonic program and potential loss of the offspring. Numerous chemical and physical toxicants are known to produce germ line mutagenesis based on their ability to produce DNA sequence mutations. Exposures to these cytotoxic and mutagenic agents pose a risk for human offspring. However, very little is known regarding the sensitivity of the epigenetic patterns involved in reproductive functions to adverse effects of chemical agents. The …

An Experimental Study Of The Effects Of Workforce Bullying On Three Affective Constructs: Self-Efficacy, Satisfaction And Stress, Elizabeth A. Nealy

LSU Doctoral Dissertations

The primary purpose of this study was to determine the effects of “bullying” behavior on the affective constructs of self-efficacy, satisfaction and stress of students enrolled in a junior level course at a research extensive university in the southern region of the United States. The sample included 35 undergraduate students at one research-extensive university in the southern region of the United States who were enrolled in a leadership course in the spring semester of 2009. The dependent variables were participants’ scores on measures of self-efficacy, satisfaction and stress. The independent variable was whether or not participants were exposed to “bullying” …

Polyunsaturated Fatty Acid Content Of Breast Milk From Women With And Without Gestational Diabetes Mellitus, Julissa Marisel Salguero

LSU Master's Theses

Reduced insulin sensitivity and abnormal nutrient metabolism in gestational diabetes mellitus (GDM) may compromise polyunsaturated fatty acid (PUFA) content of breast milk. The purpose of the present study was to evaluate and compare PUFA milk composition of women with and without GDM. Breast milk collections were performed in GDM (n=6) and controls (n=12) at weeks 2, 6, 10 and 12 postpartum using a hospital grade breast pump. Estimated dietary intake of PUFA and use of prenatal supplements containing DHA (PS/DHA) was determined by 24-hour dietary recalls conducted after each milk collection. Based on these preliminary data, milk docosahexaenoic acid (DHA; …

Deconstructing Student Perception Of Incivility In The Nursing Education Triad, Jennifer Wibbenmeyer Beck

LSU Doctoral Dissertations

This triangulated mixed methods study examines the construct of incivility in nursing higher education within the southeastern United States. A modification of the Incivility in Nursing Education (INE) survey (Clark, 2007) was administered to determine behaviors students identify as uncivil within the various contexts of the associate degree nursing educational environment – classroom and clinical area and among the nursing education triad – students, faculty, and nurses. Ten factors were isolated as a result of exploratory factor analysis. There was a statistically significant difference between beginning and graduating students’ perceptions regarding one factor, Abuse of Faculty Position. Beginning students described …

The Effects Of Geomorphology And Primary Productivity On Neotropical Leaf Litter Herpetofauna: Implications For Amazonian Rainforest Conservation, Jessica L. Deichmann

LSU Doctoral Dissertations

The Amazon rainforest encompasses over one billion acres of South America and sustains remarkable biodiversity. Despite the large body of research stemming from this region, little is known about the effects of geomorphology and primary productivity on the fauna of Amazonia, and on reptiles and amphibians in particular. In my dissertation, I examine differences in the abundance, biomass and species richness of secondary consumers in the leaf litter herpetofauna communities on young and ancient soils. Herein, I develop methods to utilize existing data sets and museum collections in new studies involving community biomass. I found that, although the process of …

Supporting Decision Making In A Complex World, Jonathan Tall

LSU Master's Theses

Recent research has questioned whether explicit thinking is necessary or even useful for complex decision making (Gladwell, 2005; Dijksterhuis & Nordgren, 2006; Newell, Wong, Cheung, & Rakow, in press). The present research approaches this issue by examining how different types of decision support facilitate/hinder performance in a diagnostic medical task. The results from 3 experiments indicate that providing an external memory aid improves performance in complex tasks. Additional support in the form of a coding procedure improved awareness of the magnitude of drug effects, but did not improve detection of negative side effects. The results suggest that while performance is …

Apolipoprotein Status And Cognitive Functioning In Adulthood: Role Of Physical Health And Social Network Characteristics, Jennifer Lee Silva

LSU Doctoral Dissertations

This study examined the relationships among cognitive function, physical health, social network characteristics, and apolipoprotein (APOE) genotype in participants from the Louisiana Healthy Aging Study. Prior literature has shown that the ε4 allele of APOE is associated with cognitive deficits (Wisdom, Callahan, & Hawkins, 2009). This study failed to find any relation between APOE genotype (ε4 carrier vs. non-carrier) and cognitive ability after controlling for age and education level. Tests for physical health mediation and social network moderation did not alter the ε4/cognition null results. This finding conflicts with prior research suggesting that physical activity and health modify the association …

Evaluation Of Dietary Alterations That Have Potential To Affect Feed Intake And Feed Preference In Swine, James Seth Monegue

University of Kentucky Master's Theses

Feed intake is a key factor affecting pig performance; thus, the objective of these studies was to assess a variety of factors that could potentially affect intake in pigs in different production stages. Studies were conducted to determine the effects of flavor and diet complexity, Appetein™ (an alternative protein source), and graded levels of salt on swine feed intake and feed preference. Two newly developed flavors were used in nursery pig diets. The use of the two flavors did not increase feed intake (P > 0.05). Nursery pigs actually showed a preference for the control diet. Complex diet formulation does increase …

A Critical Examination Into Motivation And Gender In Youth Physical Fitness Testing, Elizabeth A. Domangue

LSU Doctoral Dissertations

Fitness testing in physical education classes has emerged as an important component in efforts to assess and address health concerns related to children’s physical inactivity. To date, motivational aspects of fitness testing, especially in regard to students’ future intention to participate in fitness-related activities, have not been closely examined. Fitness testing practices have been identified as a dominant discourse in physical education that continue to separate girls’ and boys’ physicalities along gendered lines. This lack of understanding about the motivational implications of fitness testing programs, coupled with concerns related to the gendered nature of fitness testing, emphasize the significance of …

The Virgin's Daughters: Catholic Traditions And The Post-Colonial South In Contemporary Women's Writing, Elizabeth M. Beard

LSU Doctoral Dissertations

This dissertation analyzes the texts of contemporary women writers who consciously engage dominant Catholic, American, and southern ideologies in their narratives and who posit Louisiana as a liminal, hybrid space. Building upon postcolonial concepts of hybridity and performance of cultural memory, I trace a “pathway” to feminist recovery and reclamation of ancestral memory and spirituality in Valerie Martin’s A Recent Martyr, Rebecca Wells’ Little Altars Everywhere and Divine Secrets of the Ya-Ya Sisterhood, Brenda Marie Osbey’s All Saints, and Erna Brodber’s Louisiana. The authors enact spiritual and cultural reclamation through the written expression of key components of postcolonial reconstruction of …

Characterization Of Porcine Adipose Tissue-Derived Stem Cells, Kellie J. Williams

LSU Doctoral Dissertations

Nuclear transfer (NT) results in low success rates and research has reported problems with the welfare of cloned animals produced. Evidence suggests the use of a less differentiated donor cell, such as a stem cell, may lead to an increase in the efficiency of the NT procedure. Stem cell characteristics must be clearly defined in order to isolate, identify and optimally culture potential donor cells. Stem cell characteristics such as self-renewal and differentiation have not been identified in stem cells from porcine adipose tissue, an easily attainable tissue resource. The phenotypic profile of cell surface proteins and chromosomal stability of …

Remediating Impacts Of Global Climate Change-Induced Submergence On Salt Marsh Ecosystem Functions, Camille Lafosse Stagg

LSU Doctoral Dissertations

Impacts of global climate change, such as sea level rise and severe drought, have altered the hydrology of coastal salt marshes resulting in submergence and subsequent degradation of ecosystem function. A potential method of rehabilitating these systems is the addition of sediment-slurries to increase the elevation of the marsh surface, thus ameliorating the effects of excessive inundation. Although this technique is growing in popularity, the successful restoration of ecological function after sediment addition has received little attention. The purpose of this research was to determine if sediment subsidized salt marshes are functionally equivalent to natural marshes and whether salt marshes …

Isoflavone Distribution In Soy Seed And Antioxidant Activity Of Defatted Soy Flour Extract, Xiaohua Yue

LSU Doctoral Dissertations

Soy isoflavones distribution in soy cotelydon, coat and germ were determined. The ƒÀ-Glucoside form of isoflavones was the major class of isoflavones in all three soy parts. Soy germ was the richest source of the isoflavones among the three soybean parts. Distribution of the isoflavones in soy cotyledon was different from that in soy coat or germ. As defatted soy flour is a main byproduct in the soy oil refining process, utilizing the low value byproduct as a valuable food antioxidant was investigated in this study. The level of isoflavones in the defatted soy flour extract was 55 mg/g, which …

Insights Into Expression, Cellular Localization, And Regulation Of Supernatant Protein Factor, A Putative Regulator Of Cholesterol Biosynthesis, Elzbieta Ilona Stolarczyk

University of Kentucky Doctoral Dissertations

SPF (Supernatant Protein Factor) is a cytosolic protein that stimulates at least two enzymes in the cholesterol biosynthetic pathway: squalene monooxygenase and HMGCoA reductase. The mechanism of action has not been established but may be related to lipid transfer between intracellular membranes.

There are three human genes for SPF: SEC14L2 (SPF1), SEC14L3 (SPF2) and SEC14L4 (SPF3). The present study differentiates these closely related genes by evaluating their tissue-specific and relative expression levels. SPF1 mRNA was found to be most abundant in liver, mammary gland and stomach. SPF2 showed negligible expression in all tissues tested; SPF3 expression pattern was similar to …

Evaluating The Effects Of Organic And Conventional Inputs On Soil Chemical And Biological Properties In A Four-Year Vegetable Rotation And The Investigation Of Soil Microbial Properties On Plant Gene Expression, Audrey Law

University of Kentucky Doctoral Dissertations

The objective of this research was to determine the effects of conventional inputs on soil chemical and biological properties compared to organic systems in a four year vegetable rotation. Tillage and cover crops were the same in all treatments to avoid confounding factors often present in similar research. Additional experiments investigated plant gene expression in organic and conventional management systems and in soils with decreased microbial diversity. Experimental plots were prepared in the spring of 2004; four replications of three management treatments, organic, low-input and conventional, were arranged in a randomized complete block design. The rotation consisted of edamame soybean, …

The Pharmacogenomics Of Egfr-Dependent Nsclc: Predicting And Enhancing Response To Targeted Egfr Therapy, Justin M. Balko

University of Kentucky Doctoral Dissertations

The introduction of tyrosine kinase inhibitors (TKI) targeting the epidermal growth factor receptor (EGFR) inhibitors to the clinic has resulted in an improvement in the treatment of non small cell lung cancer (NSCLC). However, many patients treated with EGFR TKIs do not respond to therapy. The burden of failed treatment is largely placed on the healthcare field, limiting the effectiveness of EGFR TKIs. Furthermore, responses are hindered by the emergence of resistance. Thus, two questions must be addressed to achieve maximum benefit of EGFR inhibitors: How can patients who will benefit from EGFR TKIs be selected a priori? How …

Biology And Management Of The Bed Bug, Cimex Lectularius L. (Heteroptera: Cimicidae), Alvaro Romero

University of Kentucky Doctoral Dissertations

The near absence of bed bugs from human dwellings for fifty or more years has left us with limited knowledge of its biology and few answers to eliminate populations. I explored a diverse set of objectives to answer key questions concerning bed bug biology and control. Major objectives were studies of circadian rhythmicity, pyrethroid resistance, sublethal effects of insecticides, synergism of pyrethroids, and evaluation of a pyrrole insecticides, chlorfenapyr. Additional studies included persistence of Borrelia in bed bugs after ingestion, and aggregation factors from feces.

In the absence of host stimuli, insects were much more active in the dark than …

An Empirical Analysis Of The Utilization Patterns Of Within Facility And Secondary Healthcare Services By Kentucky State Prison Inmates, Sandra Jane Winter

University of Kentucky Doctoral Dissertations

The inmate population is increasing, aging and generally in poorer health than the non-incarcerated population. Providing healthcare to inmates is constitutionally mandated, and expensive. Little published research exists to assist corrections health policy makers strategically plan for future inmate healthcare needs. This research provides an extensive description of the healthcare utilization patterns of a sample of 577 male and female inmates incarcerated at state-operated prisons in Kentucky during the period January 1, 2007, to December 31, 2007 and who have at least one of the chronic conditions of diabetes, hypertension or hyperlipidemia. The primary outcome measures were a count of …

Role Of Oxidative Stress And T Cell Homing In The Development Of Murine Syngeneic Graft-Versus-Host Disease, Jacqueline Perez-Rodriguez

University of Kentucky Doctoral Dissertations

Syngeneic graft-versus-host disease (SGVHD) is induced by reconstituting lethally irradiated mice with syngeneic BM cells followed by a 21 day treatment with the immunosuppressive agent cyclosporine A (CsA). Clinical symptoms of the disease appear 2-3 weeks following cessation of CsA therapy and disease-associated inflammation occurs primarily in the colon and liver.

The development of SGVHD is a complex process resulting from the cooperative interaction of multiple effector cell populations including NK cells, T cells and macrophages. T_H1 cytokines (IL-12, TNF-α, IFN- γ), produced by these effector cells, serve as inflammatory mediators contributing to the pathogenesis of SGVHD. The …

A Comparison Of Mental Health Service Delivery Programs In Arkansas Public School Systems, Lisa Braddock Moon

LSU Doctoral Dissertations

This primarily descriptive research study was designed to provide an initial review of the mental health services being offered in the Arkansas public school system by assessing the current delivery of these services and examining certain demographic correlates. The study utilized an established national survey instrument, developed by SAMHSA, which was administered as an email survey to 140 Arkansas schools. The respondents for this study were the Local Education Agencies/Special Education Supervisors in individual school districts. Seventy-eight schools (55%) completed the survey, including 26 elementary schools, 25 junior high schools and 27 high schools. Sixty-two schools (79.5%) identified themselves as …

Quantitative Macro- And Microscale Methods For Characterizing Cell Viability, Julianne Forman Audiffred

LSU Doctoral Dissertations

The goal of this study is to combine molecular and microdevice methods to characterize and quantify viability of single mammalian cells. Fluorescent-based assays were optimized for adherent HeLa and suspension Jurkat cells and were used as a tool for validation of a microfabricated diagnostic device. Cell and substrate/surface interactions were considered for designing a microfluidic device that can be used to characterize cell viability for quantitative biomedical and cell biology applications, which require label-free, real-time monitoring of cells. Several interdisciplinary methods are employed to evaluate electrical impedance differences between live and dead Jurkat cells in a microfluidic device. Biological Micro-Electro-Mechanical …