Digital Commons Network^™

Mcl-1 Degradation During Hepatocyte Lipoapoptosis., Howard C. Masuoka, Justin L. Mott, Steven F. Bronk, Nathan W. Werneburg, Yuko Akazawa, Scott H. Kaufmann, Gregory J. Gores

Journal Articles: Biochemistry & Molecular Biology

The mechanisms of free fatty acid-induced lipoapoptosis are incompletely understood. Here we demonstrate that Mcl-1, an anti-apoptotic member of the Bcl-2 family, was rapidly degraded in hepatocytes in response to palmitate and stearate by a proteasome-dependent pathway. Overexpression of a ubiquitin-resistant Mcl-1 mutant in Huh-7 cells attenuated palmitate-mediated Mcl-1 loss and lipoapoptosis; conversely, short hairpin RNA-targeted knockdown of Mcl-1 sensitized these cells to lipoapoptosis. Palmitate-induced Mcl-1 degradation was attenuated by the novel protein kinase C (PKC) inhibitor rottlerin. Of the two human novel PKC isozymes, PKCdelta and PKC, only activation of PKC was observed by phospho-immunoblot analysis. As compared with …

The White Dwarfs Within 20 Parsecs Of The Sun: Kinematics And Statistics, Edward M. Sion, J. B. Holberg, Terry D. Oswalt, George P. Mccook, Richard Wasatonic

Publications

We present the kinematical properties, distribution of spectroscopic subtypes, and stellar population subcomponents of the white dwarfs within 20 pc of the Sun.We find no convincing evidence of halo white dwarfs in the total 20 pc sample of 129 white dwarfs nor is there convincing evidence of genuine thick disk subcomponent members within 20 parsecs. Virtually, the entire 20 pc sample likely belongs to the thin disk. The total DA to non-DA ratio of the 20 pc sample is 1.6, a manifestation of deepening envelope convection which transforms DA stars with sufficiently thin H surface layers into non-DAs. The addition …

Accurate Molecular Classification Of Cancer Using Simple Rules., Xiaosheng Wang, Osamu Gotoh

Journal Articles: Genetics, Cell Biology & Anatomy

BACKGROUND: One intractable problem with using microarray data analysis for cancer classification is how to reduce the extremely high-dimensionality gene feature data to remove the effects of noise. Feature selection is often used to address this problem by selecting informative genes from among thousands or tens of thousands of genes. However, most of the existing methods of microarray-based cancer classification utilize too many genes to achieve accurate classification, which often hampers the interpretability of the models. For a better understanding of the classification results, it is desirable to develop simpler rule-based models with as few marker genes as possible.

METHODS: …

Running Toward The Apocalypse: John Updike’S New America, Bob Batchelor

USF Tampa Graduate Theses and Dissertations

My dissertation explores two critical points in understanding John Updike's recent career. First, I examine him from a perspective outside the heavily-studied Rabbit tetralogy. Focusing on Updike's novel Terrorist, I attempt to counter the misperception that he offers little beyond the chronicling of middle-class, suburban America. Instead, this work digs for a deeper understanding of Updike.

Next, I consider Updike's role as an artist, professional writer, and celebrity to draw out a sense of the writer's life in the twentieth and twenty-first centuries. Using him as a case study enables the analysis to include his changing role as a …

Minutes Of Graduate College Curriculum Committee, October 30, 2009, University Of Northern Iowa. Graduate College Curriculum Committee.

Minutes - Graduate Curriculum Committee

Minutes of the committee that oversees the development of the curriculum of the University of Northern Iowa Graduate College.

The Influence Of Promotion In Constructing Country's Perception, Autobiographical Memory, Emotional Bonding, And Visiting Intention, Jony Oktavian Haryanto

The South East Asian Journal of Management

This paper aims to propose the influence of promotion toward the establishment of country's perception, autobiographical memory (AM), emotional bonding (EB), and visiting intention. The writer would like to propose the direct influence of promotion toward intention to visit. This paper is aimed to see prospects' perception toward its promotion. Next, the writer would like to explore the influence of country's perception, AM, and EB toward the intention to visit. It is interesting to understand that they function as crucial factors which are considered deeply by prospects before the decide where to go. Hence, it is important to analyze their …

Montana Kaimin, October 30, 2009, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

October 30, 2009, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Second Africa-Latin America Summit Encourages South-South Ties, Ladb Staff

NotiSur

No abstract provided.

Voluntary Faculty Retirement Incentives, Richard Coughlin

Faculty Senate Documents

This report presents the results of the exploratory research and data analysis I conducted from May-August 2009 related to the development of a policy for voluntary faculty retirement incentives.

Our Experiences With Eastern Gamagrass, Tommy R. Yankey

Kentucky Grazing Conference

As livestock producers try to reduce their cost of production, many look at ways to reduce their feed costs. Feed costs have been identified as the largest single cost of livestock production, making up 50 to 70% of the total cost of production. Grazing is the cheapest way to feed cattle on a cost per pound of nutrient basis.

"It Is Never Too Late": Optimal Penalty For Investment Delay In Public Procurement Contracts, Sergio Vergalli, Chiara D’Alpaos, Michele Moretto, Paola Valbonesi

Fondazione Eni Enrico Mattei Working Papers

We provide a general framework in which to determine the optimal penalty fee inducing the contractor to respect the contracted delivery date in public procurement contracts (PPCs). We do this by developing a real option model that enables us to investigate the contractor’s value of investment timing flexibility which the penalty rule - de facto - introduces. We then apply this setting in order to evaluate the range of penalty fees in the Italian legislation on PPCs. According to our calibration analysis, there is no evidence that the substantial delays recorded in the execution times of Italian PPCs are due …

Stationary Consistent Equilibrium Coalition Structures Constitute The Recursive Core, László Á. Kóczy

Fondazione Eni Enrico Mattei Working Papers

We study coalitional games where the proceeds from cooperation depend on the entire coalition structure. The coalition structure core (Kóczy, 2007) is a generalisation of the coalition structure core for such games. We introduce a noncooperative, sequential coalition formation model and show that the set of equilibrium outcomes coincides with the recursive core. In order to extend past results to games that are not totally balanced (understood in this special setting) we introduce subgame-consistency that requires perfectness in relevant subgames only, while subgames that are never reached are ignored.

Investing In Biogas: Timing, Technological Choice And The Value Of Flexibility From Inputs Mix, Michele Moretto, Luca Di Corato

Fondazione Eni Enrico Mattei Working Papers

In a continuous-time framework we study the technology and investment choice problem of a continuous co-digestion biogas plant dealing with randomly fluctuating relative convenience of input factor costs. Input factors enter into the productive process together mixed according to a given initial rule. Being inputs relative convenience stochastically evolving, a successive revision of the initial rule may be desirable. Hence, when the venture starts the manager may or may not install a flexible technology allowing for such option. Investment is irreversible and flexibility is costly. The problem is solved determining in the light of future prospects the optimal revision and …

Carbon Kuznets Curves: Long-Run Structural Dynamics And Policy Events, Massimiliano Mazzanti, Antonio Musolesi

Fondazione Eni Enrico Mattei Working Papers

We study the structural differences among climate change leading ‘factors’ - Northern EU members -, and lagging actors - southern EU countries and the ‘Umbrella group’ - with regard to long run carbon-income relationships. Homogeneous and heterogeneous panel models show that the groups of countries less in favour of stringent climate policy have yet to experience a Kuznets curve, though they show relative delinking. Northern EU instead robustly shows bell shapes. Exogenous policy events such as the 1992 climate change convention appear to be relevant in shaping the EKC of Northern EU. In addition, other events such as the second …

Sme, Exports, Argentina, Gianmarco Ottaviano, Christian Volpe Martincus

Fondazione Eni Enrico Mattei Working Papers

There exists a growing body of literature which looks at export decisions made by firms. Most studies focus on developed countries and do not explore whether different behavioral patterns prevail over the firm size distribution. This paper aims at filling this gap in the literature by analyzing the export behavior of a statistically representative sample of 192 Small and Medium-Size Enterprises (SMEs) in a developing country, Argentina, over the period 1996-1998. We find that the level of employment, sourcing from abroad, investment in product improvement and average productivity are associated with a higher probability of exporting. Training activities for employees …

The Advocate, October 29, 2009, Minnesota State University Moorhead

The Advocate

No abstract provided.

A Search Model For Joint Implementation, Giovanni Bella

Fondazione Eni Enrico Mattei Working Papers

The aim of this paper is to present a search model in the field of environmental economics, where so-called clean and dirty producers enter the trading market, both looking for a partner with whom to exchange the goods they are endowed with. The model derived in this paper is rather simple. Nevertheless, it is able to produce a series of interesting results and useful insights, and is conveniently used here as a framework to explain the functioning of Joint Implementation programmes for polluting emissions’ reduction.

October 29, 2009, James Madison University

The Breeze, 2000-2009

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Commonwealth Times 2009-10-29

Commonwealth Times, 1969-

No abstract provided.

Usa V. Root

2009 Decisions

USDC for the Eastern District of Pennsylvania

In Re: Constar Int'l Inc

2009 Decisions

USDC for the Eastern District of Pennsylvania

Paul Podhorn Jr. V. J. Grondolsky

2009 Decisions

USDC for the District of New Jersey

Nina Shahin V. Pamela Darling

2009 Decisions

USDC for the District of Delaware

Wilbert Hackley Jr. V. Warden Bledsoe

2009 Decisions

USDC for the Middle District of Pennsylvania

Usa V. Adam Levinson

2009 Decisions

USDC for the District of Delaware

Wayne Dreibelbis Jr. V. Leslie Young

2009 Decisions

USDC for the Middle District of Pennsylvania

Usa V. Anthony Blaso

2009 Decisions

USDC for the Middle District of Pennsylvania

Usa V. Tracey Lea

2009 Decisions

USDC for the Eastern District of Pennsylvania

The Carroll News- Vol. 86, No. 7, John Carroll University

The Carroll News

No abstract provided.