Digital Commons Network^™

Structure And Function Of Pseudomonas Aeruginosa Protein Pa1324 (21–170), Kelly A. Mercier, John R. Cort, Michael A. Kennedy, Erin E. Lockert, Shuisong Ni, Matthew D. Shortridge, Robert Powers

Robert Powers Publications

Pseudomonas aeruginosa is the prototypical biofilm-forming gram-negative opportunistic human pathogen. P. aeruginosa is causatively associated with nosocomial infections and with cystic fibrosis. Antibiotic resistance in some strains adds to the inherent difficulties that result from biofilm formation when treating P. aeruginosa infections. Transcriptional profiling studies suggest widespread changes in the proteome during quorum sensing and biofilm development. Many of the proteins found to be upregulated during these processes are poorly characterized from a functional standpoint. Here, we report the solution NMR structure of PA1324, a protein of unknown function identified in these studies, and provide a putative biological functional assignment …

Comparison Of 3 Doses Of Ropivacaine For Epidural Anesthesia In Transurethral Surgery, Gulen Guler, Recep Aksu, Kudret Dogru, Mustafa Sofikerim, Zeynep Tosun, Adem Boyaci

Saudi Medical Journal

OBJECTIVE: To investigate the use of 3 different doses of ropivacaine on the quality of anesthesia and hemodynamics in epidural anesthesia for transurethral surgery. METHODS: The current study was conducted in the Department of Anesthesiology, Medical Faculty of Erciyes University, Turkey, between May 2004 and June 2006. The study recruited 81 males of ASA I- II group, ages 60-80 years, undergoing transurethral resection of prostate or bladder tumors. Patients were randomly assigned to 3 groups receiving epidural ropivacaine in different doses and concentrations. Group I n=27 received 15 ml 102.5mg of 0.75% solution, group II n=27 received 10ml 75mg of …

Modelling Behavioural Antecedents Of Inter-Firm Linkages In The Irish Road Freight Industry: An Application Of The Theory Of Planned Behaviour, Eoin Plant

Doctoral

The Irish road haulage industry exhibits a structure dominated by singlevehicle owner-managed operators. This has implications for the Irish economy through reduced efficiency. It is crucial that Ireland’s transport policies sustain its trade-dependent economy and this study can help inform those policies. The European Union has made a commitment to promoting sustainable mobility through advanced transport logistics. One of the principal areas not previously addressed is that of barriers to ollaboration. This thesis initially examines economies of scale within the road freight industry and argues that collaborative networks can aid sustainable transport and increase efficiencies in logistics. It addresses the …

The Phases And Faces Of The Duke Lacrosse Controversy: A Conversation, James E. Coleman, Angela Davis, K.C. Johnson, Lyrissa Lidsky

Faculty Publications

The genesis of this panel is an essay I wrote arguing that the single moniker "Duke lacrosse controversy" encapsulates a broad, multi-faceted legal, political, and social controversy that more accurately consists of five related seriatim sub-controversies. Initially, it was a sexual assault case. An African-American woman, hired as an exotic dancer at a party thrown by members of the Duke University men's lacrosse team, reported to Durham police that she had been sexually assaulted by several white team members. The allegations quickly became a national story, tinged with issues of race, class, gender, privilege, and at some level, the role …

Usability Investigation Of E-Business Web-Based Forms, Gerald V. Post, Albert Kagan, Betsy Page Sigman

Journal of International Technology and Information Management

Usability on Web sites is critical because almost no training is provided for users on commercial sites. Instead, Web design relies on standards and consistency across sites. Traditional usability results indicated that computer forms should follow paper-based forms. Yet, Web paradigms have evolved that are quite different from paper-based forms. Specifically, this study reveals that users commit fewer errors and prefer simple forms limited to a single concept per screen. This conclusion significantly alters the recommendations for designing business forms.

Formal Verification Of Urban Traffic System Using The Concept Of Fuzzy Workflow Simulation, Manuj Darbari, Abhay Kumar Srivastava, Sanjay Medhavi

Journal of International Technology and Information Management

Modeling complex urban traffic system requires extensive use of workflow methodologies which can simulate almost real time traffic situations. Number of studies were done in the field of Urban Traffic Simulation like PLOTS, NETSIM and PALAMICS but none of them could provide a real formal solution. Our paper proposes a methodology using Fuzzy Petri nets for modeling real time traffic system. Fuzzy Petrinets are also visualised and tested by using Flow- Charter and HPSIM software packages. These packages help in providing successive iterations of process model for further refinement.

Rapid Development Of Multimedia Instructional Modules For Information Technology Education, Nanda Ganesan

Journal of International Technology and Information Management

A multifaceted learning model was developed for implementing e-learning in a largely commuter campus. The primary objective of the model was to build a flexible learning environment that combined the learning effectiveness of in-class learning with the flexibility and accessibility of online learning. One of the components of the model was the multimedia instructional modules produced to teach various Information Technology courses. Several different types of modules were produced representing chalk-and-talk type of lectures, PowerPoint presentations and software tutorials. The chalk-and-talk type of lecture modules and the software tutorials that emulated the in-class learning experience contributed positively towards enhancing the …

Business Risks: When Is Fails To Detect Circumvention Activities, Stanley X. Lewis Jr., J. Scott Magruder, Eddy J. Burks, Carl Smolinski

Journal of International Technology and Information Management

A business must recognize and address various risk factors when establishing and maintaining its information system. The overall risk to management is that the control environment does not protect proprietary business data and the financial reporting system that produces financial statements and other information used by investors, creditors and regulatory agencies. These risks require that management implement efforts to ensure the integrity and effectiveness of control procedures over business activities while being aware of additional system issues such as failing to adequately consider other risks which are more business-oriented including the risk of failing to prevent or detect fraudulent or …

Pentral: Pattern Based Logic Language, Manuj Darbari, Abhay Kumar Srivastava, Sanjay Medhavi

Journal of International Technology and Information Management

The article focuses on the urban traffic representation using patterns which are specifically developed for traffic situations. The framework PENTRAL (PEtri-Net TRAnsportation Language) provides conversion of these patterns into algebraic format. These formats are saved as an XML file following the three tier architecture of urban Traffic system.

Machine Translation In A Multilingual Electronic Meeting, Milam Aiken, Mina Park

Journal of International Technology and Information Management

Electronic meetings can be more efficient and effective than traditional, oral discussions, but until only recently, groups with no common language could not benefit from machine translation. Although it is possible for linguists or other staff members using machines to translate comments during a multilingual discussion, the research presented here shows that this is not feasible for large groups speaking many languages. As a solution, we propose a fully automated multilingual meeting system, and an example of its use in a meeting with Chinese, Korean, and English comments shows its potential to reduce multinational communication barriers.

Using Gps To Provide Prayer Times Onboard An Airplane While In Motion, Zakaria Saleh

Journal of International Technology and Information Management

The Global Positioning System GPS, while originally a military project, has significant applications for the civilian industry. Civilian applications benefit from GPS signals by utilizing one or more of three basic components of the GPS location, relative movement, and time. Muslims around the world perform five prayers a day. The five prayers are based on astronomical position of the sun. Many systems have been developed to serve as prayer time providers but none of these systems provide the time for users that are traveling onboard an aircraft from one country to another, where (depending on the speed and directions of …

Europe And The 'Resolution Revolution': 'European' Legal Approaches To Privacy And Their Relevance For Space Remote Sensing Activities, Frans G. Von Der Dunk

Space, Cyber, and Telecommunications Law Program: Faculty Publications

English abstract: With the increasing general availability of very high resolution (VHR) satellite remote sensing data, issues of potential invasion of personal spheres of privacy will become ever more important. As of yet, there is no international law providing for a clear-cut regime balancing the freedom of information, including information gathering, with the rights of individual persons to remain free from interference with their privacy. The latter issues therefore essentially can be tackled only at a national level, with the obvious disadvantage that any regulation remains principally limited in scope to the national jurisdiction concerned.

Also at the European level …

Tests Of The Dynamic Field Theory And The Spatial Precision Hypothesis: Capturing A Qualitative Developmental Transition In Spatial Working Memory, Anne R. Schutte, John P. Spencer

Department of Psychology: Faculty Publications

This study tested a dynamic field theory (DFT) of spatial working memory and an associated spatial precision hypothesis (SPH). Between three and six years of age there is a qualitative shift in how children use reference axes to remember locations: 3-year-olds’ spatial recall responses are biased toward reference axes after short memory delays, whereas 6-year-olds’ responses are biased away from reference axes. According to the DFT and the SPH, quantitative improvements over development in the precision of excitatory and inhibitory working memory processes lead to this qualitative shift. Simulations of the DFT in Experiment 1 predict that improvements in precision …

Attention Shaping: A Reward-Based Learning Method To Enhance Skills Training Outcomes In Schizophrenia, Steven . M. Silverstein, William D. Spaulding, Anthony A. Menditto, Adam Savitz, Robert P. Liberman, Sarah Berten, Hannah Starobin

Department of Psychology: Faculty Publications

Disturbances in sustained attention commonly interfere with the ability of persons with schizophrenia to benefit from evidence-based psychosocial treatments. Cognitive remediation interventions have thus far demonstrated minimal effects on attention, as have medications. There is thus a gap between the existence of effective psychosocial treatments and patients’ ability to effectively engage in and benefit from them. We report on the results of a multisite study of attention shaping (AS), a behavioral intervention for improving attentiveness and learning of social skills among highly distractible schizophrenia patients. Patients with chronic schizophrenia who were refractory to skills training were assigned to receive either …

Bess: BIofuel ENergy SYstems SImulator: Life Cycle Energy & Emissions Analysis Model For Corn-Ethanol Biofuel Production Systems -- User’S Guide For The Bess Model, Adam Liska, Haishun Yang, Daniel T. Walters, Kenneth Cassman, Terry Klopfenstein, Galen Erickson, Virgil R. Bremer, Richard K. Koelsch, Dan Kenney, Patrick Tracy

Adam Liska Papers

The BESS model is a software tool to calculate the energy efficiency, greenhouse gas (GHG) emissions, and natural resource requirements of corn–to-ethanol biofuel production systems. The model provides a “cradle-to-grave” analysis of the production life cycle of biofuels from the creation of material inputs to finished products, producing an inventory of distributed GHG emissions from fossil fuels and a few key indirect emissions in the production life cycle. The model parameters can be set by the user to achieve the highest accuracy in evaluating a single corn-ethanol biorefinery and its surrounding feedstock crop production zone. The model equations and summary …

An Overview Of Systematics And Evolution Of Ticks, Santiago Nava, Alberto A. Guglielmone, Atilio J. Mangold

Harold W. Manter Laboratory of Parasitology: Library Materials

All species of ticks (Acari: Ixodida) are grouped into three families: Argasidae (186 species), Ixodidae (692 species), and Nuttalliellidae (monotypic). Molecular markers have been developed and applied for tick studies along with conventional techniques. The origin of ticks is during the pre-mid Cretaceous period (with both the Argasidae and Ixodidae being established in the middle Cretaceous). Primeval hosts were probably reptiles or amphibians. The Argasidae contains two to five subfamilies according to authors but relationships among its members are far from resolved. The Ixodidae were formed by the basal Prostriata group (genus Ixodes, subfamily Ixodinae) and the Metastriata group …

Semiclassical Propagation Method For Tunneling Ionization, Ilya I. Fabrikant, Gordon A. Gallup

Gordon Gallup Publications

We apply the semiclassical propagation technique to tunneling ionization in atomic and molecular systems. Semiclassical wave functions and the tunneling flux are calculated from the solution of the classical equations of motion in the complex time plane. We illustrate this method by rederiving the known result for the decay rate of a negative ion in a weak electric field. We then obtain numerical results for atomic hydrogen, H₂⁺, H₂, and Ar, and compare them with the results of the asymptotic [Ammosov-Delone-Krainov (ADK)] theory. The asymptotic theory gives surprisingly good results for the atomic and molecular …

Triacylglyceride Metabolism By Fusarium Graminearum During Colonization And Sexual Development On Wheat, John C. Guenther, Heather E. Hallen-Adams, Heike Bücking, Yair Shachar-Hill, Frances Trail

Department of Food Science and Technology: Faculty Publications

Fusarium graminearum, a devastating pathogen of small grains, overwinters on crop residues and produces ephemeral perithecia. Accumulation of lipids in overwintering hyphae would provide reserves for overwinter survival and perithecium development. Fatty acid composition of cultures during perithecium development indicated a drop in neutral lipid levels during development but little change in fatty acid composition across stages. Microscopic examination of cultures early in sexual development revealed hyphal cells engorged with lipid bodies. In comparison, vegetative hyphae contained few lipid bodies. Microarray analysis was performed on wheat stems at stages of colonization through perithecium development. Gene expression analysis during stages of …

Sperm Competition Selects Beyond Relative Testes Size In Birds, Stefan Lupold, George M. Linz, James W. Rivers, David F. Westneat, Tim R. Birkhead

United States Department of Agriculture Wildlife Services: Staff Publications

Sperm morphology varies considerably across taxa, and postcopulatory sexual selection is thought to be one of the main forces responsible for this diversity. Several studies have investigated the effects of the variation in sperm design on sperm function, but the consequences of variation in sperm design on testis morphology have been overlooked. Testes size or architecture may determine the size of the sperm they produce, and selection for longer sperm may require concomitant adaptations in the testes. Relative testes size differs greatly between species and is often used as an index of sperm competition, but little is known about whether …

Severity Of Child Sexual Abuse And Revictimization: The Mediating Role Of Coping And Trauma Symptoms, Michelle A. Fortier, David Dilillo, Terri L. Messman-Moore, James Peugh, Kathleen A. Denardi, Kathryn J. Gaffey

Department of Psychology: Faculty Publications

Child sexual abuse (CSA) has consistently been associated with the use of avoidant coping; these coping methods have been associated with increased trauma symptoms, which have, in turn, been linked to increased risk for adult sexual revictimization. Given these previous findings, the purpose of the current study was to test a model that conceptualized the relationships among these variables. Specifically, CSA severity was conceptualized as leading to the use of avoidant coping, which was proposed to lead to maintenance of trauma symptoms, which would, in turn, impact severity of revictimization indirectly. This comprehensive model was tested in a cross-sectional study …

Low-Level Lead Exposure And Contingency-Based Responding In Preschoolers: An Exploratory Study, Melanie Mcdiarmid Nelson, Kimberly A. Espy

Department of Psychology: Faculty Publications

Two reversal paradigm tasks (spatial reversal and spatial reversal with irrelevant color cues) originally designed to assess contingency-based responding in primates were adapted for use with 139 preschool children with a mean peak blood lead level (BLL) of 4.2 μg/dl (SD = 2.2). Sixty-nine children with BLL ≥ 5 μg/dl and 70 children with BLL of < 5 μg/dl were included. Results indicated that preschool children with low-level lead exposure take longer to learn associations than preschool children with very low levels of lead exposure, and this difference cannot be attributed to increased distractibility or perseverative responding. These results support the use of these measures to assess specific cognitive functions in preschool children.

Lack Of Efficacy Of Citalopram In Children With Autism Spectrum Disorders And High Levels Of Repetitive Behavior: Citalopram Ineffective In Children With Autism, Bryan H. King, Eric Hollander, Linmarie Sikich Md, James T. Mccracken Md, Lawrence Scahill Msn, Phd, Joel D. Bregman Md, Craig L. Donnelly Md, Evdokia Anagnostou Md, Kimberly Dukes Phd, Lisa Sullivan Phd, Deborah Hirtz Md, Ann Wagner Phd, Louise Ritz Mba, Arthur C. Maerlender, Staart Psychopharmacology Network

Department of Psychology: Faculty Publications

Context—Selective serotonin reuptake inhibitors are widely prescribed for children with autism spectrum disorders.

Objectives—To determine the efficacy and safety of citalopram hydrobromide therapy for repetitive behavior in children with autism spectrum disorders.

Design—National Institutes of Health–sponsored randomized controlled trial.

Setting—Six academic centers, including Mount Sinai School of Medicine, North Shore–Long Island Jewish Health System, University of North Carolina at Chapel Hill, University of California at Los Angeles, Yale University, and Dartmouth Medical School.

Participants—One hundred forty-nine volunteers 5 to 17 years old (mean [SD] age, 9.4 [3.1] years) were randomized to receive citalopram (n = 73) or placebo (n = …

Early Speech Motor Development: Cognitive And Linguistic Considerations, Ignatius S. B. Nip, Jordan R. Green, David B. Marx

Department of Special Education and Communication Disorders: Faculty Publications

This longitudinal investigation examines developmental changes in orofacial movements occurring during the early stages of communication development. The goals were to identify developmental trends in early speech motor performance and to determine how these trends differ across orofacial behaviors thought to vary in cognitive and linguistic demands (i.e., silent spontaneous movements, babble, and first words). Movements of the lower lip and jaw were recorded using a three-dimensional motion capture system. Twenty-four infants were observed every 3 months, from 9 to 21 months of age. Jaw and lower lip speed, and lower lip range of movement increased with age. Silent spontaneous …

Accuracy Assessment For Ag500, Electromagnetic Articulograph, Yana Yunusova, Jordan R. Green, Antje Mefferd

Department of Special Education and Communication Disorders: Faculty Publications

Purpose: The goal of this article was to evaluate the accuracy and reliability of the AG500 (Carstens Medizinelectronik, Lenglern, Germany), an electromagnetic device developed recently to register articulatory movements in three dimensions. This technology seems to have unprecedented capabilities to provide rich information about time-varying positions of articulators. However, strengths and weaknesses of the system need to be better understood before the device is used for speech research.
Method: Evaluations of the sensor positions over time were obtained during (a) movements of the calibration device, (b) manual movements of sensors in a cartridge within the recording field of the cube, …

Repressive Effects Of Resveratrol On Androgen Receptor Transcriptional Activity, Wenfeng Shi, Melanie Leong, Ellen Cho, Joseph Farrell, Hanchun Chen, Jun Tian, Dianzheng Zhang

PCOM Scholarly Works

Background: The chemopreventive effects of resveratrol (RSV) on prostate cancer have been well established; the androgen receptor (AR) plays pivotal roles in prostatic tumorigenesis. However, the exact underlying molecular mechanisms about the effects of RSV on AR have not been fully elucidated. A model system is needed to determine whether and how RSV represses AR transcriptional activity. Methodology: The AR cDNA was first cloned into the retroviral vector pOZ-N and then integrated into the genome of ARnegative HeLa cells to generate the AR(+) cells. The constitutively expressed AR was characterized by monitoring hormonestimulated nuclear translocation, DNA binding, and transcriptional activation, …

Us Godae: Global Ocean Prediction With The Hybrid Coordinate Ocean Model (Hycom), Eric P. Chassignet, Harley E. Hurlburt, E. Joseph Metzger, Ole Martin Smedstad, James A. Cummings, George R. Halliwell, Rainer Bleck, Remy Baraille, Alan J. Wallcraft, Carlos Lozano, Hendrik L. Tolman, Ashwanth Srinivasan, Steven Hankin, Peter C. Cornillon, Robert Weisberg, Alexander Barth, Ruoying He, Francisco Werner, John Wilkin

Graduate School of Oceanography Faculty Publications

During the past five to ten years, a broad partnership of institutions under NOPP sponsorship has collaborated in developing and demonstrating the performance and application of eddy-resolving, real-time global- and basin-scale ocean prediction systems using the HYbrid Coordinate Ocean Model (HYCOM). The partnership represents a broad spectrum of the oceanographic community, bringing together academia, federal agencies, and industry/commercial entities, and spanning modeling, data assimilation, data management and serving, observational capabilities, and application of HYCOM prediction system outputs. In addition to providing real-time, eddy-resolving global- and basin-scale ocean prediction systems for the US Navy and NOAA, this project also offered an …

Oxygen Penetration Deep Into The Sediment Of The South Pacific Gyre, J. P. Fischer, T. G. Ferdelman, Steven D'Hondt, H. Røy, F. Wenzhöfer

Graduate School of Oceanography Faculty Publications

Sediment oxygen concentration profiles and benthic microbial oxygen consumption rates were investigated during an IODP site survey in the South Pacific Gyre. Primary production, particle fluxes and sedimentation rates are extremely low in this ultra-oligotrophic oceanic region. We derived O₂ consumption rates from vertical oxygen profiles in sediments obtained on different spatial scales ex situ (in piston cores and multi cores), and in situ (using a benthic lander equipped with a microelectrode profiler). Along a transect in the area 24 to 46° S and 165 to 117° W, cores from 10 out of 11 sites were oxygenated over their …

Numerical Simulations And Observations Of Surface Wave Fields Under An Extreme Tropical Cyclone, Yalin Fan, Isaac Ginis, Tetsu Hara, C. Wayne Wright, Edward J. Walsh

Graduate School of Oceanography Faculty Publications

The performance of the wave model WAVEWATCH III under a very strong, category 5, tropical cyclone wind forcing is investigated with different drag coefficient parameterizations and ocean current inputs. The model results are compared with field observations of the surface wave spectra from an airborne scanning radar altimeter, National Data Buoy Center (NDBC) time series, and satellite altimeter measurements in Hurricane Ivan (2004). The results suggest that the model with the original drag coefficient parameterization tends to overestimate the significant wave height and the dominant wavelength and produces a wave spectrum with narrower directional spreading. When an improved drag parameterization …

The Kuroshio Extension And Its Recirculation Gyres, Steven R. Jayne, Nelson G. Hogg, Stephanie N. Waterman, Luc Rainville, Kathleen A. Donohue, D. Randolph Watts, Karen L. Tracey, Julie L. Mcclean, Mathew E. Maltrud, Bo Qiu, Shuiming Chen, Peter Hacker

Graduate School of Oceanography Faculty Publications

This paper reports on the strength and structure of the Kuroshio Extension and its recirculation gyres. In the time average, quasi-permanent recirculation gyres are found to the north and south of the Kuroshio Extension jet. The characteristics of these recirculations gyres are determined from the combined observations from the Kuroshio Extension System Study (KESS) field program (June 2004–June 2006) and include current meters, pressure and current recording inverted echo sounders, and subsurface floats. The position and strength of the recirculation gyres simulated by a high-resolution numerical model are found to be consistent with the observations. The circulation pattern that is …