Digital Commons Network^™

Effects Of Physical Activity On Physical Self Perception Among Middle School Students, Leonard Richard Magdaleno

Theses Digitization Project

The purpose of this project was to review and identify effects of physical activity on physical self perception that can be improved through physical education.

Meeting Future Challenges Of Water And Energy Demand Using Watershed Management Strategies In The Inland Empire, Abigail Zepeda Gomez

Theses Digitization Project

The purpose of this project is to provide a cost analysis and possibliity of utilizing recycled water to the north area of Fontana and if it is even possible. Water shortage and drought conditions have increased the cost for treatment of potable water and imported water universally. This had brought much attention to recycled water far and wide. As the population and potable water demand increases over the next 20 years, the availability of recycled water is also projected to grow.

Does Sharing Financial And Creative Resources With Children Function As Extended Phenotypes In Female Ratings Of Male Attractiveness?, Margaret Anne Lanier

Theses Digitization Project

This thesis studies how women rate a man's attractiveness, according to his investments of time or money in a related or unlrelated child, the man himself or another adult. The findings demonstrate that possessing and exhibiting creativity is a powerful tool in attracting females to males, sometimes more powerful than sharing monetary resources.

Theater: A Mission, Angela Marie Sanicola

Theses Digitization Project

This project is designed with the specific goal of developing an intensely, realistic theater program for a target audience of young adults. The thesis will take the reader on a journey of development from page to stage with the transformation of John Bunyan's classic book Pilgrim's Progress.

Improvisation, Truth, And Archetyping: Establishing The Tools And Precepts Of Comedic Acting, Ann Marie Johnston-Brown

Theses Digitization Project

This research set out to prove that truth and archetyping are the primary precepts of comedic acting, and that improvisation is justifiably the most prevalent pedagogical tool for instilling these precepts in the comedic actor. To prove this theory, a comprehensive study of the history of the genre was conducted.

Peter Pan: A Journey Of Imagination, Daniel Mark Monroe

Theses Digitization Project

This project explored ways in which a group of artists can encourage an audience to actively engage their imagination while producing a classical play based on a classic story. This paper discusses the techniques and approaches used to achieve conceptual goals as a director. The directors first goal was to accurately portray the main character. Secondly, he set out to create a Neverland that would allow the entire audience to engage their imagination and capture the joy of their youth.

In Silico-Accelerated Identification Of Conserved And Immunogenic Variola/Vaccinia T-Cell Epitopes, Leonard Moise, Julie A. Mcmurry, Soren Buus, Sharon Frey, William D. Martin, Anne S. De Groot

Institute for Immunology and Informatics Faculty Publications

Epitopes shared by the vaccinia and variola viruses underlie the protective effect of vaccinia immunization against variola infection. We set out to identify a subset of cross-reactive epitopes using bioinformatics and immunological methods. Putative T-cell epitopes were computationally predicted from highly conserved open reading frames from seven complete vaccinia and variola genomes using EpiMatrix. Over 100 epitopes bearing low human sequence homology were selected and assessed in HLA binding assays and in T-cell antigenicity assays using PBMCs isolated from Dryvax-immunized subjects. This experimental validation of computational predictions illustrates the potential for immunoinformatics methods to identify candidate immunogens for a new, …

T Cell Epitope: Friend Or Foe? Immunogenicity Of Biologics In Context, Constanze A. Weber, Preema J. Mehta, Matthew Ardito, Leonard Moise, William Martin, Anne S. De Groot

Institute for Immunology and Informatics Faculty Publications

Like vaccines, biologic proteins can be very immunogenic for reasons including route of administration, dose frequency and the underlying antigenicity of the therapeutic protein. Because the impact of immunogenicity can be quite severe, regulatory agencies are developing risk-based guidelines for immunogenicity screening. T cell epitopes are at the root of the immunogenicity issue. Through their presentation to T cells, they activate the process of anti-drug antibody development. Preclinical screening for T cell epitopes can be performed in silico, followed by in vitro and in vivo validation. Importantly, screening for immunogenicity is complicated by the discovery of regulatory T cell …

Trade-Off Between Aerobic Capacity And Locomotor Capability In An Antarctic Pteropod, Joshua J. C. Rosenthal, Brad A. Seibel, Agnieszka Dymowska, Francisco Bezanilla

Biological Sciences Faculty Publications

At −1.8 °C, the waters of Antarctica pose a formidable physiological barrier for most ectotherms. The few taxa that inhabit this zone have presumably made specific adjustments to their neuromuscular function and have enhanced their metabolic capacity. However, support for this assertion is equivocal and the details of specific compensations are largely unknown. This can generally be attributed to the fact that most Antarctic organisms are either too distantly related to their temperate relatives to permit direct comparisons (e.g., notothenioid fishes) or because they are not amenable to neuromuscular recording. Here, as a comparative model, we take advantage of 2 …

Sildenafil For The Treatment Of Pulmonary Hypertension In Pediatric Patients, Alice J. Huddleston, Chad A. Knoderer, Jennifer L. Morris, Eric S. Ebenroth

Scholarship and Professional Work – COPHS

Sildenafil is a phosphodiesterase 5 inhibitor widely used for the treatment of pulmonary hypertension in children. Despite limited available safety and efficacy evidence, use of sildenafil continues to increase. To date, sildenafil use for pediatric pulmonary hypertension has been characterized for 193 children through 16 studies and 28 case series and reports. The primary efficacy data suggest that sildenafil is beneficial for facilitating the weaning of inhaled nitric oxide in children after cardiac surgery. Compiled safety data suggest that sildenafil is well tolerated among children with idiopathic pulmonary arterial hypertension and pulmonary arterial hypertension associated with congenital heart disease. This …

Insular Cortex And Consummatory Successive Negative Contrast In The Rat, Jian-You Lin, Christopher T. Roman, Steve Reilly

Scholarship and Professional Work – COPHS

Rats that are expecting a high value reward (e.g., 1.0 M sucrose) show an exaggerated underresponding when they are instead given a low value reward (e.g., 0.15% saccharin), an effect termed successive negative contrast (SNC). In the present experiment, insular cortex-lesioned (ICX) rats showed normal responsivity to sucrose and saccharin prior to the reward downshift. However, when switched from sucrose to saccharin during the postshift trials these rats displayed no evidence of SNC. Indeed, over the downshift trials these ICX rats consistently drank more saccharin than the ICX rats maintained on saccharin throughout the experiment. Potential interpretations are discussed including …

Taste-Potentiated Odor Aversion Learning In Rats With Lesions Of The Insular Cortex, Jian-You Lin, Christopher T. Roman, Steve Reilly

Scholarship and Professional Work – COPHS

The current study assessed the influence of excitotoxic lesions of the insular cortex (IC) on tastepotentiated odor aversion (TPOA) learning. Water-deprived rats initially received a single odortoxicosis or odor/taste-toxicosis pairing and were subsequently tested, in separate trials, with the odor and the taste stimulus. Indicating TPOA, neurologically intact rats conditioned with the odor/taste compound stimulus acquired significantly stronger odor aversions than normal rats conditioned with the odor stimulus. IC lesions disrupted TPOA, conditioned taste aversion and taste neophobia. The finding that taste did not potentiate odor aversion learning in the IC lesioned rats provides support for the “within-compound association” analysis …

Morphine-Induced Suppression Of Conditioned Stimulus Intake: Effects Of Stimulus Type And Insular Cortex Lesions, Jian-You Lin, Christopher T. Roman, Steve Reilly

Scholarship and Professional Work – COPHS

Intake of an unconditionally preferred taste stimulus (e.g., saccharin) is reduced by contingent administration of a drug of abuse (e.g., morphine). We examined the influence of insular cortex (IC) lesions on morphine-induced suppression of an olfactory cue and two taste stimuli with different levels of perceived innate reward value. Two major findings emerged from this study. First, morphine suppressed intake of an aqueous odor as well as each taste stimulus in neurologically intact rats. Second, IC lesions disrupted morphine-induced suppression of the taste stimuli but not the aqueous odor cue. These results indicate that the perceived innate reward value of …

Insular Cortex Lesions And Morphine-Induced Suppression Of Conditioned Stimulus Intake In The Rat, Christopher T. Roman, Steve Reilly

Scholarship and Professional Work – COPHS

The present experiment examined the influence of insular cortex (IC) lesions on the intake of a taste stimulus in a consummatory procedure that used morphine as the unconditioned stimulus. In normal rats, morphine caused a rapid reduction in saccharin intake when the taste was novel but not when it was familiar. Irrespective of stimulus novelty, morphine had little influence on the saccharin consumption of IC-lesioned rats. The results are discussed in terms of a lesion-induced disruption of (i) a reward comparison mechanism and (ii) the perception of taste novelty.

Taste, Olfactory And Trigeminal Neophobia In Rats With Forebrain Lesions, Jian-You Lin, Christopher T. Roman, Justin St. Andre, Steve Reilly

Scholarship and Professional Work – COPHS

The present study was designed to examine whether lesions of the insular cortex (IC; Experiment 1), the basolateral amygdala (BLA) or medial amygdala (MeA; Experiment 2) influence the neophobic reactions to orally consumed liquid stimuli. Three different types of stimuli were used: taste (0.5% saccharin), olfactory (0.1% amyl acetate), and trigeminal (0.01 mM capsaicin). Rats with IC, BLA and MeA lesions showed normal responses to the olfactory and trigeminal stimuli. Each type of lesion, however, disrupted the initial occurrence of neophobia to the taste stimulus. The significance of these findings to conditioned taste aversion is discussed.

Conditioned Taste Aversion And Latent Inhibition Following Extensive Taste Preexposure In Rats With Insular Cortex Lesions, Christopher T. Roman, Jian-You Lin, Steve Reilly

Scholarship and Professional Work – COPHS

Lesions of the insular cortex (IC) attenuate acquisition of conditioned taste aversions (CTAs). We have suggested that this impairment is the expected consequence of a failure of IC-lesioned (ICX) rats to recognize unfamiliar taste stimuli as novel. That is, ICX rats treat novel taste stimuli as if they are familiar and as a result show a latent inhibition-like retardation of learning. This account anticipates that ICX rats should acquire CTAs at the same slow rate as normal rats that are familiar with the taste stimulus. The present experiment confirmed this hypothesis in a design that compared CTA acquisition in normal …

Kentucky's Lethal Injection Protocol Satisfies The Eighth Amendment's Prohibition Against Cruel And Unusual Punishment: Baze V. Rees, John P. Cawley

Duquesne Law Review

The United States Supreme Court found that the risk of improper administration of Kentucky's method of execution does not constitute cruel and unusual punishment because it does not impose an objectively intolerable risk to the condemned inmate.

Baze v. Rees, 128 S. Ct. 1520 (2008).

Perspectives On Poetry In Judicial Opinions - Or - How An Elegiac Squirrel Came To Address The Pennsylvania Supreme Court, Sarah Andrews

Duquesne Law Review

No abstract provided.

Because Men Are Not Angels: Separation Of Powers In The United States, D. Brooks Smith

Duquesne Law Review

No abstract provided.

Constitutional Justice And The Separation Of Powers: The Case Of Costa Rica, Fernando Solano Carrera

Duquesne Law Review

No abstract provided.

Efficacy Of Deferasirox In Preventing Complications Of Iron Overload In The Iron Overloaded Gerbil, Rabaa M. Al-Rousan

Theses, Dissertations and Capstones

Iron overload is a significant, world-wide problem that results in several chronic diseases including cardiovascular, hepatic and pancreatic complications.The newly developed, orally effective, iron chelating agent deferasirox is thought to offer tremendous promise as an alternative to deferoxamine. However, the efficacy and safety profile of deferasirox is not yet clear. In the present study, the efficacy of deferasirox in removing iron from target tissues has been examined using the gerbil model of iron overload. Deferasirox administration resulted in a significant reduction of iron from cardiac and hepatic tissue. In addition deferasirox reduced iron induced increase in cardiac and hepatic oxidative …

Columbia Chronicle (2009-2010) Media Kit, Columbia College Chicago

Columbia Chronicle

The Columbia Chronicle's 2009-2010 Media Kit. This issue is 21 pages.

Earthwatch Expedition: Taking Research Experiences To The Classroom, Katherine J. Megivern

Iowa Science Teachers Journal

I participated in the Live from the Field Earthwatch Expedition - Mammals of Nova Scotia, through a fellowship awarded by Wells Fargo. During this experience I participated in research to study the abundance of mammals in Nova Scotia and determine the effect of climate change on natural systems. After this experience I developed an inquiry project for my students in which they study the populations of insects. The students develop their own questions, collect data and make sense of their research. By investigating populations, students are encouraged to see the wonderful biodiversity right in their backyard! This article Promotes National …

Playing The Proof Game: Intelligent Design And The Law, Frank S. Ravitch

Dickinson Law Review (1908-2003)

Intelligent design advocates argue that excluding intelligent design from educational and scientific environments discriminates in favor of methodological naturalism and against other approaches for understanding natural phenomena. These arguments are flawed both legally and philosophically. In order to succeed ID advocates need to demonstrate that ID is science and that public school classes and scientific institutions are public fora for speech. Legal scholarship has generally ignored the most relevant arguments from philosophy of science and the relationship of those arguments to constitutional concepts. This article demonstrates that even when ID is given the benefit of the best scientific, philosophical, and …

Longhunter, Southern Kentucky Genealogical Society Newsletter Volume 32, Number 1 & 2, Kentucky Library Research Collections

Longhunter, Southern Kentucky Genealogical Society Newsletter

No abstract provided.

Kentucky Humanities Council Catalog 2009-2010, Kentucky Library Research Collections

Kentucky Humanities Council Catalog

The Kentucky Humanities Council is an independent, nonprofit affiliate of the National Endowment for the Humanities committed to providing programs and services that facilitate an understanding and appreciation of Kentucky’s cultural heritage and future. The Council’s program catalog features scholars from across the Commonwealth who make presentations on a myriad of humanities topics. Later, costumed actors, who delivered dramatic monologues about Kentucky’s famous, infamous, and composite personalities, were added. The catalog has gone by various titles over the years: Kentucky Humanities Resource Center, Kentucky Humanities Council Speakers Bureau, Whole Humanities Catalog, and Humanities Catalog. This …

On The Monkeys Of The Amazon (1852), Alfred Russel Wallace

Alfred Russel Wallace Classic Writings

No abstract provided.

On The Law Which Has Regulated The Introduction Of New Species (1855), Alfred Russel Wallace

Alfred Russel Wallace Classic Writings

No abstract provided.

On The Tendency Of Varieties To Depart Indefinitely From The Original Type (1858), Alfred Russel Wallace

Alfred Russel Wallace Classic Writings

No abstract provided.

Undergraduate Review, Vol. 5, 2008/2009

Undergraduate Review

No abstract provided.