Digital Commons Network^™

Hexabromocyclododecane Decreases Tumor-Cell-Binding Capacity And Cell-Surface Protein Expression Of Human Natural Killer Cells, Natasha C. Hinkson, Margaret M. Whalen

Chemistry Faculty Research

Hexabromocyclododecane (HBCD) is a flame retardant that decreases the lytic function of human natural killer (NK) cells. NK cells defend against tumor cells and virally infected cells. Thus, HBCD has the potential to increase cancer incidence and viral infections. NK cells must bind to their targets for lysis to occur. Thus, concentrations of HBCD that decrease lytic function were examined for their ability to alter NK binding to tumor targets. Levels of HBCD that caused a loss of binding function were examined for effects on expression of cell surface proteins needed for binding. NK cells exposed to HBCD for 24 …

Usa V. Fullmer

2009 Decisions

USDC for the District of New Jersey

Ceas E-News 11.24.2009, College Of Engineering And Applied Sciences

College of Engineering and Applied Sciences News

Tues, Dec. 8, SEDP conference: 89 seniors offer 32 projects

The Current Volume 20 : Issue 15, Nova Southeastern University

Student Newspapers

No abstract provided.

Ceramide Kinase Regulates Phospholipase C And Phosphatidylinositol 4, 5, Bisphosphate In Phototransduction, Ujjaini Dasgupta, Takeshi Bamba, Salvatore Chiantia, Pusha Karim, Ahmad N. Abou Tayoun

Dartmouth Scholarship

Phosphoinositide-specific phospholipase C (PLC) is a central effector for many biological responses regulated by G-protein-coupled receptors including Drosophila phototransduction where light sensitive channels are activated downstream of NORPA, a PLCbeta homolog. Here we show that the sphingolipid biosynthetic enzyme, ceramide kinase, is a novel regulator of PLC signaling and photoreceptor homeostasis. A mutation in ceramide kinase specifically leads to proteolysis of NORPA, consequent loss of PLC activity, and failure in light signal transduction. The mutant photoreceptors also undergo activity-dependent degeneration. Furthermore, we show that a significant increase in ceramide, resulting from lack of ceramide kinase, perturbs the membrane microenvironment of …

Mustang Daily, November 24, 2009

Cal Poly Student Newspaper

Student newspaper of California Polytechnic State University, San Luis Obispo, CA.

Detection Of Sub-Clinical Cwd Infection In Conventional Test-Negative Deer Long After Oral Exposure To Urine And Feces From Cwd+ Deer, Nicholas J. Haley, Candace K. Mathiason, Mark D. Zabel, Glenn C. Telling, Edward A Hoover

Microbiology, Immunology, and Molecular Genetics Faculty Publications

BACKGROUND: Chronic wasting disease (CWD) of cervids is a prion disease distinguished by high levels of transmissibility, wherein bodily fluids and excretions are thought to play an important role. Using cervid bioassay and established CWD detection methods, we have previously identified infectious prions in saliva and blood but not urine or feces of CWD+ donors. More recently, we identified very low concentrations of CWD prions in urine of deer by cervid PrP transgenic (Tg[CerPrP]) mouse bioassay and serial protein misfolding cyclic amplification (sPMCA). This finding led us to examine further our initial cervid bioassay experiments using sPMCA.

OBJECTIVES: We sought …

The New Hampshire, Vol. 99 [100], No. 22 (Nov. 24, 2009), The New Hampshire

The New Hampshire Print Edition

An independent student produced newspaper from the University of New Hampshire. This volume was printed as 99, but it is the 100th volume in the series. This was corrected in pencil.

A Functional Role For The Ventrolateral Prefrontal Cortex In Non-Spatial Auditory Cognition, Y. E. Cohen, B. E. Russ, S. J. Davis, A. E. Baker, A. L. Ackelson, R. Niteck

Dartmouth Scholarship

Spatial and non-spatial sensory information is hypothesized to be evaluated in parallel pathways. In this study, we tested the spatial and non-spatial sensitivity of auditory neurons in the ventrolateral prefrontal cortex (vPFC), a cortical area in the non-spatial pathway. Activity was tested while non-human primates reported changes in an auditory stimulus' spatial or non-spatial features. We found that vPFC neurons were reliably modulated during a non-spatial auditory task but were not modulated during a spatial auditory task. The degree of modulation during the non-spatial task correlated positively with the monkeys' behavioral performance. These results are consistent with the hypotheses that …

Hotline Press Newspaper- November 24,2009 Vol 27 No 24, Hotline Press Newspaper

Hotline Press Newspaper 2009

No abstract provided.

Synthesis And Evaluation Of Anibamine And Its Analogs As Novel Anti-Prostate Cancer Agents, Kendra Haney

Theses and Dissertations

The chemokine receptor CCR5 has been implicated in the pathogenesis of prostate cancer. A novel natural product, anibamine, was isolated and found to be a micromolar inhibitor of the receptor. Anibamine was used as a new anti-prostate cancer lead compound. To discover the pharmacophore, analogs of anibamine were designed using the “deconstruction-reconstruction-elaboration” approach and synthesized. The establishment of a stereoselective route to only one isomer was explored, to increase yield and eliminate elaborate purification procedures. Analogs were found to have anti-prostate cancer activity at levels higher than the parent compound. The molecular modeling studies of the deconstructed analogs indicate that …

Examination Of Platelet Adhesion By Streptococcus Sanguinis, Brian Mahoney

Theses and Dissertations

Streptococcus sanguinis is a leading cause of infective endocarditis. Bacterial adhesion to platelets is likely important in the pathogenesis of infective endocarditis. Bacterial cell wall-anchored (Cwa) proteins may mediate this adhesion. To begin to test this hypothesis, S. sanguinis adhesion to platelets was examined in vitro. The requirement of 12 Cwa proteins for S. sanguinis-platelet adhesion was individually assessed, measuring adhesion of purified platelets to polystyrene wells coated with S. sanguinis strain SK36 or 12 isogenic Cwa protein mutants. Significantly fewer platelets adhered to wells coated with one mutant strain, VT1614. However, results of a whole-cell enzyme-linked immunosorbent assay (ELISA) …

The Home Of Truth: The Metaphysical World Of Marie Ogden, Stanley J. Thayne

Theses and Dissertations

Marie Ogden's Home of Truth colony—a religious community that was located in southern Utah during the 1930s and 40s—was part of a segment of the American religious landscape that has largely been overlooked. As such, her movement points to a significant gap in the historiography of American religion. In addition to documenting the history of this obscure community, I situate Marie Ogden as part of what I call the early new age of American religion, an underdeveloped part of the broader categories of metaphysical religion or Western esotericism. This thesis also points to several other overlooked figures from the same …

Students Reclaim Watering Holes

Imprint

JCCC is involved in distinguished initiatives this academic year - Achieving the Dream, reduction of our carbon footprint, a new set of strategic goals, a visit from the Higher Learning Commission, and foosball. Yes, foosball.

Imprint Winter 2009 Full Issue

Imprint

This is the full issue of Imprint for Winter 2009.

Susceptibility Of Caenorhabditis Elegans To Burkholderia Infection Depends On Prior Diet And Secreted Bacterial Attractants, Vaughn S. Cooper, Wendy A. Carlson, John J. Lipuma

Molecular, Cellular & Biomedical Sciences

The nematode Caenorhabditis elegans may be killed by certain pathogenic bacteria and thus is a model organism for studying interactions between bacteria and animal hosts. However, growing nematodes on prey bacteria may influence their susceptibility to potential pathogens. A method of axenic nematode culture was developed to isolate and quantify interactions between C. elegans and potentially pathogenic strains of the Burkholderia cepacia complex. Studying these dynamics in liquid solution rather than on agar surfaces minimized nematode avoidance behavior and resolved more differences among isolates. Most isolates of B. cenocepacia, B. ambifaria and B. cepacia caused 60-80% mortality of nematodes after …

The Murray Ledger And Times, November 23, 2009, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

Philip Getson V. State Of New Jersey

2009 Decisions

USDC for the District of New Jersey

Curricular Affairs Committee Minutes November 23, 2009, University Of Rhode Island Faculty Senate

Faculty Senate Committee Reports and Appendices

No abstract provided.

The Utah Statesman, November 23, 2009, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

The Daily Gamecok, Monday, November 23, 2009, University Of South Carolina, Office Of Student Media

November

No abstract provided.

The Role Of Cannabinoids And Cannabinoid Receptors In Enteric Neuronal Survival, Yan Li

Theses and Dissertations

The Endocannabinoid system has been found in the gastrointestinal tract, where it plays an important role in gut under both physiological and pathological conditions. Although the major effects of cannabinoids in the gut are mediated through effects on enteric neurons, the role of cannabinoids in the enteric nervous system is poorly understood. In the present study, we have used the primary cultures of myenteric ganglia and a newly developed fetal enteric neuronal cell line to identify whether the endocannabinoid, anandamide, affects ganglionic and neuronal survival and the pathways involved. Anandamide had a biphasic effect on ganglionic survival, increasing survival at …

Central Florida Future, Vol. 41 No. 90, November 23, 2009

Central Florida Future

UCF earns spot at bowl game 49-0; Service to give rides to students; Education bill will improve grants, loans; Weezer to play free show; Some push for new sign design.

Garnet & Black Holiday Issue 2009, University Of South Carolina, Office Of Student Media

Garnet & Black Magazine

No abstract provided.

A Novel Virtual Reality Curriculum Improves Laparoscopic Skill In Novices, Michael Martinez

Yale Medicine Thesis Digital Library

A NOVEL VIRTUAL REALITY-BASED CURRICULUM IMPROVES LAPAROSCOPIC SKILL IN NOVICES. Michael Joel Martinez, Andrew John Duffy. Department of Surgery, Yale School of Medicine, New Haven, CT. Surgical skills training, facing work hours restrictions and increasing numbers of procedural skills to master, requires an innovative approach to ensure success. We developed a novel basic laparoscopic skill, virtual reality-based simulator curriculum on the LapSim (Surgical Science, Goteborg, Sweden), with a training module and a skills exam enabling trainees to develop a minimum skill level. We hypothesize that unskilled trainees laparoscopic skills performance will improve when compared to controls. Also, those who are …

Bjc Today

BJC Today

No abstract provided.

Purdue Terrestrial Observatory Activities, Larry Biehl, Gilbert Rochon, Bereket Araya, Souleymane Fall, Darion Grant, Jinha Jung, Wonkook Kim, Abdur Rahman Maud, Bertin Mbongo, Joseph Quansah, Thierno Thiam

GIS Day

Recent Purdue Terrestrial Observatory (PTO) activities (in data acquisition and access, hardware, partnerships, other) are described in overview.

Design For Invisibility: Designing A Placing System Through The Study Of User-Object Relationships In Everyday Life, Gahyung Song

Theses

The world we live in is a place where people are influenced by designed objects, often without noticing their presence or the fact that they have been designed at all. Although these objects are taken for granted their impact on our everyday life is immeasurable. By examining designed objects with regard to their relationship to users, this thesis attempts to rediscover the meaning of design in everyday life by encouraging a fluid user-object relationship, rather than a passive consumer-product relationship. It is important to understand the everyday phenomena by which designed objects become invisible when they fit one's environment well. …

Sermon Of Faith Presentation: 37th Psalms, George C. Wright

President Emeritus George C. Wright Speeches

No abstract provided.

In Dreams, Jesse Bickel

Theses

Dreams are a nightly phenomenon that everyone experiences. They are full of vivid imagery, imagination, and emotion. Using dreams as a rich source of inspiration I created wooden objects and furniture for the bedroom, the place where dreams occur. Even though dreams vary from person to person, there are common themes that can be found regardless of culture or gender. I tried to combine those themes with unique and specific imagery from my own dreams. Capturing the intangible quality of dreams proved to be difficult. A dream is like a memory, at times clear and intense, or contrastingly brief and …