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Division Of Research And Economic Development Monthly Report For May 2009, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For February 2009, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For April 2009, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For July 2009, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For June 2009, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For August 2009, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For October 2009, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For September 2009, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For December 2009, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For November 2009, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Does Plasma Ss-Endorphin Influence Exercise-Induced Hypoalgesia In Healthy Adults?, Kathy Lemley

Maria Dittman Library Research Competition: Student Award Winners

Anecdotal reports can be found in the literature of athletes who suffer from an injury, yet continue to participate in their sport with little or no pain. These reports have resulted in an interest in the possible role of stress, including exercise, in analgesia. Exercise-induced hypoalgesia (EIH), a decrease in pain perception following exercise, has been found to occur in healthy adults. In the 1970’s opioid peptides with analgesic properties were discovered (Dalayeun, Nores & Bergal, 1993). One of these peptides, β-endorphin, is believed to be released from the anterior pituitary into the circulation under a variety of stressors, including …

Research & Innovation For 2008-2009, University Of Rhode Island

Publications (Research and Economic Development)

The 2008-2009 issue of Research & Innovation, a periodical focused on research at the University of Rhode Island.

Severe Lactic Acidosis In A Patient With B-Cell Lymphoma: A Case Report And Review Of The Literature, Farn Huei Chan, Daniel Carl, Laurel J. Lyckholm

Internal Medicine Publications

Lactic acidosis is commonly observed in clinical situations such as shock and sepsis, as a result of tissue hypoperfusion and hypoxia. Lymphoma and leukemia are among other clinical situations where lactic acidosis has been reported. We present a case of a 59-year-old female with lactic acidosis who was found to have aggressive B-cell lymphoma. There have been 29 cases of lymphoma induced lactic acidosis reported thus far; however all reported cases have abnormal vital signs or concomitant medical conditions that may lead to lactic acidosis. The pathogenesis of malignancy-induced lactic acidosis is not well understood; however associated factors include increased …

Estrogen Exposure, Obesity And Thyroid Disease In Women With Severe Pulmonary Hypertension, Lori Sweeney, Norbert F. Voelkel

Internal Medicine Publications

Severe pulmonary hypertension is a lethal group of disorders which preferentially afflicts women. It appears that in recent years the patient profile has shifted towards older, obese, and postmenopausal women, suggesting that endocrine factors may be important. Several studies have revealed an increased prevalence of thyroid disease in these patients, but no studies have evaluated for a coexistence of endocrine factors. In particular, no studies have attempted to evaluate for concurrent thyroid disease, obesity and long-term estrogen exposure in patients.

88 patients attending the Pulmonary Hypertension Association 8th International meeting completed a questionnaire and were interviewed. Information was collected regarding …

Hypoxia Regulates Human Lung Fibroblast Proliferation Via P53-Dependent And -Independent Pathways, Shiro Mizuno, Herman J. Bogaard, Norbert F. Voelkel, Yukihiro Umeda, Maiko Kadowaki, Shingo Ameshima, Isamu Miyamori, Takeshi Ishizaki

Internal Medicine Publications

Background Hypoxia induces the proliferation of lung fibroblasts in vivo and in vitro. However, the subcellular interactions between hypoxia and expression of tumor suppressor p53 and cyclin-dependent kinase inhibitors p21 and p27 remain unclear.

Methods Normal human lung fibroblasts (NHLF) were cultured in a hypoxic chamber or exposed to desferroxamine (DFX). DNA synthesis was measured using bromodeoxyuridine incorporation, and expression of p53, p21 and p27 was measured using real-time RT-PCR and Western blot analysis.

Results DNA synthesis was increased by moderate hypoxia (2% oxygen) but was decreased by severe hypoxia (0.1% oxygen) and DFX. Moderate hypoxia decreased p21 synthesis without …

The Biological Function Of Interacting Partners Of Zxd Family Proteins, Rupa V. Koneni

ETD Archive

We have identified several protein-protein interactions amongst the members of the zinc finger, X-linked (ZXD) family of proteins (ZXDA, ZXDB, ZXDC and ZXDC2) that have important roles in the regulation of major histocompatibility complex class II and several myeloid-specific genes. The ZXDC and ZXDA proteins share significant nucleotide sequence homology and each contain ten C2H2 zinc fingers and a transcription activation domain. In addition, ZXDC has a C-terminal region that is necessary to interact with a key cofactor, CIITA (Class II transactivator) and activate Major histocompatibility complex class II and class I (MHC II and MHC I respectively) genes. In …

Structural Investigation Of The Complex Of Filamin A Repeat 21 With Integrin Αiib And Β3 Cytoplasmic Tails – A Potential “Transmission” To Regulate Cell Migration, Jianmin Liu

ETD Archive

Cell functions in multi-cellular organisms are strongly depend on the dynamic cooperation between cell adhesion and cytoskeleton reorganization. Integrins, the major cell adhesion receptors, bind to extracellular matrix (ECM) and soluble ligands on the cell surface and link to the actin cytoskeleton inside the cell membrane. In this manner, integrins integrate cell adhesion and cytoskeleton reorganization by acting as a mechanical force transducer and a biochemical signaling hub (Zamir and Geiger 2001). Consequently, integrins are vital for development, immune responses, leukocyte traffic and hemostasis, and a variety of other cellular and physiological processes. Integrins are also are the focal point …

Fabricating New Miniaturized Biosensors For The Detection Of Dna Damage And Dna Mismatches, N. Indika Perera

ETD Archive

A large number of genetic diseases and genetic disorders are simply caused by base alterations in the genome. Therefore, developing efficient and cost effective techniques for routine detection of these alterations is of great importance. Different methods involving gel electrophoresis and Polymerase Chain Reaction have been widely employed, but majority of these methods are costly, time consuming, and lack throughput, creating a fundamental gap between the current state-of-the-art and desired characteristics of low-cost, high-speed, simplicity, versatility, and potential for miniaturization. In this study, we attempt to bridge this gap by developing new sensing platforms to detect DNA base mismatches and …

Relationship Between Foreign Film Exposure And Ethnocentrism, Lingli Ying

ETD Archive

This study looked at the relationship between foreign film exposure and ethnocentrism by both considering individual differences factors and motives to watch foreign films, based on the uses and gratifications theoretical model. The individual differences factors include cosmopoliteness, access to foreign films and environmental ethnic diversity. The uses and gratifications theory posits that social and psychological factors influence individuals' motives to use media and ultimately lead to different media effects. Accordingly, this research investigated how individual differences related to motives to view foreign films and how foreign film exposure affected people's attitudes to other cultures. A pilot study was conducted …

Evolutionary Psychology, Social Emotions And Social Networking Sites: An Integrative Model, Sandra L. Suran

ETD Archive

Humans engage their environment through the combined effort of the mind, body proper and corresponding instinctual emotive devices (Damasio, 1994). These structures are a part of the same phenomena: human biology. Our emotive devices along with the brain and body act as an interwoven organism appraising the environment and making necessary adjustments for it survival and efficient functioning. Moreover, these structures actively engage socially complex signals like those that we experience daily in our social world. Plausibly, when these devices are not utilized the interwoven organism will be in a state of atrophy. Much like an antigen would trigger a …

Curio 2009 Spring, James Madison University. College Of Arts And Letters

Curio Magazine

Curio, a magazine highlighting Harrisonburg, Virginia, and its surrounding communities, is published by students in the Media Arts & Design program at James Madison University. Curio is a nonprofit organization supported by the College of Arts and Letters and the School of Media Arts & Design. Subscriptions are not available.

''Ma Paroisse Est Dévorée Par L'Ennui'' : Secularisation In Georges Bernanos' ''Journal D'Un Curé De Campagne'' And John Mcgahern's ''That They May Face The Rising Sun''., Eamon Maher

Books/Chapters

No abstract provided.

Reusable, Interactive, Multilingual Online Avatars, Charlie Cullen, Carl Goodman, Paula Mcgloin, Anna Deegan

Conference papers

This paper details a system for delivering reusable, interactive multilingual avatars in online children’s games. The development of these avatars is based on the concept of an intelligent media object that can be repurposed across different productions. The system is both language and character independent, allowing content to be reused in a variety of contexts and locales. In the current implementation, the user is provided with an interactive animated robot character that can be dressed with a range of body parts chosen by the user in real-time. The robot character reacts to each selection of a new part in a …

The Importance Of Saccular Function To Motor Development In Children With Hearing Impairments, Mary S. Shall

Physical Therapy Publications

Children with hearing deficits frequently have delayed motor development. The purpose of this study was to evaluate saccular function in children with hearing impairments using the Vestibular Evoked Myogenic Potential (VEMP). The impact of the saccular hypofunction on the timely maturation of normal balance strategies was examined using the Movement Assessment Battery for Children (Movement ABC). Thirty-three children with bilateral severe/profound hearing impairment between 4 and 7 years of age were recruited from a three-state area. Approximately half of the sample had one or bilateral cochlear implants, one used bilateral hearing aids, and the rest used no amplification. Parents reported …

Apoptotic Engulfment Pathway And Schizophrenia, Xiangning Chen, Cuie Sun, Qi Chen, F. Anthony O'Neill, Dermot Walsh, Ayman H. Fanous, Kodavali V. Chowdari, Vishwajit L. Nimgaonkar, Adrian Scott, Sibylle G. Schwab, Dieter B. Wildenauer, Ronglin Che, Wei Tang, Yongyong Shi, Lin He, Xiong-Jian Luo, Bing Su, Todd L. Edwards, Zhongming Zhao, Kenneth S. Kendler

Human and Molecular Genetics Publications

Background

Apoptosis has been speculated to be involved in schizophrenia. In a previously study, we reported the association of the MEGF10 gene with the disease. In this study, we followed the apoptotic engulfment pathway involving the MEGF10, GULP1, ABCA1 and ABCA7 genes and tested their association with the disease.

Methodology/Principal Findings

Ten, eleven and five SNPs were genotyped in the GULP1, ABCA1 and ABCA7 genes respectively for the ISHDSF and ICCSS samples. In all 3 genes, we observed nominally significant associations. Rs2004888 at GULP1 was significant in both ISHDSF and ICCSS samples (p = 0.0083 and …

Staphylococcus Aureus Immunodominant Surface Antigen B Is A Cell-Surface Associated Nucleic Acid Binding Protein, Nicole M. Mackey-Lawrence, Denise E. Potter, Nuno Cerca, Kimberly K. Jefferson

Microbiology and Immunology Publications

Background

Staphylococcus aureus immunodominant surface antigen B (IsaB) elicits an immune response during septicemia and is generally classified as a virulence factor, but its biological function remains completely undefined. In an attempt to identify staphylococcal RNA-binding proteins, we designed an RNA Affinity Chromatography assay and subsequently isolated IsaB.

Results

Western analysis indicated that IsaB was both secreted and cell-surface associated. Gel Shift analysis confirmed the RNA binding activity but revealed that IsaB bound to any nucleic acid without sequence specificity. IsaB exhibited the highest affinity for double-stranded DNA followed by single-stranded DNA and RNA. Because extracellular DNA has been shown …

Diagnosis Of Infections Caused By Pathogenic Free-Living Amoebae, Bruno Da Rocha-Azevedo, Herbert B. Tanowitz, Francine Marciano-Cabral

Microbiology and Immunology Publications

Naegleria fowleri, Acanthamoeba spp., Balamuthia mandrillaris, and Sappinia sp. are pathogenic free-living amoebae. N. fowleri causes Primary Amoebic Meningoencephalitis, a rapidly fatal disease of the central nervous system, whileAcanthamoeba spp. and B. mandrillaris cause chronic granulomatous encephalitis.Acanthamoeba spp. also can cause cutaneous lesions and Amoebic Keratitis, a sight-threatening infection of the cornea that is associated with contact lens use or corneal trauma. Sappinia pedata has been identified as the cause of a nonlethal case of amoebic encephalitis. In view of the potential health consequences due to infection with these amoebae, rapid diagnosis is critical for early treatment. Microscopic examination and …

Irish Marketing Review, Vol. 20, No. 2, 2009, Aidan O'Driscoll

Issues

Special Issue: Finding an Irish Voice: Reflections on Celtic Consumer Society and Social Change, Edited by Alan Bradshaw, Pierre McDonagh and David Marshall

Talking Bodies: Sensitivity To Desynchronization Of Conversations, Rachel Mcdonnell, Cathy Ennis, Simon Dobbyn, Carol O'Sullivan

Articles

In this article, we investigate human sensitivity to the coordination and timing of conversational body language for virtual characters. First, we captured the full body motions (excluding faces and hands) of three actors conversing about a range of topics, in either a polite (i.e., one person talking at a time) or debate/argument style. Stimuli were then created by applying the motion-captured conversations from the actors to virtual characters. In a 2AFC experiment, participants viewed paired sequences of synchronized and desynchronized conversations and were asked to guess which was the real one. Detection performance was above chance for both conversation styles …

Tennessee Agriculture 2009, Tennessee. Department Of Agriculture

Annual Report & Statistical Summary

This annual report and statistical summary highlights the accomplishments done by the Tennessee Department of Agriculture.