Digital Commons Network^™

Naloxone's Pentapeptide Binding Site On Filamin A Blocks Mu Opioid Receptor–Gs Coupling And Creb Activation Of Acute Morphine, Hoau-Yan Wang, Lindsay H. Burns

Publications and Research

Chronic morphine causes the mu opioid receptor (MOR) to switch its coupling from Gi/o to Gs, resulting in excitatory signaling via both Gαs and its Gβγ dimer. Ultra-low-dose naloxone (NLX) prevents this switch and attenuates opioid tolerance and dependence. This protective effect is mediated via a high-affinity interaction of NLX to a pentapeptide region in c-terminal filamin A (FLNA), a scaffolding protein interacting with MOR. In organotypic striatal slice cultures, we now show that acute morphine induces a dose-dependent Go-to-Gs coupling switch at 5 and 15 min that resolves by 1 hr. The acute Gs coupling induced by 100 µM …

Detection Of Pkc-Iota As A Biomarker For Brain Tumorigenesis, Mildred Acevedo-Duncan, Rekha Patel

USF Patents

A method of detecting brain tumorigenesis in a subject, the method including the steps of (a) obtaining a sample from the brain of the human subject, (b) detecting quantitatively or semi-quantitatively in the sample a level of expression for PKC-iota and (c) comparing the expression level in (b) to a level of expression in a normal control, wherein overexpression of PKC-iota, with respect to the control, indicates the presence of a glioma or meningioma in the subject. The present invention is based upon the discovery that PKC-iota levels are elevated during brain tumorigenesis. Furthermore, the proliferation rate of the tumor …

Ras P27 Mouse Models And Uses Thereof, W. Jack Pledger, Rosalind J. Jackson, Jalila Adnane, Said M. Sebti

USF Patents

The subject invention pertains to a transgenic animal model for tumorigenesis having a genome comprising a ras transgene and which is heterozygous or homozygous for a null p27 gene, and methods of using such animal to screen compounds or evaluate treatments for oncogenic and antitumor activity. The subject invention further concerns a transgenic mouse comprising a ras transgene and which has a genome that is wild-type p27+/+, and wherein the mouse has an FVB/N and C57BL/6X 129 genetic background; and methods of using such transgenic mice to screen compounds or evaluate treatments for oncogenic or antitumor activity. Advantageously, the female …

Growth Factor-Binding Compounds And Methods Of Use, Said M. Sebti, Andrew D. Hamilton, Rishi Jain

USF Patents

Growth factor binding compounds having a plurality of acyclic isophthalic acid groups attached to a non-peptide organic scaffold and pharmaceutical compositions of the same are disclosed. Methods of administering and using the growth factor binding compounds or the growth factor binding compositions are also taught. These novel growth factor binding compounds are useful for treating angiogenesis, excessive cellular proliferation, tumor growth, and a combination thereof as well as inhibiting growth factor binding to cells and phosphorylation.

N-Thiolated 2-Oxazolidinone-Derived Antibiotics, Edward Turos, Rajesh Kumar Mishra

USF Patents

This invention describes the discovery and synthesis of N-thiolated 2-oxazolidinones as a new class of anti bacterial agents. These compounds can be synthesized from 2-oxazolidinones by Ndeprotection and N-sulfenylation. These new substances were found to exhibit potent anti-bacterial activity, including bacteriostatic properties against Staphylococcus spp., including methicillin resistant Staphylococcus aureus (MRSA), and Bacillus spp., including Bacillus anthracis.

The Daily Gamecock, Tuesday, January 27, 2009, University Of South Carolina, Office Of Student Media

January

No abstract provided.

Hotline Press Newspaper- Jan 27,2009 Vol 26 No 32, Hotline Press Newspaper

Hotline Press Newspaper 2009

No abstract provided.

January 27, 2009, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Urban Ecology & Conservation Symposium 2009: 7th Annual -- Connecting Green Research, Lands And Partners (Abstracts), Urban Ecosystem Research Consortium Of Portland/Vancouver

Urban Ecosystem Research Consortium of Portland/Vancouver

The UERC is a consortium of people from various universities and colleges, state and federal agencies, local governments, non-profit organizations and independent professionals interested in supporting urban ecosystem research and creating an information-sharing network of people that collect and use ecological data in the Portland/Vancouver area.

UERC Mission Statement:

To advance the state of the science of urban ecosystems and improve our understanding of them, with a focus on the Portland/Vancouver metropolitan region, by fostering communication and collaboration among researchers, managers and citizens at academic institutions, public agencies, local governments, non-profit organizations, and other interested groups.

The principal organizers span …

The Ticker, January 26, 2009

The Ticker

The Ticker is the student newspaper of Baruch College. It has been published continuously since 1932, when the Baruch College campus was the School of Business and Civic Administration of the City College of New York.

Commonwealth Times 2009-01-26

Commonwealth Times, 1969-

No abstract provided.

Glutathione Diminishes Tributyltin- And Dibutyltin-Induced Loss Of Lytic Function In Human Natural Killer Cells, Jeralyn J. Powell, Mclisa V. Davis, Margaret M. Whalen

Chemistry Faculty Research

This study investigated whether reduced glutathione (GSH) was able to alter the negative effects of tributyltin (TBT) or dibutyltin (DBT) on the lytic function of human natural killer (NK) cells. NK cells are an initial immune defense against the development of tumors or viral infections. TBT and DBT are widespread environmental contaminants, due to their various industrial applications. Both TBT and DBT have been shown to decrease the ability of NK cells to lyse tumor cells (lytic function). The results indicated that the presence of GSH during the exposure of NK cells to TBT or DBT diminished the negative effect …

The Statesman, V. 52, I. 27, Stony Brook University

Stony Brook Statesman-Sucolian

v. 52, i. 27

Mercury From Chlor-Alkali Plants: Measured Concentrations In Food Product Sugar, Renee Dufault, Blaise Leblanc, Roseanne Schnoll, Charles Cornett, Laura Schweitzer, David Wallinga, Jane Hightower, Lyn Patrick, Walter J. Lukiw

Publications and Research

Mercury cell chlor-alkali products are used to produce thousands of other products including food ingredients such as citric acid, sodium benzoate, and high fructose corn syrup. High fructose corn syrup is used in food products to enhance shelf life. A pilot study was conducted to determine if high fructose corn syrup contains mercury, a toxic metal historically used as an anti-microbial. High fructose corn syrup samples were collected from three different manufacturers and analyzed for total mercury. The samples were found to contain levels of mercury ranging from below a detection limit of 0.005 to 0.570 micrograms mercury per gram …

Central Florida Future, Vol. 41 No. 9, January 26, 2009

Central Florida Future

Damage to Tower III caused by grease fire; UCF grads make it in N.Y.; 'Keep that heart if serving'; Alumna's short film premieres at Sundance.

Mustang Daily, January 26, 2009

Cal Poly Student Newspaper

Student newspaper of California Polytechnic State University, San Luis Obispo, CA.

Today - January 26, 2009, Loma Linda University

TODAY

Inside this issue:

-- ‘Come Unto Me’ sculpture graces entrance to Loma Linda University Medical Center
-- Trustees approve new administrative appointment
-- Second careers benefit Children’s Hospital, volunteers
-- School of Public Health graduate receives prestigious award
-- Spiritual life,wholeness forum focuses on trauma
-- School, organizations bring cheer to LLUCH patients
-- School of Medicine plans dedication service for students
-- Kristen Cameron brings musical healing to patients with her harp
-- School of Pharmacy honors students for summer, autumn 2008 quarters
-- Trustees actions of December 10, 2008, outlined
-- Sports luncheon raises $39,835 for PossAbilities
-- …

January 26, 2009 Reporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

The Free Press Vol. 40, Issue No. 12, 01-26-2009, Matt Dodge

Free Press, The

Feel the Burn: Aging backup electrical system to blame for New Year’s Eve fire--New library entrance unlocks new worlds--Muskie School economist predicts prolonged recession--Budget gap widens--USM’s Green Team releases fall report--USM announces next Provost

2008-2009 Mostly Music: Ravel, Kay Kemper, Gareth Johnson, Maryna Yermolenko, David Pedraza, Aziz Sapaev, Jessica Willis, Brian Wahrlich, Jose Menor, Daniel Furtado, Jon Robertson, Lynn Chamber Orchestra, Marshall Turkin, Jan Mcart

Mostly Music Series

Date & Time: Saturday, January 24, 2009 at 7:30 pm & Sunday, January 25, 2009 at 4:00 pm

January 24, 2009 (Pages 399-500), Pennsylvania Legislative Reference Bureau

Volume 39 (2009)

No abstract provided.

Mustang Daily, January 23, 2009

Cal Poly Student Newspaper

Student newspaper of California Polytechnic State University, San Luis Obispo, CA.

Cross-Talk In The Gut, Jennifer E. Dinalo, David A. Relman

United States Department of Veterans Affairs: Publications

Modulation of host signaling by the products of microbial activity in the gut may affect weight gain and fat formation.

The relationship between humans and the population of indigenous microorganisms in their intestines (the gut microbiota) is ancient and important. In a recent survey exploring the relationship between mammals and their microbiota it was found that individuals of the same species were more likely to have a similar gut microbiota than mammals of different species [1]. This observation held true regardless of the geographic separation between the two hosts. These results indicate that the composition of the microbiota is dependent …

2008-2009 Ppc Recital - José Menor (Piano), Jose Menor

PPC/PSDP Recitals

No abstract provided.

We Are…Marshall, January 23, 2009, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Incompatibility With Formin Cdc12p Prevents Human Profilin From Substituting For Fission Yeast Profilin: Insights From Crystal Structures Of Fission Yeast Profilin., Obidimma Ezezika, Noah S Younger, Jia Lu, Donald A Kaiser, Zachary A Corbin, Bradley J Nolen, David R Kovar, Thomas D Pollard

Health Studies Publications

Expression of human profilin-I does not complement the temperature-sensitive cdc3-124 mutation of the single profilin gene in fission yeast Schizosaccharomyces pombe, resulting in death from cytokinesis defects. Human profilin-I and S. pombe profilin have similar affinities for actin monomers, the FH1 domain of fission yeast formin Cdc12p and poly-L-proline (Lu, J., and Pollard, T. D. (2001) Mol. Biol. Cell 12, 1161-1175), but human profilin-I does not stimulate actin filament elongation by formin Cdc12p like S. pombe profilin. Two crystal structures of S. pombe profilin and homology models of S. pombe profilin bound to actin show how the two profilins bind …

First Reading/Reflection, University Of Dayton

Blog Archive: River Reflections at the University of Dayton

The following article published 12 Jan 2008 from NYTimes.com is the first reading for Winter 2009:

Ca2+ Extrusion By Ncx Is Compromised In Olfactory Sensory Neurons Of Omp-/- Mice, Hyun J. Kwon, Jae Hyung Koo, Frank Zufall, Trese Leinders-Zufall, Frank L. Margolis

Faculty Publications

Background: The role of olfactory marker protein (OMP), a hallmark of mature olfactory sensory neurons (OSNs), has been poorly understood since its discovery. The electrophysiological and behavioral phenotypes of OMP knockout mice indicated that OMP influences olfactory signal transduction. However, the mechanism by which this occurs remained unknown. Principal Findings: We used intact olfactory epithelium obtained from WT and OMP-/- mice to monitor the Ca2+ dynamics induced by the activation of cyclic nucleotide-gated channels, voltage-operated Ca2+ channels, or Ca2+ stores in single dendritic knobs of OSNs. Our data suggested that OMP could act to modulate the Ca2+-homeostasis in these neurons …

Dietary Resistant Starch Increases Hypothalamic Pomc Expression In Rats, Li Shen, Michael J. Keenan, Roy J. Martin, Richard T. Tulley, Anne M. Raggio, Kathleen L. Mccutcheon, Jun Zhou

Faculty Publications

Resistant starch (RS) is fermentable dietary fiber. Inclusion of RS in the diet causes decreased body fat accumulation and altered gut hormone profile. This study investigates the effect of feeding RS on the neuropeptide messenger RNA (mRNA) expressions in the arcuate nucleus (ARC) of the hypothalamus and whether vagal afferent nerves are involved. The rats were injected intraperitoneally with capsaicin to destroy unmyelinated small vagal afferent nerve fibers. The cholecystokinin (CCK) food suppression test was performed to validate the effectiveness of the capsaicin treatment. Then, capsaicin-treated rats and vehicle-treated rats were subdivided into a control diet or a RS diet …

Daily Eastern News: January 23, 2009, Eastern Illinois University

January

No abstract provided.