Digital Commons Network^™

Discovering Metabolic Networks Of Bovine Fertilization, Erin Lynn Young

Undergraduate Honors Capstone Projects

At the time of fertilization, a dramatic change occurs in the oocyte that transforms this cell from a metaphase arrested state into a metabolically active and dynamic state. The view of the flow of biological processes within organisms has recently shifted from that of a linear path to a more complex network. Biological processes are no longer thought of in the simple terms of DNA to RNA, RNA to proteins, and proteins to final activity. It is now known that many biological processes involve interconnected networks and feedback loops in which DNA, RNA, proteins, and metabolites perform specific roles. We …

The Capabilities Conception Of The Individual, John B. Davis

Economics Faculty Research and Publications

This paper advances a capabilities conception of the individual, and considers some of the problems involved in developing such a conception. It also makes claims about the nature of the capability space as a whole, frames personal development in terms of the idea of moving though the capability space, and argues that people are alike in being increasingly heterogeneous. A key problem for a capabilities conception of the individual is that some capabilities, such as belonging to social groups and having social identities, can undermine individuality. The paper discusses an example in which people can have social identities but can …

The Relationship Between Soul And Spirit In Greek And Latin Patristic Thought, Alexey R. Fokin

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

Substance Dualism, Richard Swinburne

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

"The Hard Problem Of Consciousness" And Two Arguments For Interactionism, Vadim V. Vasilyev

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

Russian Orthodox Theological Anthropology Of The Twentieth Century: Major Trends, Fr. Vladimir Shmaliy

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

Law's Expressive Value In Combating Cyber Gender Harassment, Danielle Keats Citron

Michigan Law Review

The online harassment of women exemplifies twenty-first century behavior that profoundly harms women yet too often remains overlooked and even trivialized. This harassment includes rape threats, doctored photographs portraying women being strangled, postings of women's home addresses alongside suggestions that they are interested in anonymous sex, and technological attacks that shut down blogs and websites. It impedes women's full participation in online life, often driving them offline, and undermines their autonomy, identity, dignity, and well-being. But the public and law enforcement routinely marginalize women's experiences, deeming the harassment harmless teasing that women should expect, and tolerate, given the internet's Wild …

Lawyer - Winter 2009, Seattle University School Of Law

Lawyer

• Justice Doesn’t Retire: Sandra Day O'Connor Headlines National Conference Exploring Judicial Independence
• Study by the Midnight Sun: Study in Alaska Program Provides Unique view of State's Legal System
• Where his Heart is: Sean Parnell is Law School's First Governor
• On the Hill: Graduates Share Top-Secret Work and Friendship

Plato's Analogical Thought, Holly G. Moore

College of Liberal Arts & Social Sciences Theses and Dissertations

The philosophical concept of analogy is fundamental to the theory of imaging that characterizes Plato’s metaphysics, cosmology, and methodology. While Plato never explicitly conceptualizes the philosophical role of analogy, his dialogues are rife with analogies and images that are often pivotal to the thought expressed there. An analysis of celebrated analogies such as the sun and the good in the Republic, the “second sailing” in the Phaedo, the “receptacle” (chōra) in the Timaeus, and the example of weaving in the Statesman reveals that even if the theory each elucidates is not explicitly concerned with analogy, the theories these images enable …

Biological Diversity Of Prokaryotic Type Iv Secretion Systems, Cristina E Alvarez-Martinez, Peter J Christie

Faculty, Staff and Student Publications

Type IV secretion systems (T4SS) translocate DNA and protein substrates across prokaryotic cell envelopes generally by a mechanism requiring direct contact with a target cell. Three types of T4SS have been described: (i) conjugation systems, operationally defined as machines that translocate DNA substrates intercellularly by a contact-dependent process; (ii) effector translocator systems, functioning to deliver proteins or other macromolecules to eukaryotic target cells; and (iii) DNA release/uptake systems, which translocate DNA to or from the extracellular milieu. Studies of a few paradigmatic systems, notably the conjugation systems of plasmids F, R388, RP4, and pKM101 and the Agrobacterium tumefaciens VirB/VirD4 system, …

Dissolved Organic Matter Influences The Timing Of Embryonic Development Of The Purple Sea Urchin, Strongylocentrotus Purpuratus., Corbin J. Hodges

Master's Theses

Marine dissolved organic matter (DOM) comprises one of the largest carbon reservoirs on earth and has long been considered a potential energy source for marine invertebrates. The importance of DOM transport has been adequately demonstrated for unicellular organisms, where DOM can meet 100% of an organisms energy needs, but the effects of DOM uptake for marine metazoans are less well understood. In this study, three general areas involving the influence of DOM transport to marine invertebrates were explored. First, we assessed the effects of using seawater exposed to high intensity ultraviolet radiation (UVR) on the study organism; embryos of the …

Arroyo Toad (Anaxyrus Californicus) Life History, Population Status, Population Threats, And Habitat Assessment Of Conditions At Fort Hunter Liggett, Monterey County, California, Jacquelyn Petrasich Hancock

Master's Theses

The arroyo toad (Anaxyrus californicus) is a federally endangered species found on Fort Hunter Liggett, Monterey County, California. The species was discovered in 1996 and was determined to occupy 26.7 km of the San Antonio River from approximately 2.4 km northwest of the San Antonio Mission de Padua, to the river delta above the San Antonio Reservoir. The construction of the San Antonio Reservoir dam in 1963 isolated this northern population of arroyo toads. Through time, the Fort Hunter Liggett landscape has changed drastically. The land was heavily grazed by cattle until 1991, which considerably reduced vegetation in riparian areas. …

A Computational Model Of Apoptotic Osteocyte Correlation To Cortical Bone Remodeling Parameters, Michael Stephen Alexander

Master's Theses

The onset of osteoporosis caused by aging, disease states, and post-menopausal conditions significantly impacts patient quality of life, required healthcare funding, personal autonomy losses from increased fracture risk and the subsequent corrective surgery. Research has indicated that osteocyte apoptosis may be a key parameter in bone remodeling, raising the possibility of remodeling rate modulation for the mitigation of bone mass resorption. By developing therapies that target osteocyte apoptosis, it may be possible to prevent undesired bone remodeling activity while maintaining a healthy balance between damage formation in the form of microcracks induced by the strain environment and the removal of …

The Effect Of Embryo Biopsy And Vitrification On The Development Potential Of Equine Embryos, Richard O. Gearhart

Master's Theses

This study investigated the development potential of equine embryos in vitro after biopsy and vitrification. Twenty embryos were obtained from Quarter Horse, Thoroughbred, and mix-breed light mares between three and ten years old. The twenty embryos were divided into a biopsy (n=10) and control group (n=10). The biopsy group underwent microaspiration biopsy using a micromanipulator to obtain a small tissue sample from the embryo. Both groups were then vitrified using a commercially available technique originally described by Carnevale (2006) at Colorado State \ University.

All 20 embryos were cultured in DMEM/Hams F-12 medium under oil at 37°C in 5% CO2 …

Changing Portrayals Of Captain James Cook In Hawaiian Education, Christopher Aaron Straub

Master's Theses

This paper covers the portrayals of Captain James Cook within Hawaiian education. It begins by providing a backdrop to early European portrayals of Captain Cook and then proceeds to investigate how these portrayals changed as they were incorporated into Hawaiian textbooks. The paper then continues to illustrate the changes made in Cook’s portrayal within Hawaiian textbooks and how these changes coincide with the prevailing interests of the eras in which the authors wrote them.

A Neural Network Approach To Border Gateway Protocol Peer Failure Detection And Prediction, Cory B. White

Master's Theses

The size and speed of computer networks continue to expand at a rapid pace, as do the corresponding errors, failures, and faults inherent within such extensive networks. This thesis introduces a novel approach to interface Border Gateway Protocol (BGP) computer networks with neural networks to learn the precursor connectivity patterns that emerge prior to a node failure. Details of the design and construction of a framework that utilizes neural networks to learn and monitor BGP connection states as a means of detecting and predicting BGP peer node failure are presented. Moreover, this framework is used to monitor a BGP network …

Design And Performance Of Load Bearing Shear Walls Made From Composite Rice Straw Blocks, Kevin Robert Camann

Master's Theses

Although rice straw and other grains have been used in building since pre-history, in the past two decades, there has been a move to utilize this rapidly renewable, locally available, agricultural byproduct as part of the sustainable construction movement. Up to this point, this has been done by simply stacking up the full straw bales. Stak Block, invented by Oryzatech, Inc., is a modular, interlocking block made of a composite of rice straw and binding agent that serves as an evolution in straw construction. This study investigates the feasibility of using these Stak Blocks as a structural system. The report …

Outcomes Associated With Outward Bound And Nols Programs: A Means-End Study, Daniel Thomas Pronsolino

Master's Theses

Outward Bound and the National Outdoor Leadership School (NOLS) are two of the United State’s largest providers of outdoor education and adventure recreation programs. While many studies have examined the outcomes of the different organizations individually, there is very little comparative research. This study compared the attributes, consequences, and values obtained by 510 participants of courses 14 days or longer in the Rocky Mountain region during the summer of 2006.

Means-end theory was used to analyze data obtained from participants through personal interviews. Means-end theory links the physical objects or services, the means, with the outcomes and the personal values …

Russian Magical Realism And Pelevin As Its Exponent, Alexandra Berlina

CLCWeb: Comparative Literature and Culture

In her article "Russian Magical Realism and Pelevin as Its Exponent" Alexandra Berlina seeks to enrich magical realism studies as a field of comparative literature and culture by showing that, although largely ignored in scholarship, such a thing as Russian magical realism exists and provides an interesting field for analysis. First, Berlina provides an overview of relevant scholarly works on the genre, tracing mentions (as well as striking omissions) of Russian influence, followed by a discussion of the few publications which deal with Russian magical realism, concentrating on Erika Haber's The Myth of the Non-Russian. Berlina then discusses Viktor Pelevin …

Mepe/Of45 Protects Cells From Dna Damage Induced Killing Via Stabilizing Chk1., Shuang Liu, Hongyan Wang, Xiang Wang, Lin Lu, Ning Gao, Peter S N Rowe, Baocheng Hu, Ya Wang

Department of Radiation Oncology Faculty Papers

Matrix extracellular phosphoglycoprotein/osteoblast factor 45 (MEPE/OF45) was cloned in 2000 with functions related to bone metabolism. We identified MEPE/OF45 for the first time as a new co-factor of CHK1 in mammalian cells to protect cells from DNA damage induced killing. We demonstrate here that MEPE/OF45 directly interacts with CHK1. Knocking down MEPE/OF45 decreases CHK1 levels and sensitizes the cells to DNA damage inducers such as ionizing radiation (IR) or camptothicin (CPT)-induced killing. Over-expressing wild-type MEPE/OF45, but not the mutant MEPE/OF45 (depleted the key domain to interact with CHK1) increases CHK1 levels in the cells and increases the resistance of the …

Mitochondrial Mislocalization Underlies Abeta42-Induced Neuronal Dysfunction In A Drosophila Model Of Alzheimer's Disease., Kanae Iijima-Ando, Stephen A Hearn, Christopher Shenton, Anthony Gatt, Lijuan Zhao, Koichi Iijima

Department of Biochemistry and Molecular Biology Faculty Papers

The amyloid-beta 42 (Abeta42) is thought to play a central role in the pathogenesis of Alzheimer's disease (AD). However, the molecular mechanisms by which Abeta42 induces neuronal dysfunction and degeneration remain elusive. Mitochondrial dysfunctions are implicated in AD brains. Whether mitochondrial dysfunctions are merely a consequence of AD pathology, or are early seminal events in AD pathogenesis remains to be determined. Here, we show that Abeta42 induces mitochondrial mislocalization, which contributes to Abeta42-induced neuronal dysfunction in a transgenic Drosophila model. In the Abeta42 fly brain, mitochondria were reduced in axons and dendrites, and accumulated in the somata without severe mitochondrial …

Regulation Of Energy Stores And Feeding By Neuronal And Peripheral Creb Activity In Drosophila., Koichi Iijima, Lijuan Zhao, Christopher Shenton, Kanae Iijima-Ando

Department of Biochemistry and Molecular Biology Faculty Papers

The cAMP-responsive transcription factor CREB functions in adipose tissue and liver to regulate glycogen and lipid metabolism in mammals. While Drosophila has a homolog of mammalian CREB, dCREB2, its role in energy metabolism is not fully understood. Using tissue-specific expression of a dominant-negative form of CREB (DN-CREB), we have examined the effect of blocking CREB activity in neurons and in the fat body, the primary energy storage depot with functions of adipose tissue and the liver in flies, on energy balance, stress resistance and feeding behavior. We found that disruption of CREB function in neurons reduced glycogen and lipid stores …

Leadership Assessment: A Tool For Developing Future Hospitality Leaders, Sam Carlton

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this paper is to identify and confirm important key leadership behaviors and characteristics of successful hotel and hospitality leaders with the intentions of validating key leadership theories and making suggestions for future hotel and hospitality leaders. Two very relevant theories of leadership are explored- Transactional and Transformational. The traits and behaviors contained within the theories are identified and subsequently mapped against past and present hospitality industry leaders. As a result, the paper identifies the critical few traits and behaviors necessary for future leaders to be successful. Finally, a tool has been developed to be used to identify …

The Role Of Cultural And Change During Mergers And Acquisitions: Bringing The Pride Back, Geoffrey W. Denight Jr

UNLV Theses, Dissertations, Professional Papers, and Capstones

In 1998 a small family run casino operation was acquired by a large Las Vegas Casino Corporation. At the time the two companies had different cultures and there was an immediate clash between the two as the larger corporation sought to change the ways business was being conducted. Compounded by out side economic factors the business experienced a dramatic decline in revenue and employee morale. In this case study, the personalities and outside factors that had an impact on this acquisition will be revealed and the steps taken to change and manage the culture of the company, improve morale and …

Costs Of Implementing Collective Action And Capacity Building Among Pastoralists In Southern Ethiopia, D. Layne Coppock, Seyoum Tezera, Solomon Desta

Environment and Society Faculty Publications

Since 2000, the PARIMA project has implemented risk-management activities among semi-settled pastoralists in southern Ethiopia. The goal has been to improve human welfare via collective action and capacity building. Outcomes include progress in income generation, asset conservation, and livelihood diversification. Fifty-nine collective-action groups were created. Dominated by women, they included over 2,000 founding members and groups have recently merged to form 37 cooperatives, consistent with government policy. Creating sustainable impacts via collective action and capacity building requires many inputs. Taking raw, illiterate volunteers and transforming them into sustainable groups took up to three years, on average. Costs of implementing this …

An Entity Sui Generis In The Wto: Taiwan's Wto Membership And Its Trade Law Regime, Han-Wei Liu

Research Collection Yong Pung How School Of Law

As one of the founding members of the General Agreement on Tariffs and Trade (GATT), Taiwan (the Republic of China or ROC) - the 17th largest economy, was granted accession to the World Trade Organization (WTO) in November 2001 after its observer status of eleven years. Taiwan, classified by most commentators as an "unrecognized state" or an "entity sui generis", has been excluded from most of the major international organizations. Taiwan's accession to the WTO, therefore, is considered to be an important breakthrough in diplomacy for the past decades. Notwithstanding its WTO membership, the Taiwanese Government has employed numerous trade …

Does Patent Strategy Shape The Long-Run Supply Of Public Knowledge? Evidence From Human Genetics, Kenneth G. Huang, Fiona Murray

Research Collection Lee Kong Chian School Of Business

Knowledge-based firms seeking competitive advantage often draw on the public knowledge stream (ideas embedded in public commons institutions) as the foundation for private knowledge (ideas firms protect through private intellectual property [IP] institutions). However, understanding of the converse relationship—the impact of private knowledge strategies on public knowledge production—is limited. We examine this question in human genetics, where policy makers debate expanding IP ownership over the human genome. Our difference-in-differences estimates show that gene patents decrease public genetic knowledge, with broader patent scope, private sector ownership, patent thickets, fragmented patent ownership, and a gene's commercial relevance exacerbating their effect.

Tb Research At Ut-Houston – A Review Of Cord Factor: New Approaches To Drugs, Vaccines And The Pathogenesis Of Tuberculosis, Robert L Hunter, Lisa Armitige, Chinnaswamy Jagannath, Jeffrey K Actor

Faculty, Staff and Student Publications

Tuberculosis remains a major threat as drug resistance continues to increase. Pulmonary tuberculosis in adults is responsible for 80% of clinical cases and nearly 100% of transmission of infection. Unfortunately, since we have no animal models of adult type pulmonary tuberculosis, the most important type of disease remains largely out of reach of modern science and many fundamental questions remain unanswered. This paper reviews research dating back to the 1950's providing compelling evidence that cord factor (trehalose 6,6 dimycolate [TDM]) is essential for understanding tuberculosis. However, the original papers by Bloch and Noll were too far ahead of their time …

A Study Of Land Use Planning Practices And The Relationship Between Population Distribution And Transportation Infrastructure In Kathmandu, Nepal., Walter Suwal

Theses and Dissertations

This particular paper is meant to investigate planning in Kathmandu, Nepal specifically land use planning practices and the implications on the transportation network(s). Very early on in the research including existing land use (if any), and current transportation networks, it was clear that investigations must be made into the political and planning situation leading up to the modern era in Nepal. The overview of past political events is necessary to explain current planning trends and techniques, and also the mindset of the people of Kathmandu towards planning. Of course universal planning truths can be applied in various international contexts, but …

Examining Job Satisfaction Online Adjunct Instructors': A Phenomenological Study, Shalyn Lapke

Theses and Dissertations

The study of job satisfaction for professors in the work place has been prevalent in the research for decades (COACHE, 2007). As online education grows exponentially each year (Allen & Seaman, 2006), this aspect of professorial teaching is emerging as an increasingly critical factor. Many professors that teach in the online sector have taught or are currently teaching in a face-to-face setting as well (Preziosi & Gooden, 2003). Also, many of the professors teaching online courses in the higher education arena are being hired as adjunct instructors. There is a lack of literature dealing with the satisfaction of the educator …