Digital Commons Network^™

Choosing The Right Path: Enhancement Of Biologically Relevant Sets Of Genes Or Proteins Using Pathway Structure, Reuben Thomas, Julia M. Gohlke, Geffrey F. Stopper, Frederick M. Parham, Christopher J. Portier

Biology Faculty Publications

A method is proposed that finds enriched pathways relevant to a studied condition using the measured molecular data and also the structural information of the pathway viewed as a network of nodes and edges. Tests are performed using simulated data and genomic data sets and the method is compared to two existing approaches. The analysis provided demonstrates the method proposed is very competitive with the current approaches and also provides biologically relevant results.

College Students And Service: A Mixed Methods Exploration Of Motivations, Choices, And Learning Outcomes, Ronald Chesbrough

Department of Educational Administration: Dissertations, Theses, and Student Research

Advisor: James V. Griesen
The purpose of this two-phase exploratory mixed methods research was to add to an understanding of the motivations toward service among college students, to get a clearer sense of how students choose their particular service involvements, and to better understand the learning outcomes from service involvement during college. Underlying philosophical assumptions of the study were that service involvement during college contributes in several positive ways to student development, and that student descriptions of their motivations, choices, and learning from service will vary based on gender, year in college, and amount of service performed.

Findings indicated that …

National Student Advertising Competition: Century Council Binge Drinking Campaign, Volation (Team), Ruth Brown, Bettina Burklund, Stacy James, Zach Janky, Phyllis Larsen, Bruce Mitchell, Chuck Piper, Adam Wagler

College of Journalism and Mass Communications: Student Advertising Projects

April 28, 2009 — Advertising students from the University of Nebraska-Lincoln College of Journalism and Mass Communications took home first place in the District 9 American Advertising Federation's National Student Advertising Competition April 24. A first for the program, this win places the team among an elite group of 15 from across the country that will compete for the national title in Washington, D.C., June 4-5. UNL will represent District 9, which includes Nebraska, Iowa, Missouri and Kansas. Judges were unanimous in their decision that the team, Volation, stood far above the other seven teams competing, with a "risky" concept …

Front, North American Bird Bander

North American Bird Bander

No abstract provided.

Front, North American Bird Bander

North American Bird Bander

No abstract provided.

Front 34-4.Pdf, North American Bird Bander

North American Bird Bander

No abstract provided.

Development And Evaluation Of New Mask Protocols For Gene Expression Profiling In Humans And Chimpanzees, Donna M. Toleno, Gabriel Renaud, Tyra G. Wolfsberg, Munirul Islam, Derek E. Wildman, Kimberly D. Siegmund, Joseph G. Hacia

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Cross-species gene expression analyses using oligonucleotide microarrays designed to evaluate a single species can provide spurious results due to mismatches between the interrogated transcriptome and arrayed probes. Based on the most recent human and chimpanzee genome assemblies, we developed updated and accessible probe masking methods that allow human Affymetrix oligonucleotide microarrays to be used for robust genome-wide expression analyses in both species. In this process, only data from oligonucleotide probes predicted to have robust hybridization sensitivity and specificity for both transcriptomes are retained for analysis.

Results

To characterize the utility of this resource, we applied our mask protocols …

Smi Of Bcl-2 Tw-37 Is Active Across A Spectrum Of B-Cell Tumors Irrespective Of Their Proliferative And Differentiation Status, Ayad M. Al-Katib, Yuan Sun, Anton Goustin, Asfar Azmi, Ben Chen, Amro Aboukameel, Ramzi M. Mohammad

Wayne State University Associated BioMed Central Scholarship

Abstract

The Bcl-2 family of proteins is critical to the life and death of malignant B-lymphocytes. Interfering with their activity using small-molecule inhibitors (SMI) is being explored as a new therapeutic strategy for treating B-cell tumors. We evaluated the efficacy of TW-37, a non-peptidic SMI of Bcl-2 against a range spectrum of human B-cell lines, fresh patient samples and animal xenograft models. Multiple cytochemical and molecular approaches such as acridine orange/ethidium bromide assay for apoptosis, co-immunoprecipitation of complexes and western blot analysis, caspase luminescent activity assay and apoptotic DNA fragmentation assay were used to demonstrate the effect of TW-37 on …

Brain Candy: Wayne State University School Of Medicine Journal Of Art And Literature, 1st Edition, Wayne State University School Of Medicine Writing Workshop, Wayne State University School Of Medicine Gold Humanism Honor Society

Gold Humanism Honor Society

The first edition of Brain Candy, distributed in August 2009 with a generous grant from the Gold Humanism Honor Society.

Brain Candy collects poetry, nonfiction essays, short fiction, photographs, and drawings to shed light on the creative process in medicine, the city of Detroit, and the experiences of health care providers. Features submissions from medical students, physicians, and School of Medicine staff.

The Game Is Afoot: Constitutionalizing The Right To Hunt And Fish In The Tennessee Constitution, Jeffrey Omar Usman

Law Faculty Scholarship

The normative role of state constitutions, which are simultaneously paramount state law and inferior to the whims of even the most minor federal regulation, is a matter of some uncertainty. In recent years, state constitutions have been significantly affected by another wave of popular constitutionalism. As part of this movement, since 1996, seven states have adopted constitutional provisions guaranteeing a right to hunt and fish. This article explores the constitutionalization of hunting and fishing rights under state constitutions. It begins by tracing hunting and fishing rights through western legal history with a special emphasis on Ancient Rome, England, and the …

Exploring The Affective Constitution, Kathryn Abrams

Case Western Reserve Law Review

No abstract provided.

Modifying The Religious Land Use And Institutionalized Persons Act To Create A Constitutional Statutory Protection For Religious Landowners, Sara Witt

Case Western Reserve Law Review

No abstract provided.

Chinese Philanthropy In Southeast Asia: Between Continuity And Change, Thomas Menkhoff

Research Collection Lee Kong Chian School Of Business

What makes ethnic Chinese philanthropy tick? Thomas Menkhoff looks at what drives prominent Chinese business leaders to give back to society and offers a glimpse of the changing face of ethnic philanthropy.

State Of The Fisheries Report 2008/09, W.J Fletcher, K. Santoro

Status Reports of the Fisheries and Aquatic Resources

The State of the Fisheries Report summarises the outcomes of many departmental activities undertaken during 2008/09 including management changes, compliance work and research to assess stock levels, monitor breeding stocks and undertake environmental assessments. This document provides a valuable reference point for the status of Western Australian fisheries of major importance to the commercial and recreational sectors, the aquaculture industry and for those interested in aquatic management.

Alternative Sources Of Energy, David Kennedy

Conference Papers

Ireland relies on imports of fossil fuels for up to 83% of its energy needs and this statistic is relatively common in other European countries. Apart from the high import costs and pollutions associated with fossil fuels and the need to meet new targets in terms of CO2 emissions, energy security is essential. This paper provides an overview and outline of the different alternative energy sources available for use either at domestic or on large scale production, some of which are established and others less likely to succeed in our climate.
Some of the alternative energy sources such as wind …

Invertebrate Colonization And Plant Architecture: The Influence Of Two Non-Native Milfoil Species, Elizabeth W. Rielly

Theses and Dissertations

The purpose of this study was to determine if the complexity and surface area of a macrophyte’s

structure has an influence on invertebrate colonization, and to determine the influence of two non-native species on invertebrate colonization. Three plant architectures were compared. Floating leaved plants were represented by the following species: Nuphar lutea, Nymphaea odorata, and Brasenia schreberi. Moderately dissected leaved plants were represented by Potamogeton natans, and highly dissected leaved plants were represented by two non-native species, Myriophyllum spicatum and Myriophyllum heterophyllum. The number of invertebrates/g dry biomass and the number of individuals/m², diversity, evenness, and richness were calculated for …

Surgical Smoke Evacuation Guidelines: Compliance Among Perioperative Nurses, Kay A. Ball

Theses and Dissertations

Smoke (plume) is produced when tissue is cut or coagulated with lasers or electrosurgery devices during surgery. Research has documented that surgical smoke creates a serious workplace hazard for over 500,000 healthcare workers. Toxic gases create an offensive odor, small particulate matter causes respiratory complications, and pathogens may be transmitted within the surgical smoke to the surgical team. Previous research notes that smoke evacuation recommendations are not being consistently followed by perioperative nurses.

The purpose of this study is to determine key indicators that are associated with compliance with smoke evacuation recommendations by perioperative nurses. The Diffusion of Innovation theory …

Identification And Characterization Of Prevotella Intermedia 17 Toll-Like Receptor 2 Ligands, Jamie Feng-Hsia Yuan

Theses and Dissertations

Periodontal disease is one of the most prevalent human diseases affecting millions of individuals. Bacteria are the trigger of the host response that then results in initiation and progression of periodontal disease. The interactions between the host and the bacteria, although very complex and intricate, are not well understood. Species of gram-negative anaerobic bacteria implicated in the development of periodontal disease include Porphyromonas gingivalis and Prevotella intermedia. The goal of our study was to identify P. intermedia surface proteins interacting with TLR2 receptor. Using Cy5-labeled surface proteins we identified multiple proteins using our capture assay. The interaction of three …

The Bird, Katherine Ann Kisicki

Theses and Dissertations

I have always approached my paintings with confidence. Mark making has always been my strength, particularly in drawing, and I feel this comes through in my gestural use of the paint. I also believe I approach paintings in a trial and error manner, where experimentation has precedence over concept. To remain in the moment and focused on what I am doing at that moment is a fundamental base of both my process and, interestingly what the resulting image translates to the viewer. To know this, and to remain suspended in this moment requires a foundation of trust within my capabilities …

Media To Medium: Representations Of Violence, War & Women In Pop Culture, Althea Georgelas

Theses and Dissertations

My work is inspired by the mass Media and how it affects the world around me. I am interested in how violence, war and women are represented in popular culture and how this has trickled down into social behavior. I also wonder how much entertainment media reflects deep social ideals. I define mass media as the viral proliferation of ideas using television, cinema, video gaming and the Internet. I am concerned about the social and psychological affects of violent media and how it impacts the lives of women and girls. This is of particular interest to me because I am …

Pulmonary Delivery Of Anorectic Gut Secreted Peptides For Appetite Suppression In Rats, Priya Nadkarni

Theses and Dissertations

This dissertation project aimed to demonstrate that pulmonary delivery of two anorectic gut secreted peptides, peptide YY (PYY) and oxyntomodulin (OXM) enabled food intake suppression and reduced body weight gain in rats via their systemic absorption from the lung and interaction with the brain. After PYY and OXM were administered to the lungs at varying doses, food intake and body weight gain were monitored in freely feeding rats. Significant 30-35 % food intake suppression was achieved for 4-6 h following pulmonary administration of endogenously active PYY3-36 and OXM1-37 at 0.80 and 0.50 mg/kg, respectively. Moreover, when administered daily for 7 …

Spatial And Temporal Variability Of Macroinvertyebrate Communities In Vernal Pools On The Coastal Plain Of Virginia, Shrijeeta Ganguly

Theses and Dissertations

Vernal pools are often defined as seasonal pools that typically are inundated beginning in the winter and then drying out completely in summer. Though evidence of spatial and temporal variability in the macroinvertebrate communities of vernal pools has been found in previous studies, it has not been studied extensively. The primary objective of this study was to determine the extent of variability in the macroinvertebrate communities within vernal pools closely situated in a forested landscape. An effort was made to explain this variability with respect to certain physiochemical environmental variables of the pools. Significant variability was observed in the macroinvertebrate …

Identification Of Camk-Ii Protein Targets In Tissue Culture And Zebrafish Embryos Using Tandem Mass Spectrometry, Alexandra Myers

Theses and Dissertations

Calcium (Ca2+)/calmodulin-dependent kinase 2 (CaMK-II) is one member of a family of Ca2+/calmodulin-dependent protein kinases that responds to intracellular Ca2+ signals (Hudmon, A. and H. Schulman (2002)). CaMK-II is a multifunctional regulator of transcription, cell cycle progression, cell motility and neuronal development. (Wang, C., et al. (2008), Easley, C. A. IV, et al. (2008), Osterhoff, M., et al. (2003), Faison, M. O., et al. (2002)). Recently, CaMK-II has been shown to be important in the early development of vertebrates. In developing zebrafish, disruption of CaMK-II expression has been shown to induce phenotypes similar to those documented in several human diseases. …

Molecular Modeling Studies Of Heparin And Heparin Mimetics Binding To Coagulation Proteins, Chandravel Krishnasamy

Theses and Dissertations

Heparin, a glycosaminoglycan (GAG), is a complex biopolymer of varying chain length and consisting of uronic acid and glucosamine residues, which are sulfated at various positions. The interaction of heparin with antithrombin is the basis for anticoagulation therapy. Heparin accelerates the antithrombin mediated inhibition of factor Xa and thrombin by a conformational activation mechansism and bridging mechanism, respectively. The sequence specific pentasaccharide DEFGH in full length heparin is the most important fragment for high affinity and activation of antithrombin, without which the heparin is incapable of binding to antithrombin. Although heparin is a commonly used anticoagulant, it suffers from serious …

Website About Chinese Food: Information Design Promoting Culture Identify By Website, Xiaoqiu Shan

Theses

Information design for the web and interactive multimedia integrates content with visual indicators. Legibility and clear communication of information and direction are important to the success of graphical user interface design. This thesis is a systematic introduction about Chinese fish dishes. The information is built into a website. The objective of the thesis is to increase the efficiency of transmitting information to users, making it more easily understandable and less time-consuming to be comprehended. Users can find information on classic Chinese fish dishes conveniently from the website. The project includes five parts, they are: Home page, Introduction, Restaurant, Kitchen and …

Embedded Philanthropy And The Pursuit Of Civic Engagement, Mikael Karlström, Prudence Brown, Robert Chaskin, Harold Richman

The Foundation Review

· This article examines a range of civic engagement strategies pursued by embedded funders conducting community-change work in chronically disadvantaged communities.

· Embedded funders are place-based foundations that (1) commit to working in a particular community or communities over an extended period of time; (2) pursue direct and ongoing relationships with a range of community actors; (3) make community relationships and partnerships a primary vehicle of their philanthropic operation; and (4) provide extensive supports and resources beyond conventional grantmaking.

· Working as an embedded funder tends either to correlate with a prior commitment to civic engagement or to promote the …

Beyond The Npr Crowd: How Evaluation Influenced Grantmaking At The California Council For The Humanities, Clare Nolan, Alden Mudge

The Foundation Review

· This article describes an initiative designed to engage a broad cross section of Californians in the humanities. Initial findings from book reading groups were that participants were predominantly white, middle-aged women.

· Changing the type of programming to include poetry slams, photography, digital media, and writing programs broadened participation of various ages and ethnic groups.

· The location of the program also made a difference, with schools and community-based organizations drawing more diverse audiences than libraries.

Arrow's Theorem And The Exclusive Shareholder Franchise, Grant M. Hayden, Matthew T. Bodie

All Faculty Scholarship

In this essay, we contest one of the main arguments for restricting corporate board voting to shareholders. In justifying the limitation of the franchise to shareholders, scholars have repeatedly turned to social choice theory—specifically, Arrow’s theorem—to justify the exclusive shareholder franchise. Citing to the theorem, corporate law commentators have argued that lumping different groups of stakeholders together into the electorate would result in a lack of consensus and, ultimately, the lack of coherence that attends intransitive social choices, perhaps even leading the corporation to self-destruct. We contend that this argument is misguided. First, we argue that scholars have greatly overestimated …

From Ballots To Bullets: District Of Columbia V. Heller And The New Civil Rights, Anders Walker

All Faculty Scholarship

This article posits that the Supreme Court's recent Second Amendment ruling District of Columbia v. Heller is a victory for civil rights, but not in the sense that most activists from the 1960s would recognize. Rather than a product of mid-century legal liberalism, Heller marks the culmination of almost forty years of coalition-based popular constitutionalism aimed at transforming the individual right to bear arms and the common law right to "employ deadly force in self-defense" into new civil rights. The implications of this are potentially great. By declaring the right to use deadly force in self-defense an "essential" right, the …

Effective Maxillary Protraction: Hyrax Expansion Appliance Vs. Double-Hinged Expansion Appliance, Thuy B. Do-Delatour

Graduate Theses, Dissertations, and Problem Reports (ETD)

Patients with a skeletal Class III malocclusion may have one of the following conditions: midface deficiency and/or mandibular hypertrophy/prognathism. If modification of the skeletal Class III growth pattern is not effectively accomplished at an early age via maxillary protraction, then orthognathic surgery would be required to help correct the skeletal Class III malocclusion. Some of the more serious risks associated with orthognathic surgery include parasthesia, bone and tissue necrosis, and possibly death. However, if one is able to effectively protract the maxilla, the need for anterior-posterior correction of the maxilla via orthognathic surgery will be minimized if not eliminated.;The purpose …