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2009

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Articles 12061 - 12090 of 14154

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Inheritance Of Shoulder Spotting In The Tetra, Hyphessobrycon Bentosi Characidae, Jack Frankel Jan 2009

Inheritance Of Shoulder Spotting In The Tetra, Hyphessobrycon Bentosi Characidae, Jack Frankel

Department of Biology Faculty Publications

The tetra (Hyphessobrycon bentosi) exhibits two phenotypes associated with shoulder spotting. Fish possess ei-ther a prominent black vertical spot located directly behind the operculum (H. b. bentosi,  bentosi  white  tip  tetra) or  lack  this spot (H. b. rosaceus, rosy tetra). Segregation patterns observed from the progenies of ten different crosses suggest that the  inheritance  of  these  phenotypes  is  controlled  by  two  autosomal  loci  acting  in  a complementary  fashion,  with  domi-nance at both loci required for the expression of the spotted phenotype. 

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Metabolomic Investigation Of A New Rat Model Of Autosomal Recessive Polycystic Kidney Disease, Hayley White Jan 2009

Metabolomic Investigation Of A New Rat Model Of Autosomal Recessive Polycystic Kidney Disease, Hayley White

Theses : Honours

Metabolomics is complementary to genomics, transcriptomics and proteomics; however, it has the capacity to reflect the activities of the organism at a functional level. Metabolomics can therefore be used as a diagnostic tool by identifying the up- or down-regulation of metabolites in the cell, tissue, plasma, serum or urine. Specifically, these are, but are not limited to, identifying biomarkers of disease, monitoring drug treatments, and monitoring surgical procedures such as organ transplant. Autosomal recessive polycystic kidney disease (ARPKD) makes up 5-8% of patients requiring kidney dialysis and/or transplantation and of these, an estimated 50% of patients progress to end-stage renal …

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Effects Of Ancient And Modern, Avoidant And Approach Stimuli On Visual Search Task Reaction Times, Sanja Bojic Jan 2009

Effects Of Ancient And Modern, Avoidant And Approach Stimuli On Visual Search Task Reaction Times, Sanja Bojic

Theses : Honours

The threat superiority effect refers to faster and more accurate detection of fearful stimuli. This has been explained as evidence for evolution, as ancient fearful stimuli are detected more quickly than modern fearful stimuli. The aim of this study was to investigate which of two alternate evolutionary explanations best explains the findings. Whereas Ohman and Mineka (2001) dealt only with avoidant responses, Lang suggested that stimuli may evoke either an avoidant (fearful) or approach response, associated with negative or positive valence, respectively. The experiment employed a same-different task where Age (ancient, modern), and Valence (approach, avoidant, neutral) were manipulated and …

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Balancing Multiple Roles: A Pilot Study Exploring The Complexity Of Role Balance In Working Mothers With Primary School Aged Children, Katherine Prince Jan 2009

Balancing Multiple Roles: A Pilot Study Exploring The Complexity Of Role Balance In Working Mothers With Primary School Aged Children, Katherine Prince

Theses : Honours

For working mothers, maintaining a balance between work and parenting roles is a challenge. Each role presents its own set of physical, mental and temporal demands which frequently compete for the limited personal and environmental resources available to the mother. These competing demands can create conflict and stress, which prompts a coping response. The coping response initiated is a physiological reaction to the mother's appraisal of her situational conflict, and follows a process of appraisal. Firstly the working mother appraises the conflict itself. This is followed by the appraisal of the personal and environmental resources, constraints and demands. Finally, a …

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Gross Motor Abilities And Interventions In Girls And Women With Rett Syndrome: A Literature Review ; Longitudinal Video Analysis Of Gross Motor Abilities Of Girls And Women With Rett Syndrome, Kitty-Rose R. Foley Jan 2009

Gross Motor Abilities And Interventions In Girls And Women With Rett Syndrome: A Literature Review ; Longitudinal Video Analysis Of Gross Motor Abilities Of Girls And Women With Rett Syndrome, Kitty-Rose R. Foley

Theses : Honours

Objective: To explore research relevant to an understanding of gross motor abilities and highlight possible directions for gross motor intervention in girls and women with Rett syndrome. A secondary objective was to describe mouse model research which has the potential to add to an understanding of gross motor abilities in this population. Methods: Electronic searches of five databases, manual searches of an external resource library and manual searches of reference lists were undertaken. The key words imputed during these searches included; mobility, Rett syndrome, functioning, mouse model, therapy and intervention. Search terms were truncated, exploded and adjusted to achieve optimum …

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Trauma Practitioners' Lived Experience Of The Impact Of Therapy On Trauma Recovery Outcomes, Francess M. Day Jan 2009

Trauma Practitioners' Lived Experience Of The Impact Of Therapy On Trauma Recovery Outcomes, Francess M. Day

Theses : Honours

Much has been written about evidence-based treatments for Posttraumatic Stress Disorder (PTSD). A number of treatment guides have been written (e.g. AMCPH, 2007; Briere 2006; Foa Keane, & Friedman, 2000;). Medicare criteria based on empirical research and outcome measures stipulate which treatments and practitioner qualifications will be funded. However, little is known about the relationship between these guidelines and what clinicians actually utilize in trauma treatment and use as indicators of good outcomes. The research studies compromise external validity by excluding the majority of typical PTSD clientele, necessitating exploration of treatment effectiveness in diverse real-life populations (Spinazzola, Blaustein, & van …

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From Paper, Ink And Dust: Thank You (Two Words From An Archive Of Elizabeth Jolley's Writing For Students), Andrea Wood Jan 2009

From Paper, Ink And Dust: Thank You (Two Words From An Archive Of Elizabeth Jolley's Writing For Students), Andrea Wood

Theses : Honours

The installation Thank You (two words), will be an outcome of my research into the creative process through practice-led research. It will aim to communicate to the viewer something of the search and experimentation I have carried out in the studio through a material engagement with a small personal archive of writing by Elizabeth Jolley (1923-2007). Through an engagement with particular materials-paper, ink, and dust the installation will also aim to participate in a conversation of broad relevance in the visual arts, and one in which many artists, writers and thinkers have been interested since the eighteenth century: a conversation …

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Conference Events List Jan 2009

Conference Events List

Sound Scripts

No abstract provided.

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Universal Health Insurance Coverage: Progress And Issues., Jonathan Gruber Jan 2009

Universal Health Insurance Coverage: Progress And Issues., Jonathan Gruber

Center for Policy Research

Jonathan Gruber was a key architect of Massachusetts’ ambitious health reform effort, and in 2006 became an inaugural member of the Health Connector Board, the main implementing body for that effort. He delivered this lecture on October 2, 2009, and his references are to Congressional bills that were under consideration on that date. He laid out the universal coverage debate that’s gone on for a long time in the United States; described a new solution that he think they found for Massachusetts; described how the Massachusetts reform works; and how it can be extended nationally. Finally he spent time on …

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Some Thoughts On The Lawyer’S E-Volving Duties In Discovery, Steven S. Gensler Jan 2009

Some Thoughts On The Lawyer’S E-Volving Duties In Discovery, Steven S. Gensler

Faculty Articles

No abstract provided.

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Replacing Fertilizer Nitrogen With Dried Distillers Grains Supplement To Yearling Steers Grazing Bromegrass Pastures: Daily Gain And Nitrogen Use Efficiency, Matthew A. Greenquist, Terry J. Klopfenstein, Walter H. Schacht, Galen E. Erickson, Kyle J. Vander Pol, Matt K. Luebbe, Kelly Brink, Andrea K. Schwarz, Leonard B. Baleseng Jan 2009

Replacing Fertilizer Nitrogen With Dried Distillers Grains Supplement To Yearling Steers Grazing Bromegrass Pastures: Daily Gain And Nitrogen Use Efficiency, Matthew A. Greenquist, Terry J. Klopfenstein, Walter H. Schacht, Galen E. Erickson, Kyle J. Vander Pol, Matt K. Luebbe, Kelly Brink, Andrea K. Schwarz, Leonard B. Baleseng

Nebraska Beef Cattle Reports

In a three-year study, corn-dried distillers grains plus solubles (DDGS) were evaluated as a substitute for forage and nitrogen (N) fertilizer in yearling steers grazing smooth bromegrass in eastern Nebraska. Stocking rate increased with N fertilization and DDGS, and average daily gain (ADG) increased with DDGS. Total gain per acre increased by 53% with N fertilization and 105% with DDGS supplementation. N use efficiency was 139% greater per acre with DDGS supplementation compared to fertilizing with N alone. Feedlot ADG was similar among treatments with steers maintaining their BW advantage through the finishing phase.

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Replacing Fertilizer Nitrogen With Dried Distillers Grains Supplement To Yearling Steers Grazing Bromegrass Pastures: Economics And Modeling, Matthew A. Greenquist, Terry J. Klopfenstein, Walter H. Schacht, Galen E. Erickson Jan 2009

Replacing Fertilizer Nitrogen With Dried Distillers Grains Supplement To Yearling Steers Grazing Bromegrass Pastures: Economics And Modeling, Matthew A. Greenquist, Terry J. Klopfenstein, Walter H. Schacht, Galen E. Erickson

Nebraska Beef Cattle Reports

An economic analysis of a three-year study evaluated use of N fertilizer and dried distillers grains plus solubles (DDGS) supplementation to yearling steers grazing smooth bromegrass in eastern Nebraska (Nebraska Beef Report, 2009, pp. 26-28). Costs of gain tended to be lower for cattle on fertilized pastures. Grazing profitability was lowest for cattle on non-fertilized pastures, intermediate for cattle supplemented with DDGS, and highest for cattle on fertilized pastures. The weight advantage (9%) of steers supplemented with DDGS during the grazing period was maintained through the finishing period, leading to greater profitability. Profitability for steers supplemented with DDGS at the …

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Cattle Performance And Economic Analysis Of Diets Containing Wet Distillers Grains And Dry-Rolled Or Steam-Flaked Corn, Corineah Godsey, William Griffin, Matt K. Luebbe, Joshua R. Benton, Galen E. Erickson, Terry J. Klopfenstein Jan 2009

Cattle Performance And Economic Analysis Of Diets Containing Wet Distillers Grains And Dry-Rolled Or Steam-Flaked Corn, Corineah Godsey, William Griffin, Matt K. Luebbe, Joshua R. Benton, Galen E. Erickson, Terry J. Klopfenstein

Nebraska Beef Cattle Reports

A finishing study was conducted to determine the effect of utilizing dry-rolled (DRC) or steam-flaked (SFC) corn in diets containing wet distillers grains without solubles (WDG). An interaction between corn processing method and DG level was observed for average daily gain (ADG) and feed-gain ratio (F:G), but not for dry matter intake (DMI). In diets containing DRC, ADG increased quadratically (P = 0.02) as WDG level increased, but no difference was observed in gain when steers were fed SFC diets with increasing level of WDG. Feed efficiency responded quadratically for diets containing DRC, with an optimum WDG inclusion of 20% …

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Effects Of Surface Soil Temperature On Daily Water Intake In Feedlot Cattle, Rodrigo Arias, Terry L. Mader Jan 2009

Effects Of Surface Soil Temperature On Daily Water Intake In Feedlot Cattle, Rodrigo Arias, Terry L. Mader

Nebraska Beef Cattle Reports

The relationships among soil surface temperature (SST), soil temperature (ST) (4 inches depth) and daily water intake (DWI) were studied using data collected between 2004 and 2006. The equations obtained through simple and polynomial linear regression were evalu¬ated using data collected during the summer 2007. An overall model (May-October) and a summer model (June-August) were developed. The best fit was reached with the overall model using SST in a quadratic model (r2 = 0.86), whereas the summer model fit linearly with SST (r2 = 0.70). Both models tend¬ed to slightly over-predict DWI (13.5% and 12.5%, respectively).

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Effects Of Sorting Cattle By Weight And Time Of Year On Finishing Performance, Carcass Characteristics And Economics, Daniel R. Adams, Matt K. Luebbe, William Griffin, Terry J. Klopfenstein, Galen E. Erickson Jan 2009

Effects Of Sorting Cattle By Weight And Time Of Year On Finishing Performance, Carcass Characteristics And Economics, Daniel R. Adams, Matt K. Luebbe, William Griffin, Terry J. Klopfenstein, Galen E. Erickson

Nebraska Beef Cattle Reports

Sorting steers for three different finishing systems (calf-feds, summer yearlings and fall yearlings) resulted in no differences in performance or average carcass characteristics compared to unsorted steers. Sorting decreased variation in hot carcass weight and number of carcasses over 950 lb. Sorting did not increase profit when calf-feds or fall yearlings were sold live compared to unsorted calf-feds and fall yearlings. However, when sold on a grid basis, sorting did increase profit for summer and fall yearlings.

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Level Of Wet Distillers Grains Plus Solubles And Solubles Ensiled With Wheat Straw For Growing Steers, Megan Peterson, Matt K. Luebbe, Richard J. Rasby, Terry J. Klopfenstein, Galen E. Erickson, Luke Kovarik Jan 2009

Level Of Wet Distillers Grains Plus Solubles And Solubles Ensiled With Wheat Straw For Growing Steers, Megan Peterson, Matt K. Luebbe, Richard J. Rasby, Terry J. Klopfenstein, Galen E. Erickson, Luke Kovarik

Nebraska Beef Cattle Reports

A growing study compared wet distillers grains plus solubles (WDGS) and solubles ensiled with wheat straw individually fed to crossbred steers. Four blends of ensiled distillers grain and solubles were used to compare performance on growing calves versus feeding ensiled byproducts alone. Increasing the level of distillers grains in the diet increased average daily gain (ADG) and dry matter intake (DMI). The nonensiled distillers grain treatments had at least equal ADG and feed-to-gain ratio (F:G) compared to the ensiled treatments.

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Effect Of Dietary Cation-Anion Difference On Feedlot Performance, Nitrogen Mass Balance And Manure Ph In Open Feedlot Pens, Matt K. Luebbe, Galen E. Erickson, Terry J. Klopfenstein, Matthew A. Greenquist, Joshua R. Benton Jan 2009

Effect Of Dietary Cation-Anion Difference On Feedlot Performance, Nitrogen Mass Balance And Manure Ph In Open Feedlot Pens, Matt K. Luebbe, Galen E. Erickson, Terry J. Klopfenstein, Matthew A. Greenquist, Joshua R. Benton

Nebraska Beef Cattle Reports

Two experiments were conducted to evaluate the effect of dietary cation-anion difference (DCAD) at two levels (-16 and +20 mEq) on feedlot performance and nutrient mass balance in open feedlots. Decreasing DCAD did not negatively impact cattle performance or carcass characteristics. Feeding negative DCAD diets resulted in lower manure pH in both the winter and summer experiments. Final soil core pH was reduced only in the winter experiment. Percentage of N lost was not influenced by DCAD in either experiment. The decrease in manure pH is likely not enough to reduce the amount of N lost in open feedlot pens.

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Effect Of Estrus Synchronization With A Single Injection Of Prostaglandin During Natural Service Mating, Daniel Larson, Jacqueline A. Musgrave, Richard N. Funston Jan 2009

Effect Of Estrus Synchronization With A Single Injection Of Prostaglandin During Natural Service Mating, Daniel Larson, Jacqueline A. Musgrave, Richard N. Funston

Nebraska Beef Cattle Reports

Records from unsynchronized cows (n = 2073; 60-day breeding season) were compared with records from synchronized cows (n = 517; 45-day breeding season) collected between 2000 and 2006. A single injection of prostaglandin F2α was administered approximately 108 hours after bull turn-in to synchronize estrus in spring calving mature beef cows. Estrus synchronization increased the percentage of cows calving in the first 21 days without affecting pregnancy rates. However, weaning BW of calves was not significantly different. Estrus synchronization improves synchrony of calving in a shorter breeding season with similar overall pregnancy rates.

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The Effects On Ruminal Ph, Feed Intake And Digestibility When Using Wet Corn Gluten Feed To Adapt Cattle To Finishing Diets, Taia Huls, Nathan Meyer, Galen E. Erickson, Terry J. Klopfenstein, Rick Stock Jan 2009

The Effects On Ruminal Ph, Feed Intake And Digestibility When Using Wet Corn Gluten Feed To Adapt Cattle To Finishing Diets, Taia Huls, Nathan Meyer, Galen E. Erickson, Terry J. Klopfenstein, Rick Stock

Nebraska Beef Cattle Reports

A 33-day grain adaptation trial was conducted comparing wet corn gluten feed (WCGF; Sweet Bran®, Cargill) fed at decreasing levels (87.5% to 35%) to a traditional grain adaptation with decreasing forage (45% to 7.5%; CON) to test the effects on ruminal pH, dry matter intake (DMI) and in situ DM digestibility. Steers adapted by decreasing WCGF had greater DMI than CON (P < 0.01). During adaptation, DMI increased and ruminal pH decreased across both treatments. Steers adapted using WCGF had greater in situ DM digestion than steers adapted using CON. Diets containing WCGF had greater DM digestibility than diets containing forage, whether incubated in either CON or WCGF fed steers. Decreasing WCGF inclusion instead of forage is a viable method for adapting feedlot cattle to high-concentrate diets.

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Sulfur In Distillers Grains, Sarah Vanness, Terry J. Klopfenstein, Galen E. Erickson, Kip Karges Jan 2009

Sulfur In Distillers Grains, Sarah Vanness, Terry J. Klopfenstein, Galen E. Erickson, Kip Karges

Nebraska Beef Cattle Reports

Data were compiled from 4,143 cattle on byproduct feeding experiments. Incidence of polioencephalomalacia was small (0.14%) in diets containing 0.46% or less sulfur (S). Incidences of polioencephalomalacia increased when cattle were fed diets above 0.46% S and especially above 0.56%. Phosphoric acid successfully replaced sulfuric acid in ethanol fermentation, but the amount and cost of phosphoric acid likely limit the economic feasibility of its use.

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Profit Variability For Calf-Fed And Yearling Production Systems, Rebecca Small, Darrell R. Mark, Dillon Feuz, Terry J. Klopfenstein, William Griffin, Daniel R. Adams Jan 2009

Profit Variability For Calf-Fed And Yearling Production Systems, Rebecca Small, Darrell R. Mark, Dillon Feuz, Terry J. Klopfenstein, William Griffin, Daniel R. Adams

Nebraska Beef Cattle Reports

Profitability of calf-fed and backgrounding yearling systems was determined based on actual production data and prices from 1996 to 2007, and variability across years was compared. The two systems exhibited similar profits, on average, but the calf-fed system showed less profit variability, suggesting there is more risk inherent in a yearling backgrounding and finishing system. Also, profitable years were more apt to have less variable corn prices.

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Annotated Legal Bibliography On Gender Jan 2009

Annotated Legal Bibliography On Gender

Cardozo Journal of Equal Rights & Social Justice

No abstract provided.

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Temperature Impact On Nitrification And Bacterial Growth Kinetics In Acclimating Recirculating Aquaculture Systems Biofilters, Milton Maada-Gomoh Saidu Jan 2009

Temperature Impact On Nitrification And Bacterial Growth Kinetics In Acclimating Recirculating Aquaculture Systems Biofilters, Milton Maada-Gomoh Saidu

LSU Doctoral Dissertations

This project assessed short-term temperature effects on total ammonia nitrogen (TAN) utilization rates in a batch laboratory-scale recirculating system. The tank system was designed for experiments on short term steady state and diurnal temperatures. A set of numerical models was developed to simulate observed results. The performance of the biofilters was determined with three tank replicates at fixed temperatures of 13, 20 and 300C; and at diurnal transient (sinusoidal) temperature regimes of (20 ± 30C; 30 ± 30C). Ammonia utilization rates and biofilter performance for beads acclimated at different temperatures regimes separated and mixed were also determined. Total ammonia utilization …

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Production And Application Of Antibodies Produced Against The Flagella And Hemolysin Of Vibrio Parahaemolyticus, Shreya Datta Jan 2009

Production And Application Of Antibodies Produced Against The Flagella And Hemolysin Of Vibrio Parahaemolyticus, Shreya Datta

LSU Doctoral Dissertations

Vibrio parahaemolyticus is a marine bacterium which is the leading cause of bacterial gastroenteritis due to consumption of raw or undercooked bivalve molluscan shellfish in United States and is considered an important seafood-borne pathogen throughout the world. The conventional methods for enumerating this bacteria from seafood is laborious and time consuming, hence the objective of our study was to develop antibody based method which would be sensitive, user-friendly and less time consuming to detect and enumerate Vibrio parahaemolyticus from oysters. In order to condense time and material two rapid and specific antibody based test methods were developed. In the first …

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The Effect Of Rhythm-Based Computer-Assisted Music Instruction Designed For Individual Learning Style Preferences On The Learning Of Preservice Elementary Education Majors, Judy Arnette Guilbeaux-James Jan 2009

The Effect Of Rhythm-Based Computer-Assisted Music Instruction Designed For Individual Learning Style Preferences On The Learning Of Preservice Elementary Education Majors, Judy Arnette Guilbeaux-James

LSU Doctoral Dissertations

This study investigated the effect of rhythm based computer-assisted music instruction designed for individual learning style preferences. Participants were undergraduate preservice elementary education majors (N = 82) enrolled in Fundamentals of Music. The Perceptual Learning Style Preferences Survey and the Diablo Valley College Learning Style Survey were used to measure learning preferences. Two content knowledge assessments were administered as pre and posttest: (a) Music Achievement Test (MAT) Test 2-Part 3-Auditory and Visual Discrimination subtest b and (b) Researcher-Developed Rhythm Test (RDRT). Researcher-developed software programs were constructed, teaching participants the basic elements of rhythm based on learning style preferences. Forty-three of …

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Dispositional Influences On The Intent To Transfer Learning: A Test Of A Structural Equation Model, Bogdan Vladimirovich Yamkovenko Jan 2009

Dispositional Influences On The Intent To Transfer Learning: A Test Of A Structural Equation Model, Bogdan Vladimirovich Yamkovenko

LSU Doctoral Dissertations

The transfer research has evolved to a significant body of works during the last two decades. Many relationships however remain unexplored and unexplained. Among these are dispositional characteristics, which are rarely studied in combination with transfer because of difficulties and inconsistencies in measurement. In addition dispositional characteristic are so numerous that it is often difficult to identify a set of such variable that explain the most variance in transfer of training. This study explores the hypothesized relationship between dimensions of the Five Factor model of personality, goal orientation, self-efficacy and intent to transfer training on the job. Most research articles …

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Nestablishing Soil Compaction Thresholds For The M1a1 Abrams Tank At Camp Minden, Louisiana, Michael Ray Lindsey Jan 2009

Nestablishing Soil Compaction Thresholds For The M1a1 Abrams Tank At Camp Minden, Louisiana, Michael Ray Lindsey

LSU Doctoral Dissertations

Soil compaction is a primary impediment to vegetation regeneration on military land used for M1A1 Abrams tank training. As such, there is a need to identify soil compaction thresholds and develop guidelines with which military range managers can determine appropriate timing and intensity of training exercises using the 63-ton M1A1 tank. A study was initiated at the Camp Minden Louisiana Training Site (CMTS) to develop guidelines which will allow for maximum utilization of the land resource with minimum degradation. The study was designed to evaluate soil moisture content and traffic rates as experimental variables using a replicated 3 x 3 …

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Effects Of Network Capital And Social Support On Mental Health By Race And Class, Claire Norris Jan 2009

Effects Of Network Capital And Social Support On Mental Health By Race And Class, Claire Norris

LSU Doctoral Dissertations

This study investigates race and class differences in the stress-support-distress process. Incorporating the social support strand of network analysis in the stress-support-distress model allows social support theorists to understand better what network sectors enhance/restrict access to such resources as social support and, in turn, affect such outcomes as mental health. I used data collected in a 2003 study of residents in Orleans Parish, Louisiana, to construct measures used in my analyses. Using independent samples t-test and ordinary least squares regressions, I addressed five general research questions: (1) whether and how there are variations in network capital forms – the structure …

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Arthropod And Vertebrate Determinants For Horizontal Transmission Of Rickettsia Felis, Kathryn Elizabeth Reif Jan 2009

Arthropod And Vertebrate Determinants For Horizontal Transmission Of Rickettsia Felis, Kathryn Elizabeth Reif

LSU Doctoral Dissertations

Rickettsia felis is a gram-negative bacterium predominantly described in the cat flea, Ctenocephalides felis. Since first described in 1990 in a commercial cat flea colony in the United States, R. felis has been detected in numerous arthropod species in 28 countries around the world. Additionally, as the etiologic agent of flea-borne rickettsiosis, R. felis can cause disease in humans, with patients presenting with clinical symptoms typical of rickettsial diseases including: fever, headache, and myalgia. Transmission of R. felis within flea colonies is predominantly via vertical (transovarial and transstadial) transmission and mechanisms of horizontal transmission are undescribed. Studies are needed to …

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Peptide Targeting Of Platinum Anti-Cancer Drug And Synthesis Of Water Soluble Monofunctional Pt(Ii) Complexes Useful For Biological Labeling, Margaret W. Ndinguri Jan 2009

Peptide Targeting Of Platinum Anti-Cancer Drug And Synthesis Of Water Soluble Monofunctional Pt(Ii) Complexes Useful For Biological Labeling, Margaret W. Ndinguri

LSU Doctoral Dissertations

Platinum has been used as an inorganic medicinal agent with various applications such as anti cancer agents. Several new targeted Pt(II) conjugates were synthesized having the NGR and LHRH targeting motif. The platinum conjugates bearing the NGR motif revealed selective delivery and destruction of cancer cells that had CD13 receptors compared to untargeted carboplatin drug. The development of targeted chemotherapeutic has opened a new approach for efficient delivery of antitumor toxins with minimal exposure to normal cells. Several peptide sequences are known to have the ability to target tumors, for instance NGR motif which home specifically in solid tumors and …

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