Digital Commons Network^™

Evidence For An Ancient Adaptive Episode Of Convergent Molecular Evolution, Todd A. Castoe, A. P. Jason De Koning, Hyun-Min Kim, Wanjun Gu, Brice P. Noonan, Gavin Naylor, Zhi J. Jiang, Christopher L. Parkinson, David D. Pollock

Faculty Bibliography 2000s

Documented cases of convergent molecular evolution due to selection are fairly unusual, and examples to date have involved only a few amino acid positions. However, because convergence mimics shared ancestry and is not accommodated by current phylogenetic methods, it can strongly mislead phylogenetic inference when it does occur. Here, we present a case of extensive convergent molecular evolution between snake and agamid lizard mitochondrial genomes that overcomes an otherwise strong phylogenetic signal. Evidence from morphology, nuclear genes, and most sites in the mitochondrial genome support one phylogenetic tree, but a subset of mostly amino acid-altering substitutions ( primarily at the …

The Homocysteine-Inducible Endoplasmic Reticulum Stress Protein Counteracts Calcium Store Depletion And Induction Of Ccaat Enhancer-Binding Protein Homologous Protein In A Neurotoxin Model Of Parkinson Disease, Srinivasulu Chigurupati, Zelan Wei, Cherine Belal, Myrian Vandermey, George A. Kyriazis, Thiruma V. Arumugam, Sic L. Chan

Faculty Bibliography 2000s

The endoplasmic reticulum (ER) is a key organelle regulating intracellular Ca(2+) homeostasis. Oxidants and mitochondria-derived free radicals can target ER-based Ca(2+) regulatory proteins and cause uncontrolled Ca(2+) release that may contribute to protracted ER stress and apoptosis. Several ER stress proteins have been suggested to counteract the deregulation of ER Ca(2+) homeostasis and ER stress. Here we showed that knockdown of Herp, an ubiquitin-like domain containing ER stress protein, renders PC12 and MN9D cells vulnerable to 1-methyl-4-phenylpyridinium-induced cytotoxic cell death by a mechanism involving up-regulation of CHOP expression and ER Ca(2+) depletion. Conversely, Herp overexpression confers protection by blocking 1-methyl-4-phenylpyridinium-induced …

A Novel In Vitro Multiple-Stress Dormancy Model For Mycobacterium Tuberculosis Generates A Lipid-Loaded, Drug-Tolerant, Dormant Pathogen, Chirajyoti Deb, Chang-Muk Lee, Vinod S. Dubey, Jaiyanth Daniel, Bassam Abomoelak, Tatiana D. Sirakova, Santosh Pawar, Linda Rogers, Pappachan E. Kolattukudy

Faculty Bibliography 2000s

Background: Mycobacterium tuberculosis (Mtb) becomes dormant and phenotypically drug resistant when it encounters multiple stresses within the host. Inability of currently available drugs to kill latent Mtb is a major impediment to curing and possibly eradicating tuberculosis (TB). Most in vitro dormancy models, using single stress factors, fail to generate a truly dormant Mtb population. An in vitro model that generates truly dormant Mtb cells is needed to elucidate the metabolic requirements that allow Mtb to successfully go through dormancy, identify new drug targets, and to screen drug candidates to discover novel drugs that can kill dormant pathogen. Methodology/Principal Findings: …

Decorin Is A Novel Antagonistic Ligand Of The Met Receptor, Silvia Goldoni, Ashley Humphries, Alexander Nyström, Sampurna Sattar, Rick T. Owens, David J. Mcquillan, Keith Ireton, Renato V. Iozzo

Faculty Bibliography 2000s

Decorin, a member of the small leucine-rich proteoglycan gene family, impedes tumor cell growth by down-regulating the epidermal growth factor receptor. Decorin has a complex binding repertoire, thus, we predicted that decorin would modulate the bioactivity of other tyrosine kinase receptors. We discovered that decorin binds directly and with high affinity (K(d) = similar to 1.5 nM) to Met, the receptor for hepatocyte growth factor (HGF). Binding of decorin to Met is efficiently displaced by HGF and less efficiently by internalin B, a bacterial Met ligand. Interaction of decorin with Met induces transient receptor activation, recruitment of the E3 ubiquitin …

Native Fire Regime As A Reference For Establishing Management Practices, Brean Duncan

Electronic Theses and Dissertations

Our understanding of natural fire regimes in human-dominated landscapes is limited. Fire regimes operating in the pyrogenic ecosystems of Florida have been altered by fire suppression and fuel fragmentation. This is especially true of North Merritt Island, Florida, where human impacts have led to an incomplete knowledge of current fire regimes. We know that growing season fires frequently occurred within general return intervals and that many native terrestrial species require fire to remain viable. A 20-year plus period of fire suppression caused structural and compositional changes to vegetation/fuels that led to catastrophic fires and the decline of native species populations …

Beliefs Of Graduate Students About Unstructured Computer Use In Face-To-Face Classes With Internet Access And Its Influence On Student Recall, Gregory Johnson

Electronic Theses and Dissertations

The use of computers equipped with Internet access by students during face-to-face (F2F) class sessions is perceived as academically beneficial by a growing number of students and faculty members in universities across the United States. Nevertheless, some researchers suggest unstructured computer use detached from the immediate class content may negatively influence student participation, increase distraction levels, minimize recall of recently presented information, and decrease student engagement. This study investigates graduate students' beliefs about computer use with Internet access during graduate face-to-face lecture classes in which computer use is neither mandated nor integrated in the class and the effect of such …

The Chapel Of The Holy Spirit: Guide, Sacred Heart University

SHU Library Archives

The Chapel of the Holy Spirit at Sacred Heart University in Fairfield Connecticut was dedicated on September 27, 2009.

Putting Ideas To Work: A Practical Introduction To Political Thought (Book Review), Steven Michels

Political Science & Global Affairs Faculty Publications

Book review by Steven Michels.

Mattern, M. (2006). Putting ideas to work: A practical introduction to political thought. Rowman and Littlefield.

ISBN 9780742548893 (hardcover); 9780742548909 (pbk.)

The Criminalization Of Poverty, Kaaryn Gustafson

Journal of Criminal Law and Criminology

No abstract provided.

The Dna Of An Argument: A Case Study In Legal Logos, Colin Starger

Journal of Criminal Law and Criminology

No abstract provided.

How To Make A Love Box, Sarah Wienke

Theses

No abstract provided.

Rock Child, Deborah Garwood

Theses

Physician Lawrence "Doc" Bass lives in Ellington, Missouri. Forced to close his practice due to crippling arthritis, Doc has resigned himself to early retirement-until the day he meets Aubrey, a boy with an unusual birthmark on his back. Aubrey fits perfectly into the already quirky family of Hickcocks. He may be just a child, but strange things-good things-begin to happen whenever Aubrey is around. But not all of the Ellington folks feel the same way about him; some have an agenda for the boy. Doc, his good friend Sheriff Baines, and a host of other folks come in contact with …

Consciousness Is Computational: The Lida Model Of Global Workspace Theory, B. Baars, S. Franklin

CCRG Papers

No abstract provided.

Department Of Philosophy Alumni Newsletter, Vol. 12, Winter 2009-2010, Illinois State University, Department Of Philosophy

Philosophy Alumni Newsletter

Newsletter of the Illinois State University Departmetn of Philosophy

Water As A Public Good: The Status Of Water Under The General Agreement On Tariffs And Trade, Bryant W. Smith

Faculty Publications

Is water a "product" subject to the World Trade Organization (WTO)’s General Agreement on Tariffs and Trade (GATT)? I argue that it is not, because the established, widespread, and consistent assertion by states of public ownership over their water resources through both municipal and international law (the "public-ownership consensus") precludes any reading of GATT that would fundamentally alter the unique status of those resources. My reasoning therefore differs from that of others who have addressed this issue in that I first examine the broader legal context in which the WTO exists and then consider how that context compels an interpretation …

Tissue Targeted Embryonic Chimeras: Zebrafish Gastrula Cell Transplantation, Elizabeth R. Deschene, Michael J. Barresi

Biological Sciences: Faculty Publications

Certain fundamental questions in the field of developmental biology can only be answered when cells are placed in novel environments or when small groups of cells in a larger context are altered. Watching how one cell interacts with and behaves in a unique environment is essential to characterizing cell functions. Determining how the localized misexpression of a specific protein influences surrounding cells provides insightful information on the roles that protein plays in a variety of developmental processes. Our lab uses the zebrafish model system to uniquely combine genetic approaches with classical transplantation techniques to generate genotypic or phenotypic chimeras. We …

Tracking Bacterial Pollution In The Cains Brook/Mill Creek Watershed: Implications For Policy And Management, Aaron Kornbluth

Master's Theses and Capstones

Pathogenic fecal bacteria present a management challenge when they contaminate surface waters used by humans. This study examined the extent to which the ongoing Cains Brook/Mill Creek watershed restoration in Seabrook, NH has successfully characterized the problem of bacterial pollution and implemented mitigation practices. Guided by the policy sciences analytical framework, this study employed a policy implementation audit reviewing relevant bacteria source tracking data, interviews and online surveys as a means to triangulate multiple data sources. Results indicate that bacteria arise from multiple sources and impairments still exist, although bacteria levels were not generally high. Management activities have likely reduced …

Morphological Variation In Codium Fragile In The Northwest Atlantic, Lucy Elizabeth Pleticha

Master's Theses and Capstones

Codium fragile (Suringar) Hariot, an invasive Asiatic green alga, has colonized areas of the NW Atlantic within the past fifty years. The plant has a dichotomously branched cylindrical thallus made of tangled filaments surrounded by a dense covering of swollen filament tips, or utricles, terminating in pointed mucrons. This study's goal was to investigate morphological differences in NW Atlantic C. fragile populations to determine which subspecies are present. In the summer of 2008, I surveyed 24 sites from the Canadian Maritimes to Long Island Sound and evaluated size variation in utricles. Morphological investigations revealed a two-fold difference in utricle and …

Human, Life, And Other Sacred Stuff, William Robert

Religion - All Scholarship

No abstract provided.

The Changing Nature Of Supervision: Implications For Labor-Management Relations In The Twenty-First Century, John Hensley, Debra D. Burke

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

Iron-Induced Cerebellar Purkinje Cell Loss Is Ameliorated By Flunarizine, Ramazan Kozan, M. Ömer Bostanci, Tuncer Nacar, Ali̇ Aslan, Faruk Bağirici

Turkish Journal of Medical Sciences

Aim: In this study, we investigated the effect of intracerebroventricular-injected iron neurotoxicity on the total number of cerebellar Purkinje cells in rats and the possible neuroprotective effect of flunarizine, a piperazine-derived calcium channel blocker. Materials and Methods: Rats were divided into four groups: control, flunarizine, iron, and iron + flunarizine groups. Rats in the iron and iron + flunarizine groups received intracerebro-ventricular iron (FeCl_36H_2O, 200 mM, 2.5 µl), while those in flunarizine and iron + flunarizine groups were intraperitoneally injected with flunarizine (10 mg/kg/day) once a day after the operation for 10 days. After 10 days, all rats were perfused …

Impact Of Socioeconomic Conditions And Parasitic Infection On Hemoglobin Level Among Children In Um-Unnasser Village, Gaza Strip, Bassam F. Al-Zain

Turkish Journal of Medical Sciences

Aims: A cross-sectional study was conducted to examine the impact of socioeconomic conditions and intestinal parasitic infection (IPI) on hemoglobin level among children aged 2-15 years in Um-Unnasser village, North Gaza, Palestine. Materials and Methods: The data were collected using structured questionnaire and laboratory analysis of blood and fecal samples. Results: Of 256 children, 25% were anemic and prevalence was higher in children aged below six years. Overall prevalence of IPI was 46.9%. Ascaris lumbricoides (11.3%), Giardia lamblia (8.2%), Hymenolepis nana (6.2%), Entamoeba histolytica (5.1%), Strongyloides stercoralis (2.0%), Enterobius vermicularis (2.7%), and Trichuris trichiura (0.3%) were the most frequently found, …

The Effect Of Dust-Mites On Nitric Oxide Production, Süleyman Yazar, Eser Kiliç, Meti̇n Atambay, Aysun Bay Karabulut, Özlem Makbule Aycan, Gülden Sönmez Tamer, Ni̇lgün Daldal

Turkish Journal of Medical Sciences

Aim: We aimed to investigate the effect of house dust mite on the level of nitric oxide in patients who had dust mite in their houses and suffering from rhinitis and/or asthma and/or eczema-like allergic symptoms and were positive for skin tests (Prick). Materials and Methods: The effect of dust-mites on nitric oxide concentration was investigated using Griess method in patients who had allergic symptoms and were positive for skin tests. Results: The plasma nitric oxide level was found to be statistically higher in patients who had dust mite in their houses and suffering from allergic symptoms and were positive …

Recurrent Breast Abscess Caused By Corynebacterium Amycolatum And Rewiev Of The Literature, İsmet Özaydin, Mustafa Yildirim, İdri̇s Şahi̇n, Sami̇ Doğan

Turkish Journal of Medical Sciences

Corynebacterium species are an uncommon cause of breast abscess, and Corynebacterium amycolatum is rarely described in the literature. In the present case, we report recurrent breast abscess caused by C. amycolatum in a 39-year-old patient with normal immune function. Pathological diagnosis was granulomatous mastitis. The patient was treated with incision and drainage and ampicillin-sulbactam treatment. To our knowledge, this is the second report of breast abscess caused by C. amycolatum.

The Effect Of Neuronal Nitric Oxide Synthase Inhibitor 7-Nitroindazole On The Cell Death Induced By Zinc Administration In The Brain Of Rats, M. Fati̇h Gökçe, Faruk Bağirici, Şeri̇f Demi̇r, M. Ömer Bostanci, Aysel Güven

Turkish Journal of Medical Sciences

Aim: To evaluate the effect of the neuronal nitric oxide synthase (nNOS) inhibitor 7-nitroindazole (7-NI) on hippocampal cell loss induced by zinc hemisulfate salt (ZnSO4·7H2O) treatment. Materials and Methods: Rats were divided into 3 groups (n = 21; 7 rats in each group): Control, Zinc, and Zinc+7-NI. In the Zinc and Zinc+7-NI (pretreatment) groups, ZnSO4·7H2O was applied intracortically to the left sensory motor cortex. The 7-NI (50 mg/kg) was injected into the third group (Zinc+7-NI) intraperitoneally 20 min prior to zinc application and daily for the next 7 days. Cell loss in the left and right hippocampal hemispheres was quantified …

The Epidemiology Of Microsporidias In Humans (Malatya Sample), Ülkü Karaman, Ni̇lgün Daldal, Meti̇n Atambay, Cemi̇l Çolak

Turkish Journal of Medical Sciences

Aim: Microsporidias, first isolated and defined in 1857, are obligate intracellular parasites observed in animal groups and especially invertebrates. Generally homosexual patients and patients who are HIV positive and immune suppressed constitute the participants of international studies about the epidemiology of microsporidias. No previous studies about the prevalence of the parasite in Turkey have been found in the literature. This study aimed to determine the epidemiology of microsporidias in and around Malatya. Materials and Methods: Feces samples (n: 2665) from patients who presented at İnönü University Medical Faculty policlinics in 2006 with some digestive system complaints and were referred to …

Effect Of Isoflavone On Plasma Nitrite/Nitrate, Homocysteine, And Lipid Levels In Turkish Women In The Early Postmenopausal Period: A Randomized Controlled Trial, Ni̇lgün Öztürk Turhan, Candan İltemi̇r Duvan, Fatma Bolkan, Yüksel Onaran

Turkish Journal of Medical Sciences

Aim: The aim of the study was to evaluate the effect of isoflavones on cardiovascular risk markers including plasma nitrite/nitrate, homocysteine, and lipid levels in Turkish women in the early postmenopausal period. Materials and Methods: Ninety participants between 42 and 59 years of age were randomly assigned to receive twice a day either isoflavone tablet (n:45) or placebo tablets (n = 45). Plasma nitrite/nitrate, homocysteine, and lipid levels were measured at baseline and after the 6 months of treatment. Results: After 6 months, isoflavone resulted in a statistically significant decrease in total cholesterol, low-density lipoproteins, triglyceride levels, serum homocysteine and …

The Effect Of Anterior Nasal Packing With Airway Tubes On Pulmonary Function Following Septoplasty*, Hani̇fi̇ Kurtaran, Nebi̇l Ark, Fati̇h Sadikoğlu, K. Şeri̇fe Uğur, Türker Yilmaz, Zeki̇ Yildirim, Davut Aktaş

Turkish Journal of Medical Sciences

Aim: To investigate the effects of nasal packing with airway tubes on pulmonary function following septoplasty. Materials and methods: Fifty patients who were operated for nasal septal deviation between 2006 and 2008 were included in our study. Nasal packs with airway tubes were used for all patients following septoplasty. Pulmonary function tests and PO2 measurements with pulse oximetry were performed preoperatively and in the second postoperative day just before removal of the nasal pack. Forced Vital Capacity (FVC), Forced Expiratory Volume in 1 Second (FEV_1), FEV_1/FVC (FEV_1%), Forced Expiratory Flow (FEF_{25-75}%), and PO2 values were compared. Results: The mean age …

Body Fat, Dyslipidemia, Blood Pressure And The Effects Of Smoking In Germans And Turks, Günay Can, Peter Schwandt, Altan Onat, Gülay Hergenç, Gerda-Maria Haas

Turkish Journal of Medical Sciences

Aim: Determining the difference regarding obesity in German and Turkish adults. Materials and Methods: This study examined a cross-section of adults aged 30-79 years old. Age-adjustment was uniformly provided for comparisons. Results: Among 3055 Germans and 2925 Turks, Turkish women had significantly higher markers of (abdominal) obesity than German women, while waist circumference (WC) was similar among males. Blood pressure (BP), concentrations of total, LDL-cholesterol, and apolipoprotein B were significantly higher among Germans, whereas Turks had markedly higher fasting triglycerides and lower HDL-cholesterol. Unlike Germans, the current trend of smoking among Turks correlates with lower WC and lower systolic BP …

Increased P Wave Dispersion In Hypothyroidism: A Sign Of Risk Of Atrial Fibrillation, Ramazan Akdemi̇r, Nesli̇han Ebru Eryaşar, Kudret Çeli̇k, Aşkin Güngüneş, Hakan Ci̇nemre, Cemi̇l Bi̇li̇r, Nermi̇n Akdemi̇r, Harun Kiliç

Turkish Journal of Medical Sciences

Aim: As in hyperthyroidism, cardiac arrhythmias can be seen in hypothyroidism. In this study, we measured P wave dispersion among hypothyroid patients to evaluate atrial fibrillation risk. Methods: 75 patients who received first time diagnosis of hypothyroidism and 40 normal control patients were included in this study. Each patient had echocardiographic and electrocardiographic studies were carried out. Groups were compared for statistically significant difference in P wave dispersion, minimum P wave duration and maximum P wave duration. Results: The groups were similar in echocardiographic and electrocardiograpic features. P wave dispersion was significantly higher in the hypothyroid group compared to normal …