Digital Commons Network^™

Forced Abstinence Model Of Relapse To Study Pharmacological Treatments Of Substance Use Disorder, Carmela M. Reichel, Rick A. Bevins

Department of Psychology: Faculty Publications

Understanding and preventing relapse to drug use is one of the most difficult challenges faced by clinicians and practitioners in the struggle to help people remain abstinent. In this paper, we review basic preclinical research on forced abstinence periods that identify the neural substrates involved and neural adaptations that occur after a drug-free period. Our attention focuses on forced abstinence after self-administration because of its promise for translational research in the development of candidate medications to reduce relapse. This model requires subjects (often rats) to initially acquire drug self-administration. However, rather than extinguishing behavior with daily drug-free sessions as in …

Bupropion Attenuates Methamphetamine Self-Administration In Adult Male Rats, Carmela M. Reichel, Jennifer E. Murray, Kathleen M. Grant, Rick A. Bevins

Department of Psychology: Faculty Publications

Bupropion is a promising candidate medication for methamphetamine use disorder. As such, we used a preclinical model of drug-taking to determine the effects of bupropion on the reinforcing effects of methamphetamine (0.025, 0.05 or 0.1 mg/kg/infusion). Specificity was determined by investigating the effects of bupropion on responding maintained by sucrose. In the selfadministration study, rats were surgically prepared with indwelling jugular catheters and trained to self-administer methamphetamine under an FR5 schedule. A separate group of rats was trained to press a lever for sucrose. Once responding stabilized, rats were pretreated with bupropion (0, 10, 30 and 60 mg/kg IP) 5 …

Neuropharmacology Of The Interoceptive Stimulus Properties Of Nicotine, Thomas E. Wooters, Rick A. Bevins, Michael T. Bardo

Department of Psychology: Faculty Publications

Preclinical drug discrimination techniques play a significant role in advancing our knowledge of the receptor mechanisms underlying the interoceptive effects of nicotine. Early reports confirmed that nicotinic acetylcholine receptors (nAChRs) are critical for transduction of the nicotine cue. In recent years, advances in molecular biology and the discovery of novel ligands with greater selectively for specific nAChR subtypes have furthered our understanding of these mechanisms. There is now evidence regarding the specific nAChR subtypes involved in nicotine discrimination; in addition, there is also evidence suggesting that other systems (i.e., adenosine, cannabinoid, dopamine, glutamate and serotonin) may play a modulatory role. …

Meeting John Glover, Kenneth A. Kiewra

Department of Psychology: Faculty Publications

No abstract provided.

Chrysler, Gm And The Future Of Chapter 11, Edward R. Morrison

Faculty Scholarship

Although they caused great controversy, the Chrysler and GM bankruptcies broke no new ground. They invoked procedures that are commonly observed in modern Chapter 11 reorganization cases. Government involvement did not distort the bankruptcy process; it instead exposed the reality that Chapter 11 offers secured creditors – especially those that supply financing during the bankruptcy case – control over the fate of distressed firms. Because the federal government supplied financing in the Chrysler and GM cases, it possessed the creditor control normally exercised by private lenders. The Treasury Department found itself with virtually the same, unchecked power that the FDIC …

Self-Defense And The Psychotic Aggressor, George P. Fletcher, Luis E. Chiesa

Faculty Scholarship

This chapter presents an authoritative overview of self-defense against the psychotic aggressor. More specifically, it examines whether one can justifiably kill a faultless, insane assailant to save himself or another from imminent and serious harm. It considers the disagreement among scholars as to whether the defensive response should be considered justified or merely excused, or whether the specific ground of acquittal should be self-defense or necessity. The chapter includes comments by some of the nation's top legal scholars from the field of criminal law, tackling topics such as proportionality, self-defense against wrongful attack, justification of homicide against innocent aggressors without …

Understanding How Disease And Environment Combine To Structure Resistance In Estuarine Bivalve Populations, Eileen E. Hofmann, David Bushek, Susan E. Ford, Ximing Guo, Dale Haidvogel, Dennis Hedgecock, John M. Klinck, Coren Milbury, Diego Narvaez, Eric Powell, Yongping Wang, Zhiren Wang, Liusuo Zhang

CCPO Publications

Delaware Bay oyster (Crassostrea virginica) populations are influenced by two lethal parasites that cause Dermo and MSX diseases. As part of the US National Science Foundation Ecology of Infectious Diseases initiative, a program developed for Delaware Bay focuses on understanding how oyster population genetics and population dynamics interact with the environment and these parasites to structure he host populations, and how these interactions might modified by climate change. Laboratory and field studies undertaken during this program include identifying genes related to MSX and Dermo disease resistance, potential regions for refugia and the mechanisms that allow them to exist, …

What Has To Change For Forests To Be Saved? A Historical Example From The United States, Jedediah S. Purdy

Faculty Scholarship

This article looks at the conservation of American forests in the nineteenth and twentieth centuries to cast light on the prospects for global forest conservation in the twenty-first. At the beginning of the nineteenth century, Americans understood their forests as good only for cutting. By the end of the century a national scheme existed for comprehensive and permanent forest conservation. This new scheme became possible thanks to changes in scientific knowledge, the ideological self-image of the country, political institutions, and the imagination and moral commitments of citizens and social movements. A look at the changes that laid the foundations of …

A Few Questions About The Social-Obligation Norm, Jedediah S. Purdy

Faculty Scholarship

I applaud Gregory Alexander for proposing an innovative view of property, one focused on the obligations of ownership. His project locates what I think of as the liberal aim of personal freedom (meaning both formal autonomy and real opportunity) within a social context of distributive choices and conceptions of mutual obligation. That is, he is asking what counts as a free society, and he is putting property regimes at the center of the answer. I want to set out some questions about where his project goes from here.

The Cultural Defense: Reflections In Light Of The Model Penal Code And The Religious Freedom Restoration Act, Kent Greenawalt

Faculty Scholarship

I wrote this essay after participating in a 2006 workshop on Criminal Law and Cultural Diversity, which discussed, among other subjects, the wisdom of providing a "cultural defense." Uncertain just how far such a defense might expand on defenses already available, I undertook to explore that topic.

The phrase "a cultural defense" suggests an either/or choice that any legal system might make. That matters are much more complex than this is part of the burden of this essay. A "cultural defense" in its most general sense refers to a wide range of ways in which evidence about a defendant's cultural …

Multiple Stable Reference Points In Oyster Populations: Biological Relationships For The Eastern Oyster (Crassostrea Virginica) In Delaware Bay, Eric N. Powell, John M. Klinck, Kathryn A. Ashton-Alcox, John N. Kraeuter

CCPO Publications

In the first of two companion papers, a 54-yr time series for the oyster population in the New Jersey waters of Delaware Bay was analyzed to develop biological relationships necessary to evaluate maximum sustainable yield (MSY) reference points and to consider how multiple stable points affect reference point-based management. The time series encompassed two regime shifts, one circa 1970 that ushered in a 15-yr period of high abundance, and a second in 1985 that ushered in a 20-yr period of low abundance. The intervening and succeeding periods have the attributes of alternate stable states. The biological relationships between abundance, recruitment, …

Taking Action In New York On Climate Change, Michael B. Gerrard, David Driesen, Veronica Eady Famira, J. Kevin Healy, Katrina Kuh, Edward Lloyd, Eileen Millett, David Paget, Virginia Robbins, Patricia Salkin, James Sevinsky, James Van Nostrand

Faculty Scholarship

The New York State Bar Association (NYSBA) Task Force on Global Warming (the Task Force) has been convened by NYSBA President Bernice Leber to summarize New York’s existing laws and programs regarding climate change and to make specific proposals that the State can implement in a timely and cost-effective fashion to reduce greenhouse gas (GHG) emissions and to prepare for the impacts of climate change. New York has taken many steps to address climate change; however, there is much more that can be done. The Task Force has not attempted to comprehensively suggest every possible action, but rather has selected …

Vegetation Response To Restoration Treatments In A Former Pine Plantation In North Florida, Ryan C. Meyer

UNF Graduate Theses and Dissertations

As the human population in Florida continues to expand, development follows, and tree farms give way to homes and businesses. As parks are established, restoration of these semi-natural plantations may provide critical habitat for species conservation. This study evaluates vegetation response to restoration treatments at two study sites, formerly tree farms, now preserves in NE Florida. Treatments included thinning, clearing, or control (no treatment) within 10m^2 plots. Thinning reduced tree canopy to 20% (2-3 pines/plot) and removed all other vegetation; clearing treatments removed all biomass to bare soil; no herbicides were used. Within these plots richness and abundance was assessed …

Microbial Diversity And Geochemical Energy Sources Of Tutum Bay, Ambitle Island, Papua New Guinea, An Arsenic-Rich, Shallow-Sea Hydrothermal System, Nancy Akerman

All Theses and Dissertations (ETDs)

I investigate the hydrothermal system located in Tutum Bay, Ambitle Island, Papua New Guinea, a shallow-sea system ~5 - 10 meters below sea level that is arsenic-rich. Hydrothermal vents in the bay expel fluids with arsenite: AsIII) concentrations as high as 950 μg/L. To determine the role that Tutum Bay microorganisms might play in mediating As-redox reactions, three approaches were used: analyzing the geochemical environment for energy sources, characterizing the archaeal community composition of the sediments, and conducting culture-dependent As-cycling experiments. The second chapter of this dissertation discusses an energetic study of potential chemolithotrophic metabolic reactions, including As-redox reactions. Results …

Hiv-1 Envelope-Induced Signaling Mediates Actin Cytoskeleton Rearrangements Necessary For Fusion And Entry, Brooke Harmon

All Theses and Dissertations (ETDs)

Human immunodeficiency virus type-1: HIV-1) initiates infection by direct fusion of the virus membrane with the plasma membrane of the target cell. This fusion event is a multi-step process mediated by the envelope: Env) surface subunit gp120 and the transmembrane subunit gp41 which anchors gp120 into the viral membrane. First the surface subunit gp120 binds to the primary receptor CD4. This interaction promotes actin cytoskeletal rearrangements in the target membrane that bring the chemokine coreceptor, CCR5 or CXCR4, into close proximity for binding and induces conformational changes in gp120 that allow it to couple to the coreceptor. Formation of the …

Functional Significance Of Glycoprotein Clearance By The Asialoglycoprotein Receptor And The Mannose/Galnac-4-So4 Receptor, Lindsay Steirer Taylor

All Theses and Dissertations (ETDs)

Glycosylation plays an important role in many biological functions. Two highly abundant, carbohydrate-specific, endocytic receptors reside in parenchymal and endothelial cells of the liver. Our lab has shown that the asialoglycoprotein receptor: ASGR) is capable of clearing glycoproteins bearing terminal Siaalpha2,6GalNAc as well as ones bearing terminal Gal/ GalNAc and that the Mannose/GalNAc-4-SO4 receptor: MR) is capable of clearing glycoproteins bearing terminal GalNAc-4-SO4. I am taking a genetic approach identifying endogenous ligands for the ASGR and the MR in vivo and establishing the biologic significance of clearing these glycoproteins from the blood. A number of glycosylated hormones such as luteinizing …

Calling Cards For Dna-Binding Proteins, Haoyi Wang

All Theses and Dissertations (ETDs)

Organisms respond to their environment by altering patterns of gene expression. This process is orchestrated by transcription factors, which bind to specific DNA sequences near genes. In order to understand the regulatory networks that control transcription, the genomic targets of all transcription factors under various conditions and in different cell types must be identified. This remains a distant goal, mainly due to the lack of a high-throughput, in vivo method to study protein-DNA interactions. To fill this gap, I developed transposon "Calling Cards" for DNA-binding proteins. I endowed DNA binding proteins with the ability to direct the insertion of a …

An Investigation Of Acetobacter Aceti N5-Carboxyaminoimidazole Ribonucleotide Mutase And Its Pure-Purk Operon, Charles Constantine

All Theses and Dissertations (ETDs)

Acetobacter aceti oxidizes ethanol to acetic acid. While the membrane-permeable acetic acid is toxic to many bacteria, A. aceti survives exposure to acetic acid by tolerating cytoplasmic acidification. The ability to tolerate an acidic cytoplasm suggests that proteins from A. aceti are unusually suited to function in an acidic environment. The ability to tolerate an acidic cytoplasm raises additional questions about biosynthetic pathways that employ acid-labile intermediates. To examine how A. aceti metabolism may have adapted to function under acidic conditions, a biosynthetic conversion involving an acid-labile metabolite has been selected for study. The enzyme N5-carboxyaminoimidazole ribonucleotide mutase: PurE) catalyzes …

Natural Disorder: The Animal Image In French And British Art Before Darwin, C. 1790-1859, Noelle Paulson

All Theses and Dissertations (ETDs)

This study of the animal form in French and British art reveals humanity's shifting self-image as new theories of species transmutation replaced hierarchical models of nature in the half-century before the publication of Charles Darwin's On the Origin of Species in 1859. To assert various qualities of difference, distance, similitude, and proximity between species, visual artists represented animals either in humanized guises or in contexts of encounter with humans. Animal imagery was especially malleable during this period when science and pseudo-science both confronted the possibility that species were susceptible to gradual change over time rather than fixed in form since …

Genetic Variation At Hair Length Candidate Genes In Elephants And The Extinct Woolly Mammoth, Alfred L. Roca, Yasuko Ishida, Nikolaidis Sergios, Sergios-Orestis Kolokotronis, Stephen Fratpietro, Kristin Stewardson, Shannon Hensley, Michele Tisdale, Gennady Boeskorov, Alex D. Greenwood

Biological Sciences Faculty Publications

Background: Like humans, the living elephants are unusual among mammals in being sparsely covered with hair. Relative to extant elephants, the extinct woolly mammoth, Mammuthus primigenius, had a dense hair cover and extremely long hair, which likely were adaptations to its subarctic habitat. The fibroblast growth factor 5 (FGF5) gene affects hair length in a diverse set of mammalian species. Mutations in FGF5 lead to recessive long hair phenotypes in mice, dogs, and cats; and the gene has been implicated in hair length variation in rabbits. Thus, FGF5 represents a leading candidate gene for the phenotypic differences in hair length …

Regional Characterisation Of Hard-Bottom Nursery Habitat For Juvenile Caribbean Spiny Lobster (Panulirus Argus) Using Rapid Assessment Techniques, Rodney D. Bertelsen, Mark J. Butler Iv, William F. Herrnkind, John H. Hunt

Biological Sciences Faculty Publications

Shallow, hard-bottom habitat constitutes approximately 30% of the coastal waters of south Florida, United States, yet it is a chronically understudied feature of the marine seascape in this region. In this study, we characterised the general biogeographic and structural features of shallow benthic hard-bottom communities in the Florida Keys, and related those to the abundance of juvenile Caribbean spiny lobster (Panulirus argus), the target of one of Florida's most economically valuable fisheries. We used rapid assessment techniques to survey more than 100 hard-bottom sites in the Florida Keys to estimate the percentage bottom coverage of vegetation (seagrass and …

Growth And Survival In A Northern Population Of Hispid Cotton Rats, Heather A. Green, Robert K. Rose

Biological Sciences Faculty Publications

Using data from a 28-month capture–mark–recapture study that included 3 winters, we compared rates of body growth and survival for a population of hispid cotton rats (Sigmodon hispidus) in eastern Virginia with another marginal population in eastern Kansas, and where possible, with southern populations in coastal Texas and central Florida. Patterns of seasonal growth were similar in Virginia and Kansas, being low, often near 0, in winter but moderate in other seasons, unlike the uniform seasonal growth rates in Texas. Survival rates were similar between the sexes in both Virginia and Kansas but the overall monthly survival rate …

Geoarchaeology Of The Danilo Bitinj And Pokrovnik Sites, Dalmatia, Croatia, Cynthia Fadem

All Theses and Dissertations (ETDs)

This dissertation examines the paleoecology of earliest European agriculture via geological and geochemical analysis of two Neolithic settlements in central Dalmatia, Croatia. The Early Farming in Dalmatia Project, of which this geoarchaeological study is a part, is a case study in the adoption and environmental impact of agricultural technology. Dalmatia served to transmit agriculture from the domestication centers of the Middle East to mainland Europe. The record of neolithization in this region is incomplete - biased toward caves, upland storage locales. The landscape setting of the foraging-to-farming behavioral evolution is missing, even as Neolithic transition research turns to more complex …

Dietary Interventions To Reduce Metabolic Syndrome In An Uninsured Population: An Evidence-Based Approach, Michele Smith Bednarzyk

UNF Graduate Theses and Dissertations

Recent studies show that more than one-third of U.S. adults (over 72 million people) were obese in 2005–2006. This includes 33.3% of men and 35.3% of women. Obesity is a primary factor in the development of metabolic syndrome, a condition that places individuals at high absolute risk of mortality and morbidity. The use of a nutritionally balanced diet aimed at weight reduction has the potential to decrease the prevalence of obesity, therefore reducing the incidence of metabolic syndrome and its consequences.

The purpose of this project was to investigate whether individual nutrition counseling would improve the outcomes of patients with …

A Theory Of Cultural Glocality, Sarah Elizabeth Fernandez

UNF Graduate Theses and Dissertations

A Theory of Cultural Glocality shows how globalization can be salvaged from the negativity that often surrounds it. Globalization has been the target of criticism that claims globalization is pushed on cultures and in the process is destroying local cultures. The purpose of this thesis is to explore the limitations of globalization critics and show that it is not a negative force, that there is a healthy form of globalization. Therefore, globalization does not have to be considered disastrous for local cultures. Glocalizing provides cultures with a way to balance the local and the global in a healthy way where …

Panarchy: Discontinuities Reveal Similarities In The Dynamic System Structure Of Ecological And Social Systems, Ahjond S. Garmestani, Craig R. Allen, Lance Gunderson

School of Natural Resources: Faculty Publications

In this paper, we review the empirical evidence of discontinuous distributions in complex systems within the context of panarchy theory and discuss the significance of discontinuities for understanding emergent properties such as resilience. Over specific spatial-temporal scale ranges, complex systems can configure in a variety of regimes, each defined by a characteristic set of self-organized structures and processes. A system may remain within a regime or dramatically shift to another regime. Understanding the drivers of regime shifts has provided critical insight into system structure and resilience. Although analyses of regime shifts have tended to focus on the system level, new …

Probabilistic Movement Model With Emigration Simulates Movements Of Deer In Nebraska, 1990–2006, Charles J. Frost, Scott E. Hygnstrom, Andrew J. Tyre, Kent M. Eskridge, David M. Baasch, Justin R. Boner, Gregory M. Clements, Jason M. Gilsdorf, Travis C. Kinsell, Kurt C. Vercauteren

School of Natural Resources: Faculty Publications

Movements of deer can affect population dynamics, spatial redistribution, and transmission and spread of diseases. Our goal was to model the movement of deer in Nebraska in an attempt to predict the potential for spread of chronic wasting disease (CWD) into eastern Nebraska. We collared and radio-tracked >600 white-tailed deer (Odocoileus virginianus) and mule deer (Odocoileus hemionus) in Nebraska during 1990–2006.We observed large displacements (>10 km) for both species and sexes of deer, including migrations up to 100 km and dispersals up to 50 km. Average distance traveled between successive daily locations was 166m for …

Gamebird 2006: Quail Vi And Perdix Xii, Sandra B. Cederbaum, Brant C. Faircloth, Theron M. Terhune, Jeffrey J. Thompson, John P. Carroll

School of Natural Resources: Faculty Publications

Foreword v

Acknowledgements vi

Editorial Panel vii

Sponsors x

Invited Manuscripts 2

Integrating Management, Research, and Monitoring: Balancing the 3-Legged Stool. Michael J. Conroy & James T. Peterson . 2

Management of Southern African Gamebirds: Opportunities and Threats. Tim Crowe . 11

Taking the Northern Bobwhite Conservation Initiative to the Next Level. Donald F. McKenzie . 16

Restoring a Gray Partridge (Perdix perdix) Population and the Future of Predation Control. G.R. Potts . 24

Abundance Estimation 27

The GWCT Partridge Count Scheme: A Volunteer-Based Monitoring and Conservation Promotion Scheme. Julie Ewald, Nevile Kingdon, & Hugues Santin-Janin . 27

Refining the …

Alumna Atop The World: Megan Delehanty Climbs To The Summit Of Mt. Everest, Matt Lazier

Cal Poly Magazine

No abstract provided.

Pro Bono: Assessing Aims And Achievement, Lisa A. Kloppenberg, Lori E. Shaw

Faculty Publications

No abstract provided.