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Articles 89611 - 89640 of 92745
Full-Text Articles in Entire DC Network
The Role Of Neighborhood Residency In The Decision To Evacuate, Naya S. Mcmillan
The Role Of Neighborhood Residency In The Decision To Evacuate, Naya S. Mcmillan
All ETDs from UAB
No abstract provided.
Provision Of Rapid Hiv Testin G And Nevirapine Administration In Zambian Labor Ward S To Im Prove Population Antiretroviral Coverage Of Hiv-Infected Women And Their Hiv-Exposed Infants, Karen M. Megazzini
All ETDs from UAB
No abstract provided.
Green Collar Jobs, Yvonne Sims Murray
Biomimetic Self-Assembled Nanomatrix For Drug Eluting Stent Application, Meenakshi Kushwaha
Biomimetic Self-Assembled Nanomatrix For Drug Eluting Stent Application, Meenakshi Kushwaha
All ETDs from UAB
No abstract provided.
The Role Of Centaurins In Vesicular Trafficking And Neuronal Differentiation, Jennifer Lynn Larimore
The Role Of Centaurins In Vesicular Trafficking And Neuronal Differentiation, Jennifer Lynn Larimore
All ETDs from UAB
No abstract provided.
Human Leukocyte Antigen Supertypes In Relation To Human Immunodeficiency Virus Infection Among Populations Of African Ancestry, Aleksandr Lazaryan
Human Leukocyte Antigen Supertypes In Relation To Human Immunodeficiency Virus Infection Among Populations Of African Ancestry, Aleksandr Lazaryan
All ETDs from UAB
No abstract provided.
Brake Drum Production By Centrifugal Casting, Timothy Charles Lebeau
Brake Drum Production By Centrifugal Casting, Timothy Charles Lebeau
All ETDs from UAB
No abstract provided.
Progression Through The Cell Cycle Is Regulated By Dynamic Chloride Dependent Changes In Cell Volumes, Christa Whelan Habela
Progression Through The Cell Cycle Is Regulated By Dynamic Chloride Dependent Changes In Cell Volumes, Christa Whelan Habela
All ETDs from UAB
No abstract provided.
The Relationship Of Adolescent Cognitive Ability To Adult Physical Health: Socioeconomic Status And Health Behavior As Mediating Variables, Timothy M. Hale
The Relationship Of Adolescent Cognitive Ability To Adult Physical Health: Socioeconomic Status And Health Behavior As Mediating Variables, Timothy M. Hale
All ETDs from UAB
No abstract provided.
Evaluation Of Commuter Air Quality, Jason Edward Howanitz
Evaluation Of Commuter Air Quality, Jason Edward Howanitz
All ETDs from UAB
No abstract provided.
A Statistical Approach Identifying And Limiting The Effect Of Influential Observations In Linear Regression, Tamekia L. Jones
A Statistical Approach Identifying And Limiting The Effect Of Influential Observations In Linear Regression, Tamekia L. Jones
All ETDs from UAB
No abstract provided.
Diet -Induced Changes In Intra -Abdominal Adipose Tissue And Cardiovascular Disease Risk In African American And European American Women, Konstantina Katsoulis
Diet -Induced Changes In Intra -Abdominal Adipose Tissue And Cardiovascular Disease Risk In African American And European American Women, Konstantina Katsoulis
All ETDs from UAB
No abstract provided.
Regulation Of Tau Functions By Posttranslational Modifications Of Tau And Histone Deacetylase 6, Huiping Ding
Regulation Of Tau Functions By Posttranslational Modifications Of Tau And Histone Deacetylase 6, Huiping Ding
All ETDs from UAB
Alzheimer’s disease (AD), the most common neurodegenerative disease, is pathologically characterized by senile plaques composed of amyloid β peptide and neurofibrillary tangles composed of hyperphosphorylated and aberrantly cleaved microtubule-associated protein tau. Numerous studies have demonstrated the critical importance of tau in AD pathogenesis; however, the mechanisms involved in the regulation of tau functions by posttranslational modifications of tau and by other cellular factors need to be further elucidated. The first part of my study focused on how posttranslational modifications of tau, specifically, site-specific phosphorylation and C-terminal cleavage, regulate its physiological function in associating with cytoskeleton, binding to and stabilizing microtubules …
High Field Functional Magnetic Resonance Imaging In The Awake, Behaving Primate: Cortical Networks Involved In Vergence Eye Movements, Matthew K. Ward
High Field Functional Magnetic Resonance Imaging In The Awake, Behaving Primate: Cortical Networks Involved In Vergence Eye Movements, Matthew K. Ward
All ETDs from UAB
Animals with eyes positioned towards the front of the head are capable of making saccadic and smooth pursuit eye movements to fixate an object at a given distance. These eye movements are conjugate (i.e. both eyes move the same amount in the same direction). To fixate objects at different distances, such animals are also capable of making vergence eye movements in which both eyes move the same amount in opposite directions i.e. disconjugately. While purely conjugate or vergence eye movements rarely occur in daily life, it is useful to study these types of eye movements separately due to the relative …
A Dual-Action, Armed Replicating Adenovirus For The Treatment Of Bone Metastases Of Breast Cancer, James Joseph Cody
A Dual-Action, Armed Replicating Adenovirus For The Treatment Of Bone Metastases Of Breast Cancer, James Joseph Cody
All ETDs from UAB
Most patients with advanced breast cancer develop osteolytic bone metastases, which have numerous complications. Because current therapies are not curative, new treatments are needed. Conditionally replicating adenoviruses (CRAds) are anti-cancer agents designed to infect and lyse tumor cells. For increased efficacy, CRAds have been armed with therapeutic transgenes. Osteoprotegerin (OPG), an inhibitor of osteoclastic bone resorption, represents a promising candidate with which to arm a CRAd intended to treat osteolytic bone metastases. We hypothesize that a CRAd armed with OPG will inhibit breast cancer bone metastasis and reduce tumor burden in the bone by directly lysing tumor cells and by …
Mesenchymal Stem Cell Interaction With Nanostructured Biomaterials For Orthopaedic Applications, William Charles Clem
Mesenchymal Stem Cell Interaction With Nanostructured Biomaterials For Orthopaedic Applications, William Charles Clem
All ETDs from UAB
Orthopaedic implants fail when bone loss around the anchoring region of the prosthesis causes the components to loosen. A revision surgery is needed to replace worn components, and bone grafting is often required to fill the void caused by osteolysis. A solution for the problem of osteolysis may be the improvement of wear resistance at the articulating surfaces by substituting materials with greater hardness. This dissertation describes two strategies for increasing the surface hardness of titanium alloy (Ti-6Al-4V) implants, without increasing surface roughness or compromising osseointegration. The first strategy utilizes microwave plasma to induce titanium nitride formation by nitrogen diffusion. …
Thrombospondin Type-1 Repeats And Their Potential Role In Inhibiting Glioblastoma Angiogenesis, Joshua C. Anderson
Thrombospondin Type-1 Repeats And Their Potential Role In Inhibiting Glioblastoma Angiogenesis, Joshua C. Anderson
All ETDs from UAB
Thrombospondin-1 (TSP-1) is a 420 kilodalton homotrimeric protein; it is one of the first identified anti-angiogenic proteins found to be expressed in some normal tissues. Peptides derived from the type-1 repeat (TSR) domains of full length TSP-1 have been shown to have anti-angiogenic activity, and thus anti-tumor activity in some non-glioma tumor models. I hypothesized that peptides derived from the TSRs of TSP-1, such as ABT-510, could inhibit angiogenesis and thus malignant glioma tumor growth in vivo. I found that ABT-510 inhibited angiogenesis of the human brain microvascular endothelial cell (MvEC) in an in vitro tubulomorphogenesis assay. To determine the …
Human Papillomavirus: Segregation And Replication, Luan D. Dao
Human Papillomavirus: Segregation And Replication, Luan D. Dao
All ETDs from UAB
Human papillomavirus are small DNA tumor viruses. The viral genome is a small circular double stranded DNA that replicates autonomously as an extrachromosomal plasmid. Occasionally infections by the high risk HPV viruses can lead to DNA integration and progression to cancer. How the HPV DNA is maintained and becomes established in the dividing host cells is not well understood. Additionally, as a double-stranded DNA virus it is likely that double-stranded DNA breaks in the viral genome, either from replication or random damage, will trigger a DNA repair response from the host cell. Such responses have been alternatively reported to be …
Occupational Stressors, Job Satisfaction, And Back Pain In Firefighters, Mantana Damrongsak
Occupational Stressors, Job Satisfaction, And Back Pain In Firefighters, Mantana Damrongsak
All ETDs from UAB
Occupational back pain is a significant health and safety problem in many industrialized countries for persons who are required to perform work-related forceful movement and lifting. Firefighters, an occupational group at high risk for back injury, perform many job tasks under hazardous work conditions. One-third of firefighters retire due to job-related health and safety problems and 49.4% of this group retire as a result of back pain, the leading cause of early retirements in firefighters. Most studies have examined factors influencing back problems among other workers, especially nurses and hospital workers, but few studies have investigated factors that influence back …
Metabolism Of Neutrophil-Deprived Chlorinated Isoflavones, Tracy Lyn D'Alessandro
Metabolism Of Neutrophil-Deprived Chlorinated Isoflavones, Tracy Lyn D'Alessandro
All ETDs from UAB
Despite medical advances in both drug therapy and surgical techniques, Americans mostly die from heart disease. Many belong to the low- and middle-class families who do not have sufficient access to medical care due to its high costs. An alternative is the development of healthier lifestyles such as diet which may play a positive role in chronic disease management. Epidemiological and migratory studies suggest that soy plays a pivotal role in the decreased incidence of heart disease in East Asian countries, such as China, Japan, and Korea. The role of soy in cardiovascular disease progression has been the subject of …
Perception Of Motion-In-Depth: Induced Motion Effects On Monocular And Binocular Cues, John Eric Gampher
Perception Of Motion-In-Depth: Induced Motion Effects On Monocular And Binocular Cues, John Eric Gampher
All ETDs from UAB
Three cues are available to the visual system to determine motion: image displacement across the retina (retinal slip), eye movements, and configuration changes within a scene (Becklen and Wallach, 1985). Any one may lead to the false perception of motion. Induced motion is the illusory movement of one object (or objects) as a result of other movement in the visual field. A wide variety of displays have been used to study induced motion, leading to apparently different classes of induced motion. Current theories of induced motion can be categorized based on local motion, global motion, eye movement suppression, and cognitive …
Impact Of An Electronic Medical Record On Adherence To Current Diabetes Guidelines In A Family Medicine Center, Thomas Macandrew English
Impact Of An Electronic Medical Record On Adherence To Current Diabetes Guidelines In A Family Medicine Center, Thomas Macandrew English
All ETDs from UAB
OBJECTIVE: Extensive research shows that diabetic care often falls below recommended guidelines. Many believe that Electronic Medical Records (EMR) have the ability to improve quality of care. The primary goal of this study is to evaluate the changes in diabetic care and outcomes pre and post EMR implementation. RESEARCH DESIGN AND METHODS: The study took place at the UAB Huntsville Family Medicine Center. A retrospective chart review was conducted in order to determine the impact of an EMR on diabetes care. This is a natural experiment that uses a pre post model in order to determine impact. Generalized Estimating Equations …
Quasi-Static And Multi-Site High Velocity Impact Response Of Composite Structures, Lawshya J. Deka
Quasi-Static And Multi-Site High Velocity Impact Response Of Composite Structures, Lawshya J. Deka
All ETDs from UAB
Understanding of low and high velocity transverse impact of laminated fiber reinforced composites is of interest in military, aerospace, marine and civilian structures. Recent advances in the field of numerical simulation provide a means of predicting the performance characteristics of layered materials for impact protection. The overall objective of this work is to investigate the behavior of laminated composites which include both thermoplastic and thermoset systems subjected to quasi-static, low and high velocity impact; both from an experimental and numerical modeling view point. To analyze this problem, a series of quasi-static, low and high velocity impact tests have been performed …
Functionalizing Hydroxyapatite Biomaterials With Biomimetic Peptides Of Integrin Ligands, Kristin Marie Hennessy
Functionalizing Hydroxyapatite Biomaterials With Biomimetic Peptides Of Integrin Ligands, Kristin Marie Hennessy
All ETDs from UAB
Hydroxyapatite (HA) coatings of hard tissue implants have been shown to increase osseointegration, but the mechanisms by which HA improves implant integration are not well understood. Numerous studies have shown that modifying HA with adhesive peptides, including RGD, and the collagen I mimetics, DGEA and P15, stimulates the adhesion of mesenchymal stem cells (MSCs), a cell type that differentiates along the osteoblast lineage. However, HA is a highly adsorptive biomaterial, and therefore it is unlikely that cells at the implant site would ever encounter a peptidemodified HA surface in the absence of an adsorbed protein layer. In fact, our laboratory …
Using Rna Interference To Study The Function Of The Tethering Protein P115 In Er-Golgi Traffic, Robert Grabski
Using Rna Interference To Study The Function Of The Tethering Protein P115 In Er-Golgi Traffic, Robert Grabski
All ETDs from UAB
Metazoan cells are characterized with elaborate network of intracellular membranous compartments. These membranes allow the cell to spatially separate antagonistic processes and environments, and maintain sequential order of reactions necessary for maturation and secretion of biosynthetic cargo. The core transport machinery consists of coat proteins, tethering factors, SNAREs and small Ras-like GTPases. We have explored the function of the tethering factor p115 in organellogenesis and in secretory traffic. The p115-depleted system was utilized to explore structurefunction relationships within p115. Here, we analyzed the architecture of the Golgi after RNAi induced depletion of p115. We show that in p115 depleted cells …
The Role Of Melanopsin Containing Retinal Ganglion Cells In The Pupillary Responses Of Human And Non-Human Primates, David H. Mcdougal
The Role Of Melanopsin Containing Retinal Ganglion Cells In The Pupillary Responses Of Human And Non-Human Primates, David H. Mcdougal
All ETDs from UAB
Historically, the characteristics of the light-evoked neural signals driving the human pupillary light reflex (PLR) have been poorly understood. It was assumed that these light signals originated exclusively from rod and cone photoreceptors, although the measured spectral sensitivity and response dynamics of the PLR were difficult to reconcile with the known properties of rods and cones. Recently, a novel photoreceptive cell class has been discovered in the mammalian retina. These unique retinal ganglion cells not only receive rod and cone inputs, but also express the photopigment melanopsin, and exhibit intrinsic photoresponses independent of rod and cone inputs. These intrinsically photosensitive …
Mechanism Of The Cross Talk Between Growth Hormone Receptor And Epidermal Growth Factor Receptor, Xin Li
Mechanism Of The Cross Talk Between Growth Hormone Receptor And Epidermal Growth Factor Receptor, Xin Li
All ETDs from UAB
EGF receptor (EGFR) is a receptor tyrosine kinase, mediating cell growth from ectodermal and mesodermal origin. The overexpression and aberrant function of EGFR are involved in a wide range of human carcinomas. Growth hormone receptor (GHR) coexists with EGFR in various cell types and implicated in malignant tumor behavior. Previously in our lab, we found that via ERK activation GH can threonine phosphorylate EGFR and reduce EGF-induced EGFR downregulation. GH also synergizes with EGF in activating ERK. In this project, using reconstitution, we studied the mutation of the ERK phosphorylation consensus residue on EGFR, 669T. CHO-GHR cells, which lack EGFR …
Function Of Human Retinol Dehydrogenase 12 (Rdh12) In Retinoid Metabolism, Seung-Ah Lee
Function Of Human Retinol Dehydrogenase 12 (Rdh12) In Retinoid Metabolism, Seung-Ah Lee
All ETDs from UAB
Retinol dehydrogenase 12 (RDH12) is a member of the microsomal short-chain dehydrogenase/reductase superfamily of proteins that is highly expressed in photorecep-tor cells. Mutations in RDH12 are associated with severe early-onset autosomal recessive retinal dystrophy, leading to legal blindness. Disease-associated RDH12 variants exhibit lower protein levels when expressed in eukaryotic cells. However, the physiological role of RDH12 remains unclear. As established previously, RDH12 recognizes both retinoids and lipid peroxidation products (medium-chain aldehydes) as substrates and exhibits the highest catalytic efficiency for all-trans-retinaldehyde. As the main goal of this dissertation, we characterized the catalytic properties of RDH12 and its naturally occurring mutants …
Lipomatous Tissue: Variation In Treatment Procedures, Comorbidities, And Outcomes, Theresa L. Keel
Lipomatous Tissue: Variation In Treatment Procedures, Comorbidities, And Outcomes, Theresa L. Keel
All ETDs from UAB
Benign lipomas are the most common soft tissue tumors. They exhibit great variation in severity and are associated with significant comorbidity. Advanced understanding of genetic and morphological aspects of benign lesions has revealed unexpected similarities to malignant lesions, but little work has addressed variation among benign lesions. There is a need for better understanding of the effects of variation in lipomas on comorbidity, treatment, and outcomes. Improved knowledge of the effects will clarify the extent of the health and economic burden that severe forms of benign lipomas present to patients and society and may add to understanding of malignant lesions. …
The Role Of Strychnine-Sensitive Nachrs In Rabbit Retinal Off Ganglion Cells, Jordan Michael Renna
The Role Of Strychnine-Sensitive Nachrs In Rabbit Retinal Off Ganglion Cells, Jordan Michael Renna
All ETDs from UAB
that when heteroskedasticity is present, but ignored, there is significant evidence to suggest