Digital Commons Network^™

Sensitization To Trail-Induced Apoptosis In K-Ras 12 Mutant Pancreatic Cancer Cells By Bitc, Christina Ann Wicker

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Pancreatic adenocarcinoma is an aggressive cancer with a greater than 95% mortality rate and short survival after diagnosis. Chemotherapeutic resistance hinders successful treatment. This resistance is associated with mutations within codon 12 of the K-Ras gene (K-Ras 12), which is present in over 90% of all pancreatic adenocarcinomas. Codon 12 mutations maintain Ras in a constitutively active state leading to continuous cellular proliferation. Our study determined if TRAIL resistance in pancreatic adenocarcinomas with K-Ras 12 mutations could be overcome by first sensitizing the cells with Benzyl isothiocyanate (BITC). BITC is a component of cruciferous vegetable extracts and a cell cycle …

Mdm2 Amplification In Nih3t3l1 Preadipocytes Leads To Mdm2 Elevation In Terminal Adipogenesis, Vaughn Litteral

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The p53 protein is a tumor suppressor protein that is mutated or non-functional in nearly all cancers. The Mdm2 protein has the ability to functionally inactivate p53 and these two proteins have been studied extensively in the context of cellular proliferation. In this study, expression of the murine double minute 2 (mdm2) gene was examined in the mouse NIH3T3L1 cell line. Under the proper conditions, the immortalized NIH3T3L1 cells have the ability to differentiate from fibroblasts to adipocytes (Green et al., 1975). This well characterized cell line provides an excellent model to study mdm2 in differentiation. While evaluating the regulation …

The Effects Of Nutritional Supplement, Mass Fx™, On Muscular Strength, Body Composition, And Blood Chemistries In Resistance Trained Adult Males, Patrick S. Dib

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The purpose of this study was to determine the effects of a nutritional supplement, Mass FX, on muscular strength, body composition, and blood chemistries in resistance-trained adult males. Eight subjects, mean age 25 +/- 3.02 years, were randomly assigned to two groups (n=4). Each group was given either Mass FX or a Placebo in a double-blind manner to be taken orally for six weeks (4caps/day regardless of bodyweight). For the duration of the study, both groups were following the same training program and a diet customized to each subject's bodyweight in conjunction to the supplementation. Data were analyzed using Analysis …

Energy Efficient Image Video Sensor Networks, Paul Anthony Bender

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Image Video Sensor Networks are emerging applications for sensor network technologies. The relatively large size of the data collected by image video sensors presents new challenges for the sensor network in terms of energy consumption and channel capacity. We address each of these issues through the use of a high density network deployment utilizing some nodes as dedicated relay nodes.

A high density network allows network nodes to reduce their transmission power. This reduction in transmission power allows each node to conserve power and simultaneously increases the potential for spatially concurrent transmissions within the network, resulting in improved network throughputs. …

A Study Of Multi-Echelon Inventory Systems With Stochastic Capacity And Intermediate Product Demand, Suman Niranjan

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The research in this dissertation involves the study of several multi-echelon inventory systems with stochastic capacity and intermediate product demand. Specifically we analyze the behavior of the system which consists of several intermediate product demands. The analysis is primarily three fold i) developed update (relational) equations for all the multi-echelon inventory systems under several inventory allocation policies, ii) develop two simulation optimization approaches 1) OptQuest framework, and 2) IPA (Infinitesimal Perturbation Analysis) framework, used to minimize the total cost of the inventory systems that satisfy the desired customer service level, iii) obtain numerical results for all the multi-echelon inventory systems …

Shore Wives: The Lives Of British Naval Officers' Wives And Widows, 1750-1815, Amy Lynn Smallwood

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This thesis provides an analysis of the lives of mid- to late-eighteenth century Royal Navy officers'wives and widows, including how they coped with the challenges of being separated from their husbands for extended periods of time. This separation forced them to accept additional financial and management responsibilities. By successfully managing these tasks, they proved that women were capable of managing money, purchasing property, rearing and educating children, working the patronage system, being political activists, dealing with bureaucracy, and networking. Shore wives performed these duties with the very real fear that their husbands might never come home alive. By taking up …

How Openness To Experience And Prejudicial Attitudes Shape Diversity Training Outcomes, Suzanne L. Dean

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This study investigated the effectiveness of diversity training on a diversity training outcome measure when considering participant levels of Openness to Experience, sexism, and racism. Because past literature has demonstrated a positive relationship between Openness to Experience and training outcomes and a negative relationship between prejudicial attitudes and diversity training outcomes, these variables were treated as main effects in Multiple Regression equations. This study demonstrated that diversity awareness training increases participant understanding of legal issues related to workplace diversity. However, diversity training outcomes were not greatly affected by implicit or explicit prejudicial attitudes or Openness to Experience.

Creating A New Guatemala: The 1952 Agrarian Reform Law, Tiffany Kwader Harbour

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In 1952, Guatemala enacted the Agrarian Reform Law Decree 900. The Decree became an instrument for national development through land redistribution and the development of agrarian rights. Although the law was only upheld for eighteen months, the Decree influenced land and labor legislation through today. Struggles for agrarian rights continued throughout the military dictatorship and civil war which plagued Guatemala until the signing of the 1996 Peace Accords. Ideals for land reform originating in the 1952 law continue to have a pervasive influence on the Guatemalan land reform movement. This study is further contextualized and framed with quotes and analysis …

Evaluation Of Overlay/Underlay Waveform Via Sd-Smse Framework For Enhancing Spectrum Efficiency, Vasu D. Chakravarthy

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Recent studies have suggested that spectrum congestion is mainly due to the inefficient use of spectrum rather than its unavailability. Dynamic Spectrum Access (DSA) and Cognitive Radio (CR) are two terminologies which are used in the context of improved spectrum efficiency and usage. The DSA concept has been around for quite some time while the advent of CR has created a paradigm shift in wireless communications and instigated a change in FCC policy towards spectrum regulations. DSA can be broadly categorized as using a 1) Dynamic Exclusive Use Model, 2) Spectrum Commons or Open sharing model or 3) Hierarchical Access …

Object Similarity Through Correlated Third-Party Objects, Ting Sa

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Given a pair of objects, it is of interest to know how they are related to each other and the strength of their similarity. Many previous studies focused on two types of similarity measures: The first type is based on closeness of attribute values of two given objects, and the second type is based on how often the two objects co-occur in transactions/tuples.

In this thesis we study a new behavior-based similarity measure, which evaluates similarity between two objects by considering how similar their correlated third-party object sets are. Behavior-based similarity can help us find pairs of objects that have …

Transformation Of Object-Oriented Associations And Embedded References To Them, Sneha Swamy

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AFIT Wide Spectrum Object Modeling Environment (AWSOME) automatically generates executable code by applying transforms to the formal specifications developed from the domain knowledge. AWSOME uses the specification language called as AFIT Wide Spectrum Language (AWL). All the transforms developed for AWSOME depend on and manipulate Abstract Syntax Trees (ASTs) created by parsing the formal specifications of a model. The main idea is to speed the process of creating error free code, to aid reusability of code and also to make the maintenance changes to be consistent and correct. The AWSOME metamodel contains the structural (object) model, the functional (operations) model …

The Effect Of Dissolved Air On The Cooling Performance Of A Partially-Confined Fc-72 Spray, Rebekah Lee Puterbaugh

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The objective of this thesis is to investigate the heat transfer performance of a partially-confined FC-72 spray with varying dissolved air concentrations. An experimental test rig consisting of a spray chamber coupled to a fluid delivery loop system was used to obtain temperature, pressure, and critical heat flux (CHF) data. A downward facing nozzle within the spray chamber allowed the FC-72 fluid to be sprayed onto an upward facing, thick-film, resistor heater. The heater was mounted onto a glass post, with a sump system to allow removal of excess fluid. Type-E thermocouples were imbedded in the post to obtain temperature …

Exploration Of Synthetic Routes To The Sulfoxide And Sulfone Derivatives Of Benzotrithiophenes, Tiffany M. Hall

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The synthesis of new organic materials that have the potential to be utilized in a thermoelectric application are in demand because they are able to convert thermal energy directly into electrical energy. The "end-on" sulfoxide and sulfone derivatives of Benzo[1,2-c:3,4-c':5,6-c'']trithiophene 1 were synthesized for this reason. The "end-on" mode sulfoxide derivative 13 of Benzo[1,2-c:3,4-c':5,6-c'']trithiophene 1 was prepared by utilizing 3-Carboxypyridinium Chlorochromate (CPCC) 16 and AlCl₃, as an oxidizing system. The ¹H NMR (DMSO-d₆) spectrum displayed a singlet peak at 5.03 ppm, and the IR spectrum displayed an absorption at 1059.33cm^-1, which confirmed its …

Design Of A Cmos Rf Front End Receiver In 0.18Μm Technology, Vishwas Kudur Sastry

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An RF front end receiver system refers to the analog down conversion stages of the wireless communication system. The Digital base-band signals cannot be transmitted directly through wireless channels due to the properties of electromagnetic waves. The baseband signals need to be converted to analog through a digital-to-analog converter (DAC), up converted to higher frequency using an up conversion mixer and then transmitted through the channel. The received signals are down converted to base band frequency and then converted to digital again using the analog to digital converter (ADC). The processes which the analog signal undergoes at the RF front …

Paleoenvironment And Lateral Extent Of An Exposed Carbonate Build-Up: Horry County, South Carolina, Lisa A. Raterink

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A carbonate build-up exposed in the Intracoastal Waterway in Horry County, South Carolina is estimated to be Pleistocene to Pliocene in age. The carbonate build-up discontinuously spans approximately 12 kilometers of the waterway. Prominent formations in the area consist of the Waccamaw and the Canepatch Formation. A distinct sand layer is present laterally between the build-up and the excavated waterway bank, which consists primarily of well preserved fossil molluscs and echinoderms.

Field observations show that the carbonate build-up is bluish-gray in color and composed of shell fragments, predominantly mollusc, in a mud matrix. Thin sections analyzed, using a petrographic microscope, …

The Moderating Influence Of Stress Appraisals And Affect On Performance Under Fatigue, Regina M. Schmidt

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This study demonstrated that in a group of seventeen active duty soldiers, performance on an attack combat simulation significantly degraded after approximately 30 h of sleep deprivation. In addition, individual differences were identified, as approximately half of the participants maintained performance throughout the sleep deprivation period, while other participants degraded in performance. The main objective of this study was to test the efficacy of micro-level cognitive performance and subject state factors to account for this dichotomy in performance that was particular to the last testing session. Results showed that performance on a decision making test with rapid reaction time constraints …

The Dynamics Of Workplace Harassment And Revenge: Mediation And Moderation Effects, Qiang Wang

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This study examined the mediating role of rumination, state anger, and blame attribution, and the moderating role of trait forgiveness in the relationship between workplace harassment and revenge behavior. Results based on a sample of 310 employed students suggested that workplace harassment is positively associated with both major revenge and minor revenge. Also, the multiple mediation test showed that rumination, state anger, and blame attribution completely mediate the proposed relationships between workplace harassment and both types of revenge behavior. In addition, as proposed, trait forgiveness moderated the relationship between two internal states (i.e., state anger and blame attribution) and major …

Analysis And Transformation Of Post-Conditions, Abhinav Vasikarla

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Software engineers have been trying for years to develop a software synthesis system that can transform a formal specification model to a design model from which executable code can be generated. AFIT wide spectrum object modeling environment (AWESOME) is one result of their research. AWESOME presents a formal model as an abstract syntax tree. This model consists mainly of object class specifications. The methods in these classes are specified using pre and post-conditions. The intent of this thesis is to support the transformation of post-conditions to code statements. A post-condition is first categorized as dependent or independent relative to other …

Analytic-Holistic Thinking, Information Use, And Sensemaking During Unfolding Events, Mei-Hua Lin

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In complex domains such as commerce, military operations, transportation, and humanitarian efforts, practitioners are sometimes overwhelmed by uncertain, contradictory, and dynamic information. They must obtain, organize, interpret, and use this information often under time pressure and high stakes during sensemaking. While sensemaking is a gateway to information management, sensemaking also depends on information management; the gathering and use of information provides the raw material for sensemaking. These processes work together to help people understand complex situations but are vulnerable to cultural as well as individual variation in cognition. This study investigated individual cognitive and personality differences that may affect information …

Fpga Design Of A Hardware Efficient Pipelined Fft Processor, Ryan T. Bone

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Digital receivers involve fast Fourier transform (FFT) computations that require a large amount of arithmetic operations. The implementation of a FFT processor is one of the most challenging parts in the realization of a wideband receiver and its hardware complexity is very high. Hence, kernel function FFT processors have been proposed to meet real-time processing requirements and to reduce hardware complexity by rounding the kernel function to predetermined kernel points so as to eliminate the multipliers and use only shifters and adders or subtractors. Because of the nonlinear nature of this approximation by the rounding errors, spurious responses are generated …

Exploration Of Gradient-Type Poly(Arylene Ether)S Via An Abb' Monomer System, Alex V. Dolgov

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Evidence shows that a gradient like copolymer can be synthesized using nucleophilic aromatic substitution, NAS, chemistry. Using the 4-chloro-3-fluoro-4'hydroxydiphenylsulfone monomer, 5, it is possible to control the ratios of the leaving groups, in this case the fluorine and the chlorine, with the right solvent and temperature. Alternating the temperatures will alter the substitution of the leaving groups, thus forming a polymer backbone of gradient characteristics. Initial reactions to determine the relative rates of displacement of the chlorine and fluorine atoms were carried out using a model compound, 1, which possessed the chlorine and fluorine leaving groups, but not the phenol …

Evanescent Microwave Microscopy Of Porcine Skin Tissue, Richard A. Kleismit

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This thesis describes the application of a custom designed λ/4 resonant coaxial probe to measurements of the complex permittivity of in vitro freshly excised porcine skin tissue. The dielectric properties of the organic material within the near field of the tip of the probe frustrates the electric field and measurably changes the resonant frequency and quality factor Q of the coaxial sensor, where the change in resonant frequency and quality factor of a tuned resonance is measured as a function of tip-sample separation. The design of the probe enables better spatial resolution than previously developed probes. The following studies were …

Performance And Complexity Co-Evaluations Of Mpeg4-Als Compression Standard For Low-Latency Music Compression, Isaac Kevin Matthew

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In this thesis compression ratio and latency of different classical audio music tracks are analyzed with various encoder options of MPEG4ALS. Different tracks of audio music tracks are tested with MPEG4-ALS coder with different options to find the optimum values for various parameters to obtain maximum compression ratio with minimum CPU time (encoder and decoder time). Optimum frame length for which the compression ratio saturates for music audio is found out by analyzing the results when different classical music tracks are experimented with various frame lengths. Also music tracks with varying sampling rate are tested and the compression ratio and …

Electrochemistry Of Trinuclear Metal Clusters Of Molybdenum And Tungsten In 1-Ethyl-3- Methylimidazolium Tetrafluoroborate, Tracey Lynn Harris

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The imidazolium based ionic liquid: 1-ethyl-3-methylimidizoliumtetrafluoroborate, (EMIBF4) was synthesized to be used as a solvent for the electrochemical investigation of molybdenum and tungsten. The electrochemical window is about 4.2V after removing traces of impurities such as Cl^- and H₂O. Electronic spectra of metal clusters [Mo₃O₂(O₂CCH₃)₆(H₂O)₃]⁺² ; [W₃O₂(O₂CCH₃)₆(H₂O)₃]⁺² ; [MoW₂O₂(O₂CCH₃)₆(H₂O)₃]⁺² and [Mo_{2 …}

Poly(Arylene Ether)S With Truly Pendant Benzene Sulfonic Acid Groups, Mohamed Moustafa Abdellatif

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A series of new sulfonated poly(arylene ether)s containing one sulfonic acid group, located on a pendant phenyl sulfonyl moiety, at every repeat unit was synthesized using 3-sulfonated-3', 5'-difluorophenyl Sulfone, 4, and a variety of bisphenols. A conventional nucleophilic aromatic substitution (NAS) was utilized for the homopolymerization and copolymerization reactions. Polymerization reactions of 4 in NMP at 180 °C provided the corresponding linear sulfonated poly(arylene ether)s, s-PAEs, with number average molecular weight, M_n, ranging from 10,000 to 38,000 Daltons. All of the polymers were characterized by ¹H and ¹³C NMR spectroscopy, thermogravimetric analysis (TGA), and differential scanning …

Histogram-Based Template Matching Object Detection In Images With Varying Brightness And Contrast, Christina Da-Wann Schrider

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Our challenge was to develop a semi-automatic target detection algorithm to aid human operators in locating potential targets within images. In contrast to currently available methods, our approach is relatively insensitive to image brightness, image contrast and object orientation. Working on overlapping image blocks, we used a sliding difference method of histogram matching. Incrementally sliding the histograms of the known object template and the image region of interest (ROI) together, the sum of absolute histogram differences was calculated. The minimum of the resultant array was stored in the corresponding spatial position of a response surface matrix. Local minima of the …

Model And Solution Approaches For The Equipment Scheduling Under Disruption Problems In Usps Mail Processing And Distribution Centers, Arvindkumar Ravi Chakravarthy

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This research addresses the equipment scheduling problem under disruptions in United States Postal Service mail processing and distribution centers. These facilities contain a large variety of equipment and employ a non-homogeneous workforce that work on shifts of various lengths and start times. The scheduling of equipment (the determination of the configuration and usage of equipment to match mail arrivals) and the scheduling of workforce (the determination of the optimal size and composition of the workforce, their days off / lunch assignments, and overtime usage) to meet processing service commitment with a constantly changing demand are some of the most challenging …

The In Pulse, William L. Hall

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A collection of poems composed as an exercise with imagination and the attempt to convey the mind as medium for experience without forgetting the reader remembers something else.

Geologic Mapping Of The Changgo Dome In Southern Tibet Using Aster Imagery, Andrew Paul Folfas

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Within the thick TSS, south of the Indus-Tsangpo Suture, a series of granitic intrusions and gneissic domes crop out along the NHA. These culminations are common features that are seen in orogenic belts; therefore, understanding the nature and development of these features is an integral part of this study and other collisional orogenic studies. Changgo Dome is a granitic dominated feature that is characterized by the presence of two spectrally similar Tertiary granites. This zone is nearly inaccessible for ground mapping, thus it is an ideal setting for the use of satellite imagery as a cartographic medium. In a previous …

In Search For New P53 Regulated Genes, Meldrick Daniel Mpagi

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The p53 tumor suppressor protein has the ability to transactivate its target genes whose gene products are involved in carrying out cell cycle arrest, apoptosis, DNA repair, and senescence. Here, I report that two genes may be p53 regulated. Utilizing a microarray method to search for novel p53 target genes, I was able to identify a possible transcriptional target of p53 being solute carrier family 1a1 (SLC1a1). Along with that finding I also identified an E2F-target gene, minichromosome maintenance 10 (MCM10), as being p53 regulated. Gene expression profiling of MCF7 breast cancer cells treated with RNAi targeting Hdm2 and HdmX …