Digital Commons Network^™

Examination Of Health Adherence Behaviors And Cognitive Distortions In Patients With Chronic Illness , Clint C. Stankiewicz

PCOM Psychology Dissertations

The relationship between health adherence behaviors and cognitive distortions among patients with chronic illness were investigated. One-hundred eleven participants from two outpatient medical clinics were administered the Health Adherence Behavior Inventory (HABIT) and the Inventory for Cognitive Distortions (lCD), and the Health Adherence Behavior Survey was utilized to obtain demographic information. Results indicated participants who had a thinking style characterized by the use of cognitive distortions tended to engage in fewer health promoting behaviors. This finding was consistent with the predicted hypothesis. In fact, a significant correlation at the .05 level of -.173 was found between the ICD and the …

Effects Of Statin Medications On Health Related Behaviors, Stephen M. Timchack

PCOM Psychology Dissertations

The current study focuses on the psychological effects of statin medications. Specifically, this study examines the health related beliefs and behaviors that may be altered by the consumption of this fast acting class of life saving drugs. Although the statin class of medication generally produces favorable physiological results, as evidenced by reduced levels of serum cholesterol, and in some case increases in high density lipoproteins, the health related belief system and heath related behaviors may actually be altered in a negative fashion by engendering a sense of overconfidence; this in turn may alter beliefs and diminish the importance of adhering …

Dynamic Leadership: Toolbox For The Value-Based Entrepreneurship, Chun (Grace) Guo, Sinead G. Ruane, Alexandra Galli-Debicella, Phuong Anh Nguyen, Charles C. Manz

WCBT Faculty Publications

Four entrepreneurship models are proposed which lend guidance in the development of a business, from birth to exit, each examining ways to maintain the business founder’s initial vision and to continue to infuse values and ethical decision-making at each stage of development.

Optimization Studies Of The Important Drug Lead Kahalalide F Which Acts On A Novel Cancer Target Rps25, Kully Lynn Woodruff

Honors Theses

Kahalalide F (KF, 1) is the largest and most biologically active cyclic peptide of the naturally occurring kahalalide family of depsipeptides. Previous evaluations of the compound have shown significant in vitro and in vivo activity against various forms of cancer. KF has been investigated in phase I clinical trials and is being evaluated in phase II clinical studies. The objective of this experiment was to prepare analogues of KF through semisynthetic modification of the parent compound to optimize activity against a slate of pathogens, as well as cancerous cells. Data revealed that KF and analogues were not active against malaria, …

Assessing Laws And Legal Authorities For Public Health Emergency Legal Preparedness, David Fidler, Brian Kamoie, Robert M. Pestronk, Peter Baldridge, Leah Devlin, George A. Mensah, Michael Doney

Articles by Maurer Faculty

No abstract provided.

The Temporal Dimension Of Land Pollution: Another Perspective On Applying The Breaking The Logjam Principles To Waste Management, John S. Applegate

Articles by Maurer Faculty

Unlike air and water pollution, pollution from dangerous solid and liquid wastes on land remains a relatively concentrated, active hazard for long periods of time. Uncontrolled, land pollution moves through the environment slowly and often without significant diminution of toxicity. Persistence, in fact, is often regarded as the defining quality of dangerous land pollutants. Hazardous and nuclear waste regulation is very much concerned with the problem of maintaining the isolation of solid and liquid materials over decades, centuries, and even millennia, and, the author argues, there is good reason to believe that waste management practices and institutions are not well …

Loline Alkaloid Biosynthesis Gene Expression In Epichloe Endophytes Of Grasses, Dong-Xiu Zhang

University of Kentucky Doctoral Dissertations

Loline alkaloids (LA) are secondary metabolites produced by Epichloandamp;euml; (anamorph, Neotyphodium) grass endophytes. They are toxic and deterrent to a broad range of herbivorous insects but not to livestock. This protective bioactivity has spurred considerable research into the LA biosynthetic pathway. LOL, the gene cluster containing nine genes, is required for LA biosynthesis. The regulation of LOL genes during LA production in culture and in symbio is of interest. In this study, coordinate regulation between LOL gene expression and LA production level was investigated in both MM culture and symbiota. Results showed that expression of LOL genes in N. uncinatum …

Design And Evaluation Of Inflatable Wings For Uavs, Andrew D. Simpson

University of Kentucky Doctoral Dissertations

Performance of inflatable wings was investigated through laboratory, wind tunnel and flight-testing. Three airfoils were investigated, an inflatable-rigidazable wing, an inflatable polyurethane wing and a fabric wing restraint with a polyurethane bladder. The inflatable wings developed and used within this research had a unique outer airfoil profile. The airfoil surface consisted of a series of chord-wise \bumps.andamp;quot; The effect of the bumps or \surface perturbationsandamp;quot; on the performance of the wings was of concern and was investigated through smoke-wire flow visualization. Aerodynamic measurements and predictions were made to determine the performance of the wings at varying chord based Reynolds Numbers …

Induction Of The Heat Shock Response To Protect Against Polyglutamine Diseases And The Role Of Protein Sumoylation In Laminopathies And Alzheimer's Disease, Yu-Qian Zhang

University of Kentucky Doctoral Dissertations

Heat shock proteins function as molecular chaperones which help protein folding and prevent protein aggregation. My study shows that celastrol, a pharmacological compound capable of up-regulating the levels of heat shock proteins, inhibits cell death and protein aggregation caused by expanded polyglutamine containing protein, and the protective effects of celastrol are dependent on heat shock factor 1. These results suggest the potential of celastrol as a therapeutic agent in the treatment of polyglutamine diseases.

Sumoylation is a protein modification which plays diverse roles in regulating the target proteins. My study shows that lamin A is a target of protein sumoylation, …

Comparative Biology Of Seed Dormancy-Break And Germination In Convolvulaceae (Asterids, Solanales), Kariyawasam Marthinna Gamage Gehan Jayasuriya

University of Kentucky Doctoral Dissertations

The biology of seed dormancy and germination of 46 species representing 11 of the 12 tribes in Convolvulaceae were compared in laboratory (mostly), field and greenhouse experiments. Seeds were tested for kind of dormancy and storage behavior; artificial or simulated natural treatments were applied to break physical dormancy (PY); the initial route of water entry (“water gap”) into seeds was identified; the morphoanatomy of the water gap was compared in seeds of 17 species; ontogenetical differences between water gap and seed coat away from the hilum were described in Ipomoea lacunosa seeds; cycling of sensitivity to dormancy break was elucidated …

Nitration And Inactivation Of Manganese Superoxide Dismutase Plays A Critical Role In Metabolic Switch, Muthuswamy Anantharaman

University of Kentucky Doctoral Dissertations

Alzheimer’s disease (AD) is a multifactorial, progressive, age-related neurodegenerative disease. Oxidative stress hypothesis is most prevalent and is gaining significant support. Inspite of the progress achieved on oxidative stress related damages in AD brain; the modification occurring on the various cellular antioxidant enzymes antioxidant has not been identified. Tyrosine nitration, a marker for peroxynitrite induced oxidative damage to protein is widespread in AD brain and Manganese superoxide dismutase (MnSOD), primary mitochondrial antioxidant enzyme is prone to peroxynitrite induced nitration and inactivation. Nitration of proteins involved in energy metabolism has been demonstrated in AD brain, which may explain the altered glucose …

Reciprocal Regulation Of Par-4 And Caspase-8 In The Trail Signaling Pathway, Padhma Ranganathan

University of Kentucky Doctoral Dissertations

Par‐4 is a pro‐apoptotic tumor suppressor that is mutated, suppressed or inactivated in cancer. Par‐4 exploits components of the extrinsic pathway to cause apoptosis selectively of cancer cells. This study identified Par‐4 as an essential component of the apoptotic pathway induced by TRAIL, which selectively targets cancer cells. RNA interference‐mediated knockdown of Par‐4 rendered cancer cells unresponsive to TRAIL‐induced apoptosis. Cells with knocked‐down levels of Par‐4 were deficient in the activation of the apoptosis‐initiator caspase‐8 and the apoptosis‐effector caspase‐3 in response to TRAIL. Par‐4 was identified as a critical mediator of membrane translocation of caspase‐8 and the adapter protein FADD. …

Matrix Decomposition For Data Disclosure Control And Data Mining Applications, Jie Wang

University of Kentucky Doctoral Dissertations

Access to huge amounts of various data with private information brings out a dual demand for preservation of data privacy and correctness of knowledge discovery, which are two apparently contradictory tasks. Low-rank approximations generated by matrix decompositions are a fundamental element in this dissertation for the privacy preserving data mining (PPDM) applications. Two categories of PPDM are studied: data value hiding (DVH) and data pattern hiding (DPH). A matrix-decomposition-based framework is designed to incorporate matrix decomposition techniques into data preprocessing to distort original data sets. With respect to the challenge in the DVH, how to protect sensitive/confidential attribute values without …

The Role Of Stem Cell Antigen-1(Sca-1) In Muscle Aging, Sonia Angela Richards-Malcolm

University of Kentucky Master's Theses

Muscle aging is associated with a decrease in the number of satellite cells and their progeny, muscle progenitor cells (MPCs) that are available for muscle repair and regeneration. However, there is an increase in non-immuno-hematopoietic cells (CD45 negative) in regenerating muscle from aged mice characterized by high stem cell antigen -1(Sca-1) expression. In aged regenerating muscle, 14.2% of cells are CD45neg Sca-1pos while 7.2% of cells are CD45neg Sca-1pos in young adult muscle. In vitro, CD45neg Sca-1pos cells over express genes associated with fibrosis, potentially controlled by Wnt2. These cells are proliferative, non-myogenic and non-adipogenic, and arise in clonally-derived MPCs …

Adaptive, Multi-Objective Job Shop Scheduling Using Genetic Algorithms, Haritha Metta

University of Kentucky Master's Theses

This research proposes a method to solve the adaptive, multi-objective job shop scheduling problem. Adaptive scheduling is necessary to deal with internal and external disruptions faced in real life manufacturing environments. Minimizing the mean tardiness for jobs to effectively meet customer due date requirements and minimizing mean flow time to reduce the lead time jobs spend in the system are optimized simultaneously. An asexual reproduction genetic algorithm with multiple mutation strategies is developed to solve the multi-objective optimization problem. The model is tested for single day and multi-day adaptive scheduling. Results are compared with those available in the literature for …

Inorganic And Organic Phosphorus Interactions With Hydroxy-Interlayered Soil Minerals, Paul D. Shumaker Ii

University of Kentucky Master's Theses

Phosphorus (P), a necessary plant and animal nutrient, can also lead to eutrophication of fresh waters when in excess. Appropriate P management is necessary to prevent fresh water pollution. Mineralogy of soil clays has been shown to affect P adsorption, desorption, and movement through soils. Specifically, hydroxy-interlayered minerals have been shown to adsorb and retain inorganic P in soil systems. This study was designed to determine the sorption and desorption characteristics of inorganic, organic, and mixed forms of P interacting with soil hydroxy-interlayered vermiculites (HIV) and smectites (HIS), and compare the findings to sorption and desorption processes of natural aluminum …

Effects Of Fescue Herbicides Plateau® And Cimarron® On Pregnancy Maintenance In Broodmares And On Alkaloid Concentrations In Endophyte Infected Tall Fescue, Kathleen Scarlett Black

University of Kentucky Master's Theses

Ingestion of endophyte infected (E+) fescue by pregnant mares can cause significant reproductive problems. Plateau® and Cimarron® herbicides suppress fescue while leaving desired forages unharmed. To determine if these herbicides are harmful to pregnant mares, they were allowed to graze pastures treated with Plateau®, Cimarron®, or vehicle carrier. Pregnancies were monitored via ultrasonography, blood chemistry, and hematology. Of the components measured only creatinine differed among treatments over time (P=0.0003) and that increase was only significant in one of four studies.

Two additional experiments were conducted to determine the effect of the herbicides on alkaloids within E+ fescue. A greenhouse experiment …

Phylogenetic Methods For Testing Significant Codivergence Between Host Species And Their Symbionts, Skyler Speakman

University of Kentucky Master's Theses

Significant phylogenetic codivergence between plant or animal hosts (H) and their symbionts or parasites (P) indicate the importance of their interactions on evolutionary time scales. However, valid and realistic methods to test for codivergence are not fully developed. One of the systems where possible codivergence has been of interest involves the large subfamily of temperate grasses (Pooideae) and their endophytic fungi (epichloae). Here we introduce the MRCALink (most-recent-common-ancestor link) method and use it to investigate the possibility of grass-epichloё codivergence. MRCALink applied to ultrametric H and P trees identifies all corresponding nodes for pairwise comparisons of …

Quantifying Cellulase In High-Solids Environments, Alicia Renée Abadie

University of Kentucky Master's Theses

In recent years, fungal and bacterial cellulases have gained popularity for the conversion of lignocellulosic material to biofuels and biochemicals. This study investigated properties of fungal (Trichoderma. reesei) and bacterial (Clostridium thermocellum) cellulases. Enzymatic hydrolysis was carried out with T. reesei using nine enzyme concentration and substrate combinations. Initial rates and extents of hydrolysis were determined from the progress curve of each combination. Inhibition occurred at the higher enzyme concentrations and higher solids concentrations. Mechanisms to explain the observed inhibition are discussed. Samples of C. thermocellum purified free cellulase after 98% hydrolysis were assayed to determine …

Towards Cloning The Clk-3 Gene In Caenorhabditis Elegans, Suchita Umesh Desai

University of Kentucky Master's Theses

Mutations in the clk-1, clk-2, clk-3 and gro-1 genes in Caenorhabditis elegans show alterations in developmental and behavioral timing and lifespan, collectively termed the Clk phenotype. While the clk-1, clk-2, and gro-1 genes have been cloned, clk-3 gene has not been identified. Gene expression changes in clk-3 mutant worms were determined using microarray expression data. I examined genes in the region to which clk-3 gene maps, for strongly reduced expression in the clk-3 mutants and identified thirteen clk-3 candidate genes. RNAi feeding vectors for all these candidate genes were picked and cultured from the RNAi library. …

Evolutionary And Functional Characterization Of Os-Pollux, A Rice Gene Orthologous To A Common Symbiosis Gene In Legume, Cui Fan

University of Kentucky Master's Theses

Root symbioses with arbuscular mycorrhizal fungi and rhizobial bacteria share a common signaling pathway in legumes. Among the common symbiosis genes are CASTOR and POLLUX, the twin homologous genes in Lotus japonicus that encode putative ion channel proteins. Orthologs of CASTOR and POLLUX are ubiquitously present in both legumes and non-legumes, but their function in non-legumes remains to be elucidated. Here, we use reverse genetic approaches to demonstrate that the rice (Oryza sativa) ortholog of POLLUX, namely Os-POLLUX, is indispensible for mycorrhizal symbiosis in rice. Furthermore, we show that Os-POLLUX can restore nodulation, …

Performance And Physiology Of Yearling Steers Grazing Toxic Tall Fescue As Influenced By Concentrate Feeding And Steroidal Implants, Jessica Meagan Carter

University of Kentucky Master's Theses

Fescue toxicosis can produce negative effects on animal weight gain and physiology. Sixty-four steers were grazed on endophyte-infected (E+) KY-31 tall fescue for 77 days in 2007 and sixty steers grazed for 86 days in 2008 to evaluate interactions with implantation of steroidal implants and concentrate feeding on performance and physiology of yearling steers. Steers were stratified by body weight for assignment to six, 3.0-ha toxic tall fescue pastures. The main plot treatment of with or without pelleted soybean hulls (SBH) were randomly assigned to pastures. Pelleted SBH were group-fed to provide daily consumptions of 2.3 kg/steer/d (as fed). Sub-plot …

Using Forward-Looking Infrared Radiography To Estimate Elk Density And Distribution In Eastern Kentucky, Lauren M. Dahl

University of Kentucky Master's Theses

Elk (Cervus elaphus) in eastern Kentucky appear to have increased in number since reintroduction in 1997, but rugged landscapes and cryptic elk behavior have precluded use of typical population survey methods to accurately estimate population size. In December 2006, I used forward-looking infrared radiography (FLIR) to survey the elk population in eastern Kentucky. Elk locations identified by FLIR were used to create a landscape based model to estimate the density distribution of elk within a 7,088 km2 core area of the elk restoration zone. FLIR detected 76% of elk groups of < 10 individuals and 100% of elk groups of ≥ 10 individuals. The density of elk was positively associated with the amount of herbaceous area, herbaceous edge, herbaceous area weighted mean patch fractal dimensions, proximity to release sites, the number of elk released at each site and urban core area index, and negatively associated with road density. My model estimated the elk population at 7,001 (SE = 772, 95% CI = 5,488- 8,514) individuals within the core area, 53% of which were < 10 km from release sites. The predicted elk distribution pattern and abundance estimate derived from this model will be important for wildlife managers in successfully managing the Kentucky elk population.

Government Data Mining: The Need For A Legal Framework, Fred H. Cate

Articles by Maurer Faculty

The article examines the government's growing appetite for collecting personal data. Often justified on the basis of protecting national security, government data mining programs sweep up data collected through hundreds of regulatory and administrative programs, and combine them with huge datasets obtained from industry. The result is an aggregation of personal data - the "digital footprints" of individual lives - never before seen. These data warehouses are then used to determine who can work and participate in Social Security programs, who can board airplanes and enter government buildings, and who is likely to pose a threat in the future, even …

Of Persons And The Criminal Law: (Second Tier) Personhood As A Prerequisite For Victimhood, Luis E. Chiesa

Journal Articles

This article examines the implications of the Michael Vick case for the criminal law in general and for the law of victimhood in particular. It takes as its point of departure the NFL star's agreement to pay close to one million dollars to the various entities that assumed custody of the pit bulls in order to "make restitution for the full amount of the costs associated with the disposition of all dogs" that were involved in his illegal operation. According to the agreement, the authority to order such payments stems from 18 U.S.C. ý 3663, which allows for the issuance …

The Right To Research: The Student Guide To Opening Access To Scholarship, Gavin Baker, Forrest, Sparc

Open Access Resources

The Right to Research: The Student Guide to Opening Access to Scholarship

Calendar Year 2008 Report To The Rio Grande Compact Commission, Dick Wolfe, John R. D'Antonio, Patrick R. Gordon

Law of the Rio Chama

No abstract provided.

Reproductive Allometry And The Size-Number Trade-Off For Lizards, Eric Charnov, Robin Warne

Biology Faculty & Staff Publications

The yearly reproductive allocation shows a 0.75 allometry with adult size across lizard species.

Fish Growth: Bertalanffy K Is Proportional To Reproductive Effort, Eric Charnov

Biology Faculty & Staff Publications

No abstract provided.

Recreation Use Characteristics Of The Maah Daah Hey Trail, James C. Lindstrom

Theses and Dissertations

No abstract provided.