Digital Commons Network^™

Identification Of Adropin As A Secreted Factor Linking Dietary Macronutrient Intake With Energy Homeostasis And Lipid Metabolism, K. Ganesh Kumar, James L. Trevaskis, Daniel D. Lam, Gregory M. Sutton, Robert A. Koza, Vladimir N. Chouljenko, Konstantin G. Kousoulas, Pamela M. Rogers, Robert A. Kesterson, Marie Thearle, Anthony W. Ferrante, Randall L. Mynatt, Thomas P. Burris, Jesse Z. Dong, Heather A. Halem, Michael D. Culler, Lora K. Heisler, Jacqueline M. Stephens, Andrew A. Butler

Faculty Publications

Obesity and nutrient homeostasis are linked by mechanisms that are not fully elucidated. Here we describe a secreted protein, adropin, encoded by a gene, Energy Homeostasis Associated (Enho), expressed in liver and brain. Liver Enho expression is regulated by nutrition: lean C57BL/6J mice fed high-fat diet (HFD) exhibited a rapid increase, while fasting reduced expression compared to controls. However, liver Enho expression declines with diet-induced obesity (DIO) associated with 3 months of HFD or with genetically induced obesity, suggesting an association with metabolic disorders in the obese state. In DIO mice, transgenic overexpression or systemic adropin treatment attenuated hepatosteatosis and …

Glypican-1 Modulates The Angiogenic And Metastatic Potential Of Human And Mouse Cancer Cells, Takuma Aikawa, Chery A. Whipple, Martha E. Lopez, Jason Gunn, Alison Young, Arthur D. Lander, Murray Korc

Dartmouth Scholarship

Cells isolated from many types of human cancers express heparin-binding growth factors (HBGFs) that drive tumor growth, metastasis, and angiogenesis. The heparan sulfate proteoglycan glypican-1 (GPC1) is a coreceptor for HBGFs. Here we show that both cancer cell–derived and host-derived GPC1 are crucial for efficient growth, metastasis, and angiogenesis of human and mouse cancer cells. Thus downregulation of GPC1 in the human pancreatic cancer cell line PANC-1, using antisense approaches, resulted in prolonged doubling times and decreased anchorage-independent growth in vitro as well as attenuated tumor growth, angiogenesis, and metastasis when these cells were transplanted into athymic mice. Moreover, athymic …

Library And Information Support For New Partnership For Africa 'S Development (Nepad), Christopher Nkiko, Felicia O. Yusuf

Library Philosophy and Practice (e-journal)

New Partnership for Africa's Development (NEPAD) was created in October 2001 as an way of helping Africa extricate itself from the malaise of underdevelopment and exclusion in a globalizing world. Its major objectives include: eradication of poverty, promotion of accelerated growth and sustainable development, halting the marginalization of Africa in the globalizing process, and the empowerment of women. The paper examines preconditions for its success and the specific roles expected of libraries and information centres. Such roles include; popularizing the initiative, providing continental information database, human development, eradication of diseases and poverty through information, information brokerage and environmental scanning, partnering …

Importance Of Information And Communication Technologies (Icts) In Making A Heathy Information Society: A Case Study Of Ethiope East Local Government Area Of Delta State, Nigeria, Monday Obaidjevwe Ogbomo, Esoswo Francisca Ogbomo

Library Philosophy and Practice (e-journal)

ICTs are crucially important for sustainable development in developing countries. For the past two decades, most developed countries have witnessed significant changes that can be traced to ICTs. These changes have been observed in economics, education, communication, and travel. Many initiatives have been taken at the international level to support Africa's efforts to develop a communication infrastructure and. This study uses a survey that employed a two-part questionnaire that collected data on the personal characteristics of the respondents and their use of ICTs. A sample of 120 respondents was used. The respondents were drawn from the Ethiope East local government …

The Daily Egyptian, December 05, 2008, Daily Egyptian Staff

December 2008

No abstract provided.

Board Of Trustees Meeting Minutes 2008-12-05, Bowling Green State University

Board of Trustees Meeting Minutes

The official meeting minutes of Bowling Green State University's Board of Trustees.

Draft - Understanding The Subprime Mortgage Crisis, Yuliya Demyanyk, Otto Van Hemert

Documents

No abstract provided.

This Week At Sbs, V.2, N.13b | This Week At Stony Brook Southampton/In The News, Darren Johnson

Southampton Announcements and News

No abstract provided.

Reporter - December 5th 2008, Rit Reporter Staff

University Publications

No abstract provided.

Opposition Makes Gains In Venezuelan State And City Elections, Guest Author

NotiSur

No abstract provided.

Stevenson Center Compass, Vol. 2, Iss. 1, December 5, 2008, Illinois State University, Stevenson Center For Community And Economic Development

Stevenson Center Compass

Newsletter for the Stevenson Center for Community and Economic Development

The Murray Ledger And Times, December 5, 2008, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

The Bison, December 5, 2008

The Bison Newspapers

No abstract provided.

Firearms And Children: A Public Health Issue, Janet M. Benz

Theses and Graduate Projects

This is the time for nurses as individuals and collectively as a profession to realize their obligation to society in regards to the injury and death caused by firearms. Not one population or single community is immune from gun violence in America; it is an epidemic that does not discriminate. There are monumental implications for both nurses in practice and leadership to make a difference when it comes to changing policy from a public health perspective to reduce gun violence and save lives. In this project, Margaret Newman's (1994) theory of Health as Expanding consciousness is applied to the role …

Achieving Cultural Competence Through The Use Of Community Health Workers: Open Cities Health Center's Approach, Dorii Gbolo

Theses and Graduate Projects

The purpose of this project is to identify objectives necessary for incorporating a Community Health Worker (CHW) program within an urban Federally Qualified Community Clinic setting, for the purpose of enhancing the culturally specific care provided by the clinic. CHWs offer our current fragmented and complex health care system an opportunity to improve the health of underserved populations in our country. The use of CHWs dates back to the 1960's as an attempt to expand health care to the underserved residing in poor communities.

If one is poor, an immigrant, or just different from the norms of our society receiving …

How One's Cultural View Of Obesity Affects Care Giving, Marietta Kramper Farris

Theses and Graduate Projects

As the United States faces the challenge of obesity it is important to understand the cultural aspects of caring for these patients. Leininger's Transcultural Nursing Theory is used as a framework for the development of an educational program for health care professionals. The obese patients receiving care should be able to count on their care givers to appreciate the biases, stigmatization and discrimination of the culture in which they live. A review of the history of cultural views of obesity and thinness is used as a starting point. An in-depth review of related research is presented to detail bias, stigmatization, …

Supporting Lactation: Beyond Nutrition, Desiree' M. Bertilrud

Theses and Graduate Projects

Breastfeeding provides nutritional, health, immunological, psychological, economical and environmental benefits. Despite the abundance of scientific evidence and public health campaigns, the United States fails to meet national goals for breast feeding rates. Numerous barriers to lactation are identified and explored. However, by far, returning to work has the greatest impact on the duration of breastfeeding. Employers and organizations who support breastfeeding are the recipients of a multitude of benefits. The purpose of this project is to identify the strategic steps to establish a lactation room in an outpatient clinic setting for employees to support maternal-child relationships, foster employee satisfaction, and …

Flyer News, Vol. 56, No. 19 (Dec. 5, 2008), University Of Dayton

Flyer News

Student-run newspaper of the University of Dayton.

Houston V. Whittier Respondent's Brief Dckt. 35287

Idaho Supreme Court Records & Briefs, All

No abstract provided.

The Daily Gamecock, Friday, December 5, 2008, University Of South Carolina, Office Of Student Media

December

No abstract provided.

The Impact Of A Character Education Based Interactive Discipline Program On At-Risk Student Behavior In An Alternative School, Michael G. Hylen

Dissertations

Student problem behavior is incompatible with academic achievement and positive interpersonal relationships. It has become necessary for schools to develop codes of conduct to address inappropriate student behavior. But, current school disciplinary policies are ineffective instruments for effecting positive change in student problem behavior (Goodman, 2006). In response to this problem, public school districts are developing a wide variety of approaches to dealing with the needs of problem behavior students. One approach has been the development of alternative high school programs - school district initiatives specifically designed to meet the needs of students lacking success in the traditional high school …

Central Florida Future, Vol. 40 No. 111, December 5, 2008

Central Florida Future

Football player sent to hospital; Book prices still on the rise; Virtual rehabilitation; VOX tries to prevent HPV; Four-wheeled steeds prowl UCF campus.

A Correlational Study: The Relationship Between Physical Activity Levels, Physical Self-Worth, And Global Self-Worth In High School Physical Education Students, Ashley Danelle Eyre

Theses and Dissertations

The purpose of this study was to determine the relationship between physical activity levels, physical self-worth, and its sub-domains; (a) skill, (b) body attractiveness, (c) fitness and conditioning, and (d) strength, and overall global self-worth in high school students. One-Hundred and sixty-seven students (male = 66;female = 101) from the western United States, ages 13-18, participated in this study. Each participant completed a minimum of four days of physical activity (PA) data collection and completed the self-worth questionnaire. Pedometers were used to collect PA levels, calculating mean step counts, and the Children and Youth Physical Self-Perception Profile (CY-PSPP) was used …

Views And Use Of Theory By Practicing Instructional Designers, Joseph B. South

Theses and Dissertations

Formal instructional design (ID) theories, intended to guide instructional designers' decision-making and design practices, have grown in abundance in recent years. These ID theories are based on learning theories that form the foundation for applied work in the field. However, researchers are concerned that these theories may not be applicable to the day-to-day practice of instructional designers. While some studies investigate the application of ID process models, studies of learning theory and ID theory in practice are rare. Consequently, there is little information about the nature and extent of the gap between our field's theory and its practice. This qualitative …

Christmas Off Campus

News Releases

No abstract provided.

It Begins With A Wish

News Releases

No abstract provided.

A Population Genetic Study Of Middle Eastern Populations Using Dys 458 Microvariants And Cohen Modal Haplotypes, Enass Nabeel Tinah

Theses and Dissertations

A comprehensive population study in the Middle East was conducted using different genetic markers in order to establish a wider genetic profile of the Middle Eastern populations. The main goal of this study was to analyze DNA from samples collected from different locations, and produce genetic motifs and patterns that could be used to identify and distinguish the target populations. This information will allow us to analyze the ancestry of these populations, their interactions through time and space, and the effects these interactions have on the populations' structure. We have collected around 1300 individual samples from different populations in the …

V. 76, Issue 10, December 5, 2008

Archway (1946-2020)

No abstract provided.

Down-Regulation Of Ppargamma1 Suppresses Cell Growth And Induces Apoptosis In Mcf-7 Breast Cancer Cells, Yekaterina Y. Zaytseva, Xin Wang, R. Chase Southard, Natalie K. Wallis, Michael W. Kilgore

Pharmacology and Nutritional Sciences Faculty Publications

BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear hormone receptor superfamily and is highly expressed in many human tumors including breast cancer. PPARgamma has been identified as a potential target for breast cancer therapy based on the fact that its activation by synthetic ligands affects the differentiation, proliferation, and apoptosis of cancer cells. However, the controversial nature of current studies and disappointing results from clinical trials raise questions about the contribution of PPARgamma signaling in breast cancer development in the absence of stimulation by exogenous ligands. Recent reports from both in vitro and in vivo studies …

Sandspur, Vol 115, No 13, December 05, 2008, Rollins College

The Rollins Sandspur

Rollins College student newspaper, written by the students and published at Rollins College. The Sandspur started as a literary journal.