Digital Commons Network^™

Multiple Modes Of Mdmx Regulation Affect P53 Activation, Daniele M. Gilkes

USF Tampa Graduate Theses and Dissertations

MDMX has emerged as a negative regulator of p53 transcriptional activity following DNA damage, loss of ribosomal integrity, and aberrant mitogenic signaling. Disruption of rRNA biogenesis by ribosomal stress activates p53 by releasing ribosomal proteins from nucleoli which bind MDM2 and inhibit p53 degradation. We found that p53 activation by ribosomal stress requires degradation of MDMX by MDM2. This occurs by L11 binding to the acidic domain of MDM2 which promotes its E3 ligase function preferentially towards MDMX. Further, unlike DNA damage which regulates MDMX stability through ATM-dependent phosphorylation events, ribosomal stress does not require MDMX phosphorylation suggesting p53 may …

Activation Of Cytosolic Phospholipase A2Α In Resident Peritoneal Macrophages By Listeria Monocytogenes Involves Listeriolysin O And Tlr2, Shahid Noor, Howard Goldfine, Dawn E. Tucker, Saritha Suram, Laurel L. Lenz, Shizuo Akira, Satoshi Uematsu, Milena Girotti, Joseph V. Bonventre, Kevin Breuel, David L. Williams, Christina C. Leslie

ETSU Faculty Works

Eicosanoid production by macrophages is an early response to microbial infection that promotes acute inflammation. The intracellular pathogen Listeria monocytogenes stimulates arachidonic acid release and eicosanoid production from resident mouse peritoneal macrophages through activation of group IVA cytosolic phospholipase A2 (cPLA2α). The ability of wild type L. monocytogenes (WTLM) to stimulate arachidonic acid release is partially dependent on the virulence factor listeriolysin O; however, WTLM and L. monocytogenes lacking listeriolysin O (ΔhlyLM) induce similar levels of cyclooxygenase 2. Arachidonic acid release requires activation of MAPKs by WTLM and ΔhlyLM. The attenuated release of arachidonic acid that is observed in TLR2-/- …

Parasite Pathoecology Of Chacoan Great Houses: The Healthiest And Wormiest Ancestral Puebloans, Karl J. Reinhard

School of Natural Resources: Faculty Publications

Two fields of paleopathological investigation originated in the Southwest. Archaeoparasitology is the study ancient parasite infection (Reinhard 1990). It includes comparisons between time periods of single societies as well as the comparison of parasitism between different, contemporaneous cultures. For example, Fry (1980) compared Fremont and Anasazi parasitism. Fry (1984) compared Archaic hunter-gatherer parasitism and Ancestral Pueblo parasitism. All of these studies fall into the definition of Archaeoparasitology. Pathoecology is the reconstruction of the relationships between behavior, environment, and disease organisms in the development of ill-health (Martinson et al. 2003; Reinhard and Buikstra 2003, Reinhard et al. 2003, Santoro et al. …

Systems Biology Approaches Identify Atf3 As A Negative Regulator Of Toll-Like Receptor 4 (Nature (2006) 441, (173-178)), Mark Gilchrist, Vesteinn Thorsson, Bin Li, Alistair G. Rust, Martin Korb, Jared C. Roach, Kathleen Kennedy, Tsonwin Hai, Hamid Bolouri, Alan Aderem

Faculty Publications

No abstract provided.

Pathoecology And The Future Of Coprolite Studies In Bioarchaeology, Karl J. Reinhard, Vaughn M. Bryant Jr.

School of Natural Resources: Faculty Publications

Human coprolites currently provide an expanding array of information about the diet, health, and ecology of prehistoric people in the Southwest, but for many years coprolites were not recognized or preserved, or they were not considered important and thus were not saved (Bryant and Dean 2006). With the expansion of archaeological field work during the last half of the twentieth century archaeologists have increasingly explored the “complete” potentials of sites, including the collection and analysis of geomorphologic, botanical, and faunal data. In some ideal habitats (e.g., very dry or frozen) this includes exploring the scientific potential of human coprolite studies. …

The Duty Of States To Assist Other States In Need: Ethics, Human Rights, And International Law, Lawrence O. Gostin, Robert Archer

O'Neill Institute Papers

This article deals with a foreign policy question of extraordinary importance: What responsibilities do States have to provide economic and technical assistance to other states that have high levels of need affecting the health and life of their citizens? The question is important for a variety of reasons. There exist massive inequalities in health globally, with the result that poorer countries shoulder a disproportionate burden of disease and premature death. While poor countries have by far the greatest ongoing health needs, they also have the least capacity to meet those needs. In addition to the pervasive and debilitating effects of …

Rich To Be Honored For Life's Work, Reporter Staff

Browse All News

No abstract provided.

Animal Health Matters, David H. Zeman

Animal Health MATTERS Newsletter

Head/Director's Message [Page] 1- University, College and Department Missions Diagnostic News [Page] 1- Hardware Disease Associated with Tires Used as Hay Feeding Stations: A New Source of Hardware for an Old Disease [Page] 2- Holiday Hours [Page] 2- Calf Scours Submissions at SDSU ADRDL [Page] 3- Calf Scours / Enteritis Submission Guidelines Research News [Page] 3- Research Spotlight: Alan J. Young, PhD – The Immunophysiology of Prion Diseases Extension News [Page] 4- New Vaccination Guidelines for Horses Released [Page] 5- Mineral Nutrition Short Course for Beef Cattle Veterinarians [Page] 5- Master of Public Health (MPH) Program for Practicing Veterinarians [Page] …

President's Report, 2/15/2008, David Schmidly

President Schmidly's Administration

No abstract provided.

The Spinnaker Vol. 31 No. 23, University Of North Florida

Spinnaker

Student newspaper for the UNF community

Clinical Predictors Of Drug Resistance And Mortality Among Tuberculosis Patients In A Rural South African Hospital: A Case-Control Study, Jason Randolph Andrews

Yale Medicine Thesis Digital Library

The recent discovery of a high prevalence of multidrug-resistant (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) in rural South Africa, where HIV is rampant, has provoked alarms about the future of tuberculosis control in the region. Little is known about the clinical manifestations of MDR-TB in general, and XDR-TB in particular, in the high HIV prevalence settings of Sub-Saharan Africa. We performed a retrospective, case-control study of patients diagnosed with tuberculosis at a rural hospital in KwaZulu Natal, South Africa, where large numbers of MDR-TB and XDRTB cases have been identified. All MDR-TB and XDR-TB patients who began treatment for TB …

Bjc Today

BJC Today

No abstract provided.

The Wooster Voice (Wooster, Oh), 2008-02-08, Wooster Voice Editors

The Voice: 2001-2011

This edition of the College of Wooster's student run newspaper was published on February 8 of 2008 and it is eight pages long. The flu and cold are spreading across the campus making the Wellness Center a very busy place. Jorge Dominguez was the latest lecturer in the Great Decisions series, he spoke on, "Free Market and Free Politics in Latin America, Past and, Future." Dr. Grant H. Cornwell will be inaugurated as the 11th president of the college on April 26. One students writes about the negatives to nuclear power on page three. The Wooster Weekly News is sponsoring …

The Comment, February 7, 2008, Bridgewater State College

The Comment

No abstract provided.

Mothers With Chronic Physical Illness And The Parentification Of Their Children, Marie M. Duryea

Individual, Family, and Community Education ETDs

More than 133 million Americans are living with chronic conditions and this number continues to rise (Partnership for Solutions, 2004); by 2020, it is estimated that 157 million people will suffer from chronic illnesses (Anderson, 2003), a large percentage of whom are in their child-rearing stage of life. Incorporating concepts from family systems and family development theories, this exploratory study examined the impact of maternal chronic physical illness on children. Specifically, it examined the extent to which length of illness and symptom severity of fibromyalgia and rheumatoid arthritis; mothers age, educational level, and marital status; perceived effects of the illness …

Interagency Statement On Pandemic Planning, United States: Federal Financial Institutions Examination Council (Ffiec)

Documents

No abstract provided.

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Georgia Southern University offers online training for septic tank contractors
• Georgia Southern University presents Eve Ensler’s “The Vagina Monologues”

No Observed Adverse Effects: Developing Neurons, Organophosphate Insecticides, And The 1996 Food Quality Protection Act, Brendan R. Jackson

Yale Medicine Thesis Digital Library

Physicians are familiar with organophosphates (OPs) as a classic, though obscure, cause of cholinergic poisoning. Many opportunities for human exposure existsixty million pounds of OPs are applied as insecticides to sixty million acres of U.S. land each year, and, until recently, over one-fifth of Americans used these chemicals in their homes. Most physicians, however, still know little about the dangers that these pesticides pose to the developing nervous system. By the late 1980s, toxicologists increasingly recognized that toxicants such as lead and mercury, even at doses well-below the level required to cause symptomatic poisoning, could induce subtle, yet permanent, neurological …

February 4, 2008 Reporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Ozone Exposure In A Mouse Model Induces Airway Hyperreactivity That Requires The Presence Of Natural Killer T Cells And Il-17, Paul B. Savage, Muriel Pichavant, Sho Goya, Everett H. Meyer, Richard A. Johnston, Hye Y. Kim, Ponpan Matangkasombut, Ming Zhu, Yoichiro Iwakura, Rosemarie H. Dekruyff, Stephanie A. Shore, Dale T. Umetsu

Faculty Publications

Exposure to ozone, which is a major component of air pollution, induces a form of asthma that occurs in the absence of adaptive immunity. Although ozone-induced asthma is characterized by airway neutrophilia, and not eosinophilia, it is nevertheless associated with airway hyperreactivity (AHR), which is a cardinal feature of asthma. Because AHR induced by allergens requires the presence of natural killer T (NKT) cells, we asked whether ozone-induced AHR had similar requirements. We found that repeated exposure of wild-type (WT) mice to ozone induced severe AHR associated with an increase in airway NKT cells, neutrophils, and macrophages. Surprisingly, NKT cell-deficient …

Heat-Shock Protein 90 Associates With N-Terminal Extended Peptides And Is Required For Direct And Indirect Antigen Presentation, Margaret K. Callahan, Manish Garg, Pramod K. Srivastava

UCHC Articles - Research

CD8⁺ T cells recognize peptide fragments of endogenously synthesized antigens of cancers or viruses, presented by MHC I molecules. Such antigen presentation requires the generation of peptides in the cytosol, their passage to the endoplasmic reticulum, loading of MHC I with peptides, and transport of MHC I–peptide complexes to the cell surface. Heat-shock protein (hsp) 90 is a cytosolic chaperone known to associate with peptide and peptide precursors of MHC I epitopes. We report here that treatment of cells with hsp90 inhibitors leads to generation of “empty” MHC I caused by inhibited loading of MHC I with peptides. Inhibition …

Progress Notes, Lehigh Valley Health Network

Progress Notes

No abstract provided.

Innovations In Philanthropy: The Rockefeller Foundation’S Perspective, Knowledge@Smu

Knowledge@SMU

For nearly 100 years, the mission of the Rockefeller Foundation, “to promote the well-being of humanity by addressing the root causes of serious problems”, has remained the same, even as the foundation continues to adapt its programmes to changing social, economic and cultural needs. It is also a leading proponent of innovation and change in the field of philanthropy itself. Jacqueline Khor, Associate Director, Rockefeller Foundation, delivered a lecture on new trends in philanthropy and the emergence of a new generation of “philanthro-capitalists” at a lecture organised by the Singapore Management University’s Lien Foundation Centre for Social Innovation.

Brown Dog Tick: Vector For Rocky Mountain Spotted Fever, Craig Levy

Zoonotics and Wildlife Disease: Publications

The brown dog tick, Rhipicephalus sanguineus (Acari: Ixodidae), feeds primarily on dogs and until recently was not known to vector Rocky Mountain spotted fever (RMSF). In 2003–2004, fourteen cases of RMSF in humans occurred in eastern Arizona in the absence of known vectors, the Rocky Mountain wood tick, Dermacentor andersoni, and American dog tick, Dermacentor variabilis. However, health officials found brown dog ticks to be very abundant in areas associated with human cases, and the Centers for Disease Control and Prevention (CDC) implicated that the brown dog tick was responsible for transmitting RMSF. Brown dog ticks occur throughout the United …

Phar 452.00: Therapeutics Ii: Clinical Use Of Antimicrobials, Douglas R. Allington, Donna G. Beall, Sarah Miller, Michael P. Rivey, Kendra Keeley, Marian Maxwell

University of Montana Course Syllabi, 1990-2010

No abstract provided.

Pubh 595.02: International Health, Lolem Ngong, Lisa Pascopella, Craig A. Molgaard

University of Montana Course Syllabi, 1990-2010

No abstract provided.

Pubh 595.01: Epidemiology Of Infectious Diseases, Larry Frisch, Steve Helgerson, Craig A. Molgaard

University of Montana Course Syllabi, 1990-2010

No abstract provided.

The Interaction Of Customary Law And Microfinance: Women's Entry Into The World Economy, Shana Hofstetter

William & Mary Journal of Race, Gender, and Social Justice

This note examines the complicated relationship between microfinance and customary law. Microfinance, the practice of giving small, collateral-free loans to the poorest members of society, has gained great popularity in the last thirty years. These loan programs specifically target women and use women's traditional emphasis on groups to ensure success. Customary law can hinder microfinance ventures because of the restrictions these laws place on women's roles and responsibilities. Case studies on the Dominican Republic, Morocco, and Bangladesh explore how individual customary laws can hinder microfinance programs and women's micro-businesses. This note also discusses how microfinance programs act as catalysts of …

Water System Preparedness For Pandemic Influenza, Phil Van Atta

Master of Public Health Program Student Publications

This project involved an investigation of water utility preparedness and best practices for pandemic influenza. A pandemic could cause serious disruptions to the operations of critical infrastructure, including drinking water systems. These disruptions could be caused by staffing shortages, power disruptions, and shortages of chemicals and other supplies. Ensuring continuity of operations for drinking water systems is crucial to protect public health and safety, and to the economy of all communities. Literature searches, interviews, and a survey of Ohio water systems indicated that water systems in Ohio and across the United States are preparing for pandemic influenza. Pandemic influenza preparation …

Genomic Organization, Sequence Divergence, And Recombination Of Feline Immunodeficiency Virus From Lions In The Wild, Jill Pecon-Slattery, Carrie L. Mccracken, Jennifer L. Troyer, Sue Vandewoude, Melody E. Roelke, Kerry Sondgeroth, Christiaan Winterbach, Stephen J. O'Brien

Biology Faculty Articles

Background

Feline immunodeficiency virus (FIV) naturally infects multiple species of cat and is related to human immunodeficiency virus in humans. FIV infection causes AIDS-like disease and mortality in the domestic cat (Felis catus) and serves as a natural model for HIV infection in humans. In African lions (Panthera leo) and other exotic felid species, disease etiology introduced by FIV infection are less clear, but recent studies indicate that FIV causes moderate to severe CD4 depletion.

Results

In this study, comparative genomic methods are used to evaluate the full proviral genome of two geographically distinct FIV subtypes …