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Bioanalisis Metabolit Gliklazida Dalam Mikrosom Hati Manusia Dengan Metode Hplc, Suharjono Suharjono

Majalah Ilmu Kefarmasian

Gliclazide (GZ) is oral sulphonylurea-2 generation used for treatment of diabetes mellitus type-2. Gliclazide is metabolized in the smooth endoplasmic reticulum of liver, which can be made in preparation of human liver microsomes. These microsomes rich in cytochrome P450 (CYP450). Major metabolite of GZ in the microsomes are, 7β-OH-GZ, 6α-OHGz, 6β-OH-GZ, and Me-OH-GZ. HPLC method for GZ me-tabolites was done without extraction by organic solvents, but with direct precipita-tion GZ incubation results in the human liver microsomes using perchloric acid. The aim of the study is to determine the level of four GZ metabolites in human liver microsomes by HPLC …

In Re: Stone

2008 Decisions

USDC for the District of Delaware

Rodriguez V. Our Lady Lourdes Med

2008 Decisions

USDC for the District of New Jersey

Topological Structures In The Equities Market Network, Gregory Leibon, Scott Pauls, Daniel Rockmore, Robert Savell

Dartmouth Scholarship

We present a new method for articulating scale-dependent topological descriptions of the network structure inherent in many complex systems. The technique is based on “partition decoupled null models,” a new class of null models that incorporate the interaction of clustered partitions into a random model and generalize the Gaussian ensemble. As an application, we analyze a correlation matrix derived from 4 years of close prices of equities in the New York Stock Exchange (NYSE) and National Association of Securities Dealers Automated Quotation (NASDAQ). In this example, we expose (i) a natural structure composed of 2 interacting partitions of …

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Georgia Southern Expert Shares Wellness Tips for the New Year

Impact Style Of The Changeable Resistance In The Development Of Some Of The Physical & Functional Changes For The National Team For The Badminton, Abeer Dakhil Hatim

Modern Sport

Badminton is considered one of the most effective sports for developing physical fitness, as it requires competition, extensive running, jumping, quick reactions, and coordinated eye-hand movements. The game demands heightened awareness and precise timing, especially during jumps or support movements, where players must accurately judge the ball's trajectory when sending or receiving from an opponent. Given these demands, it is essential to implement advanced technical exercises to raise the performance of national team players. Based on this need, the two researchers focused on enhancing sensory perception and movement recognition, which are critical for players to maintain proper positioning during gameplay. …

Florida Sentinel Bulletin, December 30, 2008, Gwen Hayes

Florida Sentinel Bulletin Collection

The December 30, 2008, issue of the Florida Sentinel Bulletin.

Waris V. Frick

2008 Decisions

USDC for the Eastern District of Pennsylvania

Chromosomal Inversions Between Human And Chimpanzee Lineages Caused By Retrotransposons, Jungnam Lee, Kyudong Han, Thomas J. Meyer, Heui Soo Kim, Mark A. Batzer

Faculty Publications

The long interspersed element-1 (LINE-1 or L1) and Alu elements are the most abundant mobile elements comprising 21% and 11% of the human genome, respectively. Since the divergence of human and chimpanzee lineages, these elements have vigorously created chromosomal rearrangements causing genomic difference between humans and chimpanzees by either increasing or decreasing the size of genome. Here, we report an exotic mechanism, retrotransposon recombination-mediated inversion (RRMI), that usually does not alter the amount of genomic material present. Through the comparison of the human and chimpanzee draft genome sequences, we identified 252 inversions whose respective inversion junctions can clearly be characterized. …

President Bush Discusses Administration's Plan To Assist Automakers, United States: The White House: Bush Administration

Documents

No abstract provided.

Program Law (1) - 12/22/2008, Belgian Federal Public Services

Documents

Law originally written in French, translated to English by Google Translate

Denmark: 2008 Article Iv Consultation-Staff Report; Staff Statement; Public Information Notice On The Executive Board Discussion; And Statement By The Executive Director For Denmark, International Monetary Fund (Imf)

Documents

No abstract provided.

Structure Of Polc Reveals Unique Dna Binding And Fidelity Determinants, Ronald J. Evans, Douglas R. Davies, James M. Bullard, Jeffrey Christensen, Louis S. Green, Joseph W. Guiles, Janice D. Pata, Wendy K. Ribble, Nebojsa Janjic, Thale C. Jarvis

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

PolC is the polymerase responsible for genome duplication in many Gram-positive bacteria and represents an attractive target for antibacterial development. We have determined the 2.4-Å resolution crystal structure of Geobacillus kaustophilus PolC in a ternary complex with DNA and dGTP. The structure reveals nascent base pair interactions that lead to highly accurate nucleotide incorporation. A unique β-strand motif in the PolC thumb domain contacts the minor groove, allowing replication errors to be sensed up to 8 nt upstream of the active site. PolC exhibits the potential for large-scale conformational flexibility, which could encompass the catalytic residues. The structure suggests a …

Deafdigest: Gold Edition, December 28, 2008, Barry Strassler

DeafDigest Gold 2008

No abstract provided.

Deafdigest: Blue Edition, December 28, 2008, Barry Strassler

DeafDigest Blue 2008

No abstract provided.

Incidence, Types And Complications Of Chronic Gastric Ulcer (A Change In The Indications Of Surgery), Zuhair Raof Al-Bahrani

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Peptic ulcers are defects in the gastrointestinal mucosa that extend through the muscularis mucosae. They persist as a function of the acid or peptic activity in gastric juice. The natural history of peptic ulcer ranges from resolution without intervention to the development of complications with the potential for significant morbidity and mortality, such as bleeding and perforation. OBJECTIVE: Reviewing the incidence, types, complications and surgical indications for chronic gastric ulcer in Iraq and comparing it with other world reports. METHODS: Retrospective study of the data base for 5166 patients with chronic peptic ulcer disease operated upon between 1965-2000. …

Palmar Lipomas;Different Clinical Presentations, Zakaria Yahya Arajy

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Lipomas arise as soft tissue tumors almost, every where in the body and follow the distribution of the fat Those presenting in the hand are uncommon slowly growing masses within the hand spaces.. OBJECTIVE: To highlight the various presentations of large sized lipomas growing in the palm with different clinical pictures. PATIENTS AND METHODS: Five patients with hand lipomas , ages (7-45) years,pesented with palmar swellings , three were diagnosed clinically and two were diagnosed with magnetic resonance. The lipomas were surgically excised under general anesthesia. RESULTS: Compressive neuropathy was elicited in three patients, one patient had mild …

Il-1Α And Il-8levels During Gram-Negative And Gram-Positive Bacteremia In Leukopenia Leukemic Patients., Sevan N. A. Abdallah

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: A quantitative relationships between circulating leukocytes and infection was established in patients with leukemia, in particular, the probability of being infected is proportional to the severity and duration of leukopenia (1). Infection with gram- negative as well as gram-positive microorganisms may lead to septic shock and death (2, 3) . The major functional activities of cytokines are concerned with the regulation of the development and behavior of the immune effector cells. IL-1 is one of proximal cytokines. IL-1 act to stimulate the release of distal cytokines, such as IL-6 and IL-8, IL-8 is most closely related to the …

Nosocomial Bacteremia In Leukopenic Patients With Leukemia In Baghdad Teaching Hospital, Sevan N. A. Abdallah

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: The incidence of nosocomial bacteremia continues to increase despite antimicrobial therapy and supportive care; it remains a major cause of death in hospitalized patients who are undergoing chemotherapy. The prolonged survival of leukemia patients who have disturbance in their innate immune system increased the factors of risk. OBJECTIVE: This study was conducted to assess the epidemiological features of Bacteremia in adult patients with leukemia and the species distribution and antimicrobial susceptibilities of causative pathogens. In addition, nosocomial bacteremia was compared to community acquired bacteremia. METHODS: A total of (84) adult leukemic patients more than 15 years old, males …

Clinical Course Of Children And Adolescents With Primary Focal Segmental Glomerulosclerosis And The Predictors Of Their Outcome, Faleeha Obaid Hasan

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: The aim of this retrospective study is to report the clinical course of children and adolescents with primary focal segmental glomerulosclerosis (FSGS), and to study their outcome and to identify the predictors of progression to end stage renal disease (ESRD). PATIENTS AND METHODS: This is a retrospective study of 50 patients with biopsy-proven primary FSGS who were admitted from April 1995 - January 2007, during the study period from May 2005 - June 2007. Clinical, Laboratory and histopathological data were recorded. The median follow-up time of 4.5 year. RESULTS: The commonest age and sex group is male between …

Evaluation Of Imci Indicators Of Acute Bacterial Meningitis In Central Teaching Hospital For Child, Mayada Mohamed Ali Alansari

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Acute bacterial meningitis [ABM] remains an important cause of death and neurological sequel in children, the clinical feature of meningitis is often nonspecific may overlap with those of other infection. Early diagnosis and appropriate treatment are perhaps the most important steps in management, but published data suggested that fewer than half of the cases of meningitis are identified at first assessment [1,2] . OBJECTIVE: Was to evaluate the clinical indicators of ABM of IMCI [integrated management of childhood illness] referral criteria of meningitis include [lethargy, unconsciousness, in ability to feed, neck stiffness, seizures] and other symptoms and sign. …

Screening Of Hepatitis B- And C- Viral Markers In Iraqi Patients With Proteinuria, Abdul Hadi K . Hussain

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Viral hepatitis may lead to nephropathy as one of its multiple extra hepatic manifestations. Symptomatic proteinuria as detected by dipstick, and qualitative urine collection are simple tests in practice as well as useful cardinal test of underlying renal abnormalities. The aim of this study was to elucidate the impact of hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infections on the occurrence of symptomatic proteinuria amongst adults and pediatrics. PATIENTS & METHODS : A prospective study included (143) adult and pediatric Iraqi patients presented with symptomatic proteinuria, and 108 (age- and sex-matched) apparently healthy individuals (as control …

Burden Of Rotavirus Gastroenteritis Among Under Five Years Children At Al-Alwaiya Paediatric Hospital, Sinan Ghazi Mehdi

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Rotavirus is the main cause of diarrhea in 6-12) months which was (31.4%). CONCLUSION: Rotavirus cause 47.4% of acute gastroenteritis cases of the studied sample with no significant statistical difference between rotavirus and other causes of gastroenteritis regarding demographic features (except for gender, more in males), clinical features, and type of treatment and course of disease (except time of onset).Concordance rate between ELISA and Latex was found to be high confirming their validity.

Predictability In The Indian Stock Market: A Study From An Econometric Perspective., Debabrata Mukhopadhyay Dr.

Doctoral Theses

No abstract provided.

December 27, 2008 (Pages 7069-7132), Pennsylvania Legislative Reference Bureau

Volume 38 (2008)

No abstract provided.

The Murray Ledger And Times, December 27, 2008, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

A Precautionary Tale: Separating The Infant From The Fetus, Lawrence Torcello

Articles

This article confronts growing conservative opposition to abortion based on the slippery slope claim that abortion is morally equivalent to infanticide. By examining the relationship between moral skepticism and precautionary ethics the article promotes completely the permissive position on abortion from conception to birth while consistently rejecting the possibility that such a position entails permissive implications for infanticide. The article introduces and traces the implicit relationship between moral skepticism, the precautionary principle and political liberalism.

Synthesis Analysis Of Regression Models With A Continuous Outcome, Andrew Zhou, Nan Hu, Guizhou Hu, Martin Root

UW Biostatistics Working Paper Series

Synthesis Analysis of Regression Models with a Continuous Outcome Xiao-Hua Zhou 1,2, Nan Hu 2, Guizhou Hu3, and Martin Root3 1 HSR&D Center of Excellence, VA Puget Sound Health Care System, Seattle, WA 98101. 2 Department of Biostatistics, University of Washington, Seattle, WA 98195. 3 BioSignia, Inc., 1822 East NC Highway 54, Suite 350, Durham, NC 27713 To estimate the multivariate regression model from multiple individual studies, it would be challenging to obtain results if the input from individual studies only provide univariate or incomplete multivariate regression information. Samsa et al [1] proposed a simple method to combine coefficients from …

Structure Of A Complete Integrin Ectodomain In A Physiologic Resting State And Activation And Deactivation By Applied Forces, Jianghai Zhu, Bing Hao Luo, Tsan Xiao, Chengzhong Zhang, Noritaka Nishida, Timothy A. Springer

Faculty Publications

The complete ectodomain of integrin αIIbβ3 reveals a bent, closed, low-affinity conformation, the β knee, and a mechanism for linking cytoskeleton attachment to high affinity for ligand. Ca and Mg ions in the recognition site, including the synergistic metal ion binding site (SyMBS), are loaded prior to ligand binding. Electrophilicity of the ligand-binding Mg ion is increased in the open conformation. The β3 knee passes between the β3-PSI and αIIb-knob to bury the lower β leg in a cleft, from which it is released for extension. Different integrin molecules in crystals and EM reveal breathing that appears on pathway to …

Merrill Lynch 2008 10-K, Merrill Lynch International

Documents

No abstract provided.