Digital Commons Network^™

Climate Change In The Supreme Court, Lisa Heinzerling

Georgetown Law Faculty Publications and Other Works

In Massachusetts v. Environmental Protection Agency, the Supreme Court confronted the issue of climate change for the first time. The Court held that the Clean Air Act gives the Environmental Protection Agency the authority to regulate greenhouse gases and that the agency may not decline to exercise this authority based either on factors not present in the statute or inconclusive gestures toward uncertainty in the science of climate change. I had the privilege of serving as the lead author of the winning briefs in this case. This Article provides an insider's perspective on the choices that went into bringing and …

Bridging The Theory Practice Gap, Judith Wilson

Nursing Papers and Journal Articles

The gap between theory and practice has long been identified as a problem in nursing and midwifery. In the past this has been described as an “embarrassing failure” (Rafferty et al., 1996 p.685) and presently there is a strong consensus that the existence of this gap is not only pressing but increasing (Spouse 2001; Landers 2000).

This article reports the findings of a qualitative descriptive study conducted. The purpose of this study was to explore the theory practice gap from the perspective of the midwifery student. This was considered to be a unique angle on this well researched and debated …

Towards A Conceptual Framework For Preceptorship In The Clinical Education Of Undergraduate Nursing Students, Melanie Zilembo, Leanne Monterosso

Nursing Papers and Journal Articles

A recent study undertaken by the authors (2007) highlighted that undergraduate nursing students were subjected to varying experiences in clinical practice, which were mediated by a number of factors. Mediating factors included continuity of preceptors, student attitudes, the clinical setting environment, student and preceptor expectations of the clinical practice experience and interactions between the student and preceptor.

Of note, interactions with preceptors were seen to 'make or break' the practical experience. Therefore, the relationship that is forged between preceptor and student is vital in shaping the student's experience of the clinical area and of the real world of nursing work. …

Reaction To The Reactors, Ted Eisenberg

The Mathematics Enthusiast

1. A comment. I discussed the contents of my paper with colleagues on many different occasions. By their reactions they seem to divide themselves into two camps. One camp takes the stance of: Are you crazy to mention such things in the classroom? We are charged to teach mathematics, and that’s it. Who cares if Einstein never learned to swim? The other camp however takes an opposite stance: Such items are really important for students to know because they help students to think about the lives and times of the men who created the material they are studying; our lessons …

Impact Of Training In Clinical And Microscopy Diagnosis Of Childhood Malaria On Antimalarial Drug Prescription And Health Outcome At Primary Health Care Level In Tanzania: A Randomized Controlled Trial, B. Ngasala, M. Mubi, M. Warsame, M.G. Petzold, A.Y. Massele, L.L. Gustafsson, G. Tomson, Zul Premji, A. Bjorkman

Pathology, East Africa

Background: Prescribing antimalarial medicines based on parasite confirmed diagnosis of malaria is critical to rational drug use and optimal outcome of febrile illness. The impact of microscopy-based versus clinical-based diagnosis of childhood malaria was assessed at primary health care (PHC) facilities using a cluster randomized controlled training intervention trial.

Methods: Sixteen PHC facilities in rural Tanzania were randomly allocated to training of health staff in clinical algorithm plus microscopy (Arm-I, n = 5) or clinical algorithm only (Arm-II, n = 5) or no training (Arm-III, n = 6). Febrile under-five children presenting at these facilities were assessed, treated and scheduled …

Causes, Magnitude And Management Of Burns In Under-Fives In District Hospitals In Dar Es Salaam, Tanzania., M. Justin-Temu, G. Rimoy, Zul Premji, G. Matemu

Pathology, East Africa

Objectives: To determine the causes, magnitude and management of burns in children under five years of age who were admitted in the district hospitals of Dar es Salaam City, Tanzania.

Methods: In this study, a total of 204 under fives were enrolled. Questionnaires were used to elicit if the parent/caretaker had the knowledge of the cause of the burns, what was done immediately after burn injury, first aid given immediately after burn, source of the knowledge of first aid and when the child was taken to the hospital. Also the questionnaire was cited with data on the management of burns …

The Content Of African Diets Is Adequate To Achieve Optimal Efficacy With Fixed-Dose Artemether-Lumefantrine: A Review Of The Evidence, Zul Premji, S. Abdulla, B. Ogutu, A. Ndong, C.O. Falade, I. Sagara, N. Mulure, O. Nwaiwu, G. Kokwaro

Pathology, East Africa

A fixed-dose combination of artemether-lumefantrine (AL, Coartem®) has shown high efficacy, good tolerability and cost-effectiveness in adults and children with uncomplicated malaria caused by Plasmodium falciparum. Lumefantrine bioavailability is enhanced by food, particularly fat. As the fat content of sub-Saharan African meals is approximately a third that of Western countries, it raises the question of whether fat consumption by African patients is sufficient for good efficacy. Data from healthy volunteers have indicated that drinking 36 mL soya milk (containing only 1.2 g of fat) results in 90% of the lumefantrine absorption obtained with 500 mL milk (16 g fat). African …

Conclusions And Recommendations Of A Who Expert Consultation Meeting On Iron Supplementation For Infants And Young Children In Malaria Endemic Areas [Conclusions Et Recommandations À L'Issue De La Consultation De L'Oms Sur La Lutte Contre La Carence Martiale Chez Le Nourrisson Et Le Jeune Enfant Dans Les Pays D'Endémie Palustre], L. Allen, R.E. Black, N. Brandes, G. Brittenham, G. Chazot, C Chunming, J. Crawley, B. De Benoist, N. Dalmiya, I. Darnton-Hill, K. Dewey, S. El-Arifeen, O. Fontaine, C. Geissler, H. Haberle, P. Harvey, J. Hasler, C. Hershko, R. Hurrell, M.A. Juma, B. Lonnerdal, B. Lozoff, S. Lynch, H. Martines Salgado, E. Mclean, J. Metz, S. Oppenheimer, Zul Premji, A. Prentice, M. Ramsan, C. Ratledge, R. Stoltzfus, J. Tielsch

Pathology, East Africa

This article presents the results of an expert consultation meeting aimed at evaluating the safety and public health implications of administering supplemental iron to infants and young children in malaria-endemic areas. Participants at this meeting that took place in Lyon, France on June 12-14, 2006 reached consensus on several important issues related to iron supplementation for infants and young children in malaria-endemic areas. The conclusions in this report apply specifically to regions where malaria is endemic.

Cyan Fluorescent Protein Expression In Ganglion And Amacrine Cells In A Thy1-Cfp Transgenic Mouse Retina, Iona D Raymond, Alejandro Vila, Uyen-Chi N Huynh, Nicholas C Brecha

Faculty, Staff and Student Publications

PURPOSE: To characterize cyan fluorescent protein (CFP) expression in the retina of the thy1-CFP (B6.Cg-Tg(Thy1-CFP)23Jrs/J) transgenic mouse line.

METHODS: CFP expression was characterized using morphometric methods and immunohistochemistry with antibodies to neurofilament light (NF-L), neuronal nuclei (NeuN), POU-domain protein (Brn3a) and calretinin, which immunolabel ganglion cells, and syntaxin 1 (HPC-1), glutamate decarboxylase 67 (GAD(67)), GABA plasma membrane transporter-1 (GAT-1), and choline acetyltransferase (ChAT), which immunolabel amacrine cells.

RESULTS: CFP was extensively expressed in the inner retina, primarily in the inner plexiform layer (IPL), ganglion cell layer (GCL), nerve fiber layer, and optic nerve. CFP fluorescent cell bodies were in all …

Dominance Of The Proximal Coordinate Frame In Determining The Locations Of Hippocampal Place Cell Activity During Navigation, Jennifer J Siegel, Joshua P Neunuebel, James J Knierim

Faculty, Staff and Student Publications

The place-specific activity of hippocampal cells provides downstream structures with information regarding an animal's position within an environment and, perhaps, the location of goals within that environment. In rodents, recent research has suggested that distal cues primarily set the orientation of the spatial representation, whereas the boundaries of the behavioral apparatus determine the locations of place activity. The current study was designed to address possible biases in some previous research that may have minimized the likelihood of observing place activity bound to distal cues. Hippocampal single-unit activity was recorded from six freely moving rats as they were trained to perform …

Messenger Rna Half-Life Measurements In Mammalian Cells, Chyi-Ying A Chen, Nader Ezzeddine, Ann-Bin Shyu

Faculty, Staff and Student Publications

The recognition of the importance of mRNA turnover in regulating eukaryotic gene expression has mandated the development of reliable, rigorous, and "user-friendly" methods to accurately measure changes in mRNA stability in mammalian cells. Frequently, mRNA stability is studied indirectly by analyzing the steady-state level of mRNA in the cytoplasm; in this case, changes in mRNA abundance are assumed to reflect only mRNA degradation, an assumption that is not always correct. Although direct measurements of mRNA decay rate can be performed with kinetic labeling techniques and transcriptional inhibitors, these techniques often introduce significant changes in cell physiology. Furthermore, many critical mechanistic …

The Role Of Sse1 In The De Novo Formation And Variant Determination Of The [Psi+] Prion, Jaou-Chen Huang

Faculty, Staff and Student Publications

In several species, a family of nuclear receptors, the peroxisome proliferator-activated receptors (PPARs) composed of three isotypes, is expressed in somatic cells and germ cells of the ovary as well as the testis. Invalidation of these receptors in mice or stimulation of these receptors in vivo or in vitro showed that each receptor has physiological roles in the gamete maturation or the embryo development. In addition, synthetic PPAR gamma ligands are recently used to induce ovulation in women with polycystic ovary disease. These results reveal the positive actions of PPAR in reproduction. On the other hand, xenobiotics molecules (in herbicides, …

Genes In Glucose Metabolism And Association With Spina Bifida, Christina M Davidson, Hope Northrup, Terri M King, Jack M Fletcher, Irene Townsend, Gayle H Tyerman, Kit Sing Au

Faculty, Staff and Student Publications

The authors test single nucleotide polymorphisms (SNPs) in coding sequences of 12 candidate genes involved in glucose metabolism and obesity for associations with spina bifida. Genotyping was performed on 507 children with spina bifida and their parents plus anonymous control DNAs from Hispanic and Caucasian individuals. The transmission disequilibrium test was performed to test for genetic associations between transmission of alleles and spina bifida in the offspring (P < .05). A statistically significant association between Lys481 of HK1 (G allele), Arg109Lys of LEPR (G allele), and Pro196 of GLUT1 (A allele) was found ( P = .019, .039, and .040, respectively). Three SNPs on 3 genes involved with glucose metabolism and obesity may be associated with increased susceptibility to spina bifida.

Predation By Crabs On Rocky Shores In North-East Atlantic, Ana Catarina Ferreirada Silva

School of Biological and Marine Sciences Theses

Highly mobile predators are known to have an important influence on shallow-water habitats. There is, however, little information about the role of crabs on the ecology of rocky shores. Here I examine the extent and consequences of predation by crabs on shores in the North-East Atlantic. The specific aims of this thesis are to: investigate spatial variation in use of the intertidal by crabs along a horizontal gradient of exposure to wave action and a vertical gradient of tidal elevation; assess their use of the intertidal as a feeding area by examining stomach content composition; examine the extent of connectivity …

State Policies Matter: The Case Of Outpatient Drug Treatment Program Practices, Jamie Chriqui, Yvonne Terry-Mcelrath, Duane C. Mcbride, D Eidson

Faculty Publications

This study examined relationships between state policy requirements governing outpatient substance abuse treatment services and reported outpatient treatment program practices. State policies effective as of February 1, 2003, and February 1, 2004, were collected and analyzed via primary legal research; data were validated by state officials (88% response rate; > 90% validation rate). Treatment practice data were obtained from the National Survey of Substance Abuse Treatment Services for the years 2003 and 2004. Multivariate analyses clustered by state were conducted, controlling for state, program, and state-aggregated client admission characteristics. Results indicated that treatment programs located in states with requirements for comprehensive …

Gaming Towards Academic And Physical Success, Eric Burt

Graduate Research Papers

This review addresses the potential of serious video games and the benefits that serious video games can have on a student academically as well as physically. Serious video games require strategic thinking, problem solving, planning and decision making. Serious video games enable learners to experience ~eal world situations without the real-life consequences. Exergaming provides potential for combining gaming and exercise, this type of video game has tremendous upside. This review of research.investigates how video games can be used to engage learners and help students learn. Research is needed to determine which features of games and simulation~ are important for learning …

Voluntarism, Vulnerability, And Criminal Law: A Response To Professors Hills And O'Hear , Ethan J. Leib, Dan Markel, Jennifer M. Collins

Faculty Scholarship

This Response addresses the criticisms of our project by Professors Rick Hills and Michael O'Hear. Before we address those challenges, we first want to reiterate our gratitude to the B.U. Law Review for hosting an exchange based on our article, Punishing Family Status (forthcoming BU LR, December 2008), and to Professors Hills and O'Hear for their careful and subtle analysis of that article. Additionally, it's worth recapitulating what our bottom-line conclusions are so we can better see if there are any practical disagreements with our critics. Summarizing quickly: we support decriminalization in the cases of parental responsibility laws (based on …

The Constitutional Dimension Of Immigration Federalism, Clare Huntington

Faculty Scholarship

Although the federal government is traditionally understood to enjoy exclusive authority over immigration, states and localities are increasingly asserting a role in this field. This development has sparked vigorous debate on the propriety of such involvement, but the debate is predicated on a misunderstanding of the nature of federal exclusivity. Challenging the conventional wisdom that the Constitution precludes a meaningful role for state and local involvement in immigration.

This Article argues that the Constitution allows immigration authority to be shared among levels of government. After establishing the correctness of this view of immigration authority, this Article argues that the constitutionality …

Front Matter

Journal of Air Law and Commerce

No abstract provided.

Ay 2007/2008 Sec Meeting Minutes, 2007-09-05, Faculty Senate

Faculty Senate Archives

No abstract provided.

Ay 2007/2008 Sec Meeting Minutes, 2008-01-09, Faculty Senate

Faculty Senate Archives

No abstract provided.

Ay 2007/2008 Sec Meeting Minutes, 2008-04-02, Faculty Senate

Faculty Senate Archives

No abstract provided.

Ay 2007/2008 Fs Meeting Minutes, 2007-11-14, Faculty Senate

Faculty Senate Archives

No abstract provided.

Ay 2007/2008 Fs Meeting Minutes, 2008-01-23, Faculty Senate

Faculty Senate Archives

No abstract provided.

Ay 2007/2008 Fs Meeting Minutes, 2008-02-20, Faculty Senate

Faculty Senate Archives

No abstract provided.

Ay 2007/2008 Fs Meeting Minutes, 2008-03-19, Faculty Senate

Faculty Senate Archives

No abstract provided.

Ay 2007/2008 Fs Meeting Minutes, 2008-04-16, Faculty Senate

Faculty Senate Archives

No abstract provided.

Ay 2007/2008 Sec Roster, Faculty Senate

Faculty Senate Archives

No abstract provided.

Ay 2007/2008 Faculty Senate Roster, Faculty Senate

Faculty Senate Archives

No abstract provided.

Treatment Of Aqueous Waste Streams At Eli Lilly - Alternatives To Incineration, Barry Hennessy

Theses

The aim of this project was to investigate the potential to treat liquid waste (secondary) from production processes at Eli Lilly with the emphasis on minimising the volume of waste sent for thermal oxidation. In addition, the project aimed to investigate if the chosen technology was diverse and potentially capable of handling waste streams from different processes. Membrane technology was identified as one of the most suitable technologies and trials were carried out on secondary waste from three production processes. The literature review and practical thrials aswell as assessment of trial results ran from October 2003 to June 2005.

All …