Digital Commons Network^™

Muscleworms, Parelaphostrongylus Andersoni (Nematoda: Protostrongylidae), Discovered In Columbia White-Tailed Deer From Oregon And Washington: Implications For Biogeography And Host Associations, Ingrid M. Asmundsson, Jack A. Mortenson, Eric P. Hoberg

Harold W. Manter Laboratory of Parasitology: Faculty Publications

Parelaphostrongylus andersoni is considered a characteristic nematode infecting white-tailed deer (Odocoileus virginianus). Host and geographic distribution for this parasite, however, remain poorly defined in the region of western North America. Fecal samples collected from Columbia white-tailed deer (O. v. leucurus) in a restricted range endemic to Oregon and Washington, USA, were examined for dorsal-spined larvae characteristic of many protostrongylid nematodes. Multilocus DNA sequence data (internal transcribed spacer 2 and cytochrome c oxidase subunit 1) established the identity and a new record for P. andersoni in a subspecies of white-tailed deer previously unrecognized as hosts. Populations of …

The Application Of Fast-Nmr For The Identification Of Novel Drug Discovery Targets, Robert Powers, Kelly A. Mercier, Jennifer C. Copeland

Robert Powers Publications

The continued success of genome sequencing projects has resulted in a wealth of information, but 40-50% of identified genes correspond to hypothetical proteins or proteins of unknown function. The Functional Annotation Screening Technology by NMR (FAST-NMR) screen was developed to assign a biological function for these unannotated proteins with a structure solved by the Protein Structure Initiative. FAST-NMR is based on the premise that a biological function can be described by a similarity in binding sites and ligand interactions with proteins of known function. The resulting co-structure and functional assignment may provide a starting point for …

Wind Through The Buffalo Grass: A Lakota Story Cycle, Paul A. Johnsgard

Paul Johnsgard Collection

Wind Through the Buffalo Grass: A Lakota Story Cycle is a narrative history of the Pine Ridge Lakota tribe of South Dakota, following its history from 1850 to the present day through actual historical events and through the stories of four fictional Lakota children, each related by descent and separated from one another by two generations.

The ecology of the Pine Ridge region, especially its mammalian and avian wildlife, is woven into the stories of the children. Illustrated by the author, the book includes drawings of Pine Ridge wildlife, regional maps, and Native American pictorial art. Appendices include a listing …

Evidence That The Nijmegen Breakage Syndrome Protein, An Early Sensor Of Double-Strand Dna Breaks (Dsb), Is Involved In Hiv-1 Post-Integration Repair By Recruiting The Ataxia Telangiectasia-Mutated Kinase In A Process Similar To, But Distinct From, Cellular Dsb Repair., Johanna A Smith, Feng-Xiang Wang, Hui Zhang, Kou-Juey Wu, Kevin Jon Williams, René Daniel

Kimmel Cancer Center Faculty Papers

Retroviral transduction involves integrase-dependent linkage of viral and host DNA that leaves an intermediate that requires post-integration repair (PIR). We and others proposed that PIR hijacks the host cell double-strand DNA break (DSB) repair pathways. Nevertheless, the geometry of retroviral DNA integration differs considerably from that of DSB repair and so the precise role of host-cell mechanisms in PIR remains unclear. In the current study, we found that the Nijmegen breakage syndrome 1 protein (NBS1), an early sensor of DSBs, associates with HIV-1 DNA, recruits the ataxia telangiectasia-mutated (ATM) kinase, promotes stable retroviral transduction, mediates efficient integration of viral DNA …

Tax Reform And Charitable Giving, Seth H. Giertz

Department of Economics: Faculty Publications

Of the $240.7 billion donated to U.S. charities in 2003, 75 percent was from individuals. Of that total, $145.7 billion was taken as itemized deductions on federal income tax returns. In addition, non-itemizers and non-filers contributed $33.0 billion – contributions that received no special tax treatment. Under current law, only taxpayers who itemize may deduct from Adjusted Gross Income (AGI) their charitable donations in determining taxable income. In recent years, a number of different proposals have been put forth that would alter the tax treatment of giving by individuals. Some plans would extend a variant of the charitable deduction to …

Reef Foraminifera As Bioindicators Of Coral Reef Health: Low Isles Reef, Northern Great Barrier Reef, Australia, Jonathan D. Schueth, Tracy D. Frank

Department of Earth and Atmospheric Sciences: Faculty Publications

Declining water quality associated with changes in land use over the past century is considered a significant environmental threat to the health of coral platforms of the Great Barrier Reef, Australia, in particular for those situated in nearshore areas of the wet tropics. Of these reefs, perhaps the most well known is Low Isles Reef, which has been studied since 1928. Decline in scleractinian coral cover and increased abundances of soft-bodied corals and macroalgae since the 1950’s have led researchers to speculate that the reef is being affected by increased nutrient and sediment fluxes from nearby rivers. The Foraminifera in …

Corporate Social Responsibility For Solving The Housing Problem For The Poor In South Africa, Ayman Ahmed Ezzat Othman, Basheera Mia

Architectural Engineering

No abstract provided.

Incorporating Value And Risk Management Principles In Developing Low-Income Housing Projects, Ayman Ahmed Ezzat Othman

Architectural Engineering

The construction industry is concerned with satisfying its customers’ needs through delivering projects that achieve their objectives and meet their expectations on time, within budget and as specified. Despite the several housing programmes constructed by government authorities, there is a real housing problem for the poor. This problem is attributed to a number of reasons. Amongst them, the inability of the low-incomers to cover the cost of supplied houses and the lack of the constructed projects to achieve users’ satisfaction. This highlighted the need to develop innovative and creative solutions that can deliver housing projects that achieve the satisfaction of …

Contributions Of Ibn Al-Nafis 1210-1288 Ad To The Progress Of Medicine And Urology. A Study And Translations From His Medical Works, Rabie E. Abdel-Halim

Saudi Medical Journal

This primary-source study of 4 medical works of the 13th century Muslim scholar Ibn Al-Nafis confirmed that his Kitab Al-Mujaz Fi Al-Tibb was authored as an independent book meant to be a handbook for medical students and practitioners not as an epitome of Kitab Al-Qanun of Ibn Sina as thought by recent historians. His huge medical encyclopedia, Al-Shamil, represents a wave of intense scientific activity that spread among the scholars of Cairo and Damascus following the massive destruction of books by Hulako9s Army during the devastation of Baghdad in 1258. Like his predecessors in the Islamic Era, Ibn Al-Nafis critically …

Determination Of The Effects Of Extremely Low Frequency Electromagnetic Fields On The Percentages Of Peripheral Blood Leukocytes And Histology Of Lymphoid Organs Of The Mouse, Aynur E. Cicekcibasi, Ilhami Celik, Ahmet Salbacak, Yasemin Ozkan, Nilsel Okudan, Mustafa Buyukmumcu

Saudi Medical Journal

OBJECTIVE: To determine the effects of very weak, extremely low frequency (50 Hz) electromagnetic field (ELF-EMF) on the relative spleen weight, lymphoid organ histology, peripheral blood leukocyte and alpha-naphthyl acetate esterase positive (ANAE- positive) lymphocyte percentages of the mouse. METHODS: The study was carried out in Scientific Research and Application Center of Selcuk University, Konya, Turkey in 2005. A total of 120 Swiss albino mice were divided into 6 groups (20 in each group). The experimental animals were exposed to 1, 2, 3, 4 and 5 uT flux intensities (rms) of EMF at 50 Hz for 40 days. RESULTS: In …

Safety Profile Of Parenteral Ketamine And Lignocaine Infiltration In Pediatric Operations, David O. Osifo, Kennedy N. Emeagui, Sylvester E. Aghahowa

Saudi Medical Journal

OBJECTIVE: To study the safety and benefits of parenteral ketamine and lignocaine infiltration among pediatric surgical patients with co-morbidities that would preclude the use of general anesthesia requiring endotracheal intubation/face mask in a developing country. METHODS: This prospective study was undertaken at the Leadeks Medical Centre, Benin City Edo State, Nigeria between January 2002 and December 2006. Patients requiring surgery were safely operated even in the presence of co-morbidity. RESULTS: A total of 416 children were recruited and they were aged 6 days to 16 years (mean 12 -/+ 2.04 years) with a male/female ratio of 1:1.1. Appendectomy (33.2%), herniotomy …

Ileal-Conduit Following Cystectomy, Single-Institution Revision Of Indications And Outcome, Hassan A. Abol-Enein, Ausama S. Abdul-Muhsin, Yousuf M. Alhallaq

Saudi Medical Journal

OBJECTIVE: To revise indications, case fatality ratio, and postoperative early and late complications of ileal conduit as a method of urinary diversion. METHODS: This is a retrospective study in which 200 patients underwent an ileal conduit from August 1994 to December 2000 in Mansoura Urology and Nephrology Center, Mansoura, Egypt. Preoperative criteria of patient selection, peroperative findings, and postoperative follow-up data were reviewed. RESULTS: In 200 patients aged 29-75 years, with a mean age of 55.84 -/+ 8.91 years, the ileal conduit was chosen as a method of urinary diversion, due to one of the following patient or surgical factors; …

Evaluating The Trace Elements In Preoperative And Postoperative Duration Of Hydatid Surgery, Gurhan Sakman, Cem K. Parsak, Ismail S. Koltas, Gulsah Seydaoglu, Husnu Sonmez, Ismail Hanta

Saudi Medical Journal

OBJECTIVE: To evaluate the preoperative and postoperative values of serum levels of zinc, magnesium, and copper in patients with cystic echinococcosis (CE). METHODS: This study was conducted on patients with CE between 2000-2005 at the Faculty of Medicine, University of Cukurova, Adana, Turkey. Serum levels of zinc, copper, and magnesium of 85 patients with CE were measured both before and one year after the operation. Patients with liver CE (85 patients, 48 males) and healthy adults (40 adults, 17 males) as the control group were enrolled in the study. RESULTS: When compared with the control group, the mean serum levels …

Comparison Of The Clinical And Pathological Features Between Patients With Recurrent Metastatic Breast Carcinoma And Patients With Initially Metastatic Breast Carcinoma, Birsen K. Saydam, Gamze Goksel, Esra Korkmaz, Murat Kapkac, Necmettin Ozdemir, Canfeza Sezgin, Ruchan Uslu

Saudi Medical Journal

OBJECTIVE: To compare initial metastatic breast carcinoma (MBC) with recurrent MBC and assess their biologic phenotypes and clinical behaviors. METHODS: A comparison of clinical and biological characteristics and median overall survival times were assessed in the 251 patients with MBC at the Division of Medical Oncology, Ege University School of Medicine, and the Division of Radiation Oncology, Tepecik Government Hospital, Izmir, Turkey between 1995 and 2004. Hormone receptors, c-erbB-2, Ki-67, and p53 expressions were performed by immunohistochemistry. RESULTS: Out of 251 MBC patients, 206 patients had recurrent MBC, and 45 had initial MBC. Regarding survival, there was no difference between …

Characterization Of Rotavirus Strains Detected Among Children And Adults With Acute Gastroenteritis In Gizan, Saudi Arabia, Ali M. Kheyami, Mohammed Y. Areeshi, Winifred Dove, Osamu Nakagomi, Nigel A. Cunliffe, C. Anthony Hart

Saudi Medical Journal

OBJECTIVE: To assess the circulating rotavirus strains among hospitalized children and adults in Gizan City. METHODS: This cross-sectional study was based in 5 hospitals in the Gizan area. Stool samples were collected between November 2004 and March 2005, from sequential patients with acute, dehydrating diarrhea. Rotavirus antigen was detected in stool by enzyme-linked immunosorbent assay. The diversity of rotavirus strains was investigated using electropherotying and reverse transcription-polymerase chain reaction amplification of the VP7 and VP4 genes (G and P genotyping). RESULTS: Rotavirus was detected in 54 of 454 (12%) subjects. The ages of those infected with rotavirus ranged from 15 …

Quality Improvement Of Diabetes Care Using Flow Sheets In Family Health Practice, Maha M. Moharram, Fayssal M. Farahat

Saudi Medical Journal

OBJECTIVE: To show that the use of a flow sheet would improve performance of family physicians in diabetes care. METHODS: This is a one-year intervention study conducted in 7 family practice clinics in Taif Armed Forces Hospitals, Taif, Saudi Arabia from March 2006 to June 2007. Diabetic flow sheet was developed based on the clinical practice guidelines of Canada for the management of type 2 diabetes. Patients9 records were selected by systematic random sampling technique. RESULTS: Four hundred and fourteen medical records of patients with type 2 diabetes were included in the study. Compliance with the quality indicators was audited …

Factors Affecting Child Mortality In Saudi Arabia, Yagob Y. Al-Mazrou, Nasser A. Alhamdan, Abduelelah I. Alkotobi, Osman M. Nour, Mohamed A. Farag

Saudi Medical Journal

OBJECTIVE: To estimate levels and trends, gender differentials, effect of modes of living, regional differentials, and the effect of parental educational on infant and child mortality. METHODS: A nationwide stratified random sample was used to estimate levels, trends and differentials of infant and child mortality in Saudi Arabia. The study was executed during the period February 2006 to June 2006 and covered all the 20 health regions of Saudi Arabia. The randomly selected sample was limited to ever married Saudi women in the reproductive age group (15-49 years). RESULTS: The findings show a continuous and considerable infant and child mortality …

The Prevalence Of Malnutrition Among High And Low Altitude Preschool Children Of Southwestern Saudi Arabia, Fahaid H. Al-Hashem

Saudi Medical Journal

OBJECTIVE: To assess the current status of protein energy malnutrition (PEM) in the high and low altitude preschool children aged 12-71 months. METHODS: A cross-sectional study conducted during the year of 2003 and involved 572 and 469 preschool children of Southwestern Saudi Arabia born and living permanently at high and low altitude areas. Anthropometric measurements were carried out to assess the prevalence of PEM using 3 indicators such as underweight, wasting and stunting following World Health Organization standards. Prevalence differences were examined by age, gender, altitude, and parental socioeconomic status. RESULTS: The prevalence of the 3 types of PEM was …

Acceptance Of C-Flex Therapy In Patients With Obstructive Sleep Apnea Who Refused Auto-Continuous Positive Airway Pressure, Suhaila Al-Jawder, Ahmed Bahammam

Saudi Medical Journal

No abstract provided.

Spinal Cord Stimulation: An Update., Steven Falowski, Amanda Celii, Ashwini Sharan

Department of Neurosurgery Faculty Papers

Spinal cord stimulation has been used in the treatment of many chronic pain disorders since 1967. In this update, the indications for spinal cord stimulation are reviewed with attention to recent publications. A focused review of the literature on abdominal and visceral pain syndromes is also provided. Furthermore, the technology has evolved from the use of monopolar electrodes to complex electrode arrays. Similarly, the power source has changed from a radio frequency-driven system to a rechargeable impulse generator. These topics are covered, along with a short discussion of implant technique. Finally, we include a review of complications of such therapy. …

Technology Support For The Classroom: Technology Alternatives To The Traditional Classroom, Michael L. Gibson, Mari W. Buche, Jerry J. Waite

Journal of International Technology and Information Management

As technology continues to advance, instructors in higher education are able to enhance course instruction. Course support tools can be customized to meet the needs of the instructor, including file sharing, grade tracking, communicating, and making announcements. Blended learning advances course enhancements to include integrated solutions such as links to electronic textbooks and assignments. The most advanced use of technology for educational purposes is found in the distance learning format. This paper describes various uses of technology to support classroom instruction. Examples are provided.

A Quantitative Model For Crm Performance Evaluations, Sanjeev K. Bordoloi, Prabhu Aggarwal, Tom Tobin

Journal of International Technology and Information Management

This paper identifies important performance measurements for the operation of CRM units in the call center industry, and then uses Data Envelopment Analysis (DEA) to compare the performances of a selected set of call centers. The results provide several managerial insights that will assist CRM managers in effective decision making, especially in the areas of increasing efficiencies and improving customer service. Overall, this paper contributes towards managing resources and processes that would aid in the acquisition and support of information technology within a firm.

The Use Of Strategic Forces To Understand Competitive Advantages Provided By Information Technology, Gerald E. Evans, Clyde Neu

Journal of International Technology and Information Management

Porter’s Five Forces model of business strategy is foundational to understanding strategic forces and the role of information technology in the larger strategic framework of an organization. The authors describe how information technology changes the strength and/or influence of the competitive forces in Porter’s model. Furthermore, understanding how specific technologies potentially change specific forces within Porter’s model is the foundation of IT strategy. This theoretical framework of strategic alignment is developed through cases demonstrating how specific technologies change the strategic forces within specific industries and how organizations should take advantage of these changing forces. Empirical evidence for the validity of …

Migraine-Associated Vestibulopathy, Julie A. Honaker, Ravi N. Samy

Department of Special Education and Communication Disorders: Faculty Publications

Purpose of review: In the past few years, otologists have been seeing an increasing number of patients with vestibular disorders due to migraine- associated vestibulopathy. This article reviews some of the latest developments in the understanding of this disease process, specifically its incidence, symptoms, diagnosis, and treatment.
Recent findings: Migraine-associated vestibular symptoms may include episodic true vertigo, movement-provoked dysequilibrium, imbalance/unsteadiness, and complaints of lightheadedness. The pathophysiology of migraine-associated vestibulopathy is not completely understood; however, both peripheral and central deficits have been observed. Although the International Headache Society classification does not include migraine-associated vestibulopathy as a subclassification of migraine, there is …

Dimensionality Of Thoughts Of Death And Suicide: Evidence From A Study Of Homeless Adolescents, Kevin A. Yoder, Les B. Whitbeck, Dan R. Hoyt

Department of Sociology: Faculty Publications

This study used data from a sample of 444 homeless adolescents to determine whether thoughts of death and suicide form one construct (unidimensionality) or two distinct but correlated constructs (multi-dimensionality). Thoughts of death and suicide were common in the sample; over two-thirds of the adolescents positively endorsed at least one of the eight death-or suicide-related items. Evidence regarding dimensionality was mixed. Exploratory factor analysis results and similarity coefficients supported one construct; confirmatory factor analysis and external consistency results provided evidence for two constructs. The results were reconciled by considering suicidality as a continuum from thoughts of death to suicidal ideation, …

Nitrated Alpha-Synuclein-Activated Microglial Profiling For Parkinson’S Disease, Ashley D. Reynolds, Jason G. Glanzer, Irena Kadiu, Mary Ricardo-Dukelow, Anathbandhu Chaudhuri, Pawel Ciborowski, Ronald Cerny, Benjamin Gelman, Mark P. Thomas, R. Lee Mosley, Howard E. Gendelman

Ronald Cerny Publications

(PD). This can occur, in part, by modulation of glial function following activation by soluble or insoluble modified alphasynuclein (α-syn), a chief component of Lewy bodies that is released from affected dopaminergic neurons. α-Syn is nitrated during oxidative stress responses and in its aggregated form, induces inflammatory microglial functions. Elucidation of these microglial function changes in PD could lead to new insights into disease mechanisms. To this end, PD-associated inflammation was modeled by stimulation of microglia with aggregated and nitrated α-syn. These activated microglia were ameboid in morphology and elicited dopaminergic neurotoxicity. A profile of nitrated, aggregated α-syn-stimulated microglia was …

Fumonisin Level In Corn-Based Food And Feed From Linxian County, A High-Risk Area For Esophageal Cancer In China, Jiansheng Wang, Ying Zhou, Wanbo Liu, Xiangcheng Zhu, Liangcheng Du, Qiaomei Wang

Liangcheng Du Publications

The level of mycotoxin fumonisins in corn-based food and feed collected from Linxian County, a high-risk area for esophageal cancer in China, has been analyzed using high-performance liquid chromatographic coupled with evaporative laser scattering detector (HPLC-ELSD). A total of 104 corn kernel samples were obtained from local households, granaries, wholesale markets (central markets), and retail markets (stores and supermarkets). Fumonisin B1 (FB1) was detected in the samples from households, granaries, central markets, and stores, with a positive rate of 61.5%, 50%, 33.3%, and 17%, respectively. No fumonisin was detected in samples from the supermarket. The highest FB1 levels (0.30–3.20 μg/ …

Mechanisms Of Hemoglobin Adaptation To High Altitude Hypoxia, Jay F. Storz, Hideaki Moriyama

Hideaki Moriyama Publications

Evidence from a number of vertebrate taxa suggests that modifications of hemoglobin (Hb) function may often play a key role in mediating an adaptive response to high altitude hypoxia. The respiratory functions of Hb are a product of the protein’s intrinsic O₂-binding affinity and its interactions with allosteric effectors such as protons, chloride ions, CO₂, and organic phosphates. Here we review several case studies involving high altitude vertebrates where it has been possible to identify specific mechanisms of Hb adaptation to hypoxia. In addition to comparative studies of Hbs from diverse animal species, functional studies of …

Mechanisms Of Hemoglobin Adaptation To High Altitude Hypoxia, Jay F. Storz, Hideaki Moriyama

Hideaki Moriyama Publications

Evidence from a number of vertebrate taxa suggests that modifications of hemoglobin (Hb) function may often play a key role in mediating an adaptive response to high altitude hypoxia. The respiratory functions of Hb are a product of the protein’s intrinsic O₂-binding affinity and its interactions with allosteric effectors such as protons, chloride ions, CO₂, and organic phosphates. Here we review several case studies involving high altitude vertebrates where it has been possible to identify specific mechanisms of Hb adaptation to hypoxia. In addition to comparative studies of Hbs from diverse animal species, functional studies of …

Endogenous And Exogenous Control Of Ecosystem Function: N Cycling In Headwater Streams, H. M. Valett, S. A. Thomas, P. J. Mulholland, J. R. Webster, C. N. Dahm, C. S. Fellows, C. L. Crenshaw, C. G. Peterson

School of Biological Sciences: Faculty Publications

Allochthonous inputs act as resource subsidies to many ecosystems, where they exert strong influences on metabolism and material cycling. At the same time, metabolic theory proposes endogenous thermal control independent of resource supply. To address the relative importance of exogenous and endogenous influences, we quantified spatial and temporal variation in ecosystem metabolism and nitrogen (N) uptake using seasonal releases of ¹⁵N as nitrate in six streams differing in riparian–stream interaction and metabolic character. Nitrate removal was quantified using a nutrient spiraling approach based on measurements of downstream decline in ¹⁵N flux. Respiration (R) and gross primary production (GPP) …